{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:35:43Z","timestamp":1791837343584,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"5","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revue Neurologique"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neurol.2014.03.005","type":"journal-article","created":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T05:15:47Z","timestamp":1398921347000},"page":"390-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Perspectives of drug-based neuroprotection targeting mitochondria"],"prefix":"10.1016","volume":"170","author":[{"given":"V.","family":"Procaccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Chao de la Barca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Oca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chevrollier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Amati-Bonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Reynier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurol.2014.03.005_bib0005","series-title":"Mitochondrial medicine: the mitochondrial biology and genetics of metabolic and degenerative diseases, cancer, and aging. Emery and Rimoin's principle and practice of medical genetics","first-page":"1","author":"Wallace","year":"2013"},{"key":"10.1016\/j.neurol.2014.03.005_bib0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","article-title":"Mitochondrial energetics and therapeutics","volume":"5","author":"Wallace","year":"2010","journal-title":"Ann Rev Pathol"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s13311-013-0176-7","article-title":"Review of clinical trials for mitochondrial disorders: 1997\u20132012","volume":"10","author":"Kerr","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neurol.2014.03.005_bib0020","first-page":"CD004426","article-title":"Treatment for mitochondrial disorders","volume":"4","author":"Pfeffer","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.neurol.2014.03.005_bib0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/978-1-4020-6191-2_18","article-title":"Calcium and cell death: the mitochondrial connection","volume":"45","author":"Bernardi","year":"2007","journal-title":"Subcell Biochem"},{"issue":"1","key":"10.1016\/j.neurol.2014.03.005_bib0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.21217","article-title":"Prevalence of mitochondrial DNA disease in adults","volume":"63","author":"Schaefer","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2014.03.005_bib0035","doi-asserted-by":"crossref","first-page":"D823","DOI":"10.1093\/nar\/gkl927","article-title":"An enhanced MITOMAP with a global mtDNA mutational phylogeny","volume":"35","author":"Ruiz-Pesini","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.neurol.2014.03.005_bib0040","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJMra1012478","article-title":"Monogenic mitochondrial disorders","volume":"366","author":"Koopman","year":"2012","journal-title":"N Engl J Med"},{"issue":"9227","key":"10.1016\/j.neurol.2014.03.005_bib0045","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0140-6736(00)02531-9","article-title":"Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency","volume":"356","author":"Rotig","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.neurol.2014.03.005_bib0050","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1016\/j.mito.2007.03.004","article-title":"CoQ10 deficiency diseases in adults","volume":"7 Suppl.","author":"Quinzii","year":"2007","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0055","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00415-011-6174-y","article-title":"Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study","volume":"259","author":"Meier","year":"2012","journal-title":"J Neurol"},{"issue":"Pt. 9","key":"10.1016\/j.neurol.2014.03.005_bib0060","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/brain\/awr170","article-title":"A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy","volume":"134","author":"Klopstock","year":"2011","journal-title":"Brain"},{"issue":"Pt. 9","key":"10.1016\/j.neurol.2014.03.005_bib0065","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1093\/brain\/awr180","article-title":"Idebenone treatment in Leber's hereditary optic neuropathy","volume":"134","author":"Carelli","year":"2011","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.neurol.2014.03.005_bib0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ymgme.2012.09.007","article-title":"EPI-743 reverses the progression of the pediatric mitochondrial disease\u00a0\u2013\u00a0genetically defined Leigh syndrome","volume":"107","author":"Martinelli","year":"2012","journal-title":"Mol Genet Metab"},{"issue":"3","key":"10.1016\/j.neurol.2014.03.005_bib0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/archneurol.2011.2972","article-title":"Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy","volume":"69","author":"Sadun","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2014.03.005_bib0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/brain\/awt343","article-title":"Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy","volume":"137","author":"Giordano","year":"2014","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim","year":"2007","journal-title":"Arch Biochem Biophys"},{"issue":"9","key":"10.1016\/j.neurol.2014.03.005_bib0090","doi-asserted-by":"crossref","first-page":"620","DOI":"10.18632\/aging.100488","article-title":"RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice","volume":"4","author":"Thomas","year":"2012","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.neurol.2014.03.005_bib0095","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2013.09.002","article-title":"MicroRNAs as regulators