{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:16:59Z","timestamp":1793996219126,"version":"4.8.0"},"reference-count":193,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.neurobiolaging.2022.08.014","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T03:18:42Z","timestamp":1662088722000},"page":"88-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Evidence of sex differences in cellular senescence"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-395X","authenticated-orcid":false,"given":"Mitchell","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2715-1485","authenticated-orcid":false,"given":"Lili-Naz","family":"Hazrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0001","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1210\/endo.135.1.8013375","article-title":"Androgens regulate aromatase cytochrome P450 messenger ribonucleic acid in rat brain","volume":"135","author":"Abdelgadir","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0002","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0003","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1503\/jpn.150205","article-title":"Why is depression more prevalent in women?","volume":"40","author":"Albert","year":"2015","journal-title":"J. Psychiatry Neurosci. JPN"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0004","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1073\/pnas.93.24.13742","article-title":"Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts","volume":"93","author":"Alcorta","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002383","article-title":"Testosterone antagonizes doxorubicin-induced senescence of cardiomyocytes","volume":"5","author":"Altieri","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0006","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3233\/JAD-150780","article-title":"Analysis of the MIRIAD data shows sex differences in hippocampal atrophy progression","volume":"50","author":"Ardekani","year":"2016","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0007","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/neu.1038","article-title":"Brain aromatase is neuroprotective","volume":"47","author":"Azcoitia","year":"2001","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0008","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0009","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1744","article-title":"Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency","volume":"10","author":"Baker","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0011","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/archpsyc.62.6.685","article-title":"Sex differences in the clinical manifestations of Alzheimer disease pathology","volume":"62","author":"Barnes","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0012","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1474-9726.2011.00741.x","article-title":"Sex differences in telomeres and lifespan","volume":"10","author":"Barrett","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0013","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1038\/sj.onc.1210881","article-title":"DNA damage signaling guards against activated oncogenes and tumor progression","volume":"26","author":"Bartek","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0014","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/neu.2009.1068","article-title":"Sex differences in outcome after mild traumatic brain injury","volume":"27","author":"Bazarian","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0015","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1093\/emboj\/cdg417","article-title":"Reversal of human cellular senescence: roles of the p53 and p16 pathways","volume":"22","author":"Beaus\u00e9jour","year":"2003","journal-title":"EMBO J"},{"issue":"B","key":"10.1016\/j.neurobiolaging.2022.08.014_bib0016","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/S1550-8579(07)80057-X","article-title":"Anxiety disorders: sex differences in prevalence, degree, and background, but gender-neutral treatment","volume":"4","author":"Bekker","year":"2007","journal-title":"Gend. Med."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0017","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","article-title":"The signals and pathways activating cellular senescence","volume":"37","author":"Ben-Porath","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0018","doi-asserted-by":"crossref","first-page":"e45069","DOI":"10.1371\/journal.pone.0045069","article-title":"Astrocyte senescence as a component of Alzheimer's disease","volume":"7","author":"Bhat","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0019","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/js.2018-00186","article-title":"The anti-inflammatory effects of testosterone","volume":"3","author":"Bianchi","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mad.2017.08.004","article-title":"Is DNA damage indispensable for stress-induced senescence?","volume":"170","author":"Bielak-Zmijewska","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0021","doi-asserted-by":"crossref","first-page":"e31274","DOI":"10.7554\/eLife.31274","article-title":"Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium","volume":"6","author":"Brighton","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00682738","article-title":"Regulation of aromatase expression in human tissues","volume":"30","author":"Bulun","year":"1994","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0023","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0024","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0025","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0026","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/febs.14400","article-title":"Nutrient sensing, growth, and senescence","volume":"285","author":"Carroll","year":"2018","journal-title":"FEBS J"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0027","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.celrep.2014.12.055","article-title":"Global reorganization of the nuclear landscape in senescent cells","volume":"10","author":"Chandra","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0028","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/1873-3468.13498","article-title":"Mitochondrial dysfunction and cell senescence: deciphering a complex relationship","volume":"593","author":"Chapman","year":"2019","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0029","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA damage, repair, and mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2015.07.011","article-title":"MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype","volume":"59","author":"Chen","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0031","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11357-016-9910-5","article-title":"Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6\/Axl signaling pathway","volume":"38","author":"Chen","year":"2016","journal-title":"Age Dordr. Neth."