{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:16:13Z","timestamp":1793726173327,"version":"4.6.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neurobiolaging.2021.04.008","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:24:22Z","timestamp":1619115862000},"page":"35-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Obesity is associated with reduced cerebral blood flow \u2013 modified by physical activity"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1245-4870","authenticated-orcid":false,"given":"Silvin P.","family":"Knight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-5223","authenticated-orcid":false,"given":"Eamon","family":"Laird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilby","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"De Looze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-9732","authenticated-orcid":false,"given":"Andrew J.","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4214","authenticated-orcid":false,"given":"Michael A.","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Meaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0001","unstructured":"1995. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World. Health. Organ. Tech. Rep. Ser. 854, 1-452."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0002","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/13607860903586136","article-title":"Is physical activity a potential preventive factor for vascular dementia? A systematic review","volume":"14","author":"Aarsland","year":"2010","journal-title":"Aging. Ment. Health"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0004","doi-asserted-by":"crossref","first-page":"876","DOI":"10.4065\/mcp.2011.0252","article-title":"Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging","volume":"86","author":"Ahlskog","year":"2011","journal-title":"Mayo. Clin. Proc."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0005","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1176\/appi.ajp.159.5.738","article-title":"Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies","volume":"159","author":"Alexander","year":"2002","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0006","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000343222","article-title":"Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure","volume":"2","author":"Alosco","year":"2012","journal-title":"Cerebrovasc. Dis. Extra."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0007","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"Alsop","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0008","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1467-789X.2010.00825.x","article-title":"Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies","volume":"12","author":"Anstey","year":"2011","journal-title":"Obes. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0009","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s12350-011-9490-9","article-title":"Advantages and disadvantages of PET and SPECT in a busy clinical practice","volume":"19","author":"Bateman","year":"2012","journal-title":"J. Nucl. Cardiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0010","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/oby.20170","article-title":"Low cerebral blood flow is associated with lower memory function in metabolic syndrome","volume":"21","author":"Birdsill","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0011","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0012","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jmri.20462","article-title":"Quantifying CBF with arterial spin labeling","volume":"22","author":"Buxton","year":"2005","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0013","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.5888\/pcd18.170354","article-title":"Percentage of deaths associated with inadequate physical activity in the United States","volume":"15","author":"Carlson","year":"2018","journal-title":"Prev. Chronic. Dis."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0014","series-title":"Introduction to Perfusion Quantification using Arterial Spin Labelling","author":"Chappell","year":"2017"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0015","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","article-title":"Age-associated reductions in cerebral blood flow are independent from regional atrophy","volume":"55","author":"Chen","year":"2011","journal-title":"Neuroimage."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0016","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12017-008-8033-2","article-title":"Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus","volume":"10","author":"Christie","year":"2008","journal-title":"Neuromolecular. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142589","article-title":"Abdominal obesity and brain atrophy in type 2 diabetes mellitus","volume":"10","author":"Climie","year":"2015","journal-title":"PLoS. One."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0018","first-page":"8","article-title":"Waist circumference and waist-hip ratio","volume":"2008","author":"Consultation","year":"2008"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0019","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med. Sci. Sports. Exerc."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0020","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1467-789X.2011.00879.x","article-title":"Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: evidence from an individual-participant meta-analysis of 82 864 participants from nine cohort studies","volume":"12","author":"Czernichow","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0021","first-page":"1044","article-title":"A bidirectional relationship between physical activity and executive function in older adults","volume":"8","author":"Daly","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0022","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/ana.22062","article-title":"Visceral fat is associated with lower brain volume in healthy middle-aged adults","volume":"68","author":"Debette","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0023","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neurobiolaging.2004.05.004","article-title":"Measures of brain morphology and infarction in the framingham heart study: establishing what is normal","volume":"26","author":"DeCarli","year":"2005","journal-title":"Neurobiol. Aging."