{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T07:15:48Z","timestamp":1772522148652,"version":"3.50.1"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.neurobiolaging.2024.08.010","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T21:22:04Z","timestamp":1725139324000},"page":"19-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study"],"prefix":"10.1016","volume":"144","author":[{"given":"Lars","family":"Michels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"O\u2019Gorman-Tuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Studer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Saake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmeralda","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Rauen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Buchmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Zuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Gietl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Treyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2-3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3940(01)01636-6","article-title":"Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease","volume":"302","author":"Aksenov","year":"2001","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/mrm.25150","article-title":"Detection of glutamate, glutamine, and glutathione by radiofrequency suppression and echo time optimization at 7 tesla","volume":"73","author":"An","year":"2015","journal-title":"Magn. Reson Med"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jmri.27842","article-title":"Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA-PRESS Sequence in primary motor cortex and occipital cortex","volume":"55","author":"Anton","year":"2022","journal-title":"J. Magn. Reson. Imaging"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2024.08.010_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22095010","article-title":"Glutathione in the Brain","volume":"22","author":"Aoyama","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2024.08.010_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ijdevneu.2004.07.006","article-title":"Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology","volume":"22","author":"Apelt","year":"2004","journal-title":"Int J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41398-023-02572-6","article-title":"Age-, sex-, and pathology-related variability in brain structure and cognition","volume":"13","author":"Bachmann","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib7","doi-asserted-by":"crossref","unstructured":"Bachmann, D., Roman, Z.J., Buchmann, A., Zuber, I., Studer, S., Saake, A., Rauen, K., Gruber, E., Nitsch, R.M., Hock, C., Gietl, A.F., Treyer, V., 2022. Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women. Ann Neurol10.1002\/ana.26417.","DOI":"10.1002\/ana.26417"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.scr.2018.01.019","article-title":"Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-beta and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.","volume":"27","author":"Birnbaum","year":"2018","journal-title":"Stem Cell Res"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jmri.25588","article-title":"Within- and between-session reproducibility of GABA measurements with MR spectroscopy","volume":"46","author":"Brix","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"issue":"34","key":"10.1016\/j.neurobiolaging.2024.08.010_bib10","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-022-00961-5","article-title":"Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis","volume":"14","author":"Chen","year":"2022","journal-title":"Alzheimers Res Ther."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib12","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3174\/ajnr.A5143","article-title":"Relationships among cortical glutathione levels, brain amyloidosis, and memory in healthy older adults investigated in vivo with (1)H-MRS and pittsburgh compound-B PET","volume":"38","author":"Chiang","year":"2017","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11357-013-9545-8","article-title":"Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T","volume":"36","author":"Chiu","year":"2014","journal-title":"Age (Dordr.)"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jmri.24611","article-title":"Investigation of glutamine and GABA levels in patients with idiopathic generalized epilepsy using MEGAPRESS","volume":"41","author":"Chowdhury","year":"2015","journal-title":"J. Magn. Reson Imaging"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2024.08.010_bib15","first-page":"793","article-title":"Multiple roles of glutathione in the central nervous system","volume":"378","author":"Cooper","year":"1997","journal-title":"Biol. Chem."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0014-2999(99)00924-3","article-title":"Melatonin treatment does not prevent decreases in brain glutathione levels induced by sleep deprivation","volume":"390","author":"D'Almeida","year":"2000","journal-title":"Eur. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2004.02.079","article-title":"Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile","volume":"1012","author":"Dedeoglu","year":"2004","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jalz.2013.01.005","article-title":"Glutathione relates to neuropsychological functioning in mild cognitive impairment","volume":"10","author":"Duffy","year":"2014","journal-title":"Alzheimers Dement"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2024.08.010_bib19","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/nbm.1646","article-title":"Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain","volume":"24","author":"Emir","year":"2011","journal-title":"NMR Biomed."},{"issue":"14","key":"10.1016\/j.neurobiolaging.2024.08.010_bib20","first-page":"1869","article-title":"Effects of estrogen, estrogen\/progesteron combination and genistein treatments on oxidant\/antioxidant status in the brain of ovariectomized rats","volume":"17","author":"Evsen","year":"2013","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/mrm.20901","article-title":"Use of tissue water as a concentration reference for proton spectroscopic imaging","volume":"55","author":"Gasparovic","year":"2006","journal-title":"Magn. Reson Med."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119740","article-title":"Neurometabolic timecourse of healthy aging","volume":"264","author":"Gong","year":"2022","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib24","first-page":"687","article-title":"Magnetic resonance spectroscopy in Alzheimer's disease","volume":"9","author":"Graff-Radford","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"13","key":"10.1016\/j.neurobiolaging.2024.08.010_bib25","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-510X(98)00095-1","article-title":"Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases","volume":"158","author":"Gu","year":"1998","journal-title":"J. Neurol. Sci."