{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:40:36Z","timestamp":1792730436008,"version":"4.5.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["B-3001C"],"award-info":[{"award-number":["B-3001C"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX002312-03"],"award-info":[{"award-number":["CX002312-03"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020099","name":"Traumatic Brain Injury Center of Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012462","name":"Office of Academic Affiliations, Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.neurobiolaging.2026.09.010","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:33:23Z","timestamp":1790836403000},"page":"153-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cumulative burden of mild TBI in Veterans: Accelerated age-related regional white matter deterioration along major white matter pathways"],"prefix":"10.1016","volume":"169","author":[{"given":"Tyler D.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-2138","authenticated-orcid":false,"given":"Emily J.","family":"Van Etten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2982-834X","authenticated-orcid":false,"given":"Shira","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Milberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-9904","authenticated-orcid":false,"given":"Catherine B.","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Salat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.09.010_bib1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/jnnp-2012-302742","article-title":"Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis","volume":"83","author":"Aoki","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/WNL.0000000000000616","article-title":"Traumatic brain injury and risk of dementia in older veterans","volume":"83","author":"Barnes","year":"2014","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: what can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.09.010_bib5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn. Reson. Med."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib6","first-page":"75","article-title":"The development of a Clinician-Administered PTSD Scale","volume":"8","author":"Blake","year":"1995","journal-title":"J. Trauma. Stress."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/arclin\/acae079","article-title":"Critical review of recently published studies claiming long-term neurocognitive abnormalities in mild traumatic brain injury","volume":"40","author":"Boone","year":"2024","journal-title":"Arch. Clin. Neuropsychol."},{"issue":"23","key":"10.1016\/j.neurobiolaging.2026.09.010_bib8","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1089\/neu.2014.3352","article-title":"Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes","volume":"32","author":"Bramlett","year":"2015","journal-title":"J. Neurotrauma"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib9","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.neurobiolaging.2011.06.001","article-title":"Testing the white matter retrogenesis hypothesis of cognitive aging","volume":"33","author":"Brickman","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"11-12","key":"10.1016\/j.neurobiolaging.2026.09.010_bib10","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1089\/neu.2022.0185","article-title":"Post-concussion symptoms and disability in adults with mild traumatic brain injury: a systematic review and meta-analysis","volume":"40","author":"Cancelliere","year":"2023","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/16501960410023859","article-title":"Prognosis for mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury","author":"Carroll","year":"2004","journal-title":"J. Rehabil. Med. (43 Suppl."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/14737175.2023.2289573","article-title":"Current perspectives on tractography-guided deep brain stimulation for the treatment of mood disorders","volume":"24","author":"Chan","year":"2024","journal-title":"Expert. Rev. Neurother."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.09.010_bib13","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1682\/JRRD.2013.01.0006","article-title":"Traumatic brain injury, posttraumatic stress disorder, and pain diagnoses in OIF\/OEF\/OND Veterans","volume":"50","author":"Cifu","year":"2013","journal-title":"J. Rehabil. Res. Dev."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/arclin\/acae076","article-title":"Traumatic brain injury and risk of incident dementia: Forensic applications of current research","volume":"40","author":"Clem","year":"2025","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib15","article-title":"The Boston Assessment of Traumatic Brain Injury Lifetime, Second Edition (BATL-2): development and initial psychometric evaluation in post-9\/11 military veterans","author":"Colaizzi","year":"2025","journal-title":"J. Head. Trauma. Rehabil."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib16","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.neuroimage.2011.11.004","article-title":"Along-tract statistics allow for enhanced tractography analysis","volume":"59","author":"Colby","year":"2012","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1148\/radiol.2015150103","article-title":"White matter degeneration with aging: Longitudinal diffusion MR imaging analysis","volume":"279","author":"de Groot","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnhum.2013.00030","article-title":"Long-term effects of mild traumatic brain injury on cognitive performance","volume":"7","author":"Dean","year":"2013","journal-title":"Front. Hum. Neurosci."