{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:10:51Z","timestamp":1790730651425,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"am","delay-in-days":284,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neurobiolaging.2021.04.025","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:04:07Z","timestamp":1621555447000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-8352","authenticated-orcid":false,"given":"Meral A.","family":"Tubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deydeep","family":"Kothapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-6223","authenticated-orcid":false,"given":"Matthew","family":"Hapenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-2909","authenticated-orcid":false,"given":"Franklin W.","family":"Feingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith N.","family":"Braskie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"44","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0001","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1523\/JNEUROSCI.1230-20.2020","article-title":"Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid","volume":"40","author":"Albrecht","year":"2020","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0002","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1096\/fj.201802003R","article-title":"VEGF receptor-1 modulates amyloid beta 1-42 oligomer-induced senescence in brain endothelial cells","volume":"33","author":"Angom","year":"2019","journal-title":"Faseb j"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0003","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0004","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0005","doi-asserted-by":"crossref","first-page":"E1289","DOI":"10.1073\/pnas.1710329115","article-title":"Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease","volume":"115","author":"Bennett","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0006","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0007","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box","year":"1964","journal-title":"Journal of the Royal Statistical Society"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0064","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/gerona\/glaa116","article-title":"APOE \u03b54 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline","volume":"75","author":"Makkar","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0008","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0009","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2014.05.005","article-title":"Physical activity, inflammation, and volume of the aging brain","volume":"273","author":"Braskie","year":"2014","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0010","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.neuroimage.2008.03.039","article-title":"Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers","volume":"41","author":"Burggren","year":"2008","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0011","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng1395","article-title":"VEGF links hippocampal activity with neurogenesis, learning and memory","volume":"36","author":"Cao","year":"2004","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0012","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13195-018-0385-8","article-title":"Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia","volume":"10","author":"Chakraborty","year":"2018","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0013","doi-asserted-by":"crossref","first-page":"17713","DOI":"10.1038\/s41598-017-18042-1","article-title":"VEGFR2 alteration in Alzheimer's disease","volume":"7","author":"Cho","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0014","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s11682-012-9186-z","article-title":"Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI)","volume":"6","author":"Crane","year":"2012","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical Surface-Based Analysis.pdf","volume":"9","author":"Dale","year":"1999","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0016","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuroimage.2014.10.050","article-title":"The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function","volume":"105","author":"Dowling","year":"2015","journal-title":"Neuroimage"},{"issue":"20","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0017","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0018","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neuropharm.2012.04.033","article-title":"Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK\/ERK- and PI3K\/Akt-dependent signaling","volume":"63","author":"Fournier","year":"2012","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0019","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11682-012-9176-1","article-title":"A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment","volume":"6","author":"Gibbons","year":"2012","journal-title":"Brain Imaging Behav"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0020","first-page":"31","article-title":"The neuroprotective function of vascular endothelial growth factor (VEGF)","volume":"43","author":"Gora-Kupilas","year":"2005","journal-title":"Folia Neuropathol"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0021","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s11682-012-9208-x","article-title":"Relationship between baseline brain metabolism measured using [(1)(8)F]FDG PET and memory and executive function in prodromal and early Alzheimer's disease","volume":"6","author":"Habeck","year":"2012","journal-title":"Brain Imaging Behav"},{"issue":"14","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0022","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1212\/WNL.0b013e31828ab35d","article-title":"Meta-analysis of amyloid-cognition relations in cognitively normal older adults","volume":"80","author":"Hedden","year":"2013","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0063","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3233\/JAD-180859","article-title":"APOE\u025b4 Gene Dose and Sex Effects on Alzheimer's Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment","volume":"71","author":"Hobel","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0023","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamaneurol.2014.4761","article-title":"The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease","volume":"72","author":"Hohman","year":"2015","journal-title":"JAMA Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0024","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.neurobiolaging.2011.09.003","article-title":"CSF biomarkers for Alzheimer's disease: current utility and potential future use","volume":"32","author":"Holtzman","year":"2011","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0025","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41598-018-19387-x","article-title":"Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer's Disease: A Multiparametric Neuroimaging Study","volume":"8","author":"Huang","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0026","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","article-title":"Biomarker modeling of Alzheimer's disease","volume":"80","author":"Jack","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0027","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jalz.2010.03.003","article-title":"The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core","volume":"6","author":"Jagust","year":"2010","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0028","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2016.03.033","article-title":"Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity","volume":"165","author":"Jais","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0029","doi-asserted-by":"crossref","first-page":"e867","DOI":"10.1212\/WNL.0000000000006082","article-title":"CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease","volume":"91","author":"Janelidze","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroimage.2009.01.057","article-title":"Reducing between scanner differences in multi-center PET studies","volume":"46","author":"Joshi","year":"2009","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0031","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11065-007-9040-z","article-title":"The elusive nature of executive functions: a review of our current understanding","volume":"17","author":"Jurado","year":"2007","journal-title":"Neuropsychol Rev"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0032","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.23650","article-title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","volume":"72","author":"Landau","year":"2012","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0067","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0068","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0033","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrneurol.2016.88","article-title":"Vascular