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0032","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0033","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson's disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0034","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2015.03.025","article-title":"Systematic discovery of Xist RNA binding proteins","volume":"161","author":"Chu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0035","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1158\/1078-0432.CCR-16-0381","article-title":"Testosterone in androgen receptor signaling and DNA repair: enemy or frenemy?","volume":"22","author":"Chua","year":"2016","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0037","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/gast.2002.33573","article-title":"Nonalcoholic fatty liver disease","volume":"122","author":"Clark","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0038","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrneph.2017.189","article-title":"Sex-specific differences in hypertension and associated cardiovascular disease","volume":"14","author":"Colafella","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0039","first-page":"1195","article-title":"Oxidative DNA damage: mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro-ageing features of the senescent phenotype","volume":"35","author":"Correia-Melo","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0041","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.153.4.773","article-title":"Synergism of Xist Rna, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation","volume":"153","author":"Csankovszki","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0042","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molcel.2016.08.002","article-title":"53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms","volume":"64","author":"Cuella-Martin","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0043","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc2440","article-title":"Living on a break: cellular senescence as a DNA-damage response","volume":"8","author":"d'Adda di Fagagna","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0044","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jogn.2016.05.002","article-title":"Sex differences in the clinical progression of Parkinson's disease","volume":"45","author":"Dahodwala","year":"2016","journal-title":"J. Obstet. Gynecol. Neonatal Nurs. JOGNN"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003728","article-title":"Dynamic modeling of pathways to cellular senescence reveals strategies for targeted interventions","volume":"10","author":"Dalle Pezze","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0046","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1042\/BST20190987","article-title":"Mitochondrial hyperfusion: a friend or a foe","volume":"48","author":"Das","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0047","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.celrep.2019.03.048","article-title":"Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects","volume":"27","author":"Delbridge","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0048","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Di Micco","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0049","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0050","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.4161\/cc.24550","article-title":"Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells","volume":"12","author":"Diep","year":"2013","journal-title":"Cell Cycle Georget. Tex"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0051","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jagp.2018.07.005","article-title":"The molecular intersection between senescence and major depression in the elderly","volume":"26","author":"Diniz","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry Off. J. Am. Assoc. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0052","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/bcr2094","article-title":"Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB\/c-Trp53+\/- mice","volume":"10","author":"Dunphy","year":"2008","journal-title":"Breast Cancer Res. BCR"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0053","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10522-011-9322-y","article-title":"The role of estrogen deficiency in skin ageing and wound healing","volume":"13","author":"Emmerson","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0054","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM","volume":"25","author":"Engeland","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0055","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pneurobio.2015.12.008","article-title":"Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury","volume":"157","author":"Engler-Chiurazzi","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0056","doi-asserted-by":"crossref","first-page":"e14535","DOI":"10.14814\/phy2.14535","article-title":"Effect of menopausal hormone therapy on proteins associated with senescence and inflammation","volume":"8","author":"Faubion","year":"2020","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0057","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0058","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.3233\/JAD-161221","article-title":"The DNA damage response in neurons: die by apoptosis or survive in a senescence-like state?","volume":"60","author":"Fielder","year":"2017","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0059","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/gerona\/glx105","article-title":"Sex differences in aging: genomic instability","volume":"73","author":"Fischer","year":"2018","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0060","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0061","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1101\/sqb.2005.70.045","article-title":"Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer","volume":"70","author":"Ganesan","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0062","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/acel.12019","article-title":"Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells","volume":"12","author":"Garm","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0063","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1093\/nar\/gkm756","article-title":"Changes in DNA repair during aging","volume":"35","author":"Gorbunova","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0064","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13059-018-1557-3","article-title":"LaminA\/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells","volume":"19","author":"Grigoryan","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1874609807666140321150751","article-title":"Germline genetics of the p53 pathway affect longevity in a gender specific manner","volume":"7","author":"Gro\u00df","year":"2014","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0066","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","article-title":"Cellular senescence at the crossroads of inflammation and Alzheimer's disease","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0067","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1089\/neu.2018.6171","article-title":"Sex differences in traumatic brain injury: what we know and what we should know","volume":"36","author":"Gupte","year":"2019","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0068","series-title":"Handbook of Clinical Neurology, Sex Differences in Neurology and Psychiatry","first-page":"103","article-title":"Chapter 7 - Sex differences in cognition and aging and the influence of sex hormones","author":"Gurvich","year":"2020"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0069","doi-asserted-by":"crossref","first-page":"e63425","DOI":"10.7554\/eLife.63425","article-title":"Sex differences in biological aging with a focus on human studies","volume":"10","author":"H\u00e4gg","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4161\/cc.22912","article-title":"mTORC1 and p53","volume":"12","author":"Hasty","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0071","article-title":"Literature review of sex differences in mTBI","author":"Haynes","year":"2021","journal-title":"Mil. Med."