{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:25:49Z","timestamp":1787102749400,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"am","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX003853"],"award-info":[{"award-number":["I01 BX003853"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK4BX005219"],"award-info":[{"award-number":["IK4BX005219"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG056533"],"award-info":[{"award-number":["R01 AG056533"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG010161"],"award-info":[{"award-number":["P30 AG010161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG061356"],"award-info":[{"award-number":["U01 AG061356"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG079170"],"award-info":[{"award-number":["R01 AG079170"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG017917"],"award-info":[{"award-number":["R01 AG017917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG015819"],"award-info":[{"award-number":["R01 AG015819"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG075827"],"award-info":[{"award-number":["R01 AG075827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG072120"],"award-info":[{"award-number":["R01 AG072120"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072975"],"award-info":[{"award-number":["P30 AG072975"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG046152"],"award-info":[{"award-number":["U01 AG046152"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["I01 BX003853"],"award-info":[{"award-number":["I01 BX003853"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["IK4BX005219"],"award-info":[{"award-number":["IK4BX005219"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.neurobiolaging.2025.03.014","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:06:20Z","timestamp":1744002380000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Brain microRNAs differentially expressed in age-related cerebral pathologies"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0076-0976","authenticated-orcid":false,"given":"Tianze","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina M.","family":"Vattathil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-6282","authenticated-orcid":false,"given":"Thomas S.","family":"Wingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliza P.","family":"Wingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-13-33","article-title":"Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128","volume":"13","author":"Adlakha","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/bpa.12365","article-title":"The relationship of cerebral vessel pathology to brain microinfarcts","volume":"27","author":"Arvanitakis","year":"2017","journal-title":"Brain Pathol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.03.014_bib4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/STROKEAHA.110.595082","article-title":"Microinfarct pathology, dementia, and cognitive systems","volume":"42","author":"Arvanitakis","year":"2011","journal-title":"Stroke"},{"issue":"s1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib5","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"15","key":"10.1016\/j.neurobiolaging.2025.03.014_bib6","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.03.014_bib7","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/brain\/awab092","article-title":"To what degree is late life cognitive decline driven by age-related neuropathologies?","volume":"144","author":"Boyle","year":"2021","journal-title":"Brain"},{"issue":"22","key":"10.1016\/j.neurobiolaging.2025.03.014_bib8","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1212\/WNL.0000000000002175","article-title":"Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons","volume":"85","author":"Boyle","year":"2015","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nlm.2011.04.004","article-title":"MicroRNA regulation of neural plasticity and memory","volume":"96","author":"Bredy","year":"2011","journal-title":"Neurobiol. Learn Mem."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.03.014_bib10","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1161\/STROKEAHA.111.623462","article-title":"Cerebrovascular disease pathology and parkinsonian signs in old age","volume":"42","author":"Buchman","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2023.01.009","article-title":"MicroRNAs: key modulators of inflammation-associated diseases","author":"Chatterjee","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41398-022-02108-4","article-title":"Differential microRNA expression analyses across two brain regions in Alzheimer\u2019s disease","volume":"12","author":"Dobricic","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.03.014_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/cjn.2022.34","article-title":"Current concepts of mixed pathologies in neurodegenerative diseases","volume":"50","author":"Forrest","year":"2023","journal-title":"Can. J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.03.014_bib14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1261\/rna.079098.122","article-title":"The limits of human microRNA annotation have been met","volume":"28","author":"Fromm","year":"2022","journal-title":"RNA"},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib15","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3389\/fnins.2019.00866","article-title":"MicroRNA-126-3p attenuates intracerebral hemorrhage-induced blood-brain barrier disruption by regulating VCAM-1 expression","volume":"13","author":"Fu","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib17","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1007\/s12035-019-01676-9","article-title":"A systematic review of microRNA expression as biomarker of late-onset Alzheimer\u2019s disease","volume":"56","author":"Herrera-Espejo","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.03.014_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00401-008-0400-4","article-title":"Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease","volume":"116","author":"Hu","year":"2008","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.03.014_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.0000000000001831","article-title":"Multiple pathologies are common and related to dementia in the oldest-old: the 90+\u2009Study","volume":"85","author":"Kawas","year":"2015","journal-title":"Neurology"},{"issue":"D1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib20","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.03.014_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: Precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"issue":"33","key":"10.1016\/j.neurobiolaging.2025.03.014_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn7357","article-title":"Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission","volume":"8","author":"Liang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroscience.2022.08.024","article-title":"Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia\/reperfusion injury","volume":"503","author":"Luo","year":"2022","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.03.014_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2174\/138920210793175895","article-title":"MicroRNA: biogenesis, function and role in cancer","volume":"11","author":"Macfarlane","year":"2010","journal-title":"Curr. Genom."