{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:06:18Z","timestamp":1768590378359,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revue Neurologique"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.neurol.2016.08.005","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T02:15:35Z","timestamp":1474424135000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exercise training in metabolic myopathies"],"prefix":"10.1016","volume":"172","author":[{"given":"J.","family":"Vissing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurol.2016.08.005_bib0285","series-title":"Myology","first-page":"1535","article-title":"Metabolic disorders affecting muscle","author":"DiMauro","year":"2004"},{"key":"10.1016\/j.neurol.2016.08.005_bib0290","series-title":"Inborn Metabolic Diseases","first-page":"115","article-title":"The glycogen storage diseases and related disorders","author":"Laforet","year":"2012"},{"key":"10.1016\/j.neurol.2016.08.005_bib0295","series-title":"Muscle disease: pathology and genetics","first-page":"254","article-title":"Disorders of glycogen metabolism","author":"Vissing","year":"2013"},{"key":"10.1016\/j.neurol.2016.08.005_bib0300","series-title":"Oxford textbook of neuromuscular disorders","first-page":"288","article-title":"Metabolic myopathies","author":"Orngreen","year":"2014"},{"issue":"3","key":"10.1016\/j.neurol.2016.08.005_bib0305","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10545-014-9771-y","article-title":"Exercise in muscle glycogen storage diseases","volume":"38","author":"Preisler","year":"2015","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.neurol.2016.08.005_bib0310","doi-asserted-by":"crossref","first-page":"1824S","DOI":"10.1093\/jn\/135.7.1824S","article-title":"Metabolic consequences of muscle disuse atrophy","volume":"135","author":"Stein","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.neurol.2016.08.005_bib0315","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1001\/jama.1995.03520380029031","article-title":"Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men","volume":"273","author":"Blair","year":"1995","journal-title":"JAMA"},{"issue":"Suppl. 1","key":"10.1016\/j.neurol.2016.08.005_bib0320","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0838.2006.00520.x","article-title":"Evidence for prescribing exercise as therapy in chronic disease","volume":"16","author":"Pedersen","year":"2006","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.neurol.2016.08.005_bib0325","series-title":"Pompe disease","first-page":"8","author":"Baethmann","year":"2008"},{"key":"10.1016\/j.neurol.2016.08.005_bib0330","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/GIM.0b013e3181e655b6","article-title":"Glycogen storage disease type III diagnosis and management guidelines","volume":"12","author":"Kishnani","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0335","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/jnnp-2011-301593","article-title":"Genotypic and phenotypic features of McArdle disease: insights from the Spanish national registry","volume":"83","author":"Lucia","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurol.2016.08.005_bib0340","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1566524024605734","article-title":"Phosphofructokinase deficiency: past, present and future","volume":"2","author":"Nakajima","year":"2002","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0345","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-7793.2001.00295.x","article-title":"The effects of increasing exercise intensity on muscle fuel utilisation in humans","volume":"536","author":"van Loon","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0350","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1152\/jappl.1982.53.3.708","article-title":"Regulation of glycogenolysis in human muscle at rest and during exercise","volume":"53","author":"Chasiotis","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0355","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1748-1716.1967.tb03719.x","article-title":"Muscle glycogen during prolonged severe exercise","volume":"71","author":"Hermansen","year":"1967","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.neurol.2016.08.005_bib0360","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ana.410170216","article-title":"Myophosphorylase deficiency impairs muscle oxidative metabolism","volume":"17","author":"Haller","year":"1985","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0365","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1056\/NEJM199102073240603","article-title":"Glucose-induced exertional fatigue in muscle phosphofructokinase deficiency","volume":"324","author":"Haller","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0370","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/JSM.0b013e3180f6168c","article-title":"Favorable responses to acute and chronic exercise in McArdle patients","volume":"17","author":"Mate-Munoz","year":"2007","journal-title":"Clin J Sport Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0375","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ymgme.2013.02.008","article-title":"Exercise intolerance in glycogen storage disease type III: weakness or energy deficiency?","volume":"109","author":"Preisler","year":"2013","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0380","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ymgme.2012.08.019","article-title":"Fat and carbohydrate metabolism during