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0072","doi-asserted-by":"crossref","first-page":"e924","DOI":"10.1038\/cddis.2013.437","article-title":"Amyloid-\u03b21\u201342 oligomer accelerates senescence in adult hippocampal neural stem\/progenitor cells via formylpeptide receptor 2","volume":"4","author":"He","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0073","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb3225","article-title":"mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype","volume":"17","author":"Herranz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0074","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0075","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1291\/hypres.28.263","article-title":"Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells","volume":"28","author":"Imanishi","year":"2005","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0076","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.mad.2008.04.001","article-title":"Cellular senescence and organismal aging","volume":"129","author":"Jeyapalan","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0077","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40478-018-0513-5","article-title":"Cooperative p16 and p21 action protects female astrocytes from transformation","volume":"6","author":"Kfoury","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0078","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.3390\/ijms21217938","article-title":"Molecular mechanisms of sex-related differences in arthritis and associated pain","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0079","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1002\/jnr.21940","article-title":"Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number","volume":"87","author":"Kim","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0080","doi-asserted-by":"crossref","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0081","doi-asserted-by":"crossref","first-page":"344","DOI":"10.18632\/aging.100160","article-title":"The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway","volume":"2","author":"Korotchkina","year":"2010","journal-title":"Aging"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0082","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1073\/pnas.211053698","article-title":"Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging","volume":"98","author":"Krtolica","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0083","doi-asserted-by":"crossref","first-page":"R374","DOI":"10.1152\/ajpregu.90451.2008","article-title":"Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains","volume":"296","author":"Ksiazek","year":"2009","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0084","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0085","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0086","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.molcel.2015.06.027","article-title":"Repression of the heat shock response is a programmed event at the onset of reproduction","volume":"59","author":"Labbadia","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0087","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0088","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000313366","article-title":"Estrogen prevents senescence through induction of WRN, Werner syndrome protein","volume":"74","author":"Lee","year":"2010","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0089","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fnagi.2018.00124","article-title":"Mitochondria, estrogen and female brain aging","volume":"10","author":"Lejri","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227887","article-title":"Astrocyte senescence promotes glutamate toxicity in cortical neurons","volume":"15","author":"Limbad","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0091","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1073\/pnas.1818313116","article-title":"Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110836","article-title":"Cell senescence and fibrotic lung diseases","volume":"132","author":"Liu","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0093","doi-asserted-by":"crossref","first-page":"39097","DOI":"10.18632\/oncotarget.9772","article-title":"Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0094","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/hep.30626","article-title":"Sex differences in NAFLD: state of the art and identification of research gaps","volume":"70","author":"Lonardo","year":"2019","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0095","doi-asserted-by":"crossref","DOI":"10.1053\/j.seminhematol.2013.09.001","article-title":"Detectable clonal mosaicism in the human genome","volume":"50","author":"Machiela","year":"2013","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0096","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1093\/hmg\/ddx324","article-title":"Characterization of breakpoint regions of large structural autosomal mosaic events","volume":"26","author":"Machiela","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0097","doi-asserted-by":"crossref","first-page":"11843","DOI":"10.1038\/ncomms11843","article-title":"Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome","volume":"7","author":"Machiela","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0098","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/leu.2010.6","article-title":"\u03b3H2AX: a sensitive molecular marker of DNA damage and repair","volume":"24","author":"Mah","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0099","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.febslet.2008.01.034","article-title":"Redox state and gender differences in vascular smooth muscle cells","volume":"582","author":"Malorni","year":"2008","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0100","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1161\/CIRCRESAHA.120.315930","article-title":"Sex as a biological variable in atherosclerosis","volume":"126","author":"Man","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0101","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.mad.2004.07.007","article-title":"Senescent fibroblasts resist apoptosis by downregulating caspase-3","volume":"125","author":"Marcotte","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0102","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0960-9822(98)70137-X","article-title":"Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts","volume":"8","author":"McConnell","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0103","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yfrne.2013.09.001","article-title":"Sex differences in anxiety and depression: role of testosterone","volume":"35","author":"McHenry","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0104","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpsychires.2011.03.006","article-title":"Gender differences in anxiety disorders: prevalence, course of illness, comorbidity, and burden of illness","volume":"45","author":"McLean","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41586-019-0936-6","article-title":"Female-biased embryonic death from inflammation induced by genomic instability","volume":"567","author":"McNairn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0106","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/ar.21247","article-title":"Differential expression of estrogen receptors in two hippocampal regions during the estrous cycle of the rat","volume":"294","author":"Mendoza-Garc\u00e9s","year":"2011","journal-title":"Anat. Rec."