{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:39:53Z","timestamp":1771501193440,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014028","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.neurobiolaging.2021.06.019","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T19:57:22Z","timestamp":1625342242000},"page":"189-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Genetic overlap between Alzheimer's disease and blood lipid levels"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-5813","authenticated-orcid":false,"given":"Robert J.","family":"van der Linden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne M.","family":"Reus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ward","family":"De Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Olde Rikkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-6985","authenticated-orcid":false,"given":"Geert","family":"Poelmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0001","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.3892\/mmr.2015.4081","article-title":"Association of genetic variants with dyslipidemia","volume":"12","author":"Abe","year":"2015","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0002","doi-asserted-by":"crossref","first-page":"e821","DOI":"10.1016\/j.neurobiolaging.2011.07.014","article-title":"Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight","volume":"33","author":"Amtul","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0003","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12868-018-0413-4","article-title":"Haplotype analysis of APOE intragenic SNPs","volume":"19","author":"Babenko","year":"2018","journal-title":"BMC Neurosci"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0004","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0005","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/mp.2017.98","article-title":"Autism spectrum disorders and autistic traits share genetics and biology","volume":"23","author":"Bralten","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0006","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fendo.2017.00060","article-title":"Lipid processing in the brain: a key regulator of systemic metabolism","volume":"8","author":"Bruce","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0007","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/MOL.0000000000000604","article-title":"HDL from an Alzheimer's disease perspective","volume":"30","author":"Button","year":"2019","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0008","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders","volume":"9","author":"Cai","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0009","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.dadm.2017.07.006","article-title":"Blood-based metabolic signatures in Alzheimer's disease","volume":"8","author":"de Leeuw","year":"2017","journal-title":"Alzheimers Dement (Amst)"},{"issue":"23","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0010","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1161\/CIRCULATIONAHA.115.015489","article-title":"Polygenic overlap between c-reactive protein, plasma lipids, and alzheimer disease","volume":"131","author":"Desikan","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0011","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1038\/ncomms8208","article-title":"Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels","volume":"6","author":"Draisma","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/JAD-160169","article-title":"Alzheimer's disease risk genes and lipid regulators","volume":"53","author":"El Gaamouch","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0013","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/btu848","article-title":"PRSice: polygenic risk score software","volume":"31","author":"Euesden","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0014","unstructured":"Feingold, K.R., 2000. Introduction to Lipids and Lipoproteins, in: Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dungan, K., Grossman, A., Hershman, J.M., Hofland, J., Kaltsas, G., Koch, C., Kopp, P., Korbonits, M., McLachlan, R., Morley, J.E., New, M., Purnell, J., Singer, F., Stratakis, C.A., Trence, D.L., Wilson, D.P. (Eds.), Endotext. South Dartmouth (MA)."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0016","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.66.3.343","article-title":"Contribution of vascular risk factors to the progression in Alzheimer disease","volume":"66","author":"Helzner","year":"2009","journal-title":"Arch Neurol"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0017","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","article-title":"Metabolic phenotyping in health and disease","volume":"134","author":"Holmes","year":"2008","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0018","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0019","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","article-title":"Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0020","unstructured":"Johnson, T., 2013. gtx: Genetics ToolboX. R package version 0.0 8."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041505","article-title":"Lipids and Alzheimer's disease","volume":"21","author":"Kao","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0022","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1038\/ncomms11122","article-title":"Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA","volume":"7","author":"Kettunen","year":"2016","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0023","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","article-title":"Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease","volume":"14","author":"Kivipelto","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0024","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3233\/JAD-181252","article-title":"Low-density lipoprotein particle size subfractions and cerebral amyloidosis","volume":"68","author":"Lee","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"23","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0025","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1158\/0008-5472.CAN-16-1597","article-title":"Destabilization of fatty acid synthase by acetylation inhibits de novo lipogenesis and tumor cell growth","volume":"76","author":"Lin","year":"2016","journal-title":"Cancer Res"},{"issue":"10248","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0026","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0027","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins: apoe and regulation of cholesterol metabolism","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0028","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.1038\/s41598-018-24432-w","article-title":"BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia","volume":"8","author":"Miao","year":"2018","journal-title":"Sci Rep"},{"issue":"14","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0029","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1093\/bioinformatics\/btu171","article-title":"SECA: SNP effect concordance analysis using genome-wide association summary results","volume":"30","author":"Nyholt","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0030","series-title":"World Alzheimer Report 2018: the state of the art of dementia research: new frontiers","author":"Patterson","year":"2018"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0031","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"7256","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0032","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"Purcell","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0033","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11883-012-0307-3","article-title":"Dyslipidemia and the risk of Alzheimer's disease","volume":"15","author":"Reitz","year":"2013","journal-title":"Curr Atheroscler Rep"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cmet.2013.06.013","article-title":"A genome-wide association study of the human metabolome in a community-based cohort","volume":"18","author":"Rhee","year":"2013","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0035","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/archneurol.2011.203","article-title":"Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies","volume":"68","author":"Shepardson","year":"2011","journal-title":"Arch Neurol"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0036","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ng.2982","article-title":"An atlas of genetic influences on human blood metabolites","volume":"46","author":"Shin","year":"2014","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002266","article-title":"Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study","volume":"14","author":"Snowden","year":"2017","journal-title":"PLoS Med"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0038","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2796.2006.01687.x","article-title":"Cardiovascular disease and Alzheimer's disease: common links","volume":"260","author":"Stampfer","year":"2006","journal-title":"J Intern Med"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0039","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fnagi.2019.00370","article-title":"Revealing a novel landscape of the association between blood lipid levels and Alzheimer's disease: a meta-analysis of a case-control study","volume":"11","author":"Tang","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0040","doi-asserted-by":"crossref","unstructured":"Wallace, C., 2021. A more accurate method for colocalisation analysis allowing for multiple causal variants. bioRxiv.","DOI":"10.1101\/2021.02.23.432421"},{"key":"10.1016\/j.neurobiolaging.2021.06.019_bib0041","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3389\/fneur.2017.00719","article-title":"Application of metabolomics in Alzheimer's disease","volume":"8","author":"Wilkins","year":"2017","journal-title":"Front Neurol"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0042","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/jamaneurol.2019.0648","article-title":"Association of early-onset alzheimer disease with elevated low-density lipoprotein cholesterol levels and rare genetic coding variants of APOB","volume":"76","author":"Wingo","year":"2019","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2021.06.019_bib0043","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41531-021-00168-9","article-title":"Shared genetic etiology between Parkinson's disease and blood levels of specific lipids","volume":"7","author":"Xicoy","year":"2021","journal-title":"NPJ Parkinsons Dis"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802100213X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802100213X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:40:56Z","timestamp":1759318856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802100213X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"alternative-id":["S019745802100213X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.06.019","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic overlap between Alzheimer's disease and blood lipid levels","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}