{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:29:38Z","timestamp":1792045778520,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 RR032138\/GM103488"],"award-info":[{"award-number":["P30 RR032138\/GM103488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 NS081014"],"award-info":[{"award-number":["K01 NS081014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 MH11734"],"award-info":[{"award-number":["K01 MH11734"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM109098"],"award-info":[{"award-number":["P20 GM109098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 GM104942"],"award-info":[{"award-number":["U54 GM104942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG052375"],"award-info":[{"award-number":["T32 AG052375"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01 AG027956"],"award-info":[{"award-number":["P01 AG027956"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neurobiolaging.2021.04.019","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:08:46Z","timestamp":1619741326000},"page":"115-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-9107","authenticated-orcid":false,"given":"Dominic D.","family":"Quintana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-0183","authenticated-orcid":false,"given":"Yamini","family":"Anantula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Engler-Chiurazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumyendra N.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Corbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-0221","authenticated-orcid":false,"given":"Candice M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Simpkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0001","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/brain\/awr020","article-title":"Unawareness of deficits in Alzheimer's disease: role of the cingulate cortex","volume":"134","author":"Amanzio","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0002","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1179\/016164104225016272","article-title":"The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease","volume":"26","author":"Bailey","year":"2004","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0003","doi-asserted-by":"crossref","first-page":"e12873","DOI":"10.1111\/acel.12873","article-title":"Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice","volume":"18","author":"Belfiore","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0004","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0014-5793(98)01034-5","article-title":"Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-\u03baB","volume":"435","author":"Bond","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0006","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jns.2009.02.328","article-title":"Microvascular changes in the white mater in dementia","volume":"283","author":"Brown","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0007","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/jcbfm.2011.200","article-title":"Cerebral microinfarcts: a systematic review of neuropathological studies","volume":"32","author":"Brundel","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0008","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/JAD-2012-120364","article-title":"High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease","volume":"31","author":"Brundel","year":"2012","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0010","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1161\/ATVBAHA.109.193227","article-title":"Discrete contributions of elastic fiber components to arterial development and mechanical compliance","volume":"29","author":"Carta","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0011","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.disamonth.2010.06.001","article-title":"Alzheimer disease","volume":"56","author":"Castellani","year":"2010","journal-title":"Dis. Mon."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0012","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1212\/WNL.0b013e31828250af","article-title":"Alzheimer disease and risk of stroke: a population-based cohort study","volume":"80","author":"Chi","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0013","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1152\/japplphysiol.01298.2006","article-title":"Hypoxia-induced reactive oxygen species formation in skeletal muscle","volume":"102","author":"Clanton","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/ng1764","article-title":"Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome","volume":"38","author":"Coucke","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.arr.2010.04.002","article-title":"Vascular risk factor detection and control may prevent Alzheimer's disease","volume":"9","author":"de la Torre","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0018","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1179\/016164104225016254","article-title":"Alzheimer's disease is a vasocognopathy: a new term to describe its nature","volume":"26","author":"de la Torre","year":"2004","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0019","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jacc.2017.07.724","article-title":"Cerebral amyloid angiopathy: diagnosis, clinical implications, and management strategies in atrial fibrillation","volume":"70","author":"DeSimone","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0020","first-page":"H124","article-title":"Elastase, collagenase, and the biaxial elastic properties of dog carotid artery","volume":"247","author":"Dobrin","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0021","first-page":"568","article-title":"Mechanisms of arterial and aneurysmal tortuosity","volume":"104","author":"Dobrin","year":"1988","journal-title":"Surgery"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0023","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/brain\/aws243","article-title":"Amyloid-\u03b2-dependent compromise of microvascular structure and function in a model of Alzheimer's disease","volume":"135","author":"Dorr","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0024","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/VHRM.S1839","article-title":"Vascular risk factors, cognitive decline, and dementia","volume":"4","author":"Duron","year":"2008","journal-title":"Vasc. Health Risk Manag"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2009.06.015","article-title":"Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice","volume":"67","author":"Espa\u00f1a","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0026","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj3150335","article-title":"Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors of metalloproteinases-1, -2 and -3 in rabbit aortic smooth muscle cells","volume":"315","author":"Fabunmi","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0027","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0197-4580(00)00225-6","article-title":"Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain","volume":"22","author":"Farkas","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0028","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/BF00294246","article-title":"Altered angioarchitecture in selected areas of brains with Alzheimer's disease","volume":"79","author":"Fischer","year":"1990","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neubiorev.2006.07.007","article-title":"Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid","volume":"31","author":"Gim\u00e9nez-Llort","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0032","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0271678X16671146","article-title":"The capillary bed offers the largest hemodynamic resistance to the cortical blood supply","volume":"37","author":"Gould","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0033","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1371\/journal.pbio.0040043","article-title":"Redundancy in cortical surface vessels supports persistent blood flow","volume":"4","author":"Gross","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0034","doi-asserted-by":"crossref","DOI":"10.1042\/BST0380841","article-title":"A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection","author":"Halestrap","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0035","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","article-title":"The role of the mitochondrial permeability transition pore in heart disease","volume":"1787","author":"Halestrap","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0036","doi-asserted-by":"crossref","first-page":"E881","DOI":"10.1073\/pnas.1414930112","article-title":"Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice","volume":"112","author":"Han","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0037","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0038","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/5715","article-title":"SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein","volume":"2","author":"Iadecola","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad9005","article-title":"AD and CAA: independent risk factors for dementia","volume":"7","author":"Janson","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0041","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000285518","article-title":"Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases","volume":"7","author":"Jellinger","year":"2010","journal-title":"Neurodegener. Dis."