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2026.09.010_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.43416","article-title":"Differences in brain volume in military service members and veterans after blast-related mild TBI: A LIMBIC-CENC study","volume":"7","author":"Dennis","year":"2024","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.726425","article-title":"Systematic review of the long-term neuroimaging correlates of mild traumatic brain injury and repetitive head injuries","volume":"12","author":"Echlin","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib21","series-title":"In The Encyclopedia of Clinical Psychology","first-page":"1","article-title":"Structured clinical interview for the DSM (SCID)","author":"First","year":"2015"},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.nicl.2015.06.007","article-title":"Altered whole-brain white matter networks in preclinical Alzheimer's disease","volume":"8","author":"Fischer","year":"2015","journal-title":"NeuroImage Clin."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.09.010_bib24","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/jts.22501","article-title":"The impact of common psychiatric and behavioral comorbidities on functional disability across time and individuals in post-9\/11 veterans","volume":"33","author":"Fortenbaugh","year":"2020","journal-title":"J. Trauma. Stress."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/HTR.0b013e3182865859","article-title":"The Boston Assessment of Traumatic Brain Injury-Lifetime (BAT-L) semistructured interview: evidence of research utility and validity","volume":"29","author":"Fortier","year":"2014","journal-title":"J. Head. Trauma. Rehabil."},{"issue":"12","key":"10.1016\/j.neurobiolaging.2026.09.010_bib26","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1111\/acer.12568","article-title":"Widespread effects of alcohol on white matter microstructure","volume":"38","author":"Fortier","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.09.010_bib27","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.1016\/j.apmr.2013.06.036","article-title":"Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis","volume":"95","author":"Godbolt","year":"2014","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib28","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3233\/JAD-220476","article-title":"Localized white matter tract integrity measured by diffusion tensor imaging is altered in people with mild cognitive impairment and associated with dual-task and single-task gait speed","volume":"92","author":"Haddad","year":"2023","journal-title":"J. Alzheimers Dis."},{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.09.010_bib29","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.21037\/qims-24-238","article-title":"Predicting white-matter hyperintensity progression and cognitive decline in patients with cerebral small-vessel disease: a magnetic resonance-based habitat analysis","volume":"14","author":"Han","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nicl.2015.04.001","article-title":"The nature of white matter abnormalities in blast-related mild traumatic brain injury","volume":"8","author":"Hayes","year":"2015","journal-title":"Neuroimage Clin."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib31","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.48150","article-title":"Association of traumatic brain injury with mortality among military veterans serving after September 11, 2001","volume":"5","author":"Howard","year":"2022","journal-title":"JAMA Netw. Open."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2026.09.010_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4991","article-title":"Differential and correlational tractography as tract-based biomarkers in mild traumatic brain injury: A longitudinal MRI study","volume":"36","author":"Huang","year":"2023","journal-title":"NMR Biomed."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1089\/neu.2018.5838","article-title":"Comparing region of interest versus voxel-wise diffusion tensor imaging analytic methods in mild and moderate traumatic brain Injury: A systematic review and meta-analysis","volume":"36","author":"Hunter","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.09.010_bib34","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1038\/s41380-022-01524-8","article-title":"Efficacy of neurostimulation across mental disorders: systematic review and meta-analysis of 208 randomized controlled trials","volume":"27","author":"Hyde","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib35","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1177\/0271678X18761438","article-title":"Microstructural and metabolic changes in the longitudinal progression of white matter hyperintensities","volume":"39","author":"Jiaerken","year":"2019","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.expneurol.2012.01.013","article-title":"Axonal pathology in traumatic brain injury","volume":"246","author":"Johnson","year":"2013","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.09.010_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q","article-title":"Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging","volume":"42","author":"Jones","year":"1999","journal-title":"Magn. Reson. Med."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib38","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.apmr.2024.11.010","article-title":"Traumatic brain injury in US veterans: Prevalence and associations with physical, mental, and cognitive health","volume":"106","author":"Karr","year":"2025","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1172031","article-title":"Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke","volume":"14","author":"Kern","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2021.110117","article-title":"A systematic review and data synthesis of longitudinal changes in white matter integrity after mild traumatic brain injury assessed by diffusion tensor imaging in adults","volume":"147","author":"Kim","year":"2022","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molmet.2018.03.013","article-title":"Regional differences in brain glucose metabolism determined by imaging mass spectrometry","volume":"12","author":"Kleinridders","year":"2018","journal-title":"Mol. Metab."