{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:11Z","timestamp":1791910511679,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revue Neurologique"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.neurol.2020.07.021","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T19:41:09Z","timestamp":1610480469000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Melatonin (MEL) and its use in circadian rhythm sleep-wake disorders: Recommendations of the French Medical and Research Sleep Society (SFRMS)"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-9709","authenticated-orcid":false,"given":"M.A.","family":"Quera-Salva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kilic-Huck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Vecchierini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4764","key":"10.1016\/j.neurol.2020.07.021_bib0240","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.3726555","article-title":"Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle","volume":"233","author":"Czeisler","year":"1986","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neurol.2020.07.021_bib0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","article-title":"The basic physiology and pathophysiology of melatonin","volume":"9","author":"Claustrat","year":"2005","journal-title":"Sleep Med Rev"},{"issue":"13","key":"10.1016\/j.neurol.2020.07.021_bib0250","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1002\/cne.22381","article-title":"Morphology and mosaics of melanopsin-expressing retinal ganglion cell types in mice","volume":"518","author":"Berson","year":"2010","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.neurol.2020.07.021_bib0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/07420528909059144","article-title":"The dim light melatonin onset as a marker for circadian phase position","volume":"6","author":"Lewy","year":"1989","journal-title":"Chronobiol Int"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0260","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jps.21407","article-title":"A population pharmacokinetic turnover and surge-function model for describing melatonin biological rhythm in healthy male subjects","volume":"98","author":"Charles","year":"2009","journal-title":"J Pharm Sci"},{"issue":"2\u20133","key":"10.1016\/j.neurol.2020.07.021_bib0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","article-title":"Melatonin: physiological effects in humans","volume":"61","author":"Claustrat","year":"2015","journal-title":"Neurochirurgie"},{"issue":"4","key":"10.1016\/j.neurol.2020.07.021_bib0270","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/oxfordjournals.jbchem.a022352","article-title":"Genetic polymorphism in the 5\u2019-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans","volume":"125","author":"Nakajima","year":"1999","journal-title":"J Biochem"},{"issue":"3","key":"10.1016\/j.neurol.2020.07.021_bib0275","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00008571-199206000-00003","article-title":"Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites","volume":"2","author":"Butler","year":"1992","journal-title":"Pharmacogenetics"},{"issue":"6","key":"10.1016\/j.neurol.2020.07.021_bib0280","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1365-2788.2010.01283.x","article-title":"Loss of response to melatonin treatment is associated with slow melatonin metabolism","volume":"54","author":"Braam","year":"2010","journal-title":"J Intellect Disabil Res"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0285","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1113\/jphysiol.2007.143180","article-title":"A three pulse phase response curve to three milligrams of melatonin in humans","volume":"586","author":"Burgess","year":"2008","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.neurol.2020.07.021_bib0290","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.encep.2018.06.005","article-title":"Melatonin: Physiological and pharmacological aspects related to sleep: the interest of a prolonged-release formulation (Circadin((R))) in insomnia","volume":"44","author":"Quera-Salva","year":"2018","journal-title":"L\u2019Encephale"},{"issue":"24","key":"10.1016\/j.neurol.2020.07.021_bib0295","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1113\/JP275917","article-title":"Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder","volume":"596","author":"Watson","year":"2018","journal-title":"J Physiol"},{"issue":"4","key":"10.1016\/j.neurol.2020.07.021_bib0300","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000216538","article-title":"Adolescent changes in the homeostatic and circadian regulation of sleep","volume":"31","author":"Hagenauer","year":"2009","journal-title":"Dev Neurosci"},{"issue":"11","key":"10.1016\/j.neurol.2020.07.021_bib0305","doi-asserted-by":"crossref","first-page":"e111700","DOI":"10.1371\/journal.pone.0111700","article-title":"Adolescent sleep patterns and night-time technology use: results of the Australian Broadcasting Corporation's Big Sleep Survey","volume":"9","author":"Gamble","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.neurol.2020.07.021_bib0310","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1038\/srep06309","article-title":"Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder","volume":"4","author":"Hida","year":"2014","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0315","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsw038","article-title":"Effects of melatonin and bright light treatment in childhood chronic sleep onset insomnia with late melatonin onset: a randomized controlled study","volume":"40","author":"van Maanen","year":"2017","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.neurol.2020.07.021_bib0320","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/07420528.2013.823200","article-title":"A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep","volume":"31","author":"Saxvig","year":"2014","journal-title":"Chronobiol Int"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0325","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/088307380101600204","article-title":"Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial","volume":"16","author":"Smits","year":"2001","journal-title":"J Child Neurol"},{"issue":"9","key":"10.1016\/j.neurol.2020.07.021_bib0330","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3109\/07420528.2012.719962","article-title":"Melatonin treatment effects on adolescent students\u2019 sleep timing and sleepiness in a placebo-controlled crossover study","volume":"29","author":"Eckerberg","year":"2012","journal-title":"Chronobiol Int"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0335","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.chi.0000246055.76167.0d","article-title":"Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia","volume":"46","author":"Van der Heijden","year":"2007","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"11","key":"10.1016\/j.neurol.2020.07.021_bib0340","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1097\/01.chi.0000085756.71002.86","article-title":"Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial","volume":"42","author":"Smits","year":"2003","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0345","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2869.1998.00102.x","article-title":"Delayed