},{"issue":"24","key":"10.1016\/j.neurobiolaging.2024.08.010_bib27","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/bi990438f","article-title":"The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction","volume":"38","author":"Huang","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib28","article-title":"The macromolecular MR spectrum does not change with healthy aging","volume":"10","author":"Hui","year":"2021","journal-title":"Magn. Reson Med"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2024.08.010_bib29","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1093\/cercor\/bhab107","article-title":"In vivo brain glutathione is higher in older age and correlates with mobility","volume":"31","author":"Hupfeld","year":"2021","journal-title":"Cereb. Cortex"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010324","article-title":"Glutathione in brain disorders and aging","volume":"27","author":"Iskusnykh","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib31","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1471-4159.2008.05460.x","article-title":"The ketogenic diet increases mitochondrial glutathione levels","volume":"106","author":"Jarrett","year":"2008","journal-title":"J. Neurochem"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/WNL.55.2.210","article-title":"Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: a 1H MRS study","volume":"55","author":"Kantarci","year":"2000","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2024.08.010_bib33","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1212\/01.WNL.0000141849.21256.AC","article-title":"1H MR spectroscopy in common dementias","volume":"63","author":"Kantarci","year":"2004","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2024.08.010_bib34","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.neurobiolaging.2006.06.018","article-title":"Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease","volume":"28","author":"Kantarci","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0b013e31829a3329","article-title":"MRI and MRS predictors of mild cognitive impairment in a population-based sample","volume":"81","author":"Kantarci","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000066021","article-title":"Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease","volume":"14","author":"Kantarci","year":"2002","journal-title":"Dement Geriatr. Cogn. Disord."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1023\/A:1010942929678","article-title":"The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense","volume":"26","author":"Karelson","year":"2001","journal-title":"Neurochem Res"},{"issue":"19","key":"10.1016\/j.neurobiolaging.2024.08.010_bib38","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000260969.94695.56","article-title":"PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment","volume":"68","author":"Kemppainen","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/JBM.S35496","article-title":"Beta-amyloidolysis and glutathione in Alzheimer's disease","volume":"4","author":"Lasierra-Cirujeda","year":"2013","journal-title":"J. Blood Med."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3233\/JAD-2010-1401","article-title":"Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease","volume":"20","author":"Lehmann","year":"2010","journal-title":"Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fnagi.2018.00124","article-title":"Mitochondria, estrogen and female brain aging","volume":"10","author":"Lejri","year":"2018","journal-title":"Front Aging Neurosci."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib43","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.cclet.2020.10.047","article-title":"A GSH-responsive PET-based fluorescent probe for cancer cells imaging","volume":"32","author":"Li","year":"2021","journal-title":"Chin. Chem. Lett."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib44","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1523\/JNEUROSCI.2028-17.2017","article-title":"Entorhinal tau pathology, episodic memory decline, and neurodegeneration in aging","volume":"38","author":"Maass","year":"2018","journal-title":"J. Neurosci."},{"issue":"Suppl 3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib45","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.3233\/JAD-2012-120166","article-title":"Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male\/female, mild cognitive impairment, and Alzheimer's disease","volume":"31","author":"Mandal","year":"2012","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2024.08.010_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac215","article-title":"Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer's disease compared with healthy elderly participants","volume":"4","author":"Mandal","year":"2022","journal-title":"Brain Commun."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2024.08.010_bib47","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.biopsych.2015.04.005","article-title":"Brain glutathione levels-a novel biomarker for mild cognitive impairment and Alzheimer's disease","volume":"78","author":"Mandal","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib48","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuroscience.2017.04.035","article-title":"Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using (1)H magnetic resonance spectroscopy at 7 T","volume":"354","author":"Marjanska","year":"2017","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02755589","article-title":"Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease","volume":"12","author":"Mark","year":"1996","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib50","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J","article-title":"Simultaneous in vivo spectral editing and water suppression","volume":"11","author":"Mescher","year":"1998","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib51","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1148\/radiology.187.2.8475286","article-title":"Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy","volume":"187","author":"Miller","year":"1993","journal-title":"Radiology"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2024.08.010_bib52","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2024.08.010_bib53","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib54","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2967\/jnumed.106.037762","article-title":"Visual assessment versus quantitative assessment of 11C-PIB PET and 18F-FDG PET for detection of Alzheimer's disease","volume":"48","author":"Ng","year":"2007","journal-title":"J. Nucl. Med"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib55","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ab.2016.12.022","article-title":"Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy","volume":"529","author":"Rae","year":"2017","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/nbdi.1999.0273","article-title":"Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain","volume":"7","author":"Ramassamy","year":"2000","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib58","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3174\/ajnr.A5457","article-title":"Measuring cerebral and cerebellar glutathione in children using (1)H MEGA-PRESS MRS","volume":"39","author":"Raschke","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib59","first-page":"286","article-title":"L\u2019examen psychologique dans le cas d\u2019encephalopathie traumatique.","volume":"28","author":"Rey","year":"1941","journal-title":"Arch. De. Psychol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib60","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1016\/j.ejrad.2011.01.106","article-title":"Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study","volume":"81","author":"Reyngoudt","year":"2012","journal-title":"Eur. J. Radiol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib61","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neurobiolaging.2014.07.030","article-title":"Posterior cingulate gamma-aminobutyric acid and glutamate\/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype","volume":"36","author":"Riese","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"20","key":"10.1016\/j.neurobiolaging.2024.08.010_bib62","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1212\/01.wnl.0000261919.22630.ea","article-title":"Imaging beta-amyloid burden in aging and dementia","volume":"68","author":"Rowe","year":"2007","journal-title":"Neurology"},{"issue":"17","key":"10.1016\/j.neurobiolaging.2024.08.010_bib63","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","article-title":"Oxidative stress occurs prior to amyloid abeta plaque formation and tau phosphorylation in Alzheimer's disease: role of glutathione and metal ions","volume":"14","author":"Roy","year":"2023","journal-title":"ACS Chem. Neurosci."