{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:21:45Z","timestamp":1777864905496,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS042861"],"award-info":[{"award-number":["NS042861"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS058793"],"award-info":[{"award-number":["NS058793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NR010827"],"award-info":[{"award-number":["R01NR010827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007742","name":"BioClinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007333","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR023043"],"award-info":[{"award-number":["S10RR023043"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR019307"],"award-info":[{"award-number":["S10RR019307"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR021110"],"award-info":[{"award-number":["S10RR021110"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR023401"],"award-info":[{"award-number":["S10RR023401"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR019254"],"award-info":[{"award-number":["S10RR019254"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.neurobiolaging.2022.02.008","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T11:18:55Z","timestamp":1646047135000},"page":"105-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-386X","authenticated-orcid":false,"given":"Joost M.","family":"Riphagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahanand Belathur","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Salat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0001","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000226774","article-title":"White matter lesions and brain atrophy: more than shared risk factors? A systematic review","volume":"28","author":"Appelman","year":"2009","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0002","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuroimage.2013.02.059","article-title":"The effects of aging and Alzheimer's disease on cerebral cortical anatomy: specificity and differential relationships with cognition","volume":"76","author":"Bakkour","year":"2013","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0003","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/hbm.23922","article-title":"Factors influencing accuracy of cortical thickness in the diagnosis of Alzheimer's disease. Hum","volume":"39","author":"Belathur Suresh","year":"2018","journal-title":"Brain Mapp"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0004","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neurobiolaging.2013.10.072","article-title":"Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function","volume":"35","author":"Birdsill","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2015.03.005","article-title":"Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated","volume":"592","author":"Brickman","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0006","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/jnnp.2003.019273","article-title":"White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease","volume":"75","author":"Capizzano","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000515322","article-title":"Brain Atrophy Subtypes and the ATN Classification Scheme in Alzheimer's Disease","volume":"20","author":"Cedres","year":"2020","journal-title":"Neurodegener. Dis."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jnnp.70.1.9","article-title":"Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study","volume":"70","author":"de Leeuw","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0009","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/STROKEAHA.109.570044","article-title":"Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study","volume":"41","author":"Debette","year":"2010","journal-title":"Stroke."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0010","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1161\/STROKEAHA.107.488403","article-title":"Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment","volume":"38","author":"Debette","year":"2007","journal-title":"Stroke."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0011","unstructured":"DeCarli., C., Maillard., P., Fletcher., E., 2013. Available at: https:\/\/adni.bitbucket.io\/reference\/docs\/UCD_ADNI2_WMH\/UCD%20ADNI%20II%204%20tissue%20segmentation%20Method.pdf. (accessed 7 January 2021)"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0012","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13195-021-00869-6","article-title":"White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer's disease","volume":"13","author":"Desmarais","year":"2021","journal-title":"Alzheimers. Res. Ther."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0013","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"Dickerson","year":"2009","journal-title":"Cereb. Cortex."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0014","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000323014","article-title":"High White Matter Lesion Load Is Associated with Hippocampal Atrophy in Mild Cognitive Impairment","volume":"31","author":"Eckerstr\u00f6m","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0015","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1212\/WNL.0b013e3182a43e45","article-title":"Neuropathologic basis of white matter hyperintensity accumulation with advanced age","volume":"81","author":"Erten-Lyons","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neurobiolaging.2018.05.028","article-title":"The contribution of small vessel disease to subtypes of Alzheimer's disease: a study on cerebrospinal fluid and imaging biomarkers","volume":"70","author":"Ferreira","year":"2018","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0017","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","article-title":"Sequence-independent segmentation of magnetic resonance images","volume":"23","author":"Fischl","year":"2004","journal-title":"Neuroimage."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0018","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0019","first-page":"5319","article-title":"Adaptive image segmentation for robust measurement of longitudinal brain tissue change","volume":"2012","author":"Fletcher","year":"2012","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0020","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/alz.12410","article-title":"White matter hyperintensity topography in Alzheimer\u2019s disease and links to cognition","volume":"18","author":"Garnier-Crussard","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"issue":"20","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0021","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1212\/WNL.0000000000004645","article-title":"Serum neurofilament light is sensitive to active cerebral small vessel disease","volume":"89","author":"Gattringer","year":"2017","journal-title":"Neurology."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0022","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000226117","article-title":"Association of White-Matter Lesions with Brain Atrophy Markers: The Three-City Dijon MRI Study","volume":"28","author":"Godin","year":"2009","journal-title":"Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0023","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1198\/106186006X137047","article-title":"Optimal Full Matching and Related Designs via Network Flows","volume":"15","author":"Hansen","year":"2006","journal-title":"J. Comp. Graph. Stats."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0024","doi-asserted-by":"crossref","unstructured":"Ho, D., Imai, K., King, G., Stuart, E.A. , 2011. MatchIt: Nonparametric Preprocessing for Parametric Causal Inference. 2011 42(8), 28.","DOI":"10.18637\/jss.v042.i08"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0026","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet. Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0027","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods","volume":"27","author":"Jack Jr","year":"2008","journal-title":"J. Magn. Reson. Imaging."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0028","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-131232","article-title":"White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease","volume":"39","author":"Jacobs","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0029","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hbm.21412","article-title":"Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health","volume":"34","author":"Jacobs","year":"2013","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jalz.2018.11.002","article-title":"Alzheimer's disease\" is neither \"Alzheimer's clinical syndrome\" nor \"dementia\"","volume":"15","author":"Jagust","year":"2019","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0031","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.dadm.2016.03.001","article-title":"White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration","volume":"4","author":"Kandel","year":"2016","journal-title":"Alzheimers Dement. (Amst)"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0032","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/STROKEAHA.114.007847","article-title":"Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: atherosclerosis risk in communities-neurocognitive study","volume":"46","author":"Knopman","year":"2015","journal-title":"Stroke."