endothelial growth factor: a neurovascular target in neurological diseases","volume":"12","author":"Lange","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0034","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.dadm.2015.06.008","article-title":"Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study","volume":"1","author":"Leung","year":"2015","journal-title":"Alzheimers Dement (Amst)"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0035","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1073\/pnas.1007640108","article-title":"Reversible modulations of neuronal plasticity by VEGF","volume":"108","author":"Licht","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0036","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3233\/JAD-170250","article-title":"Cerebrospinal Fluid Biomarkers are Differentially Related to Structural and Functional Changes in Dementia of the Alzheimer's Type","volume":"62","author":"Malpas","year":"2018","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0037","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/gps.2229","article-title":"The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG-PET study","volume":"24","author":"Melrose","year":"2009","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2017.02.007","article-title":"Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease","author":"Nielsen","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0039","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1212\/WNL.0000000000006875","article-title":"Associations between tau, A\u03b2, and cortical thickness with cognition in Alzheimer disease","volume":"92","author":"Ossenkoppele","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0040","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1038\/tp.2014.58","article-title":"Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals","volume":"4","author":"Paterson","year":"2014","journal-title":"Transl Psychiatry"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0041","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2174\/1567202611666140520122316","article-title":"Reduction in vascular endothelial growth factor expression in the superior temporal, hippocampal, and brainstem regions in Alzheimer's disease","volume":"11","author":"Provias","year":"2014","journal-title":"Curr Neurovasc Res"},{"issue":"Pt 8","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0042","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/brain\/awp105","article-title":"Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve","volume":"132","author":"Querbes","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0043","series-title":"R: A language and environment for statistical computing","year":"2010"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0044","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/srep02053","article-title":"VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival","volume":"3","author":"Religa","year":"2013","journal-title":"Sci Rep"},{"issue":"21","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0045","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1212\/WNL.0000000000004670","article-title":"Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline","volume":"89","author":"Risacher","year":"2017","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0046","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jalz.2010.03.013","article-title":"Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans","volume":"6","author":"Saykin","year":"2010","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0066","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2012.06.004","article-title":"Alzheimer's Disease Neuroimaging Initiative. Standardization of analysis sets for reporting results from ADNI MRI data","volume":"9","author":"Wyman","year":"2013","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0047","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann Neurol"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0048","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-011-0808-0","article-title":"Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI","volume":"121","author":"Shaw","year":"2011","journal-title":"Acta Neuropathol"},{"issue":"7-8","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0049","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/prca.201400178","article-title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF","volume":"9","author":"Spellman","year":"2015","journal-title":"Proteomics Clin Appl"},{"issue":"21","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0050","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1016\/j.biomaterials.2010.03.042","article-title":"The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer's disease","volume":"31","author":"Spuch","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0051","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular dysfunction-The disregarded partner of Alzheimer's disease","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0052","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0197-4580(01)00285-8","article-title":"Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia","volume":"23","author":"Tarkowski","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0053","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3389\/fnins.2018.00930","article-title":"Impact of Metabolic Syndrome on Neuroinflammation and the Blood-Brain Barrier","volume":"12","author":"Van Dyken","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0054","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/230791","article-title":"Exercise training could improve age-related changes in cerebral blood flow and capillary vascularity through the upregulation of VEGF and eNOS","volume":"2014","author":"Viboolvorakul","year":"2014","journal-title":"Biomed Res Int"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0055","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1212\/WNL.0000000000001401","article-title":"Spatially distinct atrophy is linked to beta-amyloid and tau in preclinical Alzheimer disease","volume":"84","author":"Wang","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0056","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.bbrc.2011.07.003","article-title":"VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease","volume":"411","author":"Wang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0057","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neulet.2018.09.055","article-title":"Association of vascular endothelial growth factor levels in CSF and cerebral glucose metabolism across the Alzheimer's disease spectrum","volume":"687","author":"Wang","year":"2018","journal-title":"Neurosci Lett"},{"issue":"3-4","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0058","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000438494","article-title":"Plasma Biomarkers of Inflammation, Endothelial Function and Hemostasis in Cerebral Small Vessel Disease","volume":"40","author":"Wiseman","year":"2015","journal-title":"Cerebrovasc Dis"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0059","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0197-4580(03)00111-8","article-title":"Co-accumulation of vascular endothelial growth factor with \u03b2-amyloid in the brain of patients with Alzheimer's disease","volume":"25","author":"Yang","year":"2004","journal-title":"Neurobiology of Aging"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0060","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.media.2009.06.002","article-title":"Comparing registration methods for mapping brain change using tensor-based morphometry","volume":"13","author":"Yanovsky","year":"2009","journal-title":"Medical image analysis"},{"key":"10.1016\/j.neurobiolaging.2021.04.025_bib0061","first-page":"1","article-title":"Asymmetric and symmetric unbiased image registration: statistical assessment of performance","author":"Yanovsky","year":"2008","journal-title":"IEEE Computer Society Workshop on Mathematical Methods in Biomedical Image Analysis"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.04.025_bib0062","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2336","article-title":"Neurovascular signalling defects in neurodegeneration","volume":"9","author":"Zacchigna","year":"2008","journal-title":"Nat Rev Neurosci"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458021001482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:41:24Z","timestamp":1759318884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458021001482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":68,"alternative-id":["S0197458021001482"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.025","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}