{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:23:37Z","timestamp":1777865017316,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014041","name":"Alzheimer&apos;s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006254","name":"Ruhr University Bochum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.neurobiolaging.2025.07.007","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T12:33:37Z","timestamp":1752582817000},"page":"66-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["White matter hyperintensities contribute to early cortical thinning in addition to tau in aging"],"prefix":"10.1016","volume":"155","author":[{"given":"Riccardo","family":"Leone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"Kobeleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.07.007_bib1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/STROKEAHA.119.027544","article-title":"Common genetic variation indicates separate causes for periventricular and deep white matter hyperintensities","volume":"51","author":"Armstrong","year":"2020","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14233","article-title":"Hypertension and cerebral blood flow in the development of alzheimer\u2019s disease","author":"Bachmann","year":"2024","journal-title":"Alzheimer\u2019s Dement. J. Alzheimer\u2019s Assoc. Sept."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s44161-021-00014-4","article-title":"Blood\u2013brain barrier link to human cognitive impairment and alzheimer\u2019s disease","volume":"1","author":"Barisano","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13195-024-01606-5","article-title":"Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults","volume":"16","author":"Bernal","year":"2024","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.07.007_bib6","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1093\/brain\/awq187","article-title":"Larger temporal volume in elderly with high versus low beta-amyloid deposition","volume":"133","author":"Ch\u00e9telat","year":"2010","journal-title":"Brain A J. Neurol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/jnnp-2023-331603","article-title":"Emerging role of vascular burden in AT(N) classification in individuals with Alzheimer\u2019s and concomitant cerebrovascular burdens","volume":"95","author":"Chun","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib8","article-title":"TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models","author":"Ciric","year":"2022","journal-title":"Cold Spring Harb. Lab."},{"issue":"March","key":"10.1016\/j.neurobiolaging.2025.07.007_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2021.11.007","article-title":"White matter hyperintensities are associated with grey matter atrophy and cognitive decline in alzheimer\u2019s disease and frontotemporal dementia","volume":"111","author":"Dadar","year":"2022","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib10","article-title":"The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition","volume":"12","author":"Dadar","year":"2020","journal-title":"Alzheimer\u2019s Dement. (Amst. Neth.)"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib11","doi-asserted-by":"crossref","first-page":"fcz033","DOI":"10.1093\/braincomms\/fcz033","article-title":"Oxygenation differs among white matter hyperintensities, intersected fiber tracts and unaffected white matter","volume":"1","author":"Dalby","year":"2019","journal-title":"Brain Commun."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.STR.0000150668.58689.f2","article-title":"Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and Total WMH burden","volume":"36","author":"DeCarli","year":"2005","journal-title":"Stroke"},{"issue":"16","key":"10.1016\/j.neurobiolaging.2025.07.007_bib13","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1212\/WNL.0b013e3182166e96","article-title":"Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults","volume":"76","author":"Dickerson","year":"2011","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/STROKEAHA.115.011229","article-title":"Progression of white matter disease and cortical thinning are not related in older community-dwelling subjects","volume":"47","author":"Dickie","year":"2016","journal-title":"Stroke"},{"issue":"April","key":"10.1016\/j.neurobiolaging.2025.07.007_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trsl.2022.12.003","article-title":"Vascular contributions to alzheimer\u2019s disease","volume":"254","author":"Eisenmenger","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib16","unstructured":"Esteban, O., C. Markiewicz, R. Blair, R. Poldrack, and K. Gorgolewski. 2024. sMRIPrep: Structural MRI PREProcessing Workflows (0.16.0). https:\/\/doi.org\/10.5281\/zenodo.13376346."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.07.007_bib17","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1002\/alz.14059","article-title":"Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum","volume":"20","author":"Falcon","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3233\/JAD-160474","article-title":"White matter hyperintensities potentiate hippocampal volume reduction in non-demented older individuals with abnormal amyloid-\u03b2.