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0107","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1080\/13854046.2018.1508616","article-title":"A systematic review of sex differences in concussion outcome: what do we know?","volume":"33","author":"Merritt","year":"2019","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0108","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/neu.2021.0116","article-title":"Differences between men and women in treatment and outcome after traumatic brain injury","volume":"38","author":"Mikoli\u0107","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0109","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00018-019-03261-8","article-title":"Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells","volume":"77","author":"Miku\u0142a-Pietrasik","year":"2020","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0110","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/mds.23388","article-title":"Gender differences in parkinson's disease: clinical characteristics and cognition","volume":"25","author":"Miller","year":"2010","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0111","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/jnci\/95.2.100","article-title":"Estrogen and DNA damage: the silent source of breast cancer?","volume":"95","author":"Miller","year":"2003","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0112","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/09537104.2015.1023273","article-title":"Longitudinal effects of menopausal hormone treatments on platelet characteristics and cell-derived microvesicles","volume":"27","author":"Miller","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0113","first-page":"119","article-title":"Disorders caused by genetic mosaicism","volume":"116","author":"Moog","year":"2020","journal-title":"Dtsch. Arzteblatt Int."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0114","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nature03927","article-title":"Mesoscale conformational changes in the DNA-repair complex Rad50\/Mre11\/Nbs1 upon binding DNA","volume":"437","author":"Moreno-Herrero","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0115","doi-asserted-by":"crossref","first-page":"e12840","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0116","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/exd.14205","article-title":"SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis","volume":"30","author":"Ogata","year":"2021","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0117","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0118","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","article-title":"Obesity-induced cellular senescence drives anxiety and impairs neurogenesis","volume":"29","author":"Ogrodnik","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0119","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ceb.2019.05.005","article-title":"Putting the brakes on the cell cycle: mechanisms of cellular growth arrest","volume":"60","author":"Pack","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0120","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/sj.onc.1201212","article-title":"Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status","volume":"15","author":"Palmero","year":"1997","journal-title":"Oncogene"},{"issue":"F1000 Faculty Rev","key":"10.1016\/j.neurobiolaging.2022.08.014_bib0121","doi-asserted-by":"crossref","first-page":"998","DOI":"10.12688\/f1000research.17196.1","article-title":"mTOR as a central regulator of lifespan and aging","volume":"8","author":"Papadopoli","year":"2019","journal-title":"F1000Research"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0122","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/hep.30834","article-title":"The role of senescence in the development of nonalcoholic fatty liver disease and progression to nonalcoholic steatohepatitis","volume":"71","author":"Papatheodoridi","year":"2020","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0123","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ncb1024","article-title":"Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts","volume":"5","author":"Parrinello","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0124","doi-asserted-by":"crossref","DOI":"10.1242\/dev.183095","article-title":"X chromosome inactivation in human development","volume":"147","author":"Patrat","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0125","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1158\/0008-5472.CAN-11-3386","article-title":"Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression","volume":"72","author":"Pazolli","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0126","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1091\/mbc.e09-01-0085","article-title":"Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair","volume":"20","author":"Pedram","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0127","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.joca.2011.08.009","article-title":"The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review","volume":"19","author":"Pereira","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0128","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jnr.23827","article-title":"Sex and the development of Alzheimer's disease","volume":"95","author":"Pike","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0129","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yfrne.2009.04.015","article-title":"Protective actions of sex steroid hormones in Alzheimer's disease","volume":"30","author":"Pike","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0130","doi-asserted-by":"crossref","first-page":"21066","DOI":"10.18632\/aging.203519","article-title":"Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging","volume":"13","author":"Rall-Scharpf","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0131","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/jpet.107.134072","article-title":"Mitochondrial effects of estrogen are mediated by estrogen receptor alpha in brain endothelial cells","volume":"325","author":"Razmara","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0132","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0133","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0134","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsbmb.2007.05.014","article-title":"BRAIN