{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:52:17Z","timestamp":1793674337692,"version":"4.5.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004218","name":"Patrick Berthoud Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.neurobiolaging.2020.11.006","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T08:54:38Z","timestamp":1605344078000},"page":"172-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography"],"prefix":"10.1016","volume":"101","author":[{"given":"Elijah","family":"Mak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Nicastro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Savulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-1545","authenticated-orcid":false,"given":"Ajenthan","family":"Surendranathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-0882","authenticated-orcid":false,"given":"Negin","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-0615","authenticated-orcid":false,"given":"Luca","family":"Passamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Simon","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young T.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-6654","authenticated-orcid":false,"given":"Guy B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Aigbirhio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib2","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/brain\/awaa033","article-title":"Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum","volume":"143","author":"Bevan-Jones","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib3","doi-asserted-by":"crossref","first-page":"e013187","DOI":"10.1136\/bmjopen-2016-013187","article-title":"Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses","volume":"7","author":"Bevan-Jones","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of tau pathology by the microglial fractalkine receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/brain\/awn298","article-title":"Medial temporal lobe atrophy on MRI differentiates Alzheimer\u2019s disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis","volume":"132","author":"Burton","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.neurobiolaging.2010.12.015","article-title":"Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia","volume":"33","author":"Burton","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nicl.2013.02.006","article-title":"Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer\u2019s disease","volume":"2","author":"Chetelat","year":"2013","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1097\/NEN.0000000000000018","article-title":"Confluence of alpha-synuclein, tau, and beta-amyloid pathologies in dementia with Lewy bodies","volume":"72","author":"Colom-Cadena","year":"2013","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ana.25392","article-title":"Cognitive and pathological influences of tau pathology in Lewy body disorders","volume":"85","author":"Coughlin","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/mds.27867","article-title":"Pathological influences on clinical heterogeneity in Lewy body diseases","volume":"35","author":"Coughlin","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neurobiolaging.2020.08.003","article-title":"Multimodal in\u00a0vivo and postmortem assessments of tau in Lewy body disorders","volume":"96","author":"Coughlin","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jagp.2013.03.001","article-title":"Amyloid PET imaging in Lewy body disorders","volume":"23","author":"Donaghy","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib13","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1136\/jnnp.2007.127878","article-title":"Amyloid load in Parkinson\u2019s disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography","volume":"79","author":"Edison","year":"2008","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S1481803500013336","article-title":"Understanding receiver operating characteristic (ROC) curves","volume":"8","author":"Fan","year":"2005","journal-title":"Can. J. Emerg. Med."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib15","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3233\/JAD-2010-100138","article-title":"High resolution imaging of the medial temporal lobe in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"21","author":"Firbank","year":"2010","journal-title":"J.\u00a0Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroimage.2015.03.005","article-title":"Fast and powerful heritability inference for family-based neuroimaging studies","volume":"115","author":"Ganjgahi","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib17","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1002\/mds.22341","article-title":"The unified dyskinesia rating scale: presentation and clinimetric profile","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib18","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/jamaneurol.2016.3338","article-title":"Tau positron emission tomographic imaging in the Lewy body diseases","volume":"73","author":"Gomperts","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/mds.25048","article-title":"Brain amyloid and cognition in Lewy body diseases","volume":"27","author":"Gomperts","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1212\/01.wnl.0000326146.60732.d6","article-title":"Imaging amyloid deposition in Lewy body diseases","volume":"71","author":"Gomperts","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/nimg.1997.0303","article-title":"Parametric imaging of ligand-receptor binding in PET using a simplified reference region model","volume":"6","author":"Gunn","year":"1997","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.arr.2017.03.002","article-title":"In\u00a0vivo tau PET imaging in dementia: pathophysiology, radiotracer quantification, and a systematic review of clinical findings","volume":"36","author":"Hall","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib23","first-page":"5539","article-title":"Shared genetic factors influence head motion during MRI and body mass index","volume":"27","author":"Hodgson","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/bpa.12182","article-title":"Regional multiple pathology scores are associated with cognitive decline in Lewy body dementias","volume":"25","author":"Howlett","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib25","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S1474-4422(16)30291-5","article-title":"Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis","volume":"16","author":"Irwin","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00401-008-0347-5","article-title":"Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease","volume":"115","author":"Jellinger","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib28","first-page":"1","article-title":"AV-1451 tau and \u03b2-amyloid PET imaging in dementia with Lewy bodies","author":"Kantarci","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib29","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2011.09.024","article-title":"Multimodality imaging characteristics of dementia with Lewy bodies","volume":"33","author":"Kantarci","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib30","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1109\/23.34585","article-title":"Analytic 3D image reconstruction using all detected events","volume":"36","author":"Kinahan","year":"1989","journal-title":"IEEE Trans. Nucl. Sci."