{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:27:40Z","timestamp":1759336060847,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS029993"],"award-info":[{"award-number":["R01NS029993"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.neurobiolaging.2022.11.016","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:58:05Z","timestamp":1670248685000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study"],"prefix":"10.1016","volume":"123","author":[{"given":"Nicole","family":"Dueker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Gardener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lissette","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Beecham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan H.","family":"Blanton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Kuen","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeseon P.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton B.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell S.V.","family":"Elkind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph L.","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0001","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00213-009-1537-0","article-title":"Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats","volume":"205","author":"Bari","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0003","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1046\/j.1532-5415.2002.50609.x","article-title":"Cognitive and functional decline in adults aged 75 and older","volume":"50","author":"Black","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"17","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0004","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108498","article-title":"Distinct roles of \u03b1- and \u03b2-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration","volume":"40","author":"Bodakuntla","year":"2021","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0005","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/ejhg.2010.2","article-title":"Common genetic variation and performance on standardized cognitive tests","volume":"18","author":"Cirulli","year":"2010","journal-title":"Eur J Hum Genet"},{"year":"1996","author":"D'Elia","series-title":"Color trails test professional manual","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0006"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0007","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-psych-113011-143750","article-title":"Executive functions","volume":"64","author":"Diamond","year":"2013","journal-title":"Annu Rev Psychol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0008","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/nyas.14268","article-title":"The importance of diversity in cognitive neuroscience","volume":"1464","author":"Dotson","year":"2020","journal-title":"Ann N Y Acad Sci"},{"issue":"22","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0009","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1073\/pnas.220413297","article-title":"Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor","volume":"97","author":"Doucas","year":"2000","journal-title":"Proceed Nat Acad Sci United States Am"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0010","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1037\/0894-4105.22.5.626","article-title":"Executive function and MRI prefrontal volumes among healthy older adults","volume":"22","author":"Elderkin-Thompson","year":"2008","journal-title":"Neuropsychology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0011","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1590\/1980-57642015DN92000009","article-title":"The most frequently used tests for assessing executive functions in aging","volume":"9","author":"Faria","year":"2015","journal-title":"Dement Neuropsychol"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nlm.2013.09.017","article-title":"Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies","volume":"112","author":"Finsterwald","year":"2014","journal-title":"Neurobiology learn memory"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0013","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/jnnp.48.6.517","article-title":"The effect of parkinson's disease on the ability to maintain a mental set","volume":"48","author":"Flowers","year":"1985","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/mp.2015.37","article-title":"GWAS for executive function and processing speed suggests involvement of the CADM2 gene","volume":"21","author":"Ibrahim-Verbaas","year":"2016","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0016","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41398-020-00930-2","article-title":"Genome-wide association study of cognitive function in diverse hispanics\/latinos: Results from the hispanic community health study\/study of latinos","volume":"10","author":"Jian","year":"2020","journal-title":"Transl Psychiatry"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0017","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jpsychires.2011.11.001","article-title":"Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function","volume":"46","author":"LeBlanc","year":"2012","journal-title":"J Psychiatr Res"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0018","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s10519-012-9526-1","article-title":"Genetic influences on four measures of executive functions and their covariation with general cognitive ability: the older Australian twins study","volume":"42","author":"Lee","year":"2012","journal-title":"Behav Genet"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0019","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1212\/WNL.0b013e3181cff5d5","article-title":"Thalamic integrity underlies executive dysfunction in traumatic brain injury","volume":"74","author":"Little","year":"2010","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajhg.2013.06.020","article-title":"RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference","volume":"93","author":"Maples","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"24","key":"10.1016\/j.neurobiolaging.2022.11.016_bib43","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1212\/WNL.0b013e31821f4472","article-title":"Lower prevalence of silent brain infarcts in the physically active: the Northern Manhattan Study","volume":"76","author":"Willey","year":"2011","journal-title":"Neurology"},{"doi-asserted-by":"crossref","unstructured":"Mapstone M., Lezak M.D., Howieson D.B., Loring D.W. Neuropsychological assessment, 4th edition. LANCET NEUROL. 