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.019_bib0042","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1111\/j.1753-4887.2010.00352.x","article-title":"Vascular basis for brain degeneration: faltering controls and risk factors for dementia","volume":"68","author":"Kalaria","year":"2010","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0043","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00001756-199502000-00018","article-title":"Differential degeneration of the cerebral microvasculature in Alzheimer's disease","volume":"6","author":"Kalaria","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0044","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0045","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.bbamcr.2010.12.008","article-title":"Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion","volume":"1813","author":"Loor","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0048","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/415171a","article-title":"Fibulin-5\/DANCE is essential for elastogenesis in vivo","volume":"415","author":"Nakamura","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0049","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1073\/pnas.97.17.9735","article-title":"Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation","volume":"97","author":"Niwa","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0050","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1681\/ASN.V1051100","article-title":"Stereologic methods and their application in kidney research","volume":"10","author":"Nyengaard","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0051","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease","volume":"24","author":"Oddo","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0052","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0053","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1161\/STROKEAHA.114.005179","article-title":"Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy","volume":"45","author":"Park","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0054","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1749-6632.2009.05026.x","article-title":"Hypoxia and neurodegeneration","volume":"1177","author":"Peers","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jns.2009.02.306","article-title":"Cerebral emboli in the genesis of dementia","volume":"283","author":"Purandare","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0056","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0057","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/JAD-190964","article-title":"Amyloid-\u03b2 causes mitochondrial dysfunction via a Ca2+-driven upregulation of oxidative phosphorylation and superoxide production in cerebrovascular endothelial cells","volume":"75","author":"Quintana","year":"2020","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0058","article-title":"The cerebral angiome: High resolution MicroCT imaging of the whole brain cerebrovasculature in female and male mice","volume":"116109","author":"Quintana","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0059","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s11011-018-0312-5","article-title":"Gradual common carotid artery occlusion as a novel model for cerebrovascular hypoperfusion","volume":"33","author":"Quintana","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/jcbfm.2015.172","article-title":"Consensus statement for diagnosis of subcortical small vessel disease","volume":"36","author":"Rosenberg","year":"2016","journal-title":"J. Cereb. blood flow Metab."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0061","article-title":"Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis. Alzheimer's dement","author":"Santos","year":"2017","journal-title":"Diagnosis, Assess. Dis. Monit."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0062","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40134-013-0029-5","article-title":"Imaging Evaluation of Collaterals in the Brain: Physiology and Clinical Translation","volume":"2","author":"Sheth","year":"2014","journal-title":"Curr. Radiol. Rep"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0064","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/bjo.2007.134593","article-title":"Straight versus tortuous retinal arteries in relation to blood pressure and genetics","volume":"92","author":"Taarnh\u00f8j","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0067","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/380168a0","article-title":"\u03b2-Amyloid-mediated vasoactivity and vascular endothelial damage","volume":"380","author":"Thomas","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0068","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1212\/WNL.0b013e31827f08c5","article-title":"Incidence of stroke in people with Alzheimer disease: a national register-based approach","volume":"80","author":"Tolppanen","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0069","doi-asserted-by":"crossref","first-page":"32860","DOI":"10.1074\/jbc.M104135200","article-title":"Pathogenic effects of D23N Iowa mutant amyloid beta -protein","volume":"276","author":"Van Nostrand","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0071","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/01.STR.18.2.311","article-title":"Cerebral amyloid angiopathy. A critical review","volume":"18","author":"Vinters","year":"1987","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0072","first-page":"105","article-title":"Amyloidosis of cerebral arteries","volume":"92","author":"Vinters","year":"2003","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0074","doi-asserted-by":"crossref","first-page":"H2408","DOI":"10.1152\/ajpheart.01089.2003","article-title":"Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods","volume":"286","author":"Whitesall","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0076","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11682-018-9860-x","article-title":"Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer's disease patients","volume":"13","author":"Yamashita","year":"2019","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0077","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/415168a","article-title":"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo","volume":"415","author":"Yanagisawa","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2021.04.019_bib0078","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/ar.22983","article-title":"The role of mechanotransduction on vascular smooth muscle myocytes cytoskeleton and contractile function","volume":"297","author":"Ye","year":"2014","journal-title":"Anat. Rec."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:50:28Z","timestamp":1777528228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458021001421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":64,"alternative-id":["S0197458021001421"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.019","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}