\u201d Edited by Joel Ramirez","volume":"55","author":"Freeze","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.07.007_bib20","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1002\/alz.13057","article-title":"White matter hyperintensities in alzheimer\u2019s disease: beyond vascular contribution","volume":"19","author":"Garnier-Crussard","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.07.007_bib21","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/brain\/awz162","article-title":"White matter hyperintensities: relationship to amyloid and tau burden","volume":"142","author":"Graff-Radford","year":"2019","journal-title":"Brain"},{"issue":"April","key":"10.1016\/j.neurobiolaging.2025.07.007_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroimage.2017.03.024","article-title":"Classification and characterization of periventricular and deep white matter hyperintensities on MRI: a study in older adults","volume":"170","author":"Griffanti","year":"2018","journal-title":"NeuroImage Segm. Brain"},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102639","article-title":"Lesion quantification toolkit: a MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions","volume":"30","author":"Griffis","year":"2021","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib24","first-page":"1","article-title":"Relative importance for linear regression in r: the package relaimpo","volume":"17","author":"Groemping","year":"2007","journal-title":"J. Stat. Softw."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.07.007_bib25","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/alz.12249","article-title":"Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults","volume":"17","author":"Harrison","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib26","doi-asserted-by":"crossref","first-page":"fcaa007","DOI":"10.1093\/braincomms\/fcaa007","article-title":"Neuroanatomical spread of amyloid \u03b2 and tau in alzheimer\u2019s disease: implications for primary prevention","volume":"2","author":"Insel","year":"2020","journal-title":"Brain Commun."},{"issue":"Pt 12","key":"10.1016\/j.neurobiolaging.2025.07.007_bib27","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1093\/brain\/awv283","article-title":"Different definitions of neurodegeneration produce similar amyloid\/neurodegeneration biomarker group findings","volume":"138","author":"Jack","year":"2015","journal-title":"Brain A J. Neurol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1474-4422(17)30077-7","article-title":"Age-specific and sex-specific prevalence of cerebral \u03b2-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50\u201395 years: a cross-sectional study","volume":"16","author":"Jack","year":"2017","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.07.007_bib29","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of alzheimer\u2019s disease: alzheimer\u2019s association workgroup","volume":"20","author":"Jack Jr","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"10.1016\/j.neurobiolaging.2025.07.007_bib30","first-page":"1","article-title":"Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases","author":"Kampmann","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2025.07.007_bib31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/jnnp-2023-332067","article-title":"Rates of cortical thinning in alzheimer\u2019s disease signature regions associate with vascular burden but not with \u03b2-amyloid status in cognitively normal adults at age 70","volume":"95","author":"Keuss","year":"2024","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib32","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1212\/WNL.0000000000200524","article-title":"Associations of \u03b2-amyloid and vascular burden with rates of neurodegeneration in cognitively normal members of the 1946 British Birth Cohort","volume":"99","author":"Keuss","year":"2022","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.07.007_bib33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in alzheimer disease","volume":"18","author":"Kisler","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.07.007_bib34","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/brain\/aww009","article-title":"Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease","volume":"139","author":"Lambert","year":"2016","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.07.007_bib35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.23650","article-title":"Amyloid deposition, hypometabolism, and longitudinal cognitive decline","volume":"72","author":"Landau","year":"2012","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib36","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.24647","article-title":"White matter hyperintensities are a core feature of alzheimer\u2019s disease: evidence from the dominantly inherited alzheimer network","volume":"79","author":"Lee","year":"2016","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2025.07.007_bib37","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1093\/brain\/awad220","article-title":"Regional cortical thinning, demyelination and iron loss in cerebral small vessel disease","volume":"146","author":"Li","year":"2023","journal-title":"Brain A J. Neurol."},{"issue":"December","key":"10.1016\/j.neurobiolaging.2025.07.007_bib38","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuroimage.2018.07.005","article-title":"Fully convolutional network ensembles for white matter hyperintensities segmentation in MR images","volume":"183","author":"Li","year":"2018","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.07.007_bib39","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209801","article-title":"Association of vascular risk factors and cerebrovascular pathology with alzheimer disease pathologic changes in individuals without dementia","volume":"103","author":"Lorenzini","year":"2024","journal-title":"Neurology"},{"issue":"August","key":"10.1016\/j.neurobiolaging.2025.07.007_bib40","article-title":"Inflammation and cerebral small vessel disease: a systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib41","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1212\/WNL.0000000000207378","article-title":"Longitudinal relationships of white matter hyperintensities and alzheimer disease biomarkers across the adult life span","volume":"101","author":"Luo","year":"2023","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.07.007_bib42","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/alz.13559","article-title":"Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in alzheimer\u2019s continuum","volume":"20","author":"Lyu","year":"2024","journal-title":"Alzheimer\u2019s Dement. J. Alzheimer\u2019s Assoc."