{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:44:28Z","timestamp":1780580668230,"version":"3.54.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002631","name":"Gachon University","doi-asserted-by":"publisher","award":["2018-0682"],"award-info":[{"award-number":["2018-0682"]}],"id":[{"id":"10.13039\/501100002631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1A2B5B01002463"],"award-info":[{"award-number":["NRF-2020R1A2B5B01002463"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neurobiolaging.2020.06.020","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T11:20:25Z","timestamp":1593688825000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The influence of A\u03b2-dependent and independent pathways on TDP-43 proteinopathy in Alzheimer\u2019s disease: a possible connection to LATE-NC"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-8386","authenticated-orcid":false,"given":"Angelo","family":"Jamerlan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soo A.","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1212\/WNL.54.4.843","article-title":"Pure hippocampal sclerosis. A rare cause Demen. mimicking Alzheimer\u2019s Disease","volume":"54","author":"Ala","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","article-title":"Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules","volume":"2","author":"Alonso","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-006-0183-4","article-title":"Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration","volume":"113","author":"Amador-Ortiz","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ana.21154","article-title":"TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease","volume":"61","author":"Amador-Ortiz","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib5","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0140-6736(17)32399-1","article-title":"Why do so many clinical trials of therapies for Alzheimer's disease fail?","volume":"390","author":"Anderson","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00401-008-0480-1","article-title":"Phosphorylated TDP-43 in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"117","author":"Arai","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jmb.2005.02.038","article-title":"Human, Drosophila, and C. elegans TDP43: nucleic acid binding properties and splicing regulatory function","volume":"348","author":"Ayala","year":"2005","journal-title":"J.\u00a0Mol. Biol."},{"issue":"Pt 22","key":"10.1016\/j.neurobiolaging.2020.06.020_bib8","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1242\/jcs.038950","article-title":"Structural determinants of the cellular localization and shuttling of TDP-43","volume":"121","author":"Ayala","year":"2008","journal-title":"J.\u00a0Cel. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib9","first-page":"804","article-title":"Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline","volume":"140","author":"Boyle","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib10","doi-asserted-by":"crossref","first-page":"19958","DOI":"10.1074\/jbc.M110.194852","article-title":"Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast","volume":"286","author":"Braun","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3233\/JAD-2010-100198","article-title":"Contribution of TARDBP to Alzheimer's disease genetic etiology","volume":"21","author":"Brouwers","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib12","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing","volume":"280","author":"Buratti","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1750-1326-5-51","article-title":"Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Abeta oligomers accumulation","volume":"5","author":"Caccamo","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","article-title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration","volume":"114","author":"Cairns","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib15","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1007\/s12035-015-9264-5","article-title":"The role of TDP-43 in Alzheimer's disease","volume":"53","author":"Chang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib16","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1096\/fj.10-174482","article-title":"Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing","volume":"25","author":"Che","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib17","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/s41374-019-0196-y","article-title":"Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy","volume":"99","author":"Chornenkyy","year":"2019","journal-title":"Lab. Invest."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00401-011-0879-y","article-title":"TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype","volume":"122","author":"Davidson","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF00293396","article-title":"Hippocampal sclerosis: a common pathological feature of dementia in very old (> or\u00a0= 80 years of age) humans","volume":"88","author":"Dickson","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s004060050101","article-title":"Clinical features of Alzheimer\u2019s disease","volume":"249","author":"F\u00f6rstl","year":"1999","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib21","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1630428100","article-title":"Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease","volume":"100","author":"Gamblin","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib22","doi-asserted-by":"crossref","first-page":"e1002140","DOI":"10.1371\/journal.pbio.1002140","article-title":"The RCSB PDB \u201cmolecule of the month\u201d: inspiring a molecular view of biology","volume":"13","author":"Goodsell","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib23","doi-asserted-by":"crossref","DOI":"10.2174\/1567205016666190517121140","article-title":"Biomarkers for Alzheimer\u2019s disease","author":"Guzman-Martinez","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2011.02.052","article-title":"Beta-amyloid triggers ALS-associated TDP-43 pathology in AD models","volume":"1386","author":"Herman","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.expneurol.2012.02.011","article-title":"Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models","volume":"235","author":"Herman","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib28","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M809462200","article-title":"Expression of TDP-43 C-terminal fragments in\u00a0vitro recapitulates pathological features of TDP-43 proteinopathies","volume":"284","author":"Igaz","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1212\/WNL.55.5.735-d","article-title":"Pure hippocampal sclerosis: a rare cause of dementia mimicking Alzheimer's disease","volume":"55","author":"Jellinger","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1750-3639.1998.tb00160.x","article-title":"Senile dementia with tangles (tangle predominant form of senile dementia)","volume":"8","author":"Jellinger","year":"1998","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib31","doi-asserted-by":"crossref","first-page":"20329","DOI":"10.1074\/jbc.M109.010264","article-title":"TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity","volume":"284","author":"Johnson","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00401-018-1951-7","article-title":"Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains","volume":"137","author":"Josephs","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib33","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-016-1537-1","article-title":"Updated TDP-43 in Alzheimer's disease staging scheme","volume":"131","author":"Josephs","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-010-0659-0","article-title":"Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis","volume":"119","author":"Kraemer","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib35","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/nar\/gkp013","article-title":"Structural insights into TDP-43 in nucleic-acid binding and domain