{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:06:32Z","timestamp":1774569992258,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["216596\/Z\/19\/Z"],"award-info":[{"award-number":["216596\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.neurobiolaging.2022.09.004","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:58:19Z","timestamp":1663210699000},"page":"167-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Unbiased metabolome screen links serum urate to risk of Alzheimer's disease"],"prefix":"10.1016","volume":"120","author":[{"given":"Beyaz\u0131t Abdurrahman","family":"\u015eanl\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine J.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamuchirai K.","family":"Motsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emery","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Julian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-8689","authenticated-orcid":false,"given":"Johnathan","family":"Cooper-Knock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0001","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/mds.870100507","article-title":"No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease","volume":"10","author":"Ahlskog","year":"1995","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41586-020-2896-2","article-title":"A reference map of potential determinants for the human serum metabolome","volume":"588","author":"Bar","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0003","doi-asserted-by":"crossref","first-page":"fcac069","DOI":"10.1093\/braincomms\/fcac069","article-title":"Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis","volume":"4","author":"Boddy","year":"2022","journal-title":"Brain Commun"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0004","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0006","first-page":"2681","article-title":"Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization\u2014A Job for the Humble Heterogeneity Statistic?","volume":"187","author":"Bowden","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0007","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ije\/dyy101","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0008","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3233\/JAD-2010-1330","article-title":"Uric acid as a CNS antioxidant","volume":"19","author":"Bowman","year":"2010","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0009","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0011","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0012","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0013","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3233\/JAD-2012-121630","article-title":"Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease","volume":"33","author":"Cankurtaran","year":"2013","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0014","doi-asserted-by":"crossref","first-page":"e94084","DOI":"10.1371\/journal.pone.0094084","article-title":"Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/brain\/awn316","article-title":"Serum uric acid and cognitive function and dementia","volume":"132","author":"Euser","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0016","doi-asserted-by":"crossref","first-page":"M117","DOI":"10.1093\/gerona\/52A.2.M117","article-title":"Heritability for Alzheimer's disease: the study of dementia in Swedish twins","volume":"52","author":"Gatz","year":"1997","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0017","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0018","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/ije\/dyx028","article-title":"Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique","volume":"45","author":"Hartwig","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0019","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13075-015-0642-1","article-title":"Gout and the risk of dementia: a nationwide population-based cohort study","volume":"17","author":"Hong","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000170883","article-title":"Plasma urate and progression of mild cognitive impairment","volume":"6","author":"Irizarry","year":"2009","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0022","article-title":"A metabolite panel that differentiates Alzheimer's disease from other dementia types","author":"Jia","year":"2021","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0023","article-title":"A review of Mendelian randomization in amyotrophic lateral sclerosis","author":"Julian","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0024","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1038\/ncomms11122","article-title":"Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA","volume":"7","author":"Kettunen","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/gps.1469","article-title":"Decreased plasma antioxidants in patients with Alzheimer's disease","volume":"21","author":"Kim","year":"2006","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0026","doi-asserted-by":"crossref","first-page":"13334","DOI":"10.1096\/fj.201901148R","article-title":"Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding","volume":"33","author":"Ko","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0027","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","article-title":"Genome-wide association analyses identify 18 new loci associated with serum urate concentrations","volume":"45","author":"K\u00f6ttgen","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0028","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0029","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2009808118","article-title":"Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease","author":"Lord","year":"2021","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0031","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnmrs.2017.01.001","article-title":"Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics","volume":"100","author":"Marshall","year":"2017","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0033","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0034","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.neuron.2018.02.027","article-title":"Genome-wide Analyses Identify KIF5A as a Novel ALS Gene","volume":"97","author":"Nicolas","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0035","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JAD-2002-4608","article-title":"Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease","volume":"4","author":"Polidori","year":"2002","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001618","article-title":"Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis","volume":"11","author":"Richmond","year":"2014","journal-title":"PLoS Med"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/S0197-4580(03)00031-9","article-title":"Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease","author":"Rinaldi","year":"2003","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0038","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1037\/0894-4105.21.1.136","article-title":"Serum uric acid and cognitive function in community-dwelling older adults","volume":"21","author":"Schretlen","year":"2007","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0039","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ng.2982","article-title":"An atlas of genetic influences on human blood metabolites","volume":"46","author":"Shin","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0040","doi-asserted-by":"crossref","unstructured":"Slob, E.A.W., Burgess, S., n.d. A Comparison Of Robust Mendelian Randomization Methods Using Summary Data. https:\/\/doi.org\/10.1101\/577940","DOI":"10.1101\/577940"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0041","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-170248","article-title":"Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer's Disease and Late-Life Cognitive Disorders: A Systematic Review","author":"Solfrizzi","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0042","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170939","article-title":"Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion","volume":"38","author":"Song","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0043","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1038\/s41598-021-86279-y","article-title":"Detrimental effects of long-term elevated serum uric acid on cognitive function in rats","volume":"11","author":"Tian","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0044","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.exger.2014.10.013","article-title":"Higher baseline serum uric acid is associated with poorer cognition but not rates of cognitive decline in women","volume":"60","author":"Vannorsdall","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0045","doi-asserted-by":"crossref","first-page":"167.e11","DOI":"10.1016\/j.neurobiolaging.2020.02.018","article-title":"Impact of modifiable risk factors on Alzheimer's disease: A two-sample Mendelian randomization study","volume":"91","author":"Wang","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0046","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","article-title":"A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease","volume":"53","author":"Wightman","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0047","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ajcn\/nqy225","article-title":"Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study","volume":"109","author":"Williams","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0048","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/1567205012666150204121719","article-title":"Role of environmental contaminants in the etiology of Alzheimer's disease: a review","volume":"12","author":"Yegambaram","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2022.09.004_bib0049","doi-asserted-by":"crossref","first-page":"374.e1","DOI":"10.1016\/j.neurobiolaging.2021.04.010","article-title":"Physical activity and amyotrophic lateral sclerosis: a Mendelian randomization study","volume":"105","author":"Zhang","year":"2021","journal-title":"Neurobiol. Aging"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022002020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022002020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:45:12Z","timestamp":1759319112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458022002020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":48,"alternative-id":["S0197458022002020"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.09.004","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unbiased metabolome screen links serum urate to risk of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}