{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:55:10Z","timestamp":1787774110847,"version":"build-2784847793"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008716","name":"Science and Industry Endowment Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016005","name":"Yulgilbar Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.neurobiolaging.2026.02.003","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:15:44Z","timestamp":1771431344000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Higher sodium intake is associated with episodic memory decline in cognitively unimpaired older males: A 6-year longitudinal study"],"prefix":"10.1016","volume":"162","author":[{"given":"Francisca","family":"Chuwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Rainey-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal Salim Said","family":"Al Shamsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-5260","authenticated-orcid":false,"given":"Samantha L.","family":"Gardener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40292-013-0002-7","article-title":"The relationship between cognitive function, depressive behaviour and sleep quality with 24-h urinary sodium excretion in patients with essential hypertension","volume":"20","author":"Afsar","year":"2013","journal-title":"High. Blood Press Cardiovasc. Prev."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2026.02.003_bib2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.amjmed.2019.04.040","article-title":"Trends in dietary sodium intake in the united states and the impact of usda guidelines: Nhanes 1999-2016","volume":"132","author":"Brouillard","year":"2019","journal-title":"Am. J. Med."},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib3","article-title":"Vascular cognitive impairment","volume":"4","author":"van der Flier","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.02.003_bib4","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.neubiorev.2011.07.006","article-title":"Towards a functional organization of episodic memory in the medial temporal lobe","volume":"36","author":"Eichenbaum","year":"2012","journal-title":"Neurosci. Biobehav Rev."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib5","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1161\/HYP.0000000000000047","article-title":"Salt sensitivity of blood pressure: a scientific statement from the american heart association","volume":"68","author":"Elijovich","year":"2016","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.02.003_bib6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/S1041610209009405","article-title":"The australian imaging, biomarkers and lifestyle (aibl) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of alzheimer's disease","volume":"21","author":"Ellis","year":"2009","journal-title":"Int. Psychogeriatr."},{"issue":"18","key":"10.1016\/j.neurobiolaging.2026.02.003_bib7","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/cvr\/cvae229","article-title":"Dietary salt, vascular dysfunction, and cognitive impairment","volume":"120","author":"Faraco","year":"2025","journal-title":"Cardiovasc Res."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.02.003_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41593-017-0059-z","article-title":"Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated th17 response","volume":"21","author":"Faraco","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"7780","key":"10.1016\/j.neurobiolaging.2026.02.003_bib9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41586-019-1688-z","article-title":"Dietary salt promotes cognitive impairment through tau phosphorylation","volume":"574","author":"Faraco","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3233\/ADR-210005","article-title":"Fifteen years of the australian imaging, biomarkers and lifestyle (aibl) study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to alzheimer's disease","volume":"5","author":"Fowler","year":"2021","journal-title":"J. Alzheimers Dis. Rep."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2026.02.003_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700134","article-title":"High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression","volume":"61","author":"Ge","year":"2017","journal-title":"Mol. Nutr. Food Res"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.02.003_bib12","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1002\/alz.12962","article-title":"Sex differences in dementia risk and risk factors: individual-participant data analysis using 21 cohorts across six continents from the cosmic consortium","volume":"19","author":"Gong","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.02.003_bib13","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.02.003_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/ajh\/hpv081","article-title":"Hypertension, dietary sodium, and cognitive decline: Results from the women's health initiative memory study","volume":"29","author":"Haring","year":"2016","journal-title":"Am. J. Hypertens."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.02.003_bib15","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1467-842X.2000.tb00520.x","article-title":"The anti cancer council of victoria ffq: Relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation","volume":"24","author":"Hodge","year":"2000","journal-title":"Aust. N. Z. J. Public Health"},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib16","doi-asserted-by":"crossref","first-page":"m315","DOI":"10.1136\/bmj.m315","article-title":"Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials","author":"Huang","year":"2020","journal-title":"BMJ 368"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/STROKEAHA.122.038263","article-title":"Hippocampal vascular supply and its role in vascular cognitive impairment","volume":"54","author":"Johnson","year":"2023","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib19","first-page":"6","article-title":"Reviewing the effects of dietary salt on cognition: mechanisms and future directions","volume":"28","author":"Kendig","year":"2019","journal-title":"Asia Pac. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib20","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3233\/JAD-201058","article-title":"Genetic factors of alzheimer's disease modulate how diet is associated with long-term cognitive trajectories: a UK biobank study","volume":"78","author":"Klinedinst","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nlm.2014.04.010","article-title":"High-salt diet enhances hippocampal oxidative stress and cognitive impairment in mice","volume":"114","author":"Liu","year":"2014","journal-title":"Neurobiol. Learn Mem."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jamda.2022.10.001","article-title":"Excessive dietary salt intake exacerbates cognitive impairment progression and increases dementia risk in older adults","volume":"24","author":"Liu","year":"2023","journal-title":"J. Am. Med. Dir. Assoc."