{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:52:45Z","timestamp":1783785165998,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["2020-083 - WMN"],"award-info":[{"award-number":["2020-083 - WMN"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013794","name":"Shanxi Provincial Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["1331KSC- CJM"],"award-info":[{"award-number":["1331KSC- CJM"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2021XM33 -CHY"],"award-info":[{"award-number":["2021XM33 -CHY"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019447","name":"Applied Basic Research Project of Shanxi Province, China","doi-asserted-by":"publisher","award":["20210302123306 - WZJ"],"award-info":[{"award-number":["20210302123306 - WZJ"]}],"id":[{"id":"10.13039\/501100019447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170523"],"award-info":[{"award-number":["82170523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171428"],"award-info":[{"award-number":["82171428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271484 - WMN"],"award-info":[{"award-number":["82271484 - WMN"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.neurobiolaging.2023.01.008","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T15:20:04Z","timestamp":1674055204000},"page":"71-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid \u03b2 metabolism"],"prefix":"10.1016","volume":"124","author":[{"given":"Yi-Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0001","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","volume":"18","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0002","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nlm.2016.10.005","article-title":"Cellular activation of hypothalamic hypocretin\/orexin neurons facilitates short-term spatial memory in mice","volume":"136","author":"Aitta-Aho","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0003","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-170108","article-title":"Orexin impairs the phagocytosis and degradation of amyloid-beta fibrils by microglial cells","volume":"58","author":"An","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0004","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0306-4522(02)00745-5","article-title":"Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats","volume":"119","author":"Aou","year":"2003","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0005","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.sleep.2011.06.015","article-title":"Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy","volume":"12","author":"Baier","year":"2011","journal-title":"Sleep Med."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0006","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pneurobio.2015.04.002","article-title":"A critical appraisal of the what-where-when episodic-like memory test in rodents: Achievements, caveats and future directions","volume":"130","author":"Binder","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"6407","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0008","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-beta and tau in Alzheimer's disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0009","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3233\/JAD-210256","article-title":"A GLP-1\/GIP Dual Receptor Agonist DA4-JC effectively attenuates cognitive impairment and pathology in the APP\/PS1\/Tau model of Alzheimer's disease","volume":"83","author":"Cai","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229850","article-title":"Brain shuttle neprilysin reduces central amyloid-beta levels","volume":"15","author":"Campos","year":"2020","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0011","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/jnr.23975","article-title":"Orexin-A increases the firing activity of hippocampal CA1 neurons through orexin-1 receptors","volume":"95","author":"Chen","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0012","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2018.01.013","article-title":"Orexin knockout mice exhibit impaired spatial working memory","volume":"668","author":"Dang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0013","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000514967","article-title":"Hypocretin\/Orexin, sleep and Alzheimer's disease","volume":"45","author":"Dauvilliers","year":"2021","journal-title":"Front. Neurol. Neurosci."},{"issue":"52","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0014","doi-asserted-by":"crossref","first-page":"14239","DOI":"10.1523\/JNEUROSCI.3878-07.2007","article-title":"Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates","volume":"27","author":"Deadwyler","year":"2007","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0015","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/jps.21604","article-title":"Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system","volume":"98","author":"Dhuria","year":"2009","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0016","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","article-title":"The AMPA receptor code of synaptic plasticity","volume":"100","author":"Diering","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.758677","article-title":"Evaluating effects of glatiramer acetate treatment on amyloid deposition and tau phosphorylation in the 3xTg mouse model of Alzheimer's disease","volume":"15","author":"Dionisio-Santos","year":"2021","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0018","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hipo.23213","article-title":"The history of long-term potentiation as a memory mechanism: controversies, confirmation, and some lessons to remember","volume":"30","author":"Dringenberg","year":"2020","journal-title":"Hippocampus"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0019","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/brain\/awac177","article-title":"Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease","volume":"145","author":"Eissman","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113370","article-title":"Intranasal insulin and orexins to treat age-related cognitive decline","volume":"234","author":"Erichsen","year":"2021","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0021","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3233\/JAD-200637","article-title":"Tetrahydrobiopterin improves recognition memory in the triple-transgenic mouse model of Alzheimer's disease, without altering amyloid-beta and tau pathologies","volume":"79","author":"Fanet","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0022","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","article-title":"The probabilistic model of Alzheimer disease: the amyloid hypothesis revised","volume":"23","author":"Frisoni","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0023","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neurobiolaging.2017.01.011","article-title":"Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process","volume":"53","author":"Gabelle","year":"2017","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0024","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The beta-Secretase BACE1 in Alzheimer's Disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0025","first-page":"1","article-title":"Intranasal administration of hypocretin 1 (orexin A) bypasses the blood-brain barrier and target the brain: A new strategy for the treatment of narcolepsy","volume":"4","author":"Hanson","year":"2004","journal-title":"Drug Deliv. Tech."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0026","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neurobiolaging.2018.08.019","article-title":"CSF pro-orexin and amyloid-beta38 expression in Alzheimer's disease and frontotemporal dementia","volume":"72","author":"Heywood","year":"2018","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0027","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/joim.13406","article-title":"Hypocretins (orexins): The ultimate translational neuropeptides","volume":"291","author":"Jacobson","year":"2022","journal-title":"J. Intern. Med."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0028","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer's disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural. Regen. Res."