exercise in late-onset Pompe disease","volume":"107","author":"Preisler","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0385","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00005768-200001000-00012","article-title":"Limiting factors for maximum oxygen uptake and determinants of endurance performance","volume":"32","author":"Bassett","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.neurol.2016.08.005_bib0390","first-page":"CD007931","article-title":"Physical training for McArdle disease","author":"Quinlivan","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.neurol.2016.08.005_bib0395","first-page":"CD003907","article-title":"Strength training and aerobic exercise training for muscle disease","author":"Voet","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.neurol.2016.08.005_bib0400","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/ana.20881","article-title":"Aerobic conditioning: an effective therapy in McArdle's disease","volume":"59","author":"Haller","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0405","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.scispo.2004.11.001","article-title":"Effects of an endurance training on patients with McArdle's disease","volume":"20","author":"Ollivier","year":"2005","journal-title":"Science and Sports"},{"key":"10.1016\/j.neurol.2016.08.005_bib0410","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/mus.20251","article-title":"Exercise tolerance and daily life in McArdle's disease","volume":"31","author":"Ollivier","year":"2005","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.neurol.2016.08.005_bib0415","first-page":"334","article-title":"Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits","volume":"11","author":"Santalla","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neurol.2016.08.005_bib0420","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ymgme.2012.09.015","article-title":"Open-label extension study following the late-onset treatment study (LOTS) of alglucosidase alfa","volume":"107","author":"van der Ploeg","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0425","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa0909859","article-title":"A randomized study of alglucosidase alfa in late-onset Pompe's disease","volume":"362","author":"van der Ploeg","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0430","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ymgme.2012.09.010","article-title":"Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease","volume":"107","author":"Nilsson","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0435","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13023-015-0303-0","article-title":"Safety and efficacy of exercise training in adults with Pompe disease: evalution of endurance, muscle strength and core stability before and after a 12-week training program","volume":"10","author":"van den Berg","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.neurol.2016.08.005_bib0440","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ymgme.2011.05.013","article-title":"Effect of aerobic and resistance exercise training on late-onset Pompe disease patients receiving enzyme replacement therapy","volume":"104","author":"Terzis","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0445","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/mus.20665","article-title":"Modification of the natural history of adult-onset acid maltase deficiency by nutrition and exercise therapy","volume":"35","author":"Slonim","year":"2007","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neurol.2016.08.005_bib0450","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ymgme.2012.10.020","article-title":"Effects of exercise training during infusion on late-onset Pompe disease patients receiving enzyme replacement therapy","volume":"107","author":"Terzis","year":"2012","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0455","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00415-009-5275-3","article-title":"Enzyme replacement therapy with alglucosidase alfa in 44 patients with late-onset glycogen storage disease type II: 12-month results of an observational clinical trial","volume":"257","author":"Strothotte","year":"2010","journal-title":"J Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0460","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/jappl.1991.70.1.391","article-title":"Abnormal oxidative metabolism and O2 transport in muscle phosphofructokinase deficiency","volume":"70","author":"Lewis","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0465","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archneur.59.9.1395","article-title":"Spontaneous \u201csecond wind\u201d and glucose-induced second \u201csecond wind\u201d in McArdle disease: oxidative mechanisms","volume":"59","author":"Haller","year":"2002","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0470","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1212\/WNL.62.1.82","article-title":"No spontaneous second wind in muscle phosphofructokinase deficiency","volume":"62","author":"Haller","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0475","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1001\/archneur.65.6.786","article-title":"Effect of oral sucrose shortly before exercise on work capacity in McArdle disease","volume":"65","author":"Andersen","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0480","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/adc.2008.146548","article-title":"Carbohydrate- and