of mitochondrial function: role in cancer suppression","volume":"184","author":"Tomasetti","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neurol.2014.03.005_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.03.018","article-title":"Mitochondrial diseases of the brain","volume":"63","author":"Chaturvedi","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10.1016\/j.neurol.2014.03.005_bib0105","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4161\/auto.24135","article-title":"After the banquet: mitochondrial biogenesis, mitophagy, and cell survival","volume":"9","author":"Zhu","year":"2013","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.neurol.2014.03.005_bib0110","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neurol.2014.03.005_bib0115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2011-101356","article-title":"PPARgamma co-activator-1alpha (PGC-1alpha) reduces amyloid-beta generation through a PPARgamma-dependent mechanism","volume":"25","author":"Katsouri","year":"2011","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0120","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cmet.2012.03.019","article-title":"Elevated PGC-1alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS","volume":"15","author":"Da Cruz","year":"2012","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.neurol.2014.03.005_bib0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jnr.22225","article-title":"Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia","volume":"88","author":"Chen","year":"2010","journal-title":"J Neurosci Res"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0130","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"issue":"5968","key":"10.1016\/j.neurol.2014.03.005_bib0135","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.1179687","article-title":"Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.neurol.2014.03.005_bib0140","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tibs.2010.07.003","article-title":"Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling","volume":"35","author":"Verdin","year":"2010","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"issue":"5837","key":"10.1016\/j.neurol.2014.03.005_bib0150","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.1143780","article-title":"Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease","volume":"317","author":"Outeiro","year":"2007","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.neurol.2014.03.005_bib0155","doi-asserted-by":"crossref","first-page":"e14731","DOI":"10.1371\/journal.pone.0014731","article-title":"Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neurol.2014.03.005_bib0160","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bbrc.2010.07.081","article-title":"Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis","volume":"399","author":"Won","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.neurol.2014.03.005_bib0165","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4023","article-title":"Pharmacological approaches to restore mitochondrial function","volume":"12","author":"Andreux","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0170","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","article-title":"Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans","volume":"14","author":"Timmers","year":"2011","journal-title":"Cell Metab"},{"issue":"29","key":"10.1016\/j.neurol.2014.03.005_bib0175","doi-asserted-by":"crossref","first-page":"24460","DOI":"10.1074\/jbc.M112.382226","article-title":"trans-(-)-epsilon-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease","volume":"287","author":"Fu","year":"2012","journal-title":"J Biol Chem"},{"issue":"51","key":"10.1016\/j.neurol.2014.03.005_bib0180","doi-asserted-by":"crossref","first-page":"36662","DOI":"10.1074\/jbc.M113.466490","article-title":"Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells","volume":"288","author":"Desquiret-Dumas","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.neurol.2014.03.005_bib0185","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0190","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease","volume":"21","author":"Johri","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0195","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.mito.2012.12.003","article-title":"Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy","volume":"13","author":"Noe","year":"2013","journal-title":"Mitochondrion"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0200","doi-asserted-by":"crossref","first-page":"e64019","DOI":"10.1371\/journal.pone.0064019","article-title":"Peroxisome proliferator-activated receptor (PPAR) gamma and PPARalpha agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?","volume":"8","author":"Zolezzi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurol.2014.03.005_bib0205","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-genet-110410-132529","article-title":"Fusion and fission: interlinked processes critical for mitochondrial health","volume":"46","author":"Chan","year":"2012","journal-title":"Annu Rev Genet"},{"issue":"6","key":"10.1016\/j.neurol.2014.03.005_bib0210","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.neurol.2014.03.005_bib0215","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/jcbfm.2012.32","article-title":"Novel mitochondrial targets for neuroprotection","volume":"32","author":"Perez-Pinzon","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0220","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","article-title":"Mitochondrial dynamics in neurodegeneration","volume":"23","author":"Itoh","year":"2013","journal-title":"Trends Cell