interactions","volume":"37","author":"Kuo","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"Lewis","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib37","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/archneurol.2009.277","article-title":"Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome","volume":"66","author":"Lippa","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/WAD.0b013e318199fc7a","article-title":"Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases","volume":"23","author":"Longstreth","year":"2009","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib39","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1474-4422(10)70195-2","article-title":"TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"9","author":"Mackenzie","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1755-5949.2010.00177.x","article-title":"The role of tau in Alzheimer's disease and related disorders","volume":"17","author":"Medeiros","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0892-345","article-title":"A\u00a0pathogenic mutation for probable Alzheimer's disease in the APP gene at the N\u2013terminus of \u03b2\u2013amyloid","volume":"1","author":"Mullan","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neurobiolaging.2013.08.007","article-title":"A\u00a02-process model for neuropathology of Alzheimer's disease","volume":"35","author":"Mungas","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jre.12227","article-title":"Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-alpha expression upon lipopolysaccharide stimulation in human monocytes","volume":"50","author":"Murata","year":"2015","journal-title":"J.\u00a0Periodont. Res."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib44","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00401-014-1302-2","article-title":"Differential clinicopathologic and genetic features of late-onset amnestic dementias","volume":"128","author":"Murray","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00401-011-0907-y","article-title":"Clinical and neuropathologic heterogeneity of c9FTD\/ALS associated with hexanucleotide repeat expansion in C9ORF72","volume":"122","author":"Murray","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40478-018-0531-3","article-title":"TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease","volume":"6","author":"Nag","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib47","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/NEN.0b013e3181aacbe9","article-title":"Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease","volume":"68","author":"Nelson","year":"2009","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib48","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1750-3639.2008.00244.x","article-title":"Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons","volume":"20","author":"Nelson","year":"2010","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib49","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2020.06.020_bib50","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/brain\/awn146","article-title":"Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database","volume":"131","author":"Nestor","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib51","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib52","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1074\/jbc.M115.695379","article-title":"Phosphorylation of TAR DNA-binding protein of 43 kDa (TDP-43) by truncated casein kinase 1delta triggers mislocalization and accumulation of TDP-43","volume":"291","author":"Nonaka","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib53","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2007.04607.x","article-title":"Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice","volume":"102","author":"Oddo","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib54","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/jvi.69.6.3584-3596.1995","article-title":"Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs","volume":"69","author":"Ou","year":"1995","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/254954","article-title":"Genetics of Alzheimer's disease","volume":"2013","author":"Ridge","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib56","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib57","first-page":"1040","article-title":"The dynamics of cortical and hippocampal atrophy in Alzheimer disease","volume":"68","author":"Sabuncu","year":"2011","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000369101","article-title":"Amyloid-beta: a crucial factor in Alzheimer's disease","volume":"24","author":"Sadigh-Eteghad","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(18)31896-8","article-title":"Unsuccessful trials of therapies for Alzheimer's disease","volume":"393","author":"Schott","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib60","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib61","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2007.08.003","article-title":"Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning","volume":"186","author":"Senechal","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib62","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1074\/jbc.M109.061846","article-title":"TDP-43 is a developmentally regulated protein essential for early embryonic development","volume":"285","author":"Sephton","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/bpa.12505","article-title":"Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi","volume":"28","author":"Smith","year":"2018","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib64","first-page":"a44","article-title":"Significance of intracellular Abeta42 accumulation in Alzheimer's disease","volume":"7","author":"Tabira","year":"2002","journal-title":"Front. Biosci"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib65","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neurobiolaging.2014.09.001","article-title":"Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism","volume":"36","author":"Vanden Broeck","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib66","first-page":"147","article-title":"TDP-43 in aging and Alzheimer's disease\u2014a review","volume":"4","author":"Wilson","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib67","series-title":"Doctor Diagnoses Her Own Dementia","year":"2018"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib68","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1074\/jbc.M109.069542","article-title":"Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation","volume":"285","author":"Wu","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib69","doi-asserted-by":"crossref","first-page":"e15878","DOI":"10.1371\/journal.pone.0015878","article-title":"The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib70","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.expneurol.2012.05.018","article-title":"TDP-43: a new player on the AD field?","volume":"237","author":"Youmans","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib71","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/brb3.66","article-title":"Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample","volume":"2","author":"Zarow","year":"2012","journal-title":"Brain Behav."},{"key":"10.1016\/j.neurobiolaging.2020.06.020_bib72","doi-asserted-by":"crossref","first-page":"150","DOI":"10.15698\/cst2018.07.143","article-title":"Alzheimer's disease: amyloid-based pathogenesis and potential therapies","volume":"2","author":"Zhou","year":"2018","journal-title":"Cell stress"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802030213X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802030213X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:49:42Z","timestamp":1777528182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802030213X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":72,"alternative-id":["S019745802030213X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.06.020","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of A\u03b2-dependent and independent pathways on TDP-43 proteinopathy in Alzheimer\u2019s disease: a possible connection to LATE-NC","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}