{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:38:37Z","timestamp":1776310717747,"version":"3.50.1"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Qu\u00e9bec Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.neurobiolaging.2022.04.005","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:11:43Z","timestamp":1649711503000},"page":"77-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-6747","authenticated-orcid":false,"given":"Maggie","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Edde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-7521","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Croteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian-Alexandre","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"St-Pierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Rheault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-2672","authenticated-orcid":false,"given":"Mahsa","family":"Dadar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Duchesne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bocti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Fulop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Cunnane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-2129","authenticated-orcid":false,"given":"Maxime","family":"Descoteaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0001","author":"Ashburner"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.101001","article-title":"Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies","volume":"58","author":"Avgerinos","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0003","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pscychresns.2013.10.010","article-title":"Whole cortical and default mode network mean functional connectivity as potential biomarkers for mild Alzheimer's disease","volume":"221","author":"Balthazar","year":"2014","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0004","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis","volume":"360","author":"Beckmann","year":"2005","journal-title":"Phil. Trans. R. Soc. B"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0005","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1016\/j.neurobiolaging.2015.07.002","article-title":"PCC characteristics at rest in 10-year memory decliners","volume":"36","author":"Bernard","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0006","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/cercor\/bhaa209","article-title":"Hyperconnectivity in dementia is early and focal and wanes with progression","volume":"31","author":"Bonanni","year":"2021","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118487","article-title":"Brain parcellation selection: an overlooked decision point with meaningful effects on individual differences in resting-state functional connectivity","volume":"243","author":"Bryce","year":"2021","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0008","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/brain\/awy053","article-title":"Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing","volume":"141","author":"Chhatwal","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0009","unstructured":"Cohen, J., 1988. Statistical Power Analysis for the Behavioral Sciences, second ed. New York University, New York, USA. Lawrence Erlbaum Associates."},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.nut.2012.09.009","article-title":"Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism","volume":"29","author":"Courchesne-Loyer","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0011","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exger.2017.07.004","article-title":"A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease","volume":"107","author":"Croteau","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0012","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jhevol.2014.05.001","article-title":"Energetic and nutritional constraints on infant brain development: implications for brain expansion during human evolution","volume":"77","author":"Cunnane","year":"2014","journal-title":"J Hum Evol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0013","doi-asserted-by":"crossref","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing","author":"Cunnane","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0014","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/hbm.23894","article-title":"Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging","volume":"39","author":"Dadar","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroimage.2017.06.009","article-title":"Performance comparison of 10 different classification techniques in segmenting white matter hyperintensities in aging","volume":"157","author":"Dadar","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0016","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/alzrt106","article-title":"Resting-state fMRI as a biomarker for Alzheimer's disease?","volume":"4","author":"Damoiseaux","year":"2012","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0017","doi-asserted-by":"crossref","unstructured":"Delis, D., Kaplan, E., Kramer, J., 2001. Delis-Kaplan Executive Function System (D-KEFS). The Psychological Corporation, San Antonio, TX (USA).","DOI":"10.1037\/t15082-000"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0018","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1109\/TMI.2008.2004424","article-title":"Deterministic and probabilistic tractography based on complex fibre orientation distributions","volume":"28","author":"Descoteaux","year":"2009","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0019","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41583-018-0071-7","article-title":"Imaging-based parcellations of the human brain","volume":"19","author":"Eickhoff","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuroimage.2005.02.004","article-title":"The activation of attentional networks","volume":"26","author":"Fan","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0021","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human brainnetome atlas: a new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0022","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0023","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11745-007-3132-7","article-title":"Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation","volume":"43","author":"Forsythe","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0024","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jalz.2018.12.017","article-title":"A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment","volume":"15","author":"Fortier","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0025","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/alz.12206","article-title":"A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT","volume":"17","author":"Fortier","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0026","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1073\/pnas.0604187103","article-title":"Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems","volume":"103","author":"Fox","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0027","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fnagi.2017.00264","article-title":"Resting-state connectivity of the left frontal cortex to the default mode and dorsal attention network supports reserve in mild cognitive impairment","volume":"9","author":"Franzmeier","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.782657","article-title":"Neuroprotection by the ketogenic diet: evidence and