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/mds.27252","article-title":"Distinct patterns of amyloid-dependent tau accumulation in Lewy body diseases","volume":"33","author":"Lee","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","article-title":"An autoradiographic evaluation of AV-1451 Tau PET in dementia","volume":"4","author":"Lowe","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jalz.2019.09.079","article-title":"Tau-positron emission tomography correlates with neuropathology findings","volume":"16","author":"Lowe","year":"2020","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1212\/WNL.55.1.132","article-title":"Activated microglia in dementia with Lewy bodies","volume":"55","author":"Mackenzie","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2018.09.004","article-title":"Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies","volume":"73","author":"Mak","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1017\/S1041610216002143","article-title":"Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment , Alzheimer \u2019 s disease , and dementia with Lewy bodies","volume":"29","author":"Mak","year":"2017","journal-title":"Int. Psychogeriatrics"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mdc3.12689","article-title":"Imaging tau, neuroinflammation and A\u03b2 in dementia with Lewy bodies: a deep-phenotyping case-report","volume":"6","author":"Mak","year":"2018","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib38","first-page":"239418","article-title":"Confirmation of 123 I-FP-CIT-SPECT (ioflupane) quantification methods in dementia with Lewy body and other neurodegenerative disorders","volume":"119","author":"Maltais","year":"2020","journal-title":"J.\u00a0Nucl. Med. Jnumed."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00401-004-0869-4","article-title":"Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer\u2019s disease","volume":"108","author":"Marui","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib41","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib43","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1212\/01.WNL.0000065889.42856.F2","article-title":"Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies","volume":"60","author":"Merdes","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neurobiolaging.2014.07.005","article-title":"Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies","volume":"36","author":"Nedelska","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib45","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the Literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib46","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1097\/RLU.0000000000001477","article-title":"Added value of combined semi-quantitative and visual [123I]FP-CIT SPECT analyses for the diagnosis of dementia with Lewy bodies","volume":"42","author":"Nicastro","year":"2017","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib47","doi-asserted-by":"crossref","first-page":"e005122","DOI":"10.1136\/bmjopen-2014-005122","article-title":"Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials","volume":"4","author":"O\u2019Brien","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1212\/WNL.0b013e3181b23564","article-title":"Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study","volume":"73","author":"Okello","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib49","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/jama.2018.12917","article-title":"Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders","volume":"320","author":"Ossenkoppele","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.parkreldis.2016.07.008","article-title":"Phenotypic differences based on staging of Alzheimer\u2019s neuropathology in autopsy-confirmed dementia with Lewy bodies","volume":"31","author":"Peavy","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neurobiolaging.2014.11.008","article-title":"Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study","volume":"36","author":"Raffield","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib52","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1093\/brain\/aww193","article-title":"Amyloid-\u03b2 deposition and regional grey matter atrophy rates in dementia with Lewy bodies","volume":"139","author":"Sarro","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib53","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib54","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(00)01037-5","article-title":"Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer\u2019s disease","volume":"285","author":"Sheffield","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41598-018-23041-x","article-title":"18F-AV-1451 in Parkinson\u2019s disease with and without dementia and in dementia with Lewy bodies","volume":"8","author":"Smith","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib57","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.parkreldis.2015.10.009","article-title":"Neuroinflammation in Lewy body dementia","volume":"21","author":"Surendranathan","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib58","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/brain\/awy265","article-title":"Early microglial activation and peripheral inflammation in dementia with Lewy bodies","volume":"141","author":"Surendranathan","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0000000000003512","article-title":"Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB","volume":"88","author":"Thomas","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib60","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1001\/jamaneurol.2020.0528","article-title":"Positron emission tomography imaging with [ 18 F]flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes","volume":"77","author":"Truocchio","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib61","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jalz.2018.01.003","article-title":"Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer\u2019s disease: a prospective study in eight cohorts","volume":"14","author":"Tynkkynen","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40478-019-0754-y","article-title":"Intersection of pathological tau and microglia at the synapse","volume":"7","author":"Vogels","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib65","doi-asserted-by":"crossref","first-page":"e000380","DOI":"10.1136\/bmjopen-2011-000380","article-title":"Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer\u2019s disease: a cohort study","volume":"2","author":"Walker","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib66","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/jcbfm.2012.59","article-title":"Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[ 11C]PK11195 brain PET studies","volume":"32","author":"Yaqub","year":"2012","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2020.11.006_bib67","first-page":"637","article-title":"Tau pathology in cognitively normal older adults","volume":"11","author":"Ziontz","year":"2019","journal-title":"Alzheimers Dement."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458020303882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458020303882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:37:14Z","timestamp":1759318634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458020303882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":66,"alternative-id":["S0197458020303882"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.11.006","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}