{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:44:08Z","timestamp":1789922648885,"version":"4.0.1"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2UL1TR000445"],"award-info":[{"award-number":["2UL1TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG066159"],"award-info":[{"award-number":["R01AG066159"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG075643"],"award-info":[{"award-number":["R21AG075643"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS091856"],"award-info":[{"award-number":["P50NS091856"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS123067"],"award-info":[{"award-number":["P50NS123067"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG-21-850839"],"award-info":[{"award-number":["AARG-21-850839"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.neurobiolaging.2025.01.008","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:22:45Z","timestamp":1738257765000},"page":"50-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [18F]-fluoroethoxybenzovesamicol positron emission tomography imaging"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-1674","authenticated-orcid":false,"given":"Jason K.","family":"Russell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Patrick","family":"Begnoche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Schlossberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Stranick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lealani Mae Y.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dann","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabesh","family":"Kanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Rafii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-7185","authenticated-orcid":false,"given":"Paul A.","family":"Newhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib1","doi-asserted-by":"crossref","first-page":"71792","DOI":"10.3389\/fninf.2014.00014","article-title":"Machine learning for neuroimaging with scikit-learn","volume":"8","author":"Abraham","year":"2014","journal-title":"Front. Neuroinformatics"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.01.008_bib2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/mp.2017.183","article-title":"Quantification of brain cholinergic denervation in Alzheimer\u2019s disease using PET imaging with [18F]-FEOBV","volume":"22","author":"Aghourian","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.01.008_bib3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/jon.12921","article-title":"FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry","volume":"31","author":"Aghourian","year":"2021","journal-title":"J. Neuroimaging: Off. J. Am. Soc. Neuroimaging"},{"issue":"17","key":"10.1016\/j.neurobiolaging.2025.01.008_bib4","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1002\/cne.24541","article-title":"Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study","volume":"526","author":"Albin","year":"2018","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.01.008_bib5","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/acs.molpharmaceut.1c00961","article-title":"No dopamine agonist modulation of brain [18F]FEOBV binding in Parkinson\u2019s disease","volume":"19","author":"Albin","year":"2022","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2025.01.008_bib6","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1113\/JP275194","article-title":"Preferential cholinergic excitation of corticopontine neurons","volume":"596","author":"Baker","year":"2018","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.01.008_bib7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1017\/S0033291709990985","article-title":"Brain anatomy and ageing in non-demented adults with Down\u2019s syndrome: an in vivo MRI study","volume":"40","author":"Beacher","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.sleep.2018.12.020","article-title":"Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV","volume":"58","author":"Bedard","year":"2019","journal-title":"Sleep. Med."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(22)00408-2","article-title":"Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer\u2019s disease: a cross-sectional study","volume":"22","author":"Boerwinkle","year":"2023","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.01.008_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0378-3782(89)90019-4","article-title":"Neuronal maturation in the foetal brain in Down\u2019s syndrome","volume":"18","author":"Brooksbank","year":"1989","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib11","article-title":"Cognitive and cholinergic systems trajectories in Parkinson disease","author":"Brown","year":"2024","journal-title":"MedRxiv: Prepr. Serv. Health Sci."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ana.410180306","article-title":"Abnormalities of the nucleus basalis in Down\u2019s syndrome","volume":"18","author":"Casanova","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4939-7647-8_2","article-title":"Convolutional Neural Networks for Rapid and Simultaneous Brain Extraction and Tissue Segmentation","volume":"136","author":"Cullen","year":"2018","journal-title":"Neuromethods"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3233\/JAD-230141","article-title":"Cortical amyloid burden relates to basal forebrain volume in subjective cognitive decline","volume":"95","author":"Daamen","year":"2023","journal-title":"J. Alzheimer\u2019S. Dis.: JAD"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.10069","article-title":"Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment","volume":"51","author":"Dekosky","year":"2002","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.01.008_bib16","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/mds.28913","article-title":"Altered Cholinergic Innervation in De Novo Parkinson\u2019s Disease with and Without Cognitive Impairment","volume":"37","author":"van der Zee","year":"2022","journal-title":"Mov. Disord.: Off. J. Mov. Disord. Soc."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbb.2011.02.022","article-title":"The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation","volume":"99","author":"Dumas","year":"2011","journal-title":"Pharm. Biochem Behav."