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0033","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.23650","article-title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","volume":"72","author":"Landau","year":"2012","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0034","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hbm.22236","article-title":"Associations between T1 white matter lesion volume and regional white matter microstructure in aging","volume":"35","author":"Leritz","year":"2014","journal-title":"Hum. Brain. Mapp."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-161057","article-title":"Differential Regional Distribution of Juxtacortical White Matter Signal Abnormalities in Aging and Alzheimer's Disease","volume":"57","author":"Lindemer","year":"2017","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0036","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nicl.2017.01.022","article-title":"Regional staging of white matter signal abnormalities in aging and Alzheimer's disease","volume":"14","author":"Lindemer","year":"2017","journal-title":"NeuroImage."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0037","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.neurobiolaging.2015.05.011","article-title":"White matter signal abnormality quality differentiates mild cognitive impairment that converts to Alzheimer's disease from nonconverters","volume":"36","author":"Lindemer","year":"2015","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0038","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-015-0240-0","article-title":"Cortical tau load is associated with white matter hyperintensities","volume":"3","author":"McAleese","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0039","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-021-02376-2","article-title":"Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology","author":"McAleese","year":"2021","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0040","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta. Neuropathol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0041","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer's Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0042","doi-asserted-by":"crossref","first-page":"e56972","DOI":"10.1371\/journal.pone.0056972","article-title":"Spatial distribution of cerebral white matter lesions predicts progression to mild cognitive impairment and dementia","volume":"8","author":"Mortamais","year":"2013","journal-title":"PLoS ONE."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0043","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.2003.014910","article-title":"Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis","volume":"75","author":"O'Sullivan","year":"2004","journal-title":"J Neurol. Neurosurg. Psychiatry."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0044","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1212\/WNL.57.12.2307","article-title":"Normal-appearing white matter in ischemic leukoaraiosis: a diffusion tensor MRI study","volume":"57","author":"O'Sullivan","year":"2001","journal-title":"Neurology."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","article-title":"White matter hyperintensities, cognitive impairment and dementia: an update","volume":"11","author":"Prins","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0046","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jamaneurol.2013.1321","article-title":"White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?","volume":"70","author":"Provenzano","year":"2013","journal-title":"JAMA. Neurol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0047","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jalz.2015.06.1886","article-title":"White matter hyperintensity burden in elderly cohort studies: The Sunnybrook Dementia Study, Alzheimer's Disease Neuroimaging Initiative, and Three-City Study","volume":"12","author":"Ramirez","year":"2016","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0048","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neurobiolaging.2018.03.029","article-title":"Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia","volume":"68","author":"Riphagen","year":"2018","journal-title":"Neurobiol. Aging."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0049","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.25166","article-title":"Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults","volume":"4","author":"Rizvi","year":"2021","journal-title":"JAMA. Netw. Open."},{"key":"10.1016\/j.neurobiolaging.2022.02.008_bib0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2017.12.006","article-title":"The effect of white matter hyperintensities on cognition is mediated by cortical atrophy","volume":"64","author":"Rizvi","year":"2018","journal-title":"Neurobiol. Aging."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0051","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/brain.2011.0056","article-title":"The declining infrastructure of the aging brain","volume":"1","author":"Salat","year":"2011","journal-title":"Brain Connect."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0052","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.neurobiolaging.2010.12.003","article-title":"Cortical thinning related to periventricular and deep white matter hyperintensities","volume":"33","author":"Seo","year":"2012","journal-title":"Neurobiol. Aging."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0053","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical TrialEffect of Intensive vs Standard Blood Pressure Control on Probable DementiaEffect of Intensive vs Standard Blood Pressure Control on Probable Dementia","volume":"321","year":"2019","journal-title":"JAMA."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0054","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular dysfunction\u2014The disregarded partner of Alzheimer's disease","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimer's Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/STROKEAHA.114.007146","article-title":"Relationship between white matter hyperintensities, cortical thickness, and cognition","volume":"46","author":"Tuladhar","year":"2015","journal-title":"Stroke."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0056","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hipo.23308","article-title":"Influence of regional white matter hyperintensity volume and apolipoprotein E \u03b54 status on hippocampal volume in healthy older adults","volume":"31","author":"Van Etten","year":"2021","journal-title":"Hippocampus."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0057","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archgenpsychiatry.2009.5","article-title":"White matter microstructural integrity and cognitive function in a general elderly population","volume":"66","author":"Vernooij","year":"2009","journal-title":"Arch. Gen. Psychiatry."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0058","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1212\/WNL.0000000000000550","article-title":"Vascular risk and A\u03b2 interact to reduce cortical thickness in AD vulnerable brain regions","volume":"83","author":"Villeneuve","year":"2014","journal-title":"Neurology."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0059","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000334607","article-title":"Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4\/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis","volume":"38","author":"Ward","year":"2012","journal-title":"Neuroepidemiology."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0060","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroimage.2005.08.057","article-title":"Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample","volume":"29","author":"Wen","year":"2006","journal-title":"Neuroimage."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0061","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jamaneurol.2016.5755","volume":"74","author":"Xia","year":"2017","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.02.008_bib0062","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10571-014-0127-9","article-title":"From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration","volume":"35","author":"Zhao","year":"2015","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802200029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802200029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:50:42Z","timestamp":1777528242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802200029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":62,"alternative-id":["S019745802200029X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.02.008","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}