AROMATASE: ROLES IN REPRODUCTION AND NEUROPROTECTION","volume":"106","author":"Roselli","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0135","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1210\/endo-128-3-1310","article-title":"Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain","volume":"128","author":"Roselli","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0136","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/oxfordjournals.aje.a117079","article-title":"Reproductive risk factors in a prospective study of breast cancer: the Nurses\u2019 Health Study","volume":"139","author":"Rosner","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0137","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13293-020-00291-x","article-title":"Sex differences in cancer mechanisms","volume":"11","author":"Rubin","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0138","doi-asserted-by":"crossref","first-page":"E822","DOI":"10.3390\/cancers12040822","article-title":"Therapy-induced senescence: an \u201cOld\u201d friend becomes the enemy","volume":"12","author":"Saleh","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0139","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1460-9568.2011.07738.x","article-title":"Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype","volume":"34","author":"Salminen","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0140","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2265.1998.00390.x","article-title":"Aromatase in the human central nervous system","volume":"48","author":"Sasano","year":"1998","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0141","doi-asserted-by":"crossref","first-page":"19393","DOI":"10.1073\/pnas.0909265106","article-title":"Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations","volume":"106","author":"Schoeftner","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0142","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s40478-019-0822-3","article-title":"DNA repair deficiency and senescence in concussed professional athletes involved in contact sports","volume":"7","author":"Schwab","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0143","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.742632","article-title":"Cellular senescence in traumatic brain injury: evidence and perspectives","volume":"13","author":"Schwab","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0144","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/humupd\/dmab038","article-title":"The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions","volume":"28","author":"Secomandi","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0145","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/archgenpsychiatry.2009.36","article-title":"Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys","volume":"66","author":"Seedat","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0146","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.gde.2009.03.003","article-title":"Xist gene regulation at the onset of X inactivation","volume":"19","author":"Senner","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0147","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0092-8674(00)81079-X","article-title":"Role of the INK4a locus in tumor suppression and cell mortality","volume":"85","author":"Serrano","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0148","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0149","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131620","article-title":"High throughput measurement of \u03b3H2AX DSB repair kinetics in a healthy human population","volume":"10","author":"Sharma","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10522-021-09936-9","article-title":"Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology","volume":"22","author":"Sharma","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0151","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/bjc.1988.88","article-title":"Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy","volume":"57","author":"Sinha","year":"1988","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0152","doi-asserted-by":"crossref","first-page":"9286","DOI":"10.1523\/JNEUROSCI.0845-21.2021","article-title":"DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response","volume":"41","author":"Song","year":"2021","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0153","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1042\/BST20210777","article-title":"X-chromosome reactivation: a concise review","volume":"49","author":"Spaziano","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0154","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.dnarep.2004.03.014","article-title":"The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together","volume":"3","author":"Stracker","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2020.100879","article-title":"Sex and gender differences in cognitive and brain reserve: implications for Alzheimer's disease in women","volume":"60","author":"Subramaniapillai","year":"2021","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0156","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc3344","article-title":"Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer","volume":"12","author":"Sulli","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0157","doi-asserted-by":"crossref","first-page":"bqab185","DOI":"10.1210\/endocr\/bqab185","article-title":"Neurodegenerative disease: roles for sex, hormones, and oxidative stress","volume":"162","author":"Sumien","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0158","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1172\/JCI71048","article-title":"Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males","volume":"124","author":"Sun","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0159","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3233\/JAD-141134","article-title":"Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America","volume":"43","author":"Takizawa","year":"2015","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0160","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10522-014-9532-1","article-title":"Are there roles for brain cell senescence in aging and neurodegenerative disorders?","volume":"15","author":"Tan","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0161","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213673","article-title":"Senescence-associated-\u03b2-galactosidase staining following traumatic brain injury in the mouse cerebrum","volume":"14","author":"Tominaga","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0162","doi-asserted-by":"crossref","first-page":"E50","DOI":"10.1210\/jc.2014-2751","article-title":"Alternative activation of human macrophages is rescued by estrogen treatment in vitro and impaired by menopausal status","volume":"100","author":"Toniolo","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0163","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2017.10.003","article-title":"17\u03b2-estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle","volume":"27","author":"Torres","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0164","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.mad.2006.05.001","article-title":"Sex-specific regulation of aging and