{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:23:28Z","timestamp":1776396208595,"version":"3.51.2"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neurobiolaging.2020.07.031","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T02:09:01Z","timestamp":1596506941000},"page":"250-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis"],"prefix":"10.1016","volume":"95","author":[{"given":"Mei","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarivin","family":"Vanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Tao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook-Yoong","family":"Chia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Eun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Hua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-2286","authenticated-orcid":false,"given":"Li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib1","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.1607079113","article-title":"FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice","volume":"113","author":"Ahlenius","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib2","doi-asserted-by":"crossref","first-page":"e1008097","DOI":"10.1371\/journal.pgen.1008097","article-title":"FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells","volume":"15","author":"Audesse","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.neuron.2016.12.017","article-title":"Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis","volume":"93","author":"Beckervordersandforth","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib4","doi-asserted-by":"crossref","first-page":"41443","DOI":"10.1074\/jbc.M110.141390","article-title":"The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a \u03b2-secretase-dependent pathway","volume":"285","author":"Belyaev","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neubiorev.2017.04.030","article-title":"The effects of aging in the hippocampus and cognitive decline","volume":"79","author":"Bettio","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000116984","article-title":"Staging of Alzheimer-related cortical destruction","volume":"33","author":"Braak","year":"1993","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1176\/appi.ajp.161.4.598","article-title":"Lower hippocampal volume in patients suffering from depression: a meta-analysis","volume":"161","author":"Campbell","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A\u00a0transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib9","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1016\/j.cub.2007.01.008","article-title":"FOXO transcription factors","volume":"17","author":"Carter","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib10","first-page":"120","article-title":"Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model","volume":"18","author":"Cawthorne","year":"2007","journal-title":"J.\u00a0Biomol. Tech."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib11","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0067-18.2018","article-title":"BACE1 regulates proliferation and neuronal differentiation of newborn cells in the adult hippocampus in mice","volume":"5","author":"Chatila","year":"2018","journal-title":"eneuro"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib12","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1080\/15548627.2017.1363950","article-title":"Presenilins at the crossroad of a functional interplay between PARK2\/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases","volume":"13","author":"Checler","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib13","doi-asserted-by":"crossref","first-page":"eaam6790","DOI":"10.1126\/scisignal.aam6790","article-title":"Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson\u2019s disease","volume":"10","author":"Chen","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib14","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s12035-018-1167-9","article-title":"Neuronal and glial differentiation of human neural stem cells is regulated by Amyloid Precursor Protein (APP) levels","volume":"56","author":"Coronel","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1046\/j.1471-4159.2001.00516.x","article-title":"The amyloid precursor protein (APP)-cytoplasmic fragment generated by \u03b3-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture","volume":"78","author":"Cupers","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib16","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2007.07.010","article-title":"Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain","volume":"130","author":"Duan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib17","doi-asserted-by":"crossref","first-page":"13389","DOI":"10.1074\/jbc.M111571200","article-title":"Insulin-degrading enzyme rapidly removes the \u03b2-amyloid precursor protein intracellular domain (AICD)","volume":"277","author":"Edbauer","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib18","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid \u03b2-protein, and the \u03b2-amyloid precursor protein intracellular domain in\u00a0vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib19","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1073\/pnas.0604066103","article-title":"Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells","volume":"103","author":"Fish","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib20","doi-asserted-by":"crossref","first-page":"e0159435","DOI":"10.1371\/journal.pone.0159435","article-title":"Tau protein mediates APP intracellular domain (AICD)-induced Alzheimer\u2019s-like pathological features in mice","volume":"11","author":"Ghosal","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib21","doi-asserted-by":"crossref","first-page":"e11866","DOI":"10.1371\/journal.pone.0011866","article-title":"APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation","volume":"5","author":"Ghosal","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib22","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.1073\/pnas.0907652106","article-title":"Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain","volume":"106","author":"Ghosal","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib23","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.biopsych.2017.04.011","article-title":"\u03b2-Amyloid precursor protein intracellular domain controls mitochondrial function by modulating phosphatase and tensin homolog\u2013induced kinase 1 transcription in cells and in Alzheimer mice models","volume":"83","author":"Goiran","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","article-title":"Adult neurogenesis in the hippocampus: from stem cells to behavior","volume":"167","author":"Gon\u00e7alves","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.60.5.753","article-title":"Depression as a risk factor for Alzheimer disease: the MIRAGE Study","volume":"60","author":"Green","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer's disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib27","doi-asserted-by":"crossref","first-page":"a019026","DOI":"10.1101\/cshperspect.a019026","article-title":"Adult neurogenesis and psychiatric disorders","volume":"8","author":"Kang","year":"2016","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib28","doi-asserted-by":"crossref","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib29","doi-asserted-by":"crossref","first-page":"40288","DOI":"10.1074\/jbc.C100447200","article-title":"The intracellular domain of the \u03b2-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner","volume":"276","author":"Kimberly","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib30","first-page":"121","article-title":"Intracellular domain generation of amyloid precursor protein by \u03b5-cleavage depends on C-terminal fragment by \u03b1-secretase cleavage","volume":"13","author":"Kume","year":"2004","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib31","doi-asserted-by":"crossref","first-page":"e1002270","DOI":"10.1371\/journal.pmed.1002270","article-title":"APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: a genetic screening study of familial and sporadic cases","volume":"14","author":"Lanoisel\u00e9e","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3233\/JAD-170393","article-title":"Increased