{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:24:08Z","timestamp":1783337048899,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG0124335"],"award-info":[{"award-number":["P01AG0124335"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.neuroimage.2009.02.004","type":"journal-article","created":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T02:20:04Z","timestamp":1235269204000},"page":"T58-T65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"S2","title":["Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation"],"prefix":"10.1016","volume":"47","author":[{"given":"Wang","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne G.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lorenzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stathis","family":"Hadjidemetriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2009.02.004_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/1522-2594(200008)44:2<283::AID-MRM16>3.0.CO;2-V","article-title":"A Geometric analysis of diffusion tensor measurements of the human brain","volume":"44","author":"Alexander","year":"2000","journal-title":"Magn. Reson. Med."},{"issue":"5","key":"10.1016\/j.neuroimage.2009.02.004_bib2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1440-1819.2004.01294.x","article-title":"White matter hyperintensities in subjects with bipolar disorder","volume":"58","author":"Ahn","year":"2004","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1602\/neurorx.2.2.277","article-title":"Imaging of multiple sclerosis: role in neurotherapeutics","volume":"2","author":"Bakshi","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.neuroimage.2009.02.004_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J. Magn. Reson. Series B."},{"issue":"1","key":"10.1016\/j.neuroimage.2009.02.004_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/mrm.10690","article-title":"Eddy current correction in diffusion-weighted imaging using pairs of images acquired with opposite diffusion gradient polarity","volume":"51","author":"Bodammer","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2009.02.004_bib6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1118\/1.595535","article-title":"A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1\u2013100\u00a0MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age","volume":"11","author":"Bottomly","year":"1984","journal-title":"Med. Phys."},{"issue":"11","key":"10.1016\/j.neuroimage.2009.02.004_bib7","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1109\/34.969114","article-title":"Fast approximate energy minimization via graph cuts","volume":"23","author":"Boykov","year":"2001","journal-title":"IEEE Trans. PAMI"},{"issue":"14","key":"10.1016\/j.neuroimage.2009.02.004_bib8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1097\/WNR.0b013e32830abc35","article-title":"Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia","volume":"19","author":"Carpenter","year":"2008","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib9","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuroimage.2004.12.007","article-title":"The Talairach coordinate of a point in the MNI space: how to interpret it","volume":"25","author":"Chau","year":"2005","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.neuroimage.2009.02.004_bib10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1109\/83.536892","article-title":"Deformable templates using large deformation kinematics","volume":"5","author":"Christensen","year":"1996","journal-title":"IEEE Trans. Image Process."},{"key":"10.1016\/j.neuroimage.2009.02.004_bib11","series-title":"Christensen's Physics of Diagnostic Radiology,","author":"Curry","year":"1990"},{"issue":"3","key":"10.1016\/j.neuroimage.2009.02.004_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d, A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"issue":"5","key":"10.1016\/j.neuroimage.2009.02.004_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00415-005-0075-x","article-title":"Fluid-attenuated inversion recovery (FLAIR) sequences for the assessment of acute stroke: inter observer and inter technique reproducibility","volume":"253","author":"Gauvrit","year":"2006","journal-title":"J. Neurol."},{"issue":"6","key":"10.1016\/j.neuroimage.2009.02.004_bib14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/mrm.10171","article-title":"Generalized autocalibrating partially parallel acquisition (GRAPPA)","volume":"47","author":"Griswold","year":"2002","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2009.02.004_bib15","first-page":"65121L","article-title":"Restoration of MRI data for field nonuniformities using high order neighborhood statistics","volume":"6512","author":"Hadjidemetriou","year":"2007","journal-title":"Proc. Soc. Photo Opt. Instrum. Eng."},{"issue":"1","key":"10.1016\/j.neuroimage.2009.02.004_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jalz.2007.08.006","article-title":"Core candidate neurochemical and imaging biomarkers of Alzheimer's disease","volume":"4","author":"Hampel","year":"2008","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.neuroimage.2009.02.004_bib17","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1161\/01.STR.31.9.2182","article-title":"Impact of white matter changes on clinical manifestation of Alzheimer's disease: a quantitative study","volume":"31","author":"Hirono","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.neuroimage.2009.02.004_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/mrm.1910340210","article-title":"Analytical expressions for the NMR apparent diffusion coefficients in an anisotropic system and a simplified method for determining fiber orientation","volume":"34","author":"Hsu","year":"1995","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1361-8415(03)00002-1","article-title":"Structural and radiometric asymmetry in brain images","volume":"7","author":"Joshi","year":"2003","journal-title":"Med. Image Anal."