apoptosis","volume":"127","author":"Tower","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101488","article-title":"Sex differences in the response to oxidative and proteolytic stress","volume":"31","author":"Tower","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0166","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.freeradbiomed.2008.08.031","article-title":"Age, sex, and race influence single-strand break repair capacity in a human population","volume":"45","author":"Trzeciak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0167","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/cdd.2016.37","article-title":"p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration","volume":"23","author":"Turnquist","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0168","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1677\/JOE-07-0250","article-title":"17Beta-estradiol abrogates apoptosis in murine skeletal muscle cells through estrogen receptors: role of the phosphatidylinositol 3-kinase\/Akt pathway","volume":"196","author":"Vasconsuelo","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0169","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.steroids.2011.08.001","article-title":"Role of 17\u03b2-estradiol and testosterone in apoptosis","volume":"76","author":"Vasconsuelo","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0170","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/JOE-16-0018","article-title":"Positive and negative effects of cellular senescence during female reproductive aging and pregnancy","volume":"230","author":"Velarde","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0171","doi-asserted-by":"crossref","first-page":"10564","DOI":"10.1093\/nar\/gkx684","article-title":"Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress","volume":"45","author":"Venkatachalam","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0172","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101316","article-title":"From DNA damage to mutations: all roads lead to aging","volume":"68","author":"Vijg","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0173","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1101\/gad.331272.119","article-title":"Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence","volume":"34","author":"Vizioli","year":"2020","journal-title":"Genes Dev"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0174","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exger.2015.11.009","article-title":"Age-related arterial telomere uncapping and senescence is greater in women compared with men","volume":"73","author":"Walker","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0175","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1177\/15353702211026566","article-title":"Megestrol acetate drives endometrial carcinoma cell senescence via interacting with progesterone receptor B\/FOXO1 axis","volume":"246","author":"Wang","year":"2021","journal-title":"Exp. Biol. Med. Maywood NJ"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0176","first-page":"E2029","article-title":"Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0177","article-title":"Autophagy dysfunction, cellular senescence, and abnormal immune-inflammatory responses in amd: from mechanisms to therapeutic potential","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0178","doi-asserted-by":"crossref","first-page":"eabd2655","DOI":"10.1126\/scitranslmed.abd2655","article-title":"A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0179","doi-asserted-by":"crossref","first-page":"903","DOI":"10.18632\/aging.100099","article-title":"Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy","volume":"1","author":"Waskar","year":"2009","journal-title":"Aging"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0960-9822(01)00626-1","article-title":"Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway","volume":"12","author":"Weiss","year":"2002","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0181","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/jnnp.2003.020982","article-title":"Are men at greater risk for Parkinson's disease than women?","volume":"75","author":"Wooten","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0182","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/JOE-19-0518","article-title":"JAK2\/STAT3 regulates estrogen-related senescence of bone marrow stem cells","volume":"245","author":"Wu","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0183","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0184","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature05529","article-title":"Senescence and tumor clearance is triggered by p53 restoration in murine liver carcinomas","volume":"445","author":"Xue","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0185","article-title":"Sex differences in osteoarthritis pathogenesis: a comprehensive study based on bioinformatics","volume":"26","author":"Yang","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0186","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.01.034","article-title":"Xist RNA is a potent suppressor of hematologic cancer in mice","volume":"152","author":"Yildirim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0187","doi-asserted-by":"crossref","first-page":"e13094","DOI":"10.1111\/acel.13094","article-title":"Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice","volume":"19","author":"Yousefzadeh","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0188","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1196\/annals.1354.025","article-title":"Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular production of H2O2","volume":"1067","author":"Zdanov","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0189","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/s41467-018-04010-4","article-title":"The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0190","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/07420520701420410","article-title":"Estrous cycle-dependent expression of estrogen receptor \u03b1 in periodontal tissue","volume":"24","author":"Zhao","year":"2007","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0191","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.cr.7290203","article-title":"Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts","volume":"14","author":"Zhao","year":"2004","journal-title":"Cell Res"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0192","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2022.08.014_bib0193","doi-asserted-by":"crossref","first-page":"992","DOI":"10.7150\/ijbs.10918","article-title":"MDC1 enhances estrogen receptor-mediated transactivation and contributes to breast cancer suppression","volume":"11","author":"Zou","year":"2015","journal-title":"Int. J. Biol. Sci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022001956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022001956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:44:06Z","timestamp":1759319046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458022001956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":193,"alternative-id":["S0197458022001956"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.08.014","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence of sex differences in cellular senescence","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}