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib64","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3233\/JAD-132483","article-title":"The emerging role of glutathione in Alzheimer's disease","volume":"40","author":"Saharan","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib65","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuroimage.2016.07.056","article-title":"Simultaneous edited MRS of GABA and glutathione","volume":"142","author":"Saleh","year":"2016","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib66","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3174\/ajnr.A6543","article-title":"Effect of age on GABA+ and glutathione in a pediatric sample","volume":"41","author":"Saleh","year":"2020","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4227","article-title":"Simultaneous edited MRS of GABA, glutathione, and ethanol","volume":"33","author":"Saleh","year":"2020","journal-title":"NMR Biomed."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-019-0478-z","article-title":"Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers","volume":"11","author":"Salvado","year":"2019","journal-title":"Alzheimers Res. Ther."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2024.08.010_bib69","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/mrm.26532","article-title":"Quantification of glutathione in the human brain by MR spectroscopy at 3 tesla: comparison of PRESS and MEGA-PRESS","volume":"78","author":"Sanaei Nezhad","year":"2017","journal-title":"Magn. Reson. Med."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib70","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neures.2006.01.002","article-title":"Contribution of reduced and oxidized glutathione to signals detected by magnetic resonance spectroscopy as indicators of local brain redox state","volume":"55","author":"Satoh","year":"2006","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib71","first-page":"23","article-title":"Evaluating the fit of structural equation models: Tests of significance and descriptive goodness-of-fit measures","volume":"8","author":"Schermelleh-Engel","year":"2003","journal-title":"Methods Psychol. Res. Online"},{"issue":"16","key":"10.1016\/j.neurobiolaging.2024.08.010_bib72","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib73","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2000.tb05554.x","article-title":"Towards a comprehensive theory for Alzheimer\u2019s disease. Hypothesis: Alzheimer\u2019s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein","volume":"924","author":"Selkoe","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib74","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/hbm.24799","article-title":"Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS","volume":"41","author":"Shukla","year":"2020","journal-title":"Hum. Brain Mapp."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib75","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.neuropharm.2003.11.032","article-title":"Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice","volume":"46","author":"Silva","year":"2004","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib76","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mri.2009.06.008","article-title":"MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis","volume":"28","author":"Srinivasan","year":"2010","journal-title":"Magn. Reson Imaging"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2024.08.010_bib78","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/JGP.0b013e3181e0450d","article-title":"Optimizing mild cognitive impairment for discriminating dementia risk in the general older population","volume":"18","author":"Stephan","year":"2010","journal-title":"Am. J. Geriat. Psychiat."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.neuroimage.2017.03.031","article-title":"Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex","volume":"152","author":"Suri","year":"2017","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib80","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/mrm.10499","article-title":"Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra","volume":"50","author":"Terpstra","year":"2003","journal-title":"Magn. Reson. Med."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2024.08.010_bib81","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/mrm.21086","article-title":"Detection of an antioxidant profile in the human brain in vivo via double editing with MEGA-PRESS","volume":"56","author":"Terpstra","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib82","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2016.01.029","article-title":"Do glutathione levels decline in aging human brain?","volume":"93","author":"Tong","year":"2016","journal-title":"Free Radic. Bio Med."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2024.08.010_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247225","article-title":"Physical activity is associated with lower cerebral beta-amyloid and cognitive function benefits from lifetime experience-a study in exceptional aging","volume":"16","author":"Treyer","year":"2021","journal-title":"PLoS One"},{"issue":"2-3","key":"10.1016\/j.neurobiolaging.2024.08.010_bib84","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/jsbi.2000.4274","article-title":"Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity","volume":"130","author":"Varadarajan","year":"2000","journal-title":"J. Struct. Biol."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2024.08.010_bib85","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s11064-012-0755-8","article-title":"Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease","volume":"37","author":"Venkateshappa","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neurobiolaging.2024.08.010_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101410","article-title":"Sexual dimorphism in glutathione metabolism and glutathione-dependent responses","volume":"31","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2024.08.010_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mrm.22579","article-title":"A constrained least-squares approach to the automated quantitation of in vivo (1)H magnetic resonance spectroscopy data","volume":"65","author":"Wilson","year":"2011","journal-title":"Magn. Reson. Med."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458024001477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458024001477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:33:03Z","timestamp":1729233183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458024001477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":87,"alternative-id":["S0197458024001477"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2024.08.010","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2024.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}