},{"issue":"3 Suppl","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0024","first-page":"77","article-title":"Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease","volume":"29","author":"Despr\u00e9s","year":"2006","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0026","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1093\/ije\/dyy163","article-title":"Cohort profile update: The Irish Longitudinal Study on Ageing (TILDA)","volume":"47","author":"Donoghue","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0027","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1001\/jama.2016.21042","article-title":"Genetic association of Waist-to-Hip Ratio With cardiometabolic traits, Type 2 Diabetes, and coronary heart disease","volume":"317","author":"Emdin","year":"2017","journal-title":"JAMA."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0028","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1001\/jama.1984.03350140051025","article-title":"Detecting alcoholism. The CAGE questionnaire","volume":"252","author":"Ewing","year":"1984","journal-title":"JAMA."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0029","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1177\/0271678X16636393","article-title":"Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: a systematic review","volume":"36","author":"Fan","year":"2016","journal-title":"J. Cereb. Blood. Flow. Metab"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0030","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0031","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1148\/radiol.2016150789","article-title":"Arterial spin labeling perfusion of the brain: emerging clinical applications","volume":"281","author":"Haller","year":"2016","journal-title":"Radiology."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0032","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1212\/WNL.0000000000006879","article-title":"Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study","volume":"92","author":"Hamer","year":"2019","journal-title":"Neurology."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0033","doi-asserted-by":"crossref","first-page":"e1298","DOI":"10.1212\/WNL.0000000000005290","article-title":"Midlife cardiovascular fitness and dementia. A 44-year longitudinal population study in women","volume":"90","author":"H\u00f6rder","year":"2018","journal-title":"Neurology."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0034","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1210\/jc.2014-3081","article-title":"Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age","volume":"100","author":"Irving","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0035","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.118.032410","article-title":"Higher aortic stiffness is related to lower cerebral blood flow and preserved cerebrovascular reactivity in older adults","volume":"138","author":"Jefferson","year":"2018","journal-title":"Circulation."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0037","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/ije\/dyr116","article-title":"Cohort profile: the Irish Longitudinal Study on","volume":"40","author":"Kearney","year":"2011","journal-title":"Ageing. Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0038","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5603\/NMR.2021.0002","article-title":"Age, BMI and diabetes as independent predictors of brain hypoperfusion","volume":"24","author":"K\u00e9pes","year":"2021","journal-title":"Nucl. Med. Rev. Cent. East. Eur."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0039","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0040","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.9261","article-title":"Changes in age distribution of obesity-associated cancers","volume":"2","author":"Koroukian","year":"2019","journal-title":"JAMA. Netw. Open."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0041","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/hbm.22021","article-title":"Relationships between gray matter, body mass index, and waist circumference in healthy adults","volume":"34","author":"Kurth","year":"2013","journal-title":"Hum. Brain. Mapp."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0042","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/bmj.288.6428.1401","article-title":"Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913","volume":"288","author":"Larsson","year":"1984","journal-title":"Br. Med. J. (Clin Res Ed)"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0043","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archneur.58.3.498","article-title":"Physical activity and risk of cognitive impairment and dementia in elderly persons","volume":"58","author":"Laurin","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0044","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1552-6569.2008.00277.x","article-title":"Imaging cerebral blood flow in the cognitively normal aging brain with arterial spin labeling: implications for imaging of neurodegenerative disease","volume":"19","author":"Lee","year":"2009","journal-title":"J.Neuroimaging."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0045","doi-asserted-by":"crossref","first-page":"e12989","DOI":"10.1111\/obr.12989","article-title":"Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia","volume":"21","author":"Lee","year":"2020","journal-title":"Obes. Rev"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0046","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy","volume":"380","author":"Lee","year":"2012","journal-title":"Lancet."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117741","article-title":"Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)","volume":"229","author":"Leidhin","year":"2021","journal-title":"Neuroimage."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0048","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1037\/0882-7974.12.2.277","article-title":"Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults","volume":"12","author":"Lewinsohn","year":"1997","journal-title":"Psychol. Aging."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0049","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1600-0447.1989.tb10303.x","article-title":"An epidemiological survey of age-related dementia in an urban area of Beijing","volume":"79","author":"Li","year":"1989","journal-title":"Acta. Psychiatr. Scand."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0050","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/mrm.23286","article-title":"Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics","volume":"68","author":"Liu","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0051","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/cercor\/bhq224","article-title":"Alterations in cerebral metabolic rate and blood supply across the adult lifespan","volume":"21","author":"Lu","year":"2011","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0052","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1073\/pnas.200377097","article-title":"Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors \u03b1 and \u03b2","volume":"97","author":"Mueller","year":"2000","journal-title":"Proc. Nat. