{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:39:27Z","timestamp":1792726767945,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2022-KH129293"],"award-info":[{"award-number":["RS-2022-KH129293"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.neuroimage.2026.122249","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:27:58Z","timestamp":1790137678000},"page":"122249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Developmental inflection in glymphatic system\u2013related MRI parameters during childhood: DTI-ALPS index and choroid plexus volume analyses in a retrospective clinical cohort"],"prefix":"10.1016","volume":"341","author":[{"given":"Arim","family":"Pak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonjung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hye","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hye","family":"Byeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungjun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ho","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2026.122249_bib0001","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1148\/radiol.212400","article-title":"Choroid plexus volume and permeability at brain MRI within the Alzheimer disease clinical spectrum","volume":"304","author":"Choi","year":"2022","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0002","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78132-9","article-title":"Evaluating the robustness of DTI-ALPS in clinical context: a meta-analytic parallel on Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"14","author":"Costa","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0003","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.neuroimage.2012.03.057","article-title":"Quantitative tract-based white matter development from birth to age 2 years","volume":"61","author":"Geng","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0004","first-page":"552","article-title":"Choroid plexus volume, amyloid burden, and cognition in the Alzheimer\u2019s disease continuum","volume":"16","author":"Jeong","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13195-024-01520-w","article-title":"Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer\u2019s continuum","volume":"16","author":"Jiang","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0006","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/jmri.28977","article-title":"Noninvasive magnetic resonance imaging measures of glymphatic system activity","volume":"59","author":"Kamagata","year":"2024","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0007","article-title":"Diffusion tensor imaging along the perivascular space for characterizing cerebral interstitial fluid dynamics in Alzheimer's disease: a systematic review and meta-analysis","author":"Khalafi","year":"2025","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0008","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.213254","article-title":"MRI-visible dilated perivascular space in the brain by age: the human connectome project","volume":"306","author":"Kim","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0009","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1148\/radiol.2021202043","article-title":"Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I\u2014anatomy and physiology","volume":"301","author":"Klostranec","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1148\/radiol.2021204088","article-title":"Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II\u2014imaging techniques and clinical applications","volume":"301","author":"Klostranec","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0011","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.26648","article-title":"Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment","volume":"94","author":"Li","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0012","article-title":"Development of diffusion analysis along the perivascular space (DTI-ALPS) index during childhood and adolescence: evidence from two longitudinal cohorts","volume":"305","author":"Lin","year":"2025","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0013","first-page":"1885","article-title":"Cross-vendor test-retest validation of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating glymphatic system function","volume":"15","author":"Liu","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0014","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s00247-020-04875-y","article-title":"The Haskins pediatric atlas: a magnetic-resonance-imaging-based pediatric template and atlas","volume":"51","author":"Molfese","year":"2021","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0015","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.26695","article-title":"Diffusion-tensor-imaging 1-year-old and 2-year-old infant brain atlases with comprehensive gray and white matter labels","volume":"45","author":"Song","year":"2024","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0017","article-title":"White matter development from birth to 6 years of age: a longitudinal study","volume":"14","author":"Stephens","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0019","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s11604-022-01275-0","article-title":"Diffusion-weighted image analysis along the perivascular space (DWI\u2013ALPS) for evaluating interstitial fluid status: age dependence in normal subjects","volume":"40","author":"Taoka","year":"2022","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0020","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2463\/mrms.rev.2023-0175","article-title":"Diffusion tensor image analysis along the perivascular space (DTI-ALPS): revisiting the meaning and significance of the method","volume":"23","author":"Taoka","year":"2024","journal-title":"Magn. Reson. Med. Sci."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0018","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.neuroimage.2026.122249_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.mri.2025.110398","article-title":"Age-related change of glymphatic function in normative children assessed using diffusion tensor imaging-analysis along the perivascular space","author":"Wong","year":"2025","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0023","doi-asserted-by":"crossref","first-page":"0633","DOI":"10.34133\/research.0633","article-title":"Retinal vascular morphology reflects and predicts cerebral small vessel disease: evidences from eye-brain imaging analysis","volume":"6","author":"Wu","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.neuroimage.2026.122249_bib0025","first-page":"1","article-title":"DTI-ALPS index-assessed glymphatic dysfunction mediates Alzheimer\u2019s cognitive decline via amyloid-\u03b2-dependent pathways: multimodal PET\/MRI study","author":"Zhang","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926005641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926005641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:15:57Z","timestamp":1792725357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811926005641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":23,"alternative-id":["S1053811926005641"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.122249","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental inflection in glymphatic system\u2013related MRI parameters during childhood: DTI-ALPS index and choroid plexus volume analyses in a retrospective clinical cohort","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.122249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122249"}}