{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:10:49Z","timestamp":1791198649777,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revue Neurologique"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.neurol.2010.03.024","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T01:34:28Z","timestamp":1275442468000},"page":"978-986","source":"Crossref","is-referenced-by-count":62,"title":["Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis"],"prefix":"10.1016","volume":"166","author":[{"given":"C.","family":"Lamirel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Biousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurol.2010.03.024_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3341\/kjo.2005.19.3.195","article-title":"Quantitative analysis of retinal nerve fiber layer thickness of normal children and adolescents","volume":"19","author":"Ahn","year":"2005","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10633-007-9091-8","article-title":"Correlation between retinal morphological and functional findings and clinical severity in Parkinson's disease","volume":"116","author":"Altintas","year":"2008","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2009.41","article-title":"Imaging outcomes for neuroprotection and repair in multiple sclerosis trials","volume":"5","author":"Barkhof","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib4","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1167\/iovs.06-1029","article-title":"Retinal abnormalities in early Alzheimer's disease","volume":"48","author":"Berisha","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib5","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/archneurol.2009.230","article-title":"Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis","volume":"66","author":"Burkholder","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib6","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1167\/iovs.07-0738","article-title":"The relationship between visual field and retinal nerve fiber layer measurements in patients with multiple sclerosis","volume":"48","author":"Cheng","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20851","article-title":"Quantifying axonal loss after optic neuritis with optical coherence tomography","volume":"59","author":"Costello","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/1352458508091367","article-title":"Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography","volume":"14","author":"Costello","year":"2008","journal-title":"Mult Scler"},{"key":"10.1016\/j.neurol.2010.03.024_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jns.2009.02.354","article-title":"Differences in retinal nerve fiber layer atrophy between multiple sclerosis subtypes","volume":"281","author":"Costello","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1017\/S031716710000915X","article-title":"Retinal nerve fiber layer and future risk of multiple sclerosis","volume":"35","author":"Costello","year":"2008","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib11","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1167\/iovs.07-1127","article-title":"In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors","volume":"49","author":"Danesh-Meyer","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib12","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/archneur.65.7.920","article-title":"Optical coherence tomography in neuromyelitis optica","volume":"65","author":"de Seze","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib13","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/brain\/121.8.1469","article-title":"Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study","volume":"121","author":"De Stefano","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.neurol.2010.03.024_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ophtha.2005.10.040","article-title":"Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis","volume":"113","author":"Fisher","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.neurol.2010.03.024_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archopht.1974.01010010097001","article-title":"Insidious atrophy of retinal nerve fibers in multiple sclerosis. Funduscopic identification in patients with and without visual complaints","volume":"92","author":"Frisen","year":"1974","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/archneurol.2007.10","article-title":"Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis","volume":"65","author":"Frohman","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2009.04.010","article-title":"Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study","volume":"282","author":"Frohman","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ncpneuro0950","article-title":"Optical coherence tomography: a window into the mechanisms of multiple sclerosis","volume":"4","author":"Frohman","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib19","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1109\/TMI.2009.2016958","article-title":"Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images","volume":"28","author":"Garvin","year":"2009","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.neurol.2010.03.024_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jns.2007.10.020","article-title":"Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis","volume":"268","author":"Grazioli","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib21","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1167\/iovs.07-0834","article-title":"Is optical coherence tomography really a new biomarker candidate in multiple sclerosis?\u2013A structural and functional evaluation","volume":"48","author":"Gundogan","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archophthalmol.2009.106","article-title":"Inner retinal layer thinning in Parkinson disease","volume":"127","author":"Hajee","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1167\/iovs.06-0688","article-title":"The relationship between nerve fiber layer and perimetry measurements","volume":"48","author":"Harwerth","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib24","first-page":"277","article-title":"An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography","volume":"131","author":"Henderson","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurol.2010.03.024_bib25","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.08-2697","article-title":"A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements","volume":"50","author":"Hood","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1212\/WNL.26.6_Part_2.26","article-title":"Distribution of plaques in seventy autopsy cases of multiple sclerosis in the United States","volume":"26","author":"Ikuta","year":"1976","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib27","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1016\/j.visres.2004.06.009","article-title":"Retinal nerve fiber layer thinning in Parkinson disease","volume":"44","author":"Inzelberg","year":"2004","journal-title":"Vision Res"},{"key":"10.1016\/j.neurol.2010.03.024_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.wno.0000204645.56873.26","article-title":"Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease","volume":"26","author":"Iseri","year":"2006","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neurol.2008.03.008","article-title":"Retinal atrophy using optical coherence tomography (OCT) in 15 patients with multiple sclerosis and comparison with healthy subjects","volume":"164","author":"Jeanjean","year":"2008","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.neurol.2010.03.024_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneumeth.2005.12.008","article-title":"A feasibility study of optical coherence tomography for guiding deep brain probes","volume":"154","author":"Jeon","year":"2006","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neurol.2010.03.024_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10633-008-9147-4","article-title":"Multifocal VEP and OCT in optic neuritis: a topographical study of the structure-function relationship","volume":"118","author":"Klistorner","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib32","first-page":"105","article-title":"The