{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:39:13Z","timestamp":1792726753428,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIA\/NIH R01AG077677-04"],"award-info":[{"award-number":["NIA\/NIH R01AG077677-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIA\/NIH 1P30AG066506-01"],"award-info":[{"award-number":["NIA\/NIH 1P30AG066506-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018038","name":"Ware Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS-1920182"],"award-info":[{"award-number":["CNS-1920182"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS-2018611"],"award-info":[{"award-number":["CNS-2018611"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.neuroimage.2026.122265","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:38Z","timestamp":1790688218000},"page":"122265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multiscale organization of amyloid-associated vulnerability across the hippocampal memory system"],"prefix":"10.1016","volume":"341","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5482-6131","authenticated-orcid":false,"given":"Xueting","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0034-0442","authenticated-orcid":false,"given":"Thony","family":"Yan Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheal","family":"Adeyosoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ezzati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipul","family":"Simkhada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Cabrerizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-7030","authenticated-orcid":false,"given":"Rosie","family":"Curiel Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Rosselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-284X","authenticated-orcid":false,"given":"Armando","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-4067","authenticated-orcid":false,"given":"Naphtali D.","family":"Rishe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Loewenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-3155","authenticated-orcid":false,"given":"Malek","family":"Adjouadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.neuroimage.2026.122265_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049072","article-title":"Diffusion tensor metrics as biomarkers in Alzheimer's disease","volume":"7","author":"Acosta-Cabronero","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2026.122265_bib2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.nicl.2017.05.022","article-title":"A protocol for manual segmentation of medial temporal lobe subregions in 7 tesla MRI","volume":"15","author":"Berron","year":"2017","journal-title":"NeuroImage: Clin."},{"issue":"4","key":"10.1016\/j.neuroimage.2026.122265_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroimage.2026.122265_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2018.05.008","article-title":"The cingulum bundle: anatomy, function, and dysfunction","volume":"92","author":"Bubb","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroimage.2026.122265_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117931","article-title":"Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates","volume":"233","author":"Bussy","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.122265_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroimage.2015.12.055","article-title":"The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study","volume":"130","author":"Christiansen","year":"2016","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.neuroimage.2026.122265_bib7","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137","author":"Crossley","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2026.122265_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.08.033","article-title":"Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease","volume":"309","author":"de Flores","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroimage.2026.122265_bib9","series-title":"The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections With MRI","author":"Duvernoy","year":"2013"},{"key":"10.1016\/j.neuroimage.2026.122265_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-psych-010416-044131","article-title":"Memory: organization and control","volume":"68","author":"Eichenbaum","year":"2017","journal-title":"Annu. Rev. Psychol."},{"issue":"2","key":"10.1016\/j.neuroimage.2026.122265_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"6","key":"10.1016\/j.neuroimage.2026.122265_bib12","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.neuroimage.2026.122265_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuroimage.2007.07.053","article-title":"Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification","volume":"39","author":"Hua","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.122265_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","article-title":"A computational atlas of the hippocampal formation using ex vivo ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI","volume":"115","author":"Iglesias","year":"2015","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.neuroimage.2026.122265_bib15","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer's Dement."},{"issue":"4","key":"10.1016\/j.neuroimage.2026.122265_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's Dement."},{"issue":"11","key":"10.1016\/j.neuroimage.2026.122265_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275233","article-title":"Can hippocampal subfield measures supply information that could be used to improve the diagnosis of Alzheimer\u2019s disease?","volume":"17","author":"Kannappan","year":"2022","journal-title":"PLoS One"},{"issue":"7902","key":"10.1016\/j.neuroimage.2026.122265_bib18","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41586-022-04492-9","article-title":"Reproducible brain-wide association studies require thousands of individuals","volume":"603","author":"Marek","year":"2022","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neuroimage.2026.122265_bib19","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/brain\/awx355","article-title":"Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment","volume":"141","author":"Mito","year":"2018","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.neuroimage.2026.122265_bib20","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hbm.20934","article-title":"Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease","volume":"31","author":"Mueller","year":"2010","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.neuroimage.2026.122265_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jalz.2005.06.003","article-title":"Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's disease neuroimaging initiative (ADNI)","volume":"1","author":"Mueller","year":"2005","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.neuroimage.2026.122265_bib22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.neuroimage.2014.04.054","article-title":"Multi-atlas segmentation of the whole hippocampus and subfields using multiple automatically generated templates","volume":"101","author":"Pipitone","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.122265_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116932","article-title":"Amygdalar nuclei and hippocampal subfields on MRI: test\u2013retest reliability of automated volumetry across different MRI sites and vendors","volume":"218","author":"Quattrini","year":"2020","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.neuroimage.2026.122265_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrn3338","article-title":"Two cortical systems for memory-guided behaviour","volume":"13","author":"Ranganath","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.122265_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2024.120767","article-title":"Fully automated hippocampus segmentation using T2-informed deep convolutional neural networks","volume":"298","author":"Sackl","year":"2024","journal-title":"Neuroimage"},{"issue":"10284","key":"10.1016\/j.neuroimage.2026.122265_bib26","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neuroimage.2026.122265_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.122265_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116798","article-title":"Longitudinal automatic segmentation of hippocampal subfields (LASHiS) using multi-contrast MRI","volume":"218","author":"Shaw","year":"2020","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.neuroimage.2026.122265_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.neuroimage.2026.122265_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70142","article-title":"Quantification of perforant path fibers for early detection of Alzheimer\u2019s disease","volume":"21","author":"Uchida","year":"2025","journal-title":"Alzheimer's Dement."},{"issue":"3","key":"10.1016\/j.neuroimage.2026.122265_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcag164","article-title":"Hippocampal subregional texture features associated with Alzheimer\u2019s disease severity and cognition","volume":"8","author":"Uchida","year":"2026","journal-title":"Brain Commun."},{"issue":"8","key":"10.1016\/j.neuroimage.2026.122265_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70544","article-title":"Change points for dynamic biomarkers in the Alzheimer\u2019s disease pathological cascade: a 30-year cohort study","volume":"21","author":"Uchida","year":"2025","journal-title":"Alzheimer's Dement."},{"issue":"5","key":"10.1016\/j.neuroimage.2026.122265_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in Alzheimer's disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuroimage.2026.122265_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2025.121343","article-title":"Hippocampal subfields in aging: Sex-specific trajectories in structure and hemodynamics","volume":"317","author":"Wen","year":"2025","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neuroimage.2026.122265_bib35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hbm.25234","article-title":"Hippocampal subfield volumetry from structural isotropic 1 mm\u00b3 MRI scans: a note of caution","volume":"42","author":"Wisse","year":"2021","journal-title":"Hum. Brain Mapp."},{"issue":"10","key":"10.1016\/j.neuroimage.2026.122265_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.neuroimage.2026.122265_bib37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hbm.22627","article-title":"Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment","volume":"36","author":"Yushkevich","year":"2015","journal-title":"Hum. Brain Mapp."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381192600580X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381192600580X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:09:53Z","timestamp":1792724993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105381192600580X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":37,"alternative-id":["S105381192600580X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.122265","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiscale organization of amyloid-associated vulnerability across the hippocampal memory system","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.122265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122265"}}