{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:22:59Z","timestamp":1790169779068,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","award":["GEENA-Q-19-595850"],"award-info":[{"award-number":["GEENA-Q-19-595850"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007333","name":"Alzheimer&apos;s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["115009"],"award-info":[{"award-number":["115009"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neurobiolaging.2019.12.019","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T11:19:44Z","timestamp":1577704784000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["CSF cutoffs for MCI due to AD depend on APOE\u03b54 carrier status"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-2988","authenticated-orcid":false,"given":"Moira","family":"Marizzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-9839","authenticated-orcid":false,"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-6723","authenticated-orcid":false,"given":"Diego","family":"Albani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libera","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Didic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Galluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Hensch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-7503","authenticated-orcid":false,"given":"Jorge","family":"Jovicich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-0897","authenticated-orcid":false,"given":"Flavio","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-102X","authenticated-orcid":false,"given":"Jean-Philippe","family":"Ranjeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ribaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rolandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Maria","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Soricelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-9727","authenticated-orcid":false,"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5330","authenticated-orcid":false,"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill C.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Blin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-7082","authenticated-orcid":false,"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Sex modifies the APOE-related risk of developing Alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib3","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1523\/JNEUROSCI.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2217\/bmm.12.49","article-title":"Determining cut-points for Alzheimer\u2019s disease biomarkers: statistical issues, methods and challenges","volume":"6","author":"Bartlett","year":"2012","journal-title":"Biomark. Med."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13195-016-0233-7","article-title":"Unbiased estimates of cerebrospinal fluid beta-amyloid 1-42 cutoffs in a large memory clinic population","volume":"9","author":"Bertens","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib6","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/nm.3365","article-title":"Semagacestat\u2019s fall: where next for AD therapies?","volume":"19","author":"Blennow","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib7","doi-asserted-by":"crossref","first-page":"e940","DOI":"10.1212\/WNL.0000000000005124","article-title":"Tau-negative amnestic dementia masquerading as Alzheimer disease dementia","volume":"90","author":"Botha","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/biof.1002","article-title":"Ascorbic acid, cognitive function, and Alzheimer\u2019s disease: a current review and future direction","volume":"38","author":"Bowman","year":"2012","journal-title":"Biofactors"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer\u2019s disease: pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archgenpsychiatry.2011.155","article-title":"Cerebrospinal fluid levels of \u03b2-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia","volume":"69","author":"Buchhave","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00265-010-1029-6","article-title":"AIC model selection and multimodel inference in behavioral ecology: some background, observations, and comparisons","volume":"65","author":"Burnham","year":"2011","journal-title":"Behav. Ecol. Sociobiol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib12","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1523\/JNEUROSCI.22-24-10539.2002","article-title":"Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation","volume":"22","author":"Buttini","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2896","article-title":"Alzheimer\u2019s disease: strategies for disease modification","volume":"9","author":"Citron","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.2010.2008","article-title":"Use of florbetapir-PET for imaging beta-amyloid pathology","volume":"305","author":"Clark","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/archneurol.2010.179","article-title":"Diagnosis-independent alzheimer disease biomarker signature in cognitively normal elderly people","volume":"67","author":"De Meyer","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib16","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer\u2019s disease: the IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jalz.2013.12.023","article-title":"The cerebrospinal fluid \u201calzheimer profile\u201d: easily said, but what does it mean?","volume":"10","author":"Duits","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib18","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/joim.12482","article-title":"Clinical and biomarker profiling of prodromal Alzheimer\u2019s disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a \u201cEuropean ADNI study","volume":"279","author":"Galluzzi","year":"2016","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/1531-8249(200009)48:3<297::AID-ANA3>3.0.CO;2-Z","article-title":"Mitochondrial damage in Alzheimer\u2019s disease varies with apolipoprotein E genotype","volume":"48","author":"Gibson","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib20","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1212\/WNL.47.2.444","article-title":"Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer\u2019s disease","volume":"47","author":"Growdon","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib21","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3174\/ajnr.A3601","article-title":"Higher rates of decline for women and apolipoprotein E epsilon4 