use of optical coherence tomography in neurology","volume":"6","author":"Lamirel","year":"2009","journal-title":"Rev Neurol Dis"},{"key":"10.1016\/j.neurol.2010.03.024_bib33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/112067211002000122","article-title":"Retinal nerve fiber layer thickness and spatial and temporal contrast sensitivity in multiple sclerosis","volume":"20","author":"Merle","year":"2009","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1212\/01.wnl.0000345042.53843.d5","article-title":"Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis","volume":"72","author":"Naismith","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410410314","article-title":"Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions","volume":"41","author":"Narayanan","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib36","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1600-0420.2006.00724.x","article-title":"Optical coherence tomography versus automated perimetry for follow-up of optic neuritis","volume":"84","author":"Noval","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.neurol.2010.03.024_bib37","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1001\/archneurol.2009.265","article-title":"Optical coherence tomography in clinically isolated syndrome: no evidence of subclinical retinal axonal loss","volume":"66","author":"Outteryck","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2007.02.090","article-title":"Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease","volume":"420","author":"Paquet","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurol.2010.03.024_bib39","first-page":"2520","article-title":"Correlation between morphological and functional retinal impairment in multiple sclerosis patients","volume":"40","author":"Parisi","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib40","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/S1388-2457(01)00620-4","article-title":"Morphological and functional retinal impairment in Alzheimer's disease patients","volume":"112","author":"Parisi","year":"2001","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.neurol.2010.03.024_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jns.2006.08.012","article-title":"Imaging of the optic disc and retinal nerve fiber layer in acute optic neuritis","volume":"250","author":"Pro","year":"2006","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib42","article-title":"Sub-clinical atrophy of the retinal nerve fibre layer in multiple sclerosis","author":"Pueyo","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib43","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/1352458507087326","article-title":"Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis","volume":"14","author":"Pueyo","year":"2008","journal-title":"Mult Scler"},{"key":"10.1016\/j.neurol.2010.03.024_bib44","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1212\/01.wnl.0000294876.49861.dc","article-title":"Optical coherence tomography and disease subtype in multiple sclerosis","volume":"69","author":"Pulicken","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1212\/WNL.0b013e3181af78b8","article-title":"Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies","volume":"73","author":"Ratchford","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib46","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1167\/iovs.08-2528","article-title":"Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography","volume":"50","author":"Rebolleda","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1442-9071.2009.02015.x","article-title":"Optical coherence tomography of the retina and optic nerve\u00a0\u2013\u00a0a review","volume":"37","author":"Sakata","year":"2009","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib48","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/01.wnl.0000260612.51849.ed","article-title":"Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS","volume":"68","author":"Sepulcre","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2007.05.024","article-title":"The role of optical coherence tomography in multiple sclerosis: expert panel consensus","volume":"263","author":"Sergott","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neurol.2010.03.024_bib50","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00415-008-0985-5","article-title":"Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy","volume":"255","author":"Siger","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib51","first-page":"303","article-title":"Quantification of the retinal nerve fibre layer thickness in normal Indian eyes with optical coherence tomography","volume":"52","author":"Sony","year":"2004","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1682\/JRRD.2008.11.0156","article-title":"Thickness of retinal nerve fiber layer correlates with disease duration in parallel with corticospinal tract dysfunction in untreated multiple sclerosis","volume":"46","author":"Spain","year":"2009","journal-title":"J Rehabil Res Dev"},{"key":"10.1016\/j.neurol.2010.03.024_bib53","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1364\/OL.18.001864","article-title":"In vivo retinal imaging by optical coherence tomography","volume":"18","author":"Swanson","year":"1993","journal-title":"Opt Lett"},{"key":"10.1016\/j.neurol.2010.03.024_bib54","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1212\/01.wnl.0000277704.56189.85","article-title":"Clinically isolated syndromes: predicting and delaying multiple sclerosis","volume":"68","author":"Thrower","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2010.03.024_bib55","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/1352458508090221","article-title":"Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis","volume":"14","author":"Toledo","year":"2008","journal-title":"Mult Scler"},{"key":"10.1016\/j.neurol.2010.03.024_bib56","first-page":"211","article-title":"Clinicopathological study of the visual pathways, eyes, and cerebral hemispheres in 32\u00a0cases of disseminated sclerosis","volume":"3","author":"Toussaint","year":"1983","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","article-title":"Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis","volume":"58","author":"Trip","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2010.03.024_bib58","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neuroimage.2005.11.051","article-title":"Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy","volume":"31","author":"Trip","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurol.2010.03.024_bib59","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/1352458507076952","article-title":"Optic nerve magnetization transfer imaging and measures of axonal loss and demyelination in optic neuritis","volume":"13","author":"Trip","year":"2007","journal-title":"Mult Scler"},{"key":"10.1016\/j.neurol.2010.03.024_bib60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ajo.2004.04.049","article-title":"Ophthalmic imaging by spectral optical coherence tomography","volume":"138","author":"Wojtkowski","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.neurol.2010.03.024_bib61","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ophtha.2005.05.023","article-title":"Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography","volume":"112","author":"Wojtkowski","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.neurol.2010.03.024_bib62","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/archneur.65.7.924","article-title":"Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis","volume":"65","author":"Zaveri","year":"2008","journal-title":"Arch Neurol"}],"container-title":["Revue Neurologique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378710002237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378710002237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:08:50Z","timestamp":1559142530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0035378710002237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0035378710002237"],"URL":"https:\/\/doi.org\/10.1016\/j.neurol.2010.03.024","relation":{},"ISSN":["0035-3787"],"issn-type":[{"value":"0035-3787","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}