Biol"},{"issue":"6098","key":"10.1016\/j.neurol.2014.03.005_bib0225","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00401-011-0921-0","article-title":"Neurodegeneration as a consequence of failed mitochondrial maintenance","volume":"123","author":"Karbowski","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0235","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.201008084","article-title":"Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL","volume":"191","author":"Jin","year":"2010","journal-title":"J Cell Biol"},{"issue":"4","key":"10.1016\/j.neurol.2014.03.005_bib0240","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbabio.2013.11.010","article-title":"Mitochondrial dismissal in mammals, from protein degradation to mitophagy","volume":"1837","author":"Campello","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1016\/j.neurol.2014.03.005_bib0245","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2013.07.030","article-title":"A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1","volume":"154","author":"Hertz","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0250","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrneurol.2011.200","article-title":"Control of autophagy as a therapy for neurodegenerative disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"10.1016\/j.neurol.2014.03.005_bib0255","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/hmg\/ddt450","article-title":"Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation","volume":"23","author":"Dai","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"6165","key":"10.1016\/j.neurol.2014.03.005_bib0260","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1244360","article-title":"mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome","volume":"342","author":"Johnson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neurol.2014.03.005_bib0265","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1749-6632.2010.05624.x","article-title":"MELAS and L-arginine therapy: pathophysiology of stroke-like episodes","volume":"1201","author":"Koga","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"10.1016\/j.neurol.2014.03.005_bib0270","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mito.2006.11.006","article-title":"MELAS and L-arginine therapy","volume":"7","author":"Koga","year":"2007","journal-title":"Mitochondrion"},{"issue":"11","key":"10.1016\/j.neurol.2014.03.005_bib0275","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/01.wnl.0000220197.36849.1e","article-title":"Endothelial dysfunction in MELAS improved by l-arginine supplementation","volume":"66","author":"Koga","year":"2006","journal-title":"Neurology"},{"issue":"6302","key":"10.1016\/j.neurol.2014.03.005_bib0280","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/348651a0","article-title":"A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies","volume":"348","author":"Goto","year":"1990","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.neurol.2014.03.005_bib0285","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nrneurol.2013.129","article-title":"New treatments for mitochondrial disease-no time to drop our standards","volume":"9","author":"Pfeffer","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurol.2014.03.005_bib0290","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fphar.2012.00059","article-title":"The ketogenic diet as a treatment paradigm for diverse neurological disorders","volume":"3","author":"Stafstrom","year":"2012","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.neurol.2014.03.005_bib0295","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1528-1167.2006.00906.x","article-title":"Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects","volume":"48","author":"Kang","year":"2007","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.neurol.2014.03.005_bib0300","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ana.20240","article-title":"Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells","volume":"56","author":"Santra","year":"2004","journal-title":"Ann Neurol"},{"issue":"7","key":"10.1016\/j.neurol.2014.03.005_bib0305","doi-asserted-by":"crossref","first-page":"e21788","DOI":"10.1371\/journal.pone.0021788","article-title":"2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease","volume":"6","author":"Yao","year":"2011","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.neurol.2014.03.005_bib0310","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.227439.113","article-title":"Calorie restriction and sirtuins revisited","volume":"27","author":"Guarente","year":"2013","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.neurol.2014.03.005_bib0315","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.taap.2013.06.014","article-title":"High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury","volume":"272","author":"Wills","year":"2013","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Revue Neurologique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003537871400811X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003537871400811X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T08:27:51Z","timestamp":1716712071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003537871400811X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S003537871400811X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurol.2014.03.005","relation":{},"ISSN":["0035-3787"],"issn-type":[{"value":"0035-3787","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perspectives of drug-based neuroprotection targeting mitochondria","name":"articletitle","label":"Article Title"},{"value":"Revue Neurologique","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurol.2014.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}