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/brain\/awaa012","article-title":"Basal forebrain volume reliably predicts the cortical spread of Alzheimer\u2019s degeneration","volume":"143","author":"Fern\u00e1ndez-Cabello","year":"2020","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1744629506067615","article-title":"The cholinergic system in Down\u2019s syndrome","volume":"10","author":"Fodale","year":"2006","journal-title":"J. Intellect. Disabil.: JOID"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.01.008_bib20","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S1474-4422(21)00245-3","article-title":"Down syndrome-associated Alzheimer\u2019s disease: a genetic form of dementia","volume":"20","author":"Fortea","year":"2021","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.01.008_bib21","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1046\/j.1471-4159.1998.71062411.x","article-title":"Coordinate expression of the vesicular acetylcholine transporter and choline acetyltransferase following septohippocampal pathway lesions","volume":"71","author":"Gilmor","year":"1998","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00213-010-2153-8","article-title":"Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings","volume":"215","author":"Graef","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neuroimage.2013.12.021","article-title":"Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data","volume":"92","author":"Greve","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroimage.2016.02.042","article-title":"Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging","volume":"132","author":"Greve","year":"2016","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118610","article-title":"A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images","volume":"244","author":"Greve","year":"2021","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2025.01.008_bib26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.biopsych.2011.06.019","article-title":"Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer\u00b4s disease","volume":"71","author":"Grothe","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2025.01.008_bib27","first-page":"S344","article-title":"Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects","volume":"10","author":"Grothe","year":"2014","journal-title":"Alzheimer\u2019S. Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inform."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2007-11110","article-title":"Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention","volume":"11","author":"Head","year":"2007","journal-title":"J. Alzheimer\u2019S. Dis.: JAD"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ajmg.a.30184","article-title":"Donepezil effects on language in children with Down syndrome: results of the first 22-week pilot clinical trial","volume":"130A","author":"Heller","year":"2004","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/jamaneurol.2018.3616","article-title":"Association of dementia with mortality among adults with down syndrome older than 35 Years","volume":"76","author":"Hithersay","year":"2019","journal-title":"JAMA Neurol."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.01.008_bib33","first-page":"2493","article-title":"Mapping cholinergic synaptic loss in Parkinson\u2019s disease: an [18F]FEOBV PET case-control study","volume":"12","author":"Horsager","year":"2022","journal-title":"J. Park. \u2019S. Dis."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hbm.23432","article-title":"Simultaneous total intracranial volume and posterior fossa volume estimation using multi-atlas label fusion","volume":"38","author":"Huo","year":"2017","journal-title":"Hum. Brain Mapp."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2025.01.008_bib35","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.12910","article-title":"Association of Alzheimer disease with life expectancy in people with down syndrome","volume":"5","author":"Iulita","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.01.008_bib36","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s. Dement.: J. Alzheimer\u2019s. Assoc."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbas.2022.100039","article-title":"Cerebral topography of vesicular cholinergic transporter changes in neurologically intact adults: a [18F]FEOBV PET study","volume":"2","author":"Kanel","year":"2022","journal-title":"Aging Brain"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.01.008_bib38","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1471-4159.1989.tb01864.x","article-title":"Down\u2019s syndrome individuals begin life with normal levels of brain cholinergic markers","volume":"52","author":"Kish","year":"1989","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.01.008_bib39","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/ajmg.a.32953","article-title":"The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome","volume":"149A","author":"Kishnani","year":"2009","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.01.008_bib40","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/ajmg.a.33730","article-title":"Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17","volume":"152A","author":"Kishnani","year":"2010","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61962-y","article-title":"Cerebrovascular disease emerges with age and Alzheimer\u2019s disease in adults with Down syndrome","volume":"14","author":"Lao","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/nbdi.1996.0003","article-title":"Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation","volume":"3","author":"Lemere","year":"1996","journal-title":"Neurobiol. Dis."},{"issue":"September","key":"10.1016\/j.neurobiolaging.2025.01.008_bib43","doi-asserted-by":"crossref","first-page":"11465","DOI":"10.1073\/pnas.95.19.11465","article-title":"Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells","volume":"95","author":"Marino","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.01.008_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jlcr.2580330704","article-title":"Synthesis of [18F]fluoroethoxy-benzovesamicol, a radiotracer for cholinergic neurons","volume":"33","author":"Mulholland","year":"1993","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1098-2396(199811)30:3<263::AID-SYN4>3.0.CO;2-9","article-title":"[18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses","volume":"30","author":"Mulholland","year":"1998","journal-title":"Synapse"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2025.01.008_bib46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/brain\/awac385","article-title":"Cholinergic white matter pathways along the Alzheimer\u2019s disease continuum","volume":"146","author":"Nemy","year":"2023","journal-title":"Brain: A J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.119908","article-title":"Distribution of cholinergic nerve terminals in the aged human brain measured with [18F]FEOBV PET and its correlation with histological data","volume":"269","author":"Okkels","year":"2023","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.01.008_bib48","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1093\/brain\/awae069","article-title":"Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes","volume":"147","author":"Okkels","year":"2024","journal-title":"Brain: A J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib49","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.nicl.2018.01.024","article-title":"A longitudinal study of brain anatomy changes preceding dementia in Down syndrome","volume":"18","author":"Pujol","year":"2018","journal-title":"NeuroImage. Clin."