{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:02:51Z","timestamp":1789646571090,"version":"4.0.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.neurobiolaging.2022.07.010","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T02:22:30Z","timestamp":1659234150000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Association of glial tau pathology and LATE-NC in the ageing brain"],"prefix":"10.1016","volume":"119","author":[{"given":"Shelley L.","family":"Forrest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ain","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-5511","authenticated-orcid":false,"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0001","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jnen\/nlz126","article-title":"Limbic predominant age-related TDP-43 encephalopathy (LATE): clinical and neuropathological associations","volume":"79","author":"Besser","year":"2020","journal-title":"J Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-020-02235-6","article-title":"Brain arteriolosclerosis","volume":"141","author":"Blevins","year":"2021","journal-title":"Acta. Neuropathol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0003","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta. Neuropathol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0004","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0005","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2022.07.010_bib0006","first-page":"1","article-title":"Current concepts of mixed pathologies in neurodegenerative diseases","volume":"31","author":"Forrest","year":"2022","journal-title":"Can. J Neurol Sci."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0007","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/jnen\/nlz017","article-title":"Chronic traumatic encephalopathy (CTE) is absent from a European community-based aging cohort while cortical aging-related tau astrogliopathy (ARTAG) is highly prevalent","volume":"78","author":"Forrest","year":"2019","journal-title":"J Neuropathol Exp Neurol."},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0008","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/brain\/awr128","article-title":"Oxidative damage in multiple sclerosis lesions","volume":"134","author":"Haider","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.07.010_bib0009","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neurobiolaging.2017.04.024","article-title":"White-matter integrity on DTI and the pathologic staging of Alzheimer's disease","volume":"56","author":"Kantarci","year":"2017","journal-title":"Neurobiol Aging"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0010","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/jamaneurol.2020.1741","article-title":"Prevalence and clinical phenotype of quadruple misfolded proteins in older adults","volume":"77","author":"Karanth","year":"2020","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0011","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0012","doi-asserted-by":"crossref","first-page":"e12792","DOI":"10.1111\/nan.12792","article-title":"Classification of diseases with accumulation of Tau protein","volume":"48","author":"Kovacs","year":"2022","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0013","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0014","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/NEN.0b013e318187a80f","article-title":"White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration","volume":"67","author":"Kovacs","year":"2008","journal-title":"J Neuropathol Exp Neurol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0015","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00401-013-1157-y","article-title":"Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series","volume":"126","author":"Kovacs","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0016","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00401-011-0819-x","article-title":"A peculiar constellation of tau pathology defines a subset of dementia in the elderly","volume":"122","author":"Kovacs","year":"2011","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0017","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/jnen\/nlx007","article-title":"Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases","volume":"76","author":"Kovacs","year":"2017","journal-title":"J Neuropathol Exp Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0018","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40478-018-0552-y","article-title":"Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain","volume":"6","author":"Kovacs","year":"2018","journal-title":"Acta Neuropathol Commun."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40478-016-0330-7","article-title":"ARTAG in the basal forebrain: widening the constellation of astrocytic tau pathology","volume":"4","author":"Liu","year":"2016","journal-title":"Acta Neuropathol Commun."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0020","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00401-021-02376-2","article-title":"Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology","volume":"142","author":"McAleese","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0021","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/nan.12664","article-title":"Concomitant LATE-NC in Alzheimer's disease is not associated with increased tau or amyloid-beta pathological burden","volume":"46","author":"McAleese","year":"2020","journal-title":"Neuropathol Appl Neurobiol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0022","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/bpa.12424","article-title":"TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing","volume":"27","author":"McAleese","year":"2017","journal-title":"Brain Pathol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0023","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0024","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jnen\/nlx099","article-title":"The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases","volume":"77","author":"Nelson","year":"2018","journal-title":"J Neuropathol Exp Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00401-022-02444-1","article-title":"Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts","volume":"144","author":"Nelson","year":"2022","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0026","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"issue":"Pt B","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0027","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.arr.2015.07.007","article-title":"ABCC9\/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target","volume":"24","author":"Nelson","year":"2015","journal-title":"Ageing Res Rev."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0028","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00401-013-1154-1","article-title":"Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease","volume":"126","author":"Nelson","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0029","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/jnen\/nlz094","article-title":"Astrocytic tau deposition is frequent in typical and atypical Alzheimer disease presentations","volume":"78","author":"Nolan","year":"2019","journal-title":"J Neuropathol Exp Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.25246","article-title":"Combined neuropathological pathways account for age-related risk of dementia","volume":"84","author":"Power","year":"2018","journal-title":"Ann Neurol."},{"issue":"13","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0031","doi-asserted-by":"crossref","first-page":"e1353","DOI":"10.1212\/WNL.0000000000008937","article-title":"Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes","volume":"94","author":"Resende","year":"2020","journal-title":"Neurology"},{"issue":"51","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0032","doi-asserted-by":"crossref","first-page":"26038","DOI":"10.1073\/pnas.1913741116","article-title":"Corpora amylacea act as containers that remove waste products from the brain","volume":"116","author":"Riba","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0033","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00401-018-1872-5","article-title":"Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study","volume":"136","author":"Robinson","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0034","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/brain\/awaa219","article-title":"Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration","volume":"143","author":"Robinson","year":"2020","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0035","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/jnen\/nlw034","article-title":"Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study","volume":"75","author":"Rodriguez","year":"2016","journal-title":"J Neuropathol Exp Neurol."},{"key":"10.1016\/j.neurobiolaging.2022.07.010_bib0036","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/ncomms3932","article-title":"Pericyte loss influences Alzheimer-like neurodegeneration in mice","volume":"4","author":"Sagare","year":"2013","journal-title":"Nat Commun."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0037","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00005072-199602000-00008","article-title":"Extrusion of corpora amylacea from the marginal gila at the vestibular root entry zone","volume":"55","author":"Sbarbati","year":"1996","journal-title":"J Neuropathol Exp Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0038","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/jnen\/59.1.39","article-title":"Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons","volume":"59","author":"Schultz","year":"2000","journal-title":"J Neuropathol Exp Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0039","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1212\/WNL.0000000000005864","article-title":"Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions","volume":"91","author":"Strain","year":"2018","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0040","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/jnen\/nlab098","article-title":"Differences in Symptomatic Presentation and Cognitive Performance Among Participants With LATE-NC Compared to FTLD-TDP","volume":"80","author":"Teylan","year":"2021","journal-title":"J Neuropathol Exp Neurol."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0041","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"18","key":"10.1016\/j.neurobiolaging.2022.07.010_bib0042","first-page":"1","article-title":"Amygdala granular fuzzy astrocytes as lesions preceding development of argyrophilic grains: data from 239 non-selected cases","volume":"3","author":"Yokota","year":"2022","journal-title":"Free Neuropathology"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802200166X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802200166X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:42:58Z","timestamp":1759318978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802200166X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":42,"alternative-id":["S019745802200166X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.07.010","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of glial tau pathology and LATE-NC in the ageing brain","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}