Foxo3a nuclear translocation and activity is an early neuronal response to \u03b2\u03b3-secretase-mediated processing of the amyloid-\u03b2 protein precursor: utility of an A\u03b2PP-GAL4 reporter assay","volume":"61","author":"Law","year":"2018","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fnins.2012.00081","article-title":"All in the family: how the APPs regulate neurogenesis","volume":"6","author":"Lazarov","year":"2012","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pneurobio.2008.05.002","article-title":"The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics\u2014relevance for Alzheimer's disease","volume":"85","author":"M\u00fcller","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/cam.2.1.5790","article-title":"A\u00a0TAG on to the neurogenic functions of APP","volume":"2","author":"Ma","year":"2008","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ncb1690","article-title":"A\u00a0TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis","volume":"10","author":"Ma","year":"2008","journal-title":"Nat. Cel. Biol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainresbull.2018.09.002","article-title":"Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise","volume":"143","author":"Micheli","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2007.02.001","article-title":"Foxo3a is essential for maintenance of the hematopoietic stem cell pool","volume":"1","author":"Miyamoto","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1159\/000375235","article-title":"FOXO3: a major gene for human longevity-a mini-review","volume":"61","author":"Morris","year":"2015","journal-title":"Gerontology"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegen."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib41","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/(SICI)1097-4695(19990615)39:4<569::AID-NEU10>3.0.CO;2-F","article-title":"Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory","volume":"39","author":"Nilsson","year":"1999","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.10646","article-title":"Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease \u03b2-amyloid protein precursor: effect of C-terminal truncation on production of \u03b2-amyloid protein","volume":"74","author":"Nunan","year":"2003","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","article-title":"FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis","volume":"5","author":"Paik","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib44","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1073\/pnas.85.21.8266","article-title":"Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21","volume":"85","author":"Patterson","year":"1988","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib45","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.stem.2009.09.014","article-title":"FoxO3 regulates neural stem cell homeostasis","volume":"5","author":"Renault","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.abb.2012.07.017","article-title":"FoxOs in neural stem cell fate decision","volume":"534","author":"Ro","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1083\/jcb.200505078","article-title":"Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain","volume":"171","author":"Ryan","year":"2005","journal-title":"J.\u00a0Cell Biol"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib48","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression","volume":"10","author":"Sahay","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib49","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib50","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.neuron.2018.08.017","article-title":"FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis","volume":"99","author":"Sch\u00e4ffner","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib51","doi-asserted-by":"crossref","first-page":"44195","DOI":"10.1074\/jbc.M208110200","article-title":"Processing of \u03b2-amyloid precursor-like protein-1 and-2 by \u03b3-secretase regulates transcription","volume":"277","author":"Scheinfeld","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib52","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.biopsych.2017.05.013","article-title":"Stress and loss of adult neurogenesis differentially reduce hippocampal volume","volume":"82","author":"Schoenfeld","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer's disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib54","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/35066584","article-title":"Neurogenesis in the adult is involved in the formation of trace memories","volume":"410","author":"Shors","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib55","doi-asserted-by":"crossref","first-page":"e1651","DOI":"10.1038\/cddis.2015.10","article-title":"APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation","volume":"6","author":"Shu","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib56","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/1566523216666160524144041","article-title":"Tet-On systems for doxycycline-inducible gene expression","volume":"16","author":"T Das","year":"2016","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib57","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuroscience.2008.10.048","article-title":"Intracranial self-stimulation enhances neurogenesis in hippocampus of adult mice and rats","volume":"158","author":"Takahashi","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib58","doi-asserted-by":"crossref","first-page":"29615","DOI":"10.1074\/jbc.R800019200","article-title":"Amyloid precursor protein trafficking, processing, and function","volume":"283","author":"Thinakaran","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib59","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression: a meta-analysis of MRI studies","volume":"161","author":"Videbech","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib60","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.neurobiolaging.2009.09.002","article-title":"Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain","volume":"32","author":"Vogt","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib61","doi-asserted-by":"crossref","first-page":"e1233","DOI":"10.1038\/cddis.2014.196","article-title":"FoxO mediates APP-induced AICD-dependent cell death","volume":"5","author":"Wang","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib62","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/acel.12479","article-title":"Characterization of the direct targets of FOXO transcription factors throughout evolution","volume":"15","author":"Webb","year":"2016","journal-title":"Aging cell"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib63","doi-asserted-by":"crossref","first-page":"13987","DOI":"10.1073\/pnas.0801030105","article-title":"FOXO3A genotype is strongly associated with human longevity","volume":"105","author":"Willcox","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib64","doi-asserted-by":"crossref","first-page":"e11324","DOI":"10.7554\/eLife.11324","article-title":"MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex","volume":"5","author":"Zhang","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib65","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1038\/ncomms4330","article-title":"Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2020.07.031_bib66","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/bi027117f","article-title":"The transcriptional activity of the APP intracellular Domain\u2212 Fe65 complex is inhibited by activation of the NF-\u03baB pathway","volume":"42","author":"Zhao","year":"2003","journal-title":"Biochemistry"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458020302487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458020302487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:37:58Z","timestamp":1759318678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458020302487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":66,"alternative-id":["S0197458020302487"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.07.031","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}