},{"issue":"3","key":"10.1016\/j.neuroimage.2009.02.004_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/mrm.1910060304","article-title":"Nuclear magnetic resonance relaxation in experimental brain edema: effects of water concentration, protein concentration, and temperature","volume":"6","author":"Kamman","year":"1988","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2009.02.004_bib21","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0006-3495(00)76763-4","article-title":"Protein-bound water molecule counting by resolution of 1H spin\u2013lattice relaxation mechanisms","volume":"78","author":"Kiihne","year":"2000","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.neuroimage.2009.02.004_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmri.10230","article-title":"Three-pool model of white matter","volume":"17","author":"Lancaster","year":"2003","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2009.02.004_bib23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"Le Bihan","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"issue":"12","key":"10.1016\/j.neuroimage.2009.02.004_bib24","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1161\/01.STR.0000249416.77132.1a","article-title":"Intra- and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI","volume":"37","author":"Luby","year":"2006","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.neuroimage.2009.02.004_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/neu.2006.0214","article-title":"Magnetic resonance imaging of diffuse axonal injury: quantitative assessment of white matter lesion volume","volume":"24","author":"Marquez de la Plata","year":"2007","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.neuroimage.2009.02.004_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0891988706297089","article-title":"MR spectroscopy, functional MRI, and diffusion-tensor imaging in the aging brain: a conceptual review","volume":"20","author":"Minati","year":"2007","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"4","key":"10.1016\/j.neuroimage.2009.02.004_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.eurpsy.2004.12.012","article-title":"Fluid-attenuated inversion-recovery MR imaging in schizophrenia-associated with idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome)","volume":"20","author":"Miyaoka","year":"2005","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.neuroimage.2009.02.004_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuroimage.2008.04.174","article-title":"Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4\u00a0T","volume":"42","author":"Mueller","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2009.02.004_bib29","series-title":"Applied Linear Statistical Models: Regression, Analysis of Variance, and Experimental Designs","author":"Neter","year":"1990"},{"issue":"7","key":"10.1016\/j.neuroimage.2009.02.004_bib30","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2337\/dc06-0261","article-title":"Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes","volume":"29","author":"Novak","year":"2006","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.neuroimage.2009.02.004_bib31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0730-725X(00)00151-X","article-title":"Minimal gradient encoding for robust estimation of diffusion anisotropy","volume":"18","author":"Papadakis","year":"2000","journal-title":"Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.neuroimage.2009.02.004_bib32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmri.21076","article-title":"Application of voxelwise analysis in the detection of regions of reduced fractional anisotropy in multiple sclerosis patients","volume":"26","author":"Patel","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"issue":"5","key":"10.1016\/j.neuroimage.2009.02.004_bib33","first-page":"855","article-title":"Focal lesion in the splenium of the corpus callosum on FLAIR MR images: a common finding with aging and after brain radiation therapy","volume":"24","author":"Pekala","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"Pt 1","key":"10.1016\/j.neuroimage.2009.02.004_bib34","first-page":"48","article-title":"Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage","volume":"130","author":"Pfefferbaum","year":"2007","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/mrm.21122","article-title":"Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo","volume":"57","author":"Rooney","year":"2007","journal-title":"Magn. Reson. Med."},{"issue":"3","key":"10.1016\/j.neuroimage.2009.02.004_bib36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3174\/ajnr.A0856","article-title":"White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study","volume":"29","author":"Rutgers","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neuroimage.2009.02.004_bib37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/mrm.1910340612","article-title":"Contrast optimization of fluid-attenuated inversion recovery (FLAIR) imaging","volume":"34","author":"Rydberg","year":"1995","journal-title":"Magn. Reson. Med."},{"issue":"Suppl 2","key":"10.1016\/j.neuroimage.2009.02.004_bib38","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000049145","article-title":"Evolution of white matter lesions","volume":"13","author":"Schmidt","year":"2002","journal-title":"Cerebrovasc. Dis."},{"issue":"4","key":"10.1016\/j.neuroimage.2009.02.004_bib39","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2214\/ajr.176.2.1760519","article-title":"Sulcal hyperintensity on fluid-attenuated inversion recovery MR images in patients without apparent cerebrospinal fluid abnormality","volume":"176","author":"Taoka","year":"2001","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2","key":"10.1016\/j.neuroimage.2009.02.004_bib41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mri.2003.09.004","article-title":"Signal characteristics of FLAIR related to water content: comparison with conventional spin echo imaging in infarcted rat brain","volume":"22","author":"Taoka","year":"2004","journal-title":"Magn. Reson. Imaging"},{"issue":"5","key":"10.1016\/j.neuroimage.2009.02.004_bib42","first-page":"977","article-title":"Initial and follow-up MR imaging findings in AIDS-related progressive multifocal leukoencephalopathy treated with highly active antiretroviral therapy","volume":"22","author":"Thurnher","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.neuroimage.2009.02.004_bib43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1148\/radiol.2411050792","article-title":"Detection of simulated multiple sclerosis lesions on T2-weighted and FLAIR images of the brain: observer performance","volume":"241","author":"Woo","year":"2006","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.neuroimage.2009.02.004_bib44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1399-5618.2007.00395.x","article-title":"White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study","volume":"9","author":"Yurgelun-Todd","year":"2007","journal-title":"Bipolar Disord."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811909001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811909001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:43:45Z","timestamp":1760953425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811909001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":44,"alternative-id":["S1053811909001426"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2009.02.004","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2009.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}