carriers","volume":"34","author":"Holland","year":"2013","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib22","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1073\/pnas.151254698","article-title":"Apolipoprotein E fragments present in Alzheimer\u2019s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons","volume":"98","author":"Huang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib25","doi-asserted-by":"crossref","first-page":"21821","DOI":"10.1074\/jbc.M112109200","article-title":"Apolipoprotein E4 potentiates amyloid \u03b2 peptide-induced lysosomal leakage and apoptosis in neuronal cells","volume":"277","author":"Ji","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of A\u03b2","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/archneur.63.5.674","article-title":"Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia","volume":"63","author":"Jicha","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1056\/NEJMe1313943","article-title":"Antiamyloid therapy for alzheimer\u2019s disease \u2014 are we on the right road?","volume":"370","author":"Karran","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3233\/JAD-2009-0999","article-title":"CSF biomarkers in alzheimer\u2019s disease and controls: associations with apoe genotype are modified by age","volume":"16","author":"Kester","year":"2009","journal-title":"J.\u00a0Alzheimer\u2019s Dis."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib30","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ana.21696","article-title":"Apolipoprotein E-dependent accumulation of alzheimer disease-related lesions begins in middle age","volume":"65","author":"Kok","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib31","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1001\/jamapsychiatry.2014.1060","article-title":"Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for alzheimer disease","volume":"71","author":"Lautner","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2014.09.003","article-title":"Can we rely only on ratios of cerebrospinal fluid biomarkers for AD biological diagnosis?","author":"Lehmann","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib33","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1212\/WNL.0b013e318295d6cf","article-title":"Application of the national institute on aging-alzheimer\u2019s association AD criteria to ADNI","volume":"80","author":"Lowe","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jalz.2011.05.2243","article-title":"The Alzheimer\u2019s Association external quality control program for cerebrospinal fluid biomarkers","volume":"7","author":"Mattsson","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/jama.2009.1064","article-title":"CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment","volume":"302","author":"Mattsson","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib36","series-title":"Tutorials in Biostatistics, Statistical Methods in Clinical Studies","first-page":"187","article-title":"Prognostic variables: categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments","author":"Mazumdar","year":"2005"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib37","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1212\/01.wnl.0000224698.67660.45","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"66","author":"Mckeith","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging- Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib39","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1001\/archneur.58.11.1803","article-title":"Clinical and pathological diagnosis of frontotemporal dementia: report of the work group on frontotemporal dementia and pick\u2019s disease","volume":"58","author":"McKhann","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib40","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1212\/WNL.0000000000001991","article-title":"Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease","volume":"85","author":"Palmqvist","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib41","first-page":"409","article-title":"R: a language and environment for statistical computing","volume":"1","year":"2015","journal-title":"R.\u00a0Found. Stat. Comput."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib42","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/archneurol.2012.277","article-title":"Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype","volume":"69","author":"Ringman","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnagi.2013.00011","article-title":"The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)","volume":"5","author":"Risacher","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa1304839","article-title":"Two phase 3 trials of bapineuzumab in mild-to-moderate alzheimer\u2019s disease","volume":"370","author":"Salloway","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib45","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in alzheimer\u2019s disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib47","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib48","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.biopsych.2004.07.021","article-title":"Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer\u2019s disease: the effect of APOE epsilon4 allele","volume":"56","author":"Sunderland","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib49","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/ana.21953","article-title":"Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease","volume":"67","author":"Vemuri","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-2012-120082","article-title":"Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer\u2019s disease","volume":"31","author":"Wang","year":"2012","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.12.019_bib51","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1037\/1040-3590.7.4.445","article-title":"Wechsler memory Scale - revised","volume":"7","author":"Woodard","year":"1987","journal-title":"Psychol. Assess."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019304488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019304488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:32:11Z","timestamp":1759318331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458019304488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":51,"alternative-id":["S0197458019304488"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.12.019","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSF cutoffs for MCI due to AD depend on APOE\u03b54 carrier status","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}