controversies","volume":"8","author":"Gough","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0029","doi-asserted-by":"crossref","DOI":"10.1093\/advances\/nmaa073","article-title":"To keto or not to keto? A systematic review of randomized controlled trials assessing the effects of ketogenic therapy on Alzheimer Disease","author":"Grammatikopoulou","year":"2020","journal-title":"Adv Nutr"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0030","doi-asserted-by":"crossref","first-page":"17108","DOI":"10.1038\/s41598-021-96333-4","article-title":"Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults","volume":"11","author":"Greeley","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0031","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.758298","article-title":"Baseline neuroimaging predicts decline to dementia from amnestic mild cognitive impairment","volume":"13","author":"Gullett","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0033","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00429-020-02111-9","article-title":"MRI spectroscopic and tractography studies indicate consequences of long-term ketogenic diet","volume":"225","author":"Gzie\u0142o","year":"2020","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0034","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-022-00535-1","article-title":"Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults","author":"Hardcastle","year":"2022","journal-title":"Geroscience"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0035","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tics.2017.03.003","article-title":"Injured Brains and adaptive networks: the benefits and costs of hyperconnectivity","volume":"21","author":"Hillary","year":"2017","journal-title":"Trends in Cognitive Sciences"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0036","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/neu0000110","article-title":"Hyperconnectivity is a fundamental response to neurological disruption","volume":"29","author":"Hillary","year":"2015","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0037","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2018.08.026","article-title":"Increased posterior default mode network activity and structural connectivity in young adult APOE-epsilon4 carriers: a multimodal imaging investigation","volume":"73","author":"Hodgetts","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0038","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3233\/ADR-210017","article-title":"Alzheimer's disease progressively reduces visual functional network connectivity","volume":"5","author":"Huang","year":"2021","journal-title":"ADR"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0039","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cortex.2017.09.018","article-title":"Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum","volume":"97","author":"Jones","year":"2017","journal-title":"Cortex"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0040","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/brain\/awv338","article-title":"Cascading network failure across the Alzheimer's disease spectrum","volume":"139","author":"Jones","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0041","doi-asserted-by":"crossref","DOI":"10.1002\/trc2.12259","article-title":"Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: a randomized, double-blind, placebo-controlled, crossover study, with an open-label extension","volume":"8","author":"Juby","year":"2022","journal-title":"A&D Transl Res & Clin Interv"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0042","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2008173118","article-title":"Communication consumes 35 times more energy than computation in the human cortex, but both costs are needed to predict synapse number","volume":"118","author":"Levy","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0043","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresrev.2008.09.002","article-title":"The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies","volume":"59","author":"Maalouf","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0044","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jmr.2016.11.013","article-title":"The physical mechanism of \u201cinhomogeneous\u201d magnetization transfer MRI","volume":"274","author":"Manning","year":"2017","journal-title":"J Magn Reson"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0045","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuint.2005.12.037","article-title":"Neuronal-glial interactions in rats fed a ketogenic diet","volume":"48","author":"Mel\u00f8","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0046","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/brain\/awx355","article-title":"Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment","volume":"141","author":"Mito","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0047","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00259-005-1762-7","article-title":"Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD","volume":"32","author":"Mosconi","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0048","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2019.09.015","article-title":"Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study","volume":"86","author":"Neth","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0049","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.neurobiolaging.2013.11.027","article-title":"Brain glucose and acetoacetate metabolism: a comparison of young and older adults","volume":"35","author":"Nugent","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jcbfm.1983.1","article-title":"Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data","volume":"3","author":"Patlak","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0052","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J Intern Med"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0053","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1179\/1476830510Y.0000000001","article-title":"Mild experimental ketosis increases brain uptake of 11 C-acetoacetate and 18 F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats","volume":"14","author":"Pifferi","year":"2011","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0054","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/psyp.12395","article-title":"Single bouts of exercise selectively sustain attentional processes","volume":"52","author":"Pontifex","year":"2015","journal-title":"Psychophysiology"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118201","article-title":"Inter-subject and inter-parcellation variability of resting-state whole-brain dynamical modeling","volume":"236","author":"Popovych","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0056","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuroimage.2016.09.029","article-title":"Investigating white matter fibre density and morphology using fixel-based analysis","volume":"144","author":"Raffelt","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0057","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/ncomms4944","article-title":"The \u03b2-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages","volume":"5","author":"Rahman","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0058","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrn3338","article-title":"Two cortical systems for memory-guided behaviour","volume":"13","author":"Ranganath","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0059","doi-asserted-by":"crossref","first-page":"195.e27","DOI":"10.1016\/j.neurobiolaging.2010.05.014","article-title":"Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease","volume":"33","author":"Redel","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0060","series-title":"Presented