},{"issue":"23","key":"10.1016\/j.neurobiolaging.2026.09.010_bib42","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1212\/WNL.0000000000000505","article-title":"Presence and progression of white matter hyperintensities and cognition: a meta-analysis","volume":"82","author":"Kloppenborg","year":"2014","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.09.010_bib43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11357-011-9357-7","article-title":"Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline","volume":"34","author":"Kohama","year":"2012","journal-title":"Age"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11357-020-00164-6","article-title":"Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease","volume":"42","author":"Levit","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib45","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.3389\/fnbeh.2018.00160","article-title":"Excitatory repetitive transcranial magnetic stimulation induces contralesional cortico-cerebellar pathways after acute ischemic stroke: A preliminary DTI study [Original Research]","volume":"12","author":"Li","year":"2018","journal-title":"Front. Behav. Neurosci."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.09.010_bib46","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00422-014-0626-2","article-title":"Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque","volume":"108","author":"Liewald","year":"2014","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib47","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nicl.2013.04.009","article-title":"Reduced cortical thickness with increased lifetime burden of PTSD in OEF\/OIF Veterans and the impact of comorbid TBI","volume":"2","author":"Lindemer","year":"2013","journal-title":"Neuroimage Clin."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.09.010_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1176\/appi.neuropsych.16050100","article-title":"Traumatic brain injury in Iraq and Afghanistan veterans: New results from a national random sample study","volume":"29","author":"Lindquist","year":"2017","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib49","doi-asserted-by":"crossref","DOI":"10.1097\/HTR.0000000000000514","article-title":"A systematic review and meta-analysis on PTSD following TBI among military\/veteran and civilian populations","volume":"35","author":"Loignon","year":"2020","journal-title":"J. Head. Trauma. Rehabil."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118863","article-title":"Using diffusion tensor imaging to effectively target TMS to deep brain structures","volume":"249","author":"Luber","year":"2022","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5853\/jos.2022.02936","article-title":"Collateral circulation in ischemic stroke: An updated review","volume":"25","author":"Maguida","year":"2023","journal-title":"J. Stroke"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3174\/ajnr.A3146","article-title":"FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities","volume":"34","author":"Maillard","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"10","key":"10.1016\/j.neurobiolaging.2026.09.010_bib53","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1017\/S1355617724000626","article-title":"Traumatic brain injury, posttraumatic stress disorder, and vascular risk are independently associated with white matter aging in Vietnam-Era veterans","volume":"30","author":"McGill","year":"2024","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174847","article-title":"Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review","volume":"12","author":"McInnes","year":"2017","journal-title":"PLoS. One"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2026.09.010_bib55","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/brainsci13101402","article-title":"The rehabilitation potential of neurostimulation for mild traumatic brain injury in animal and human studies","volume":"13","author":"McNerney","year":"2023","journal-title":"Brain Sci."},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib56","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/00332747.2024.2392226","article-title":"Mild traumatic brain injury in U.S. military veterans: Results from the national health and resilience in veterans study","volume":"87","author":"Meshberg-Cohen","year":"2024","journal-title":"Psychiatry"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/gps.5974","article-title":"Does repetitive transcranial magnetic stimulation improve cognitive function in age-related neurodegenerative diseases? A systematic review and meta-analysis","volume":"38","author":"Miller","year":"2023","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1545968315584004","article-title":"Dynamic changes in white matter abnormalities correlate with late improvement and deterioration following TBI: A diffusion tensor imaging study","volume":"30","author":"Newcombe","year":"2016","journal-title":"Neurorehabilitation Neural Repair."