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Lett."},{"key":"10.1016\/j.neurobiolaging.2020.12.010_bib93","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCRESAHA.117.311054","article-title":"Brain perivascular macrophages initiate the neurovascular dysfunction of Alzheimer abeta peptides","volume":"121","author":"Park","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.neurobiolaging.2020.12.010_bib94","doi-asserted-by":"crossref","first-page":"e1309","DOI":"10.1212\/WNL.0000000000007124","article-title":"Perivascular spaces contribute to cognition beyond other small vessel disease markers","volume":"92","author":"Passiak","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2020.12.010_bib95","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/biomet\/64.2.231","article-title":"Tests for departure from normality: comparison of powers","volume":"64","author":"Pearson","year":"1977","journal-title":"Biometrika"},{"key":"10.1016\/j.neurobiolaging.2020.12.010_bib96","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/jcbfm.1987.9","article-title":"Regional asymmetries of cerebral blood flow, blood volume, and oxygen utilization and extraction in normal subjects","volume":"7","author":"Perlmutter","year":"1987","journal-title":"J.\u00a0Cereb. 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