},{"issue":"5955","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0029","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/bpa.12734","article-title":"Abeta oligomers trigger and accelerate Abeta seeding","volume":"30","author":"Katzmarski","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-Maze for assessment of spatial working and reference memory in mice","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0032","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/C6CS00731G","article-title":"Towards an understanding of amyloid-beta oligomers: characterization, toxicity mechanisms, and inhibitors","volume":"46","author":"Lee","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134741","article-title":"Orexin-A exacerbates Alzheimer's disease by inducing mitochondrial impairment","volume":"718","author":"Li","year":"2020","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0034","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yfrne.2014.01.002","article-title":"Sex differences in cognitive impairment and Alzheimer's disease","volume":"35","author":"Li","year":"2014","journal-title":"Front. Neuroendocrinol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0035","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1007\/s12035-022-02809-3","article-title":"Tau Toxicity in Neurodegeneration","volume":"59","author":"Liang","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0036","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00415-017-8613-x","article-title":"Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer's disease","volume":"264","author":"Liguori","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0037","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.sleep.2019.01.003","article-title":"Obstructive sleep apnea may induce orexinergic system and cerebral beta-amyloid metabolism dysregulation: is it a further proof for Alzheimer's disease risk?","volume":"56","author":"Liguori","year":"2019","journal-title":"Sleep Med."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0038","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neurobiolaging.2016.01.007","article-title":"Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer's disease","volume":"40","author":"Liguori","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0039","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jamaneurol.2014.2510","article-title":"Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease","volume":"71","author":"Liguori","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-neuro-080317-061813","article-title":"A motor theory of sleep-wake control: arousal-action circuit","volume":"42","author":"Liu","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0041","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0042","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuropharm.2016.03.005","article-title":"Orexin A induces bidirectional modulation of synaptic plasticity: Inhibiting long-term potentiation and preventing depotentiation","volume":"107","author":"Lu","year":"2016","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0043","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11596-017-1732-x","article-title":"Role of microtubule-associated protein tau phosphorylation in Alzheimer's disease","volume":"37","author":"Ma","year":"2017","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182707","article-title":"Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation","volume":"12","author":"Modi","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0046","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smrv.2017.05.002","article-title":"The role of sleep in regulating structural plasticity and synaptic strength: Implications for memory and cognitive function","volume":"39","author":"Raven","year":"2018","journal-title":"Sleep Med. Rev."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0047","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","article-title":"Amyloid toxicity in Alzheimer's disease","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0048","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4103\/1673-5374.332127","article-title":"Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease","volume":"17","author":"Roda","year":"2022","journal-title":"Neural. Regen. Res."},{"issue":"13","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0049","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1084\/jem.20141788","article-title":"Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease","volume":"211","author":"Roh","year":"2014","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0050","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.3390\/ijms22115991","article-title":"An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?","volume":"22","author":"Sciaccaluga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0051","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1748-1716.2009.02021.x","article-title":"Orexins\/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases","volume":"198","author":"Selbach","year":"2010","journal-title":"Acta. Physiol. (Oxf)"},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0052","unstructured":"Serge, G., Pedro, R.-N., Jos\u00e9, A.M., Claire, W., 2021. World Alzheimer Report 2021 Journey through the diagnosis of dementia."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0053","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13195-019-0541-9","article-title":"Amyloid \u03b2-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation","volume":"11","author":"Shin","year":"2019","journal-title":"Alzheimers Res. Ther."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0054","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.3390\/ijms22126355","article-title":"Neurotoxic soluble amyloid oligomers drive Alzheimer's pathogenesis and represent a clinically validated target for slowing disease progression","volume":"22","author":"Tolar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101451","article-title":"Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery","volume":"71","author":"Ullah","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0056","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/acschemneuro.7b00357","article-title":"Positron emission tomography assessment of the intranasal delivery route for Orexin A","volume":"9","author":"Van de Bittner","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113400","article-title":"Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP\/PS1 transgenic mice","volume":"412","author":"Wang","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0058","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fnmol.2018.00220","article-title":"The Orexin\/Receptor system: molecular mechanism and therapeutic potential for neurological diseases","volume":"11","author":"Wang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0059","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","article-title":"The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy","volume":"262","author":"Weinhold","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2018.04.008","article-title":"Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease","volume":"676","author":"Wu","year":"2018","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0061","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3233\/JAD-215063","article-title":"Adiponectin ameliorates cognitive behaviors and in vivo synaptic plasticity impairments in 3xTg-AD Mice","volume":"85","author":"Yan","year":"2022","journal-title":"J. Alzheimers Dis."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0062","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1523\/JNEUROSCI.3200-12.2013","article-title":"Hypocretin\/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice","volume":"33","author":"Yang","year":"2013","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103207","article-title":"Synthetic amyloid-beta oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates","volume":"24","author":"Yue","year":"2021","journal-title":"iScience"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2023.01.008_bib0064","doi-asserted-by":"crossref","first-page":"e16231","DOI":"10.1038\/lsa.2016.231","article-title":"Red light at intensities above 10 lx alters sleep-wake behavior in mice","volume":"6","author":"Zhang","year":"2017","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.neurobiolaging.2023.01.008_bib0065","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neurobiolaging.2020.02.020","article-title":"Suvorexant ameliorates cognitive impairments and pathology in APP\/PS1 transgenic mice","volume":"91","author":"Zhou","year":"2020","journal-title":"Neurobiol. Aging"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458023000088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458023000088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:44:26Z","timestamp":1759319066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458023000088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":65,"alternative-id":["S0197458023000088"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2023.01.008","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid \u03b2 metabolism","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2023.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}