2005.","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0021","DOI":"10.1212\/01.WNL.0000156290.58489.54"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0022","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41562-017-0260-9","article-title":"Functional alignment with anatomical networks is associated with cognitive flexibility","volume":"2","author":"Medaglia","year":"2018","journal-title":"Nat Hum Behav"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0023","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tins.2004.11.002","article-title":"Physiological functions for brain NF-kappaB","volume":"28","author":"Meffert","year":"2005","journal-title":"Trends neurosci"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0024","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1021\/bi802047y","article-title":"Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway","volume":"48","author":"Mukai","year":"2009","journal-title":"Biochemistry"},{"issue":"23","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0025","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1093\/hmg\/ddp413","article-title":"A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB","volume":"18","author":"Need","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cortex.2018.03.025","article-title":"APOE genotype and cognition in healthy individuals at risk of alzheimer\u2019s disease: A review","volume":"104","author":"O\u2019Donoghue","year":"2018","journal-title":"Cortex"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0027","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1046\/j.1460-9568.2000.00183.x","article-title":"Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task","volume":"12","author":"Passetti","year":"2000","journal-title":"Eur J Neurosci"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0028","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0029","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/oxfordjournals.aje.a009445","article-title":"Stroke incidence among white, black, and hispanic residents of an urban community: The northern manhattan stroke study","volume":"147","author":"Sacco","year":"1998","journal-title":"Am J Epidemiol"},{"doi-asserted-by":"crossref","unstructured":"Seshadri, S., DeStefano, A.L., Au, R., Massaro, J.M., Beiser, A.S., Kelly-Hayes, M., Kase, C.S., D'Agostino, R.B. Sr., Decarli, C., Atwood, L.D., Wolf, P.A., 2007. Genetic correlates of brain aging on MRI and cognitive test measures: A genome-wide association and linkage analysis in the framingham study. BMC Med Genet 8 (Suppl 1) Suppl 1S15-S15. doi: 1471-2350-8-S1-S15.","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0032","DOI":"10.1186\/1471-2350-8-S1-S15"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0033","first-page":"77","article-title":"NF-kappaB signaling pathways in neurological inflammation: a mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front Molecu Neurosci"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0034","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1017\/S1355617709090857","article-title":"Construct validity of cognitive reserve in a multiethnic cohort: The northern manhattan study","volume":"15","author":"Siedlecki","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/geronb\/57.2.P133","article-title":"Evidence for genetic mediation of executive control: a study of aging male twins","volume":"57","author":"Swan","year":"2002","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0036","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/arclin\/acr112","article-title":"Factor analysis of nineteen executive function tests in a healthy adult population","volume":"27","author":"Testa","year":"2012","journal-title":"Arch Clin Neuropsychol"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0037","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.neuropsychologia.2004.02.009","article-title":"Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities","volume":"42","author":"Van Petten","year":"2004","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0038","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neuropsychologia.2013.11.015","article-title":"Cognitive flexibility depends on white matter microstructure of the basal ganglia","volume":"53","author":"van Schouwenburg","year":"2014","journal-title":"Neuropsychologia"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0039","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1037\/a0026768","article-title":"Genetic architecture of the delis-kaplan executive function system trail making test: Evidence for distinct genetic influences on executive function","volume":"26","author":"Vasilopoulos","year":"2012","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2022.11.016_bib0040","doi-asserted-by":"crossref","first-page":"40205","DOI":"10.1038\/srep40205","article-title":"Increase in \u03b1-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and alzheimer's disease","volume":"7","author":"Vu","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0041","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41398-021-01510-8","article-title":"A genome-wide association study of the longitudinal course of executive functions","volume":"11","author":"Wendel","year":"2021","journal-title":"Transl Psychiatry"},{"issue":"17","key":"10.1016\/j.neurobiolaging.2022.11.016_bib0042","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: Fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022002524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458022002524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:45:29Z","timestamp":1759319129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458022002524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":41,"alternative-id":["S0197458022002524"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.11.016","relation":{},"ISSN":["0197-4580"],"issn-type":[{"type":"print","value":"0197-4580"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}