},{"issue":"32","key":"10.1016\/j.neurobiolaging.2026.09.010_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz6892","article-title":"The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study","volume":"6","author":"Palacios","year":"2020","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.neurobiolaging.2026.09.010_bib60","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/jnnp-2017-316822","article-title":"Superficial white matter damage in anti-NMDA receptor encephalitis","volume":"89","author":"Phillips","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41398-022-01853-w","article-title":"Plasma biomarkers associated with deployment trauma and its consequences in post-9\/11 era veterans: initial findings from the TRACTS longitudinal cohort","volume":"12","author":"Pierce","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00001199-200501000-00008","article-title":"Update of neuropathology and neurological recovery after traumatic brain injury","volume":"20","author":"Povlishock","year":"2005","journal-title":"J. Head. Trauma. Rehabil."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib63","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-034494","article-title":"Challenges in the acute identification of mild traumatic brain injuries: results from an emergency department surveillance study","volume":"10","author":"Pozzato","year":"2020","journal-title":"BMJ Open."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13195-019-0521-0","article-title":"Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set","volume":"11","author":"Puzo","year":"2019","journal-title":"Alzheimers Res. Ther."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.09.010_bib65","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s13760-020-01322-5","article-title":"White matter changes from mild cognitive impairment to Alzheimer\u2019s disease: a meta-analysis","volume":"121","author":"Qin","year":"2021","journal-title":"Acta Neurol. Belg."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib66","doi-asserted-by":"crossref","first-page":"fcab106","DOI":"10.1093\/braincomms\/fcab106","article-title":"Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition","volume":"3","author":"Raghavan","year":"2021","journal-title":"Brain Commun."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib67","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mrm.10308","article-title":"Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo","volume":"49","author":"Reese","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib68","article-title":"Developmental order, fibre caliber, and vascularization predict tract-wise declines: Testing retrogenesis and physiological predictions in white matter aging","author":"Robinson","year":"2024","journal-title":"bioRxiv"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2026.09.010_bib69","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.neuroimage.2008.10.030","article-title":"Regional white matter volume differences in nondemented aging and Alzheimer's disease","volume":"44","author":"Salat","year":"2009","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2026.09.010_bib70","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1080\/02699052.2017.1327672","article-title":"Neuroimaging of deployment-associated traumatic brain injury (TBI) with a focus on mild TBI (mTBI) since 2009","volume":"31","author":"Salat","year":"2017","journal-title":"Brain Inj."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib71","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neurobiolaging.2004.09.017","article-title":"Age-related alterations in white matter microstructure measured by diffusion tensor imaging","volume":"26","author":"Salat","year":"2005","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.09.010_bib72","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00429-022-02503-z","article-title":"Aging and white matter microstructure and macrostructure: a longitudinal multi-site diffusion MRI study of 1218 participants","volume":"227","author":"Schilling","year":"2022","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.107048","article-title":"Along-tract analysis of the white matter is more informative about brain ageing, compared to whole-tract analysis","volume":"211","author":"Shirazi","year":"2021","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.09.010_bib74","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/hbm.24522","article-title":"Evolution of white matter tract microstructure across the life span","volume":"40","author":"Slater","year":"2019","journal-title":"Hum. Brain Mapp."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib75","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3233\/JAD-200662","article-title":"Does mild traumatic brain injury increase the risk for dementia? A systematic review and meta-analysis","volume":"78","author":"Snowden","year":"2020","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib76","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000545553","article-title":"Transcranial magnetic stimulation induces white matter microstructure alterations in patients with mild cognitive impairment","volume":"15","author":"Song","year":"2025","journal-title":"Dement. Geriatr. Cogn. Dis. Extra"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.09.010_bib77","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/cercor\/bhj045","article-title":"Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking","volume":"16","author":"Sullivan","year":"2006","journal-title":"Cereb. Cortex"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.09.010_bib78","article-title":"White matter fractional anisotropy decreases precede hyperintensities in Alzheimer's disease","volume":"6","author":"Sun","year":"2025","journal-title":"Cell. Rep. Med."