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.02.003_bib23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11011-024-01358-z","article-title":"High salt diet induces cognitive impairment and is linked to the activation of igf1r\/mtor\/p70s6k signaling","volume":"39","author":"Liu","year":"2024","journal-title":"Metab. Brain Dis."},{"issue":"10452","key":"10.1016\/j.neurobiolaging.2026.02.003_bib24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.02.003_bib25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1037\/neu0000987","article-title":"P-tau\/abeta42 ratio associates with cognitive decline in alzheimer's disease, mild cognitive impairment, and cognitively unimpaired older adults","volume":"39","author":"McKenna","year":"2025","journal-title":"Neuropsychology"},{"issue":"3-4","key":"10.1016\/j.neurobiolaging.2026.02.003_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000446082","article-title":"Hypertension and the brain: A risk factor for more than heart disease","volume":"42","author":"Meissner","year":"2016","journal-title":"Cereb. Dis."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12877-019-1326-5","article-title":"Diet quality and cognitive function in mid-aged and older men and women","volume":"19","author":"Milte","year":"2019","journal-title":"BMC Geriatr."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.02.003_bib28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3233\/JAD-191339","article-title":"Link between dietary sodium intake, cognitive function, and dementia risk in middle-aged and older adulTS: A Systematic review","volume":"76","author":"Mohan","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.02.003_bib29","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1056\/NEJMoa1304127","article-title":"Global sodium consumption and death from cardiovascular causes","volume":"371","author":"Mozaffarian","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.02.003_bib30","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/j.neuropsychologia.2011.04.012","article-title":"Cognition and beta-amyloid in preclinical alzheimer's disease: Data from the aibl study","volume":"49","author":"Pike","year":"2011","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fcvm.2019.00136","article-title":"New insights on the role of sodium in the physiological regulation of blood pressure and development of hypertension","volume":"6","author":"Polychronopoulou","year":"2019","journal-title":"Front. Cardiovasc Med."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib32","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3233\/JAD-180713","article-title":"Utility of an alzheimer's disease risk-weighted polygenic risk score for predicting rates of cognitive decline in preclinical alzheimer's disease: A prospective longitudinal study","volume":"66","author":"Porter","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fnagi.2018.00423","article-title":"A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical alzheimer's disease","volume":"10","author":"Porter","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2026.02.003_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003733","article-title":"Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24h urinary sodium excretion and dietary surveys worldwide","volume":"3","author":"Powles","year":"2013","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12603-016-0766-2","article-title":"Association between dietary sodium intake and cognitive function in older adults","volume":"21","author":"Rush","year":"2017","journal-title":"J. Nutr. Health Aging"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib36","first-page":"3","article-title":"Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (dash) diet","volume":"344","author":"Sacks","year":"2001","journal-title":"DashSodium Collab. Res. Group. N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/HYPERTENSIONAHA.120.15581","article-title":"Endothelium-macrophage crosstalk mediates blood-brain barrier dysfunction in hypertension","volume":"76","author":"Santisteban","year":"2020","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/HYPERTENSIONAHA.122.18085","article-title":"Hypertension, neurovascular dysfunction, and cognitive impairment","volume":"80","author":"Santisteban","year":"2023","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu15010208","article-title":"Sex differences in salt appetite: perspectives from animal models and human studies","volume":"15","author":"Santollo","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.02.003_bib40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/HYPERTENSIONAHA.111.187021","article-title":"Vascular remodeling in hypertension: mechanisms and treatment","volume":"59","author":"Schiffrin","year":"2012","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.02.003_bib41","article-title":"Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults","volume":"2","author":"Sible","year":"2022","journal-title":"Neuroimage Rep."},{"issue":"21","key":"10.1016\/j.neurobiolaging.2026.02.003_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214564","article-title":"Diet in the prevention of alzheimer's disease: Current knowledge and future research requirements","volume":"14","author":"Stefaniak","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2026.02.003_bib44","doi-asserted-by":"crossref","DOI":"10.1007\/7854_2024_527","article-title":"Cognitive decline in alzheimer's disease","author":"Testo","year":"2024","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.02.003_bib45","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment--beyond controversies, towards a consensus: Report of the international working group on mild cognitive impairment","volume":"256","author":"Winblad","year":"2004","journal-title":"J. Intern Med."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.02.003_bib46","doi-asserted-by":"crossref","first-page":"e501","DOI":"10.1016\/S2666-7568(22)00120-9","article-title":"Nutrition state of science and dementia prevention: recommendations of the nutrition for dementia prevention working group","volume":"3","author":"Yassine","year":"2022","journal-title":"Lancet Healthy Longev."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458026000242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458026000242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:27:23Z","timestamp":1781857643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458026000242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":46,"alternative-id":["S0197458026000242"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.02.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher sodium intake is associated with episodic memory decline in cognitively unimpaired older males: A 6-year longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}