},{"issue":"22","key":"10.1016\/j.neurobiolaging.2025.03.014_bib25","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies","volume":"26","author":"Manichaikul","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-018-0531-3","article-title":"TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer\u2019s disease","volume":"6","author":"Nag","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.03.014_bib27","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ana.24388","article-title":"Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease","volume":"77","author":"Nag","year":"2015","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.03.014_bib28","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1750-3639.2007.00120.x","article-title":"MicroRNAs (miRNAs) in neurodegenerative diseases","volume":"18","author":"Nelson","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.brainres.2017.11.009","article-title":"MicroRNA expression patterns in human anterior cingulate and motor cortex: a study of dementia with Lewy bodies cases and controls","volume":"1678","author":"Nelson","year":"2018","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ejhg.2015.61","article-title":"Mutation in the 3\u2019untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy","volume":"24","author":"Nicolas","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13024-017-0191-y","article-title":"Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease","volume":"12","author":"Patrick","year":"2017","journal-title":"Mol. Neurodegener."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2025.03.014_bib34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13195-014-0082-1","article-title":"Prevalence of mixed pathologies in the aging brain","volume":"6","author":"Rahimi","year":"2014","journal-title":"Alzheimers Res. Ther."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.03.014_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.03.014_bib36","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1093\/brain\/awad059","article-title":"Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated","volume":"146","author":"Robinson","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146327","article-title":"Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer's disease-like pathology","volume":"1721","author":"Sarkar","year":"2019","journal-title":"Brain Res."},{"issue":"24","key":"10.1016\/j.neurobiolaging.2025.03.014_bib38","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"issue":"Pt 10","key":"10.1016\/j.neurobiolaging.2025.03.014_bib39","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/brain\/aws234","article-title":"Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies","volume":"135","author":"Schneider","year":"2012","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.03.014_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ana.21142","article-title":"Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons","volume":"62","author":"Schneider","year":"2007","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.03.014_bib41","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1212\/01.WNL.0000055863.87435.B2","article-title":"Relation of cerebral infarctions to dementia and cognitive function in older persons","volume":"60","author":"Schneider","year":"2003","journal-title":"Neurology"},{"issue":"16","key":"10.1016\/j.neurobiolaging.2025.03.014_bib42","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur. J. Biochem."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.03.014_bib43","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jalz.2019.06.4952","article-title":"Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid","volume":"15","author":"Takousis","year":"2019","journal-title":"Alzheimer'S. Dement."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.03.014_bib44","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.3390\/cells10123479","article-title":"Co-expression network analysis of micro-RNAs and proteins in the Alzheimer\u2019s brain: a systematic review of studies in the last 10 years","volume":"10","author":"Tasker","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.03.014_bib45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1253\/circrep.CR-20-0135","article-title":"Exosome miR-501-3p elevation contributes to progression of vascular stiffness","volume":"3","author":"Toyama","year":"2021","journal-title":"Circ. Rep."},{"key":"10.1016\/j.neurobiolaging.2025.03.014_bib46","article-title":"Genetic regulation of microRNAs in the older adult brain and their contribution to neuropsychiatric conditions","author":"Vattathil","year":"2024","journal-title":"bioRxiv"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.03.014_bib47","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.3390\/biomedicines10081856","article-title":"MicroRNAs in learning and memory and their impact on Alzheimer\u2019s disease","volume":"10","author":"Wang","year":"2022","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.03.014_bib48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1212\/WNL.0000000000002480","article-title":"Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia aging studies","volume":"86","author":"White","year":"2016","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2025.03.014_bib49","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1038\/s41591-023-02509-y","article-title":"Sex differences in brain protein expression and disease","volume":"29","author":"Wingo","year":"2023","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2025.03.014_bib50","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1038\/s41380-022-01476-z","article-title":"Differential expression of MicroRNAs in Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"27","author":"Yoon","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.03.014_bib51","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1177\/0271678X18800593","article-title":"Role of microRNA-126 in vascular cognitive impairment in mice","volume":"39","author":"Yu","year":"2019","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"16","key":"10.1016\/j.neurobiolaging.2025.03.014_bib52","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/bioinformatics\/bts366","article-title":"GO-Elite: a flexible solution for pathway and ontology over-representation","volume":"28","author":"Zambon","year":"2012","journal-title":"Bioinformatics"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458025000624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458025000624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:49:07Z","timestamp":1778676547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458025000624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":52,"alternative-id":["S0197458025000624"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.03.014","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain microRNAs differentially expressed in age-related cerebral pathologies","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}