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2026.09.010_bib79","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0387-7604(95)00141-7","article-title":"Diffuse white matter lesions associated with herpes simplex encephalitis as observed on magnetic resonance imaging","volume":"18","author":"Tamura","year":"1996","journal-title":"Brain Dev."},{"issue":"11","key":"10.1016\/j.neurobiolaging.2026.09.010_bib80","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.41388","article-title":"Posttraumatic stress disorder symptoms and cardiovascular and brain health in women","volume":"6","author":"Thurston","year":"2023","journal-title":"JAMA Netw. Open."},{"issue":"6181","key":"10.1016\/j.neurobiolaging.2026.09.010_bib81","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1126\/science.1249766","article-title":"Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex","volume":"344","author":"Tomassy","year":"2014","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.neurobiolaging.2026.09.010_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142860","article-title":"Decreased and increased anisotropy along major cerebral white matter tracts in preterm children and adolescents","volume":"10","author":"Travis","year":"2015","journal-title":"PLoS. One"},{"issue":"Pt 8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib83","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/brain\/awv139","article-title":"Military blast exposure, ageing and white matter integrity","volume":"138","author":"Trotter","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib84","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neurobiolaging.2021.07.002","article-title":"Distant histories of mild traumatic brain injury exacerbate age-related differences in white matter properties","volume":"107","author":"Vakhtin","year":"2021","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib85","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.55622","article-title":"Peritraumatic context and long-term outcomes of concussion","volume":"8","author":"Van Etten","year":"2025","journal-title":"JAMA Netw. Open."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.09.010_bib86","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1192\/bjp.bp.111.096461","article-title":"Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers","volume":"201","author":"Vasterling","year":"2012","journal-title":"Br. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib87","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cpr.2009.08.004","article-title":"Mild traumatic brain injury and posttraumatic stress disorder in returning veterans: perspectives from cognitive neuroscience","volume":"29","author":"Vasterling","year":"2009","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib88","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neubiorev.2018.05.023","article-title":"The relationship between diffusion tensor imaging findings and cognitive outcomes following adult traumatic brain injury: A meta-analysis","volume":"92","author":"Wallace","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib89","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pneurobio.2016.04.005","article-title":"White matter injury in ischemic stroke","volume":"141","author":"Wang","year":"2016","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.neurobiolaging.2026.09.010_bib90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-015-0132-3","article-title":"Diffusion imaging changes in grey matter in Alzheimer\u2019s disease: a potential marker of early neurodegeneration","volume":"7","author":"Weston","year":"2015","journal-title":"Alzheimer's. Res. & Ther."},{"issue":"8","key":"10.1016\/j.neurobiolaging.2026.09.010_bib91","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.14336\/AD.2021.0414","article-title":"Pathogeneses and imaging features of cerebral white matter lesions of vascular origins","volume":"12","author":"Wu","year":"2021","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.neurobiolaging.2026.09.010_bib92","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/archgenpsychiatry.2010.61","article-title":"Posttraumatic stress disorder and risk of dementia among US veterans","volume":"67","author":"Yaffe","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"7","key":"10.1016\/j.neurobiolaging.2026.09.010_bib93","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jnr.21986","article-title":"The myelinated fiber changes in the white matter of aged female Long-Evans rats","volume":"87","author":"Yang","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.neurobiolaging.2026.09.010_bib94","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac132","article-title":"Longitudinal changes of white matter microstructure following traumatic brain injury in U.S. military service members","volume":"4","author":"Yeh","year":"2022","journal-title":"Brain Commun."},{"key":"10.1016\/j.neurobiolaging.2026.09.010_bib95","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fninf.2011.00023","article-title":"Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy","volume":"5","author":"Yendiki","year":"2011","journal-title":"Front. Neuroinform."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802600165X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745802600165X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:35:01Z","timestamp":1792730101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745802600165X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":95,"alternative-id":["S019745802600165X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.09.010","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cumulative burden of mild TBI in Veterans: Accelerated age-related regional white matter deterioration along major white matter pathways","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}