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2025.07.007_bib43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer\u2019s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.07.007_bib44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/NEN.0b013e318277387e","article-title":"A quantitative postmortem MRI design sensitive to white matter hyperintensity differences and their relationship with underlying pathology","volume":"71","author":"Murray","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib45","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nn.4018","article-title":"Three dimensions of the amyloid hypothesis: time, space, and \u2018wingmen.\u2019","volume":"18","author":"Musiek","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hbm.22173","article-title":"Covarying alterations in A\u03b2 deposition, glucose metabolism, and gray matter volume in cognitively normal elderly","volume":"35","author":"Oh","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib47","article-title":"Amyloid \u03b2 influences the relationship between cortical thickness and vascular load","volume":"12","author":"Parker","year":"2020","journal-title":"Alzheimer\u2019s Dement. Diagn. Assess. Dis. Monit."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib48","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1038\/s41467-024-53689-1","article-title":"Genetic risk factors underlying white matter hyperintensities and cortical atrophy","volume":"15","author":"Patel","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2025.07.007_bib49","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"NeuroImage"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2025.07.007_bib50","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.25166","article-title":"Association of regional white matter hyperintensities with longitudinal alzheimer-like pattern of neurodegeneration in older adults","volume":"4","author":"Rizvi","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13195-021-00836-1","article-title":"Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach","volume":"13","author":"Royse","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib52","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The Amyloid hypothesis of alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.07.007_bib53","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/jamaneurol.2023.3618","article-title":"Etiology of white matter hyperintensities in autosomal dominant and sporadic alzheimer disease","volume":"80","author":"Shirzadi","year":"2023","journal-title":"JAMA Neurol."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2025.07.007_bib54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41582-018-0014-y","article-title":"Cerebral small vessel disease: from a focal to a global perspective","volume":"14","author":"Ter Telgte","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/STROKEAHA.114.007146","article-title":"Relationship between white matter hyperintensities, cortical thickness, and cognition","volume":"46","author":"Tuladhar","year":"2015","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib56","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4itk: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2025.07.007_bib57","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1038\/s41598-021-87564-6","article-title":"The ANTsX ecosystem for quantitative biological and medical imaging","volume":"11","author":"Tustison","year":"2021","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2025.07.007_bib58","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1161\/STROKEAHA.112.661793","article-title":"Physical activity prevents progression for cognitive impairment and vascular dementia","volume":"43","author":"Verdelho","year":"2012","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.114.001140","article-title":"What are white matter hyperintensities made of?","volume":"4","author":"Wardlaw","year":"2015","journal-title":"J. Am. Heart Assoc."},{"issue":"September","key":"10.1016\/j.neurobiolaging.2025.07.007_bib60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroimage.2018.05.027","article-title":"Population-averaged atlas of the macroscale human structural connectome and its network topology","volume":"178","author":"Yeh","year":"2018","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2025.07.007_bib61","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1002\/alz.13845","article-title":"Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in alzheimer\u2019s disease","volume":"20","author":"Zhang","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2025.07.007_bib62","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11682-018-9855-7","article-title":"Blood\u2013brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging","volume":"13","author":"Zhang","year":"2019","journal-title":"Brain Imaging Behav."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458025001216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458025001216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:52:30Z","timestamp":1777528350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458025001216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":62,"alternative-id":["S0197458025001216"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.07.007","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter hyperintensities contribute to early cortical thinning in addition to tau in aging","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}