protein-rich diets in McArdle disease: effects on exercise capacity","volume":"79","author":"Andersen","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurol.2016.08.005_bib0485","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1056\/NEJMoa031836","article-title":"The effect of oral sucrose on exercise tolerance in patients with McArdle's disease","volume":"349","author":"Vissing","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0490","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1212\/01.wnl.0000343002.74480.e4","article-title":"Fat metabolism during exercise in patients with McArdle disease","volume":"72","author":"Orngreen","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0495","doi-asserted-by":"crossref","first-page":"E1235","DOI":"10.1210\/jc.2013-1651","article-title":"Fat and carbohydrate metabolism during exercise in phosphoglucomutase type I deficiency","volume":"98","author":"Preisler","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.neurol.2016.08.005_bib0500","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1212\/WNL.0000000000000118","article-title":"Bezafibrate in skeletal muscle fatty oxidation disorders: a randomized clinical trial","volume":"82","author":"Orngreen","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0505","first-page":"709","article-title":"American College of Sports Medicine position stand. Nutrition and athletic performance","volume":"41","author":"Rodriguez","year":"2009","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.neurol.2016.08.005_bib0510","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1212\/WNL.0b013e31824365f9","article-title":"Muscle phosphorylase kinase deficiency: a neutral metabolic variant or a disease?","volume":"78","author":"Preisler","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0515","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1212\/01.wnl.0000289190.66955.67","article-title":"Is muscle glycogenolysis impaired in X-linked phosphorylase b kinase deficiency?","volume":"70","author":"Orngreen","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0520","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/archneur.62.9.1440","article-title":"Effect of fuels on exercise capacity in muscle phosphoglycerate mutase deficiency","volume":"62","author":"Vissing","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0525","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa1206605","article-title":"Multiple phenotypes in phosphoglucomutase 1 deficiency","volume":"370","author":"Tegtmeyer","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0530","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJMc0901158","article-title":"Muscle glycogenosis due to phosphoglucomutase 1 deficiency","volume":"361","author":"Stojkovic","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurol.2016.08.005_bib0535","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ana.20320","article-title":"Fuel utilization in subjects with carnitine palmitoyltransferase II gene mutations","volume":"57","author":"Orngreen","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0540","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1212\/WNL.59.7.1046","article-title":"Exercise tolerance in carnitine palmitoyltransferase II deficiency with IV and oral glucose","volume":"59","author":"Orngreen","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurol.2016.08.005_bib0545","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1212\/01.WNL.0000078195.05396.20","article-title":"Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency","volume":"61","author":"Orngreen","year":"2003","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neurol.2016.08.005_bib0550","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1210\/jc.2012-3791","article-title":"Patients with medium-chain acyl-coenzyme A-dehydrogenase deficiency have impaired oxidation of fat during exercise but no effect of L-carnitine supplementation","volume":"98","author":"Madsen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.neurol.2016.08.005_bib0555","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ana.20168","article-title":"Fuel utilization in patients with very long-chain acyl-CoA-dehydrogenase deficiency","volume":"56","author":"Orngreen","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurol.2016.08.005_bib0560","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1212\/01.wnl.0000265854.41013.84","article-title":"Effects of IV glucose and oral medium-chain triglyceride in patients with VLCAD deficiency","volume":"69","author":"Orngreen","year":"2007","journal-title":"Neurology"}],"container-title":["Revue Neurologique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378716302077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378716302077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T20:29:36Z","timestamp":1568406576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0035378716302077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0035378716302077"],"URL":"https:\/\/doi.org\/10.1016\/j.neurol.2016.08.005","relation":{},"ISSN":["0035-3787"],"issn-type":[{"value":"0035-3787","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise training in metabolic myopathies","name":"articletitle","label":"Article Title"},{"value":"Revue Neurologique","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurol.2016.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}