at the virtual annual Meeting","article-title":"Connectoflow: A cutting-edge Nextflow pipeline for structural connectomics","author":"Rheault","year":"2021"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0061","doi-asserted-by":"crossref","first-page":"e12217","DOI":"10.1002\/trc2.12217","article-title":"A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment","volume":"7","author":"Roy","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0062","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2012.10.008","article-title":"The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study","volume":"1488","author":"Roy","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0063","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3233\/JAD-200213","article-title":"Fascicle- and glucose-specific deterioration in white matter energy supply in Alzheimer's disease","volume":"76","author":"Roy","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0064","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.conb.2017.09.013","article-title":"Myelin dynamics: protecting and shaping neuronal functions","volume":"47","author":"Saab","year":"2017","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0065","doi-asserted-by":"crossref","DOI":"10.1002\/alz.12310","article-title":"Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression","author":"Saito","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0066","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.102052","article-title":"Longitudinal degradation of the default\/salience network axis in symptomatic individuals with elevated amyloid burden","volume":"26","author":"Schultz","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0068","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0069","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1523\/JNEUROSCI.3067-17.2018","article-title":"The longitudinal trajectory of default mode network connectivity in healthy older adults varies as a function of age and is associated with changes in episodic memory and processing speed","volume":"38","author":"Staffaroni","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbadis.2011.09.012","article-title":"Exploring the neural basis of cognitive reserve in aging","volume":"1822","author":"Steffener","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0071","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1017\/S1355617702813248","article-title":"What is cognitive reserve? Theory and research application of the reserve concept","volume":"8","author":"Stern","year":"2002","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0072","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jalz.2018.07.219","article-title":"Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance","volume":"16","author":"Stern","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0073","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3390\/nu13072186","article-title":"Graph theory-based electroencephalographic connectivity and its association with ketogenic diet effectiveness in epileptic children","volume":"13","author":"Su","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0074","article-title":"TractoFlow-ABS (Atlas-Based Segmentation) (preprint)","author":"Theaud","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0075","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jamaneurol.2014.1654","article-title":"Functional connectivity in autosomal dominant and late-onset Alzheimer disease","volume":"71","author":"Thomas","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0076","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exger.2018.07.009","article-title":"Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study","volume":"111","author":"Torosyan","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0077","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0078","doi-asserted-by":"crossref","first-page":"fcab269","DOI":"10.1093\/braincomms\/fcab269","article-title":"Brain atrophy progression in Parkinson's disease is shaped by connectivity and local vulnerability","volume":"3","author":"Tremblay","year":"2021","journal-title":"Brain Commun"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.781465","article-title":"Altered interplay among large-scale brain functional networks modulates multi-domain anosognosia in early Alzheimer's disease","volume":"13","author":"Valera-Bermejo","year":"2022","journal-title":"Front. Aging Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.102952","article-title":"Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease","volume":"33","author":"van Balkom","year":"2022","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0081","unstructured":"Wechsler, D., 1997. Wechsler Memory Scale. The Psychological Corporation, San Antonio, TX (USA)."},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0082","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/1567205011666140131114716","article-title":"Default mode, executive function, and language functional connectivity networks are compromised in mild Alzheimer's disease","volume":"11","author":"Weiler","year":"2014","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0083","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/BPL-160039","article-title":"The acute effects of aerobic exercise on the functional connectivity of human brain networks","volume":"2","author":"Weng","year":"2017","journal-title":"BPL"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0084","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0085","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3233\/JAD-160353","article-title":"Differential effects of APOE genotypes on the anterior and posterior subnetworks of default mode network in amnestic mild cognitive impairment","volume":"54","author":"Yuan","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0086","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.plefa.2003.07.005","article-title":"Ketogenic diet, brain glutamate metabolism and seizure control","volume":"70","author":"Yudkoff","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0087","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.783634","article-title":"altered intra- and inter-network connectivity in drug-na\u00efve patients with early Parkinson's disease","volume":"14","author":"Zeng","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0088","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2014.11.050","article-title":"Functional degeneration in dorsal and ventral attention systems in amnestic mild cognitive impairment and Alzheimer's disease: an fMRI study","volume":"585","author":"Zhang","year":"2015","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.neurobiolaging.2022.04.005_bib0089","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4103\/1673-5374.332161","article-title":"Abnormal characterization of dynamic functional connectivity in Alzheimer's disease","volume":"17","author":"Zhao","year":"2022","journal-title":"Neural Regen Res"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022000744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022000744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:42:48Z","timestamp":1759318968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458022000744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":89,"alternative-id":["S0197458022000744"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.04.005","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}