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0053","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1093\/brain\/awu041","article-title":"Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia","volume":"137","author":"Nyberg","year":"2014","journal-title":"Brain."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0054","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/mrm.20023","article-title":"Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects","volume":"51","author":"Parkes","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0055","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev-physiol-020518-114339","article-title":"The physiology of optimizing health with a focus on exercise as medicine","volume":"81","author":"Pedersen","year":"2019","journal-title":"Ann. Rev. Physiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0056","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ageing\/27.4.469","article-title":"The effects of resistance training on well-being and memory in elderly volunteers","volume":"27","author":"Peig-Chiello","year":"1998","journal-title":"Age. Ageing."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0057","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s41465-018-0080-5","article-title":"Associations between short and long bouts of physical activity with executive function in older adults","volume":"2","author":"Peven","year":"2018","journal-title":"J. Cogn. Enhanc."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0058","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/jmri.22788","article-title":"Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling","volume":"34","author":"Preibisch","year":"2011","journal-title":"J. Magn. Reson. Imaging."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0059","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/s-0032-1331812","article-title":"Transcranial Doppler ultrasound: technique and application","volume":"32","author":"Purkayastha","year":"2012","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum. Brain. Mapp."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0061","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/bmj.331.7514.455","article-title":"Obesity in middle age and future risk of dementia: midlife obesity increases risk of future dementia","volume":"331","author":"Razay","year":"2005","journal-title":"BMJ."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0062","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2796.1995.tb01219.x","article-title":"Walking exercise and improved neuropsychological functioning in elderly patients with cardiac disease","volume":"238","author":"Satoh","year":"1995","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0063","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10286-008-0490-z","article-title":"The effects of body mass index on cerebral blood flow velocity","volume":"18","author":"Selim","year":"2008","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0064","doi-asserted-by":"crossref","first-page":"e65174","DOI":"10.1371\/journal.pone.0065174","article-title":"The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS. One."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0065","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0066","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/oby.2007.4","article-title":"Relationship between body mass index and gray matter volume in 1,428 healthy individuals","volume":"16","author":"Taki","year":"2008","journal-title":"Obesity (Silver Spring)"},{"issue":"Suppl 2","key":"10.1016\/j.neurobiolaging.2021.04.008_bib0067","first-page":"S265","article-title":"Design and methodology of the Irish Longitudinal Study on Ageing","volume":"61","author":"Whelan","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0068","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/oby.2011.16","article-title":"Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults","volume":"19","author":"Willeumier","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0069","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.2018.11498","article-title":"Association of cardiovascular risk factors with MRI indices of cerebrovascular structure and function and white matter hyperintensities in young adults","volume":"320","author":"Williamson","year":"2018","journal-title":"JAMA."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0150-9861(05)83159-1","article-title":"Comparative overview of brain perfusion imaging techniques","volume":"32","author":"Wintermark","year":"2005","journal-title":"J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0071","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/CIRCULATIONAHA.117.027448","article-title":"Cerebral perfusion and the risk of dementia: a population-based study","volume":"136","author":"Wolters","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0072","first-page":"35","article-title":"Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor","volume":"4","author":"Zeng","year":"2001","journal-title":"J. Gend. Specif. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0073","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neubiorev.2016.11.023","article-title":"Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease","volume":"72","author":"Zhang","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0074","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fnagi.2018.00214","article-title":"The age-related perfusion pattern measured with arterial spin labeling MRI in healthy subjects","volume":"10","author":"Zhang","year":"2018","journal-title":"Front. Aging. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2021.04.008_bib0075","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/jcbfm.2015.157","article-title":"The bidirectional association between reduced cerebral blood flow and brain atrophy in the general population","volume":"35","author":"Zonneveld","year":"2015","journal-title":"J. Cereb. Blood. Flow. Metab."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:38:06Z","timestamp":1759318686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458021001238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":73,"alternative-id":["S0197458021001238"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.008","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity is associated with reduced cerebral blood flow \u2013 modified by physical activity","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}