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaneurol.2018.3443","article-title":"Prevalence and severity of Alzheimer disease in individuals with down syndrome","volume":"76","author":"Rafii","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/B978-0-12-804766-8.00017-0","article-title":"Down syndrome","volume":"167","author":"Rafii","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib52","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroimage.2014.06.031","article-title":"The integrity of the cholinergic system determines memory performance in healthy elderly","volume":"100","author":"Richter","year":"2014","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib53","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/JAD-210261","article-title":"Age and anterior basal forebrain volume predict the cholinergic deficit in patients with mild cognitive impairment due to Alzheimer\u2019s disease","volume":"86","author":"Richter","year":"2022","journal-title":"J. Alzheimer\u2019S. Dis.: JAD"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.01.008_bib54","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1002\/alz.12999","article-title":"Basal forebrain atrophy along the Alzheimer\u2019s disease continuum in adults with Down syndrome","volume":"19","author":"Rozalem Aranha","year":"2023","journal-title":"Alzheimer\u2019S. Dement.: J. Alzheimer\u2019S. Assoc."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2018.101612","article-title":"Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD)","volume":"21","author":"Scheef","year":"2019","journal-title":"NeuroImage. Clin."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib56","first-page":"1","article-title":"Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer\u2019s pathology","author":"Schmitz","year":"2016","journal-title":"Nat. Commun. 2016 7:1, 7"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib57","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.celrep.2018.06.001","article-title":"Longitudinal Alzheimer\u2019s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections","volume":"24","author":"Schmitz","year":"2018","journal-title":"Cell Rep."},{"issue":"13","key":"10.1016\/j.neurobiolaging.2025.01.008_bib58","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/ajmg.a.31790","article-title":"Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: a clinical report series","volume":"143A","author":"Spiridigliozzi","year":"2007","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.01.008_bib59","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/ajmg.a.37650","article-title":"Safety and efficacy of rivastigmine in children with Down syndrome: A double blind placebo controlled trial","volume":"170","author":"Spiridigliozzi","year":"2016","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib60","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The cholinergic hypothesis of age and Alzheimer\u2019s disease-related cognitive deficits: recent challenges and their implications for novel drug development","volume":"306","author":"Terry","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.01.008_bib61","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-011-1745-9","article-title":"The importance of appropriate partial volume correction for PET quantification in Alzheimer\u2019s disease","volume":"38","author":"Thomas","year":"2011","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.01.008_bib62","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ana.410100203","article-title":"Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis","volume":"10","author":"Whitehouse","year":"1981","journal-title":"Ann. Neurol."},{"issue":"4537","key":"10.1016\/j.neurobiolaging.2025.01.008_bib63","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7058341","article-title":"Alzheimer\u2019s disease and senile dementia: loss of neurons in the basal forebrain","volume":"215","author":"Whitehouse","year":"1982","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.01.008_bib64","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410170310","article-title":"Occurrence of neuropathological changes and dementia of Alzheimer\u2019s disease in Down\u2019s syndrome","volume":"17","author":"Wisniewski","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.102992","article-title":"Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment","volume":"34","author":"Xia","year":"2022","journal-title":"NeuroImage. Clin."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib66","article-title":"Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome","volume":"31","author":"Zammit","year":"2021","journal-title":"NeuroImage: Clin."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib67","first-page":"388","article-title":"Characterizing the emergence of amyloid and tau burden in Down syndrome. Alzheimer\u2019s & Dementia","volume":"20","author":"Zammit","year":"2024","journal-title":"J. Alzheimer\u2019s. Assoc."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.01.008_bib68","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1515\/revneuro-2016-0008","article-title":"The cholinergic system in the cerebellum: from structure to function","volume":"27","author":"Zhang","year":"2016","journal-title":"Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.01.008_bib69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ddrr.1128","article-title":"Atypical aging in Down syndrome","volume":"18","author":"Zigman","year":"2013","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2025.01.008_bib70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2017.10.002","article-title":"GABAergic over-inhibition, a promising hypothesis for cognitive deficits in Down syndrome","volume":"114","author":"Zorrilla de San Martin","year":"2018","journal-title":"Free Radic. Biol. Med."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802500020X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802500020X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:53:39Z","timestamp":1777528419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802500020X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":70,"alternative-id":["S019745802500020X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.01.008","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.28.24316136","asserted-by":"object"}]},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [18F]-fluoroethoxybenzovesamicol positron emission tomography imaging","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}