{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:26:23Z","timestamp":1791195983412,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"am","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.neurobiolaging.2021.03.007","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T16:41:33Z","timestamp":1616517693000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults"],"prefix":"10.1016","volume":"103","author":[{"given":"Priya","family":"Palta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Rippon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Tahmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-5650","authenticated-orcid":false,"given":"Zeljko","family":"Tomljanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-8179","authenticated-orcid":false,"given":"Hengda","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal K.","family":"Laing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-8062","authenticated-orcid":false,"given":"Qolamreza R.","family":"Razlighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne A.","family":"Teresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Kreisl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-3648","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Luchsinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0001","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/archpsyc.62.6.685","article-title":"Sex differences in the clinical manifestations of Alzheimer disease pathology","volume":"62","author":"Barnes","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0002","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2967\/jnumed.118.209650","article-title":"In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer Disease dementia to young controls","volume":"60","author":"Betthauser","year":"2019","journal-title":"J Nucl Med"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0003","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/brain\/awz378","article-title":"Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age","volume":"143","author":"Betthauser","year":"2020","journal-title":"Brain"},{"issue":"Pt 10","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0004","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/brain\/awv236","article-title":"The preclinical phase of the pathological process underlying sporadic Alzheimer's disease","volume":"138","author":"Braak","year":"2015","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamaneurol.2018.4693","article-title":"Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults","volume":"76","author":"Buckley","year":"2019","journal-title":"JAMA Neurol"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0006","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jalz.2013.10.005","article-title":"Gender and incidence of dementia in the Framingham Heart Study from mid-adult life","volume":"11","author":"Chene","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0007","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2021.03.007_bib0008","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ana.25406","article-title":"Longitudinal tau accumulation and atrophy in aging and Alzheimer's disease","volume":"85","author":"Harrison","year":"2018","journal-title":"Ann Neurol"},{"issue":"19","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0009","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010-2050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0010","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jamaneurol.2018.0821","article-title":"Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau","volume":"75","author":"Hohman","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0011","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa007","article-title":"Neuroanatomical spread of amyloid beta and tau in Alzheimer's disease: implications for primary prevention","volume":"2","author":"Insel","year":"2020","journal-title":"Brain Commun"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0012","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dementia"},{"issue":"19","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0013","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysisprevalence of cerebral amyloid pathology in persons without dementiaprevalence of cerebral amyloid pathology in persons without dementia","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"issue":"15","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0014","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1212\/WNL.0000000000002576","article-title":"Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI","volume":"86","author":"Landau","year":"2016","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/PSY.0000000000000208","article-title":"Glycemia, Diabetes Status, and Cognition in Hispanic Adults Aged 55-64 Years","volume":"77","author":"Luchsinger","year":"2015","journal-title":"Psychosom Med"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0016","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3233\/JAD-200232","article-title":"Pre-diabetes, but not type 2 diabetes, is related to brain amyloid in late middle-age","volume":"75","author":"Luchsinger","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0017","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3233\/JAD-191183","article-title":"Sex differences in in vivo Alzheimer's disease neuropathology in late middle-aged hispanics","volume":"74","author":"Luchsinger","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2021.03.007_bib0018","series-title":"Proceedings of the Berkeley Symposium on Mathematical Statistics and Probability","first-page":"281","article-title":"Some methods for classification and analysis of multivariate observations","volume":"1","author":"MacQueen","year":"1967"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0019","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1097\/GME.0000000000001405","article-title":"Lifetime estrogen exposure and cognition in late life: the Cache County Study","volume":"26","author":"Matyi","year":"2019","journal-title":"Menopause"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0020","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1474-4422(16)00067-3","article-title":"Sex differences in Alzheimer's disease and other dementias","volume":"15","author":"Mazure","year":"2016","journal-title":"The Lancet. Neurology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0021","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/oxfordjournals.aje.a117244","article-title":"Estrogen deficiency and risk of Alzheimer's disease in women","volume":"140","author":"Paganini-Hill","year":"1994","journal-title":"Am J Epidemiol"},{"issue":"15","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0022","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000010707","article-title":"Apolipoprotein E genotype and in vivo amyloid burden in middle-aged Hispanics","volume":"95","author":"Palta","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2021.03.007_bib0023","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neurobiolaging.2020.09.023","article-title":"Metabolic syndrome and its components in relation to in vivo brain amyloid and neurodegeneration in late middle age","volume":"97","author":"Palta","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"1-2","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000109998","article-title":"Prevalence of dementia in the United States: the aging, demographics, and memory study","volume":"29","author":"Plassman","year":"2007","journal-title":"Neuroepidemiology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1212\/01.wnl.0000339037.76336.cf","article-title":"Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study","volume":"72","author":"Resnick","year":"2009","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0026","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2967\/jnumed.113.136069","article-title":"Molecular imaging insights into neurodegeneration: focus on Tau PET radiotracers","volume":"55","author":"Shah","year":"2014","journal-title":"J Nucl Med"},{"issue":"20","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0027","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","article-title":"Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Shumaker","year":"2003","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0028","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2967\/jnumed.119.228510","article-title":"A fully automatic technique for precise localization and quantification of Amyloid-\u03b2 PET scans","volume":"60","author":"Tahmi","year":"2019","journal-title":"J Nucl Med"},{"key":"10.1016\/j.neurobiolaging.2021.03.007_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.529930","article-title":"Brain Amyloid Burden and Resting-State Functional Connectivity in Late Middle-Aged Hispanics","volume":"11","author":"Tahmi","year":"2020","journal-title":"Front Neurol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.03.007_bib0030","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ana.22239","article-title":"Timing of hormone therapy and dementia: the critical window theory revisited","volume":"69","author":"Whitmer","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2021.03.007_bib0031","article-title":"Sex-related differences in tau positron emission tomography (PET) and the effects of hormone therapy (HT)","author":"Wisch","year":"2020","journal-title":"Alzheimer Dis Assoc Disord"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021000981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021000981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:37:45Z","timestamp":1759318665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458021000981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"alternative-id":["S0197458021000981"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.03.007","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}