sleep phase syndrome: a placebo-controlled crossover study on the effects of melatonin administered five hours before the individual dim light melatonin onset","volume":"7","author":"Nagtegaal","year":"1998","journal-title":"J Sleep Res"},{"issue":"1","key":"10.1016\/j.neurol.2020.07.021_bib0350","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00006842-200101000-00005","article-title":"A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome","volume":"63","author":"Kayumov","year":"2001","journal-title":"Psychosom Med"},{"issue":"6","key":"10.1016\/j.neurol.2020.07.021_bib0355","doi-asserted-by":"crossref","first-page":"e1002587","DOI":"10.1371\/journal.pmed.1002587","article-title":"Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: a double-blind, randomized clinical trial","volume":"15","author":"Sletten","year":"2018","journal-title":"PLoS Med"},{"issue":"8750","key":"10.1016\/j.neurol.2020.07.021_bib0360","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0140-6736(91)92787-3","article-title":"Delayed sleep phase syndrome response to melatonin","volume":"337","author":"Dahlitz","year":"1991","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.neurol.2020.07.021_bib0365","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00213-010-1962-0","article-title":"Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT","volume":"212","author":"van Geijlswijk","year":"2010","journal-title":"Psychopharmacology"},{"issue":"15","key":"10.1016\/j.neurol.2020.07.021_bib0370","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1056\/NEJM200010123431503","article-title":"Entrainment of free-running circadian rhythms by melatonin in blind people","volume":"343","author":"Sack","year":"2000","journal-title":"N Engl J Med"},{"issue":"10005","key":"10.1016\/j.neurol.2020.07.021_bib0375","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/S0140-6736(15)60031-9","article-title":"Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomized, double-masked, placebo-controlled phase 3 trials","volume":"386","author":"Lockley","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neurol.2020.07.021_bib0380","first-page":"13","article-title":"Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial","volume":"7","author":"Roth","year":"2015","journal-title":"Nat Sci Sleep"},{"issue":"11","key":"10.1016\/j.neurol.2020.07.021_bib0385","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1517\/14740338.2015.1093112","article-title":"Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies","volume":"14","author":"Leger","year":"2015","journal-title":"Expert Opin Drug Saf"},{"issue":"3","key":"10.1016\/j.neurol.2020.07.021_bib0390","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1440-1819.2000.00722.x","article-title":"Effect of 3mg melatonin on jet lag syndrome in an 8-h eastward flight","volume":"54","author":"Takahashi","year":"2000","journal-title":"Psychiatry Clin Neurosci"},{"issue":"2","key":"10.1016\/j.neurol.2020.07.021_bib0395","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/07853899908998789","article-title":"Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics","volume":"31","author":"Dijk","year":"1999","journal-title":"Ann Med"},{"issue":"5","key":"10.1016\/j.neurol.2020.07.021_bib0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.10.024","article-title":"Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism","volume":"33","author":"Viola","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurol.2020.07.021_bib0405","doi-asserted-by":"crossref","first-page":"36716","DOI":"10.1038\/srep36716","article-title":"Circadian rhythms of European and African-Americans after a large delay of sleep as in jet lag and night work","volume":"6","author":"Eastman","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.neurol.2020.07.021_bib0410","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/074873049100600304","article-title":"Influence of melatonin treatment on human circadian rhythmicity before and after a simulated 9-hr time shift","volume":"6","author":"Samel","year":"1991","journal-title":"J Biol Rhythms"},{"issue":"3","key":"10.1016\/j.neurol.2020.07.021_bib0415","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00213-009-1737-7","article-title":"Melatonin treatment for eastward and westward travel preparation","volume":"208","author":"Paul","year":"2010","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.neurol.2020.07.021_bib0420","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/07420529808993201","article-title":"Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag","volume":"15","author":"Suhner","year":"1998","journal-title":"Chronobiol Int"},{"issue":"5","key":"10.1016\/j.neurol.2020.07.021_bib0425","first-page":"439","article-title":"Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews","volume":"75","author":"Paul","year":"2004","journal-title":"Aviation Space Environ Med"},{"issue":"9","key":"10.1016\/j.neurol.2020.07.021_bib0430","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1176\/ajp.156.9.1392","article-title":"Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial","volume":"156","author":"Spitzer","year":"1999","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.neurol.2020.07.021_bib0435","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0006-3223(92)90300-O","article-title":"Melatonin and jet lag: confirmatory result using a simplified protocol","volume":"32","author":"Claustrat","year":"1992","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.neurol.2020.07.021_bib0440","first-page":"638","article-title":"Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag","volume":"72","author":"Suhner","year":"2001","journal-title":"Aviation Space Environ Med"},{"issue":"7","key":"10.1016\/j.neurol.2020.07.021_bib0445","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0006-3223(93)90007-Z","article-title":"A double-blind trial of melatonin as a treatment for jet lag in international cabin crew","volume":"33","author":"Petrie","year":"1993","journal-title":"Biol Psychiatry"},{"issue":"6389","key":"10.1016\/j.neurol.2020.07.021_bib0450","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/bmj.287.6389.426-b","article-title":"Can melatonin alleviate jet lag?","volume":"287","author":"Arendt","year":"1983","journal-title":"Br Med J"},{"issue":"1\u20132","key":"10.1016\/j.neurol.2020.07.021_bib0455","first-page":"144","article-title":"Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin","volume":"85","author":"Pierard","year":"2001","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"10.1016\/j.neurol.2020.07.021_bib0460","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1152\/japplphysiol.00940.2002","article-title":"Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel","volume":"96","author":"Beaumont","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neurol.2020.07.021_bib0465","first-page":"2014","article-title":"Jet lag","author":"Herxheimer","year":"2014","journal-title":"BMJ Clin Evid"},{"issue":"14","key":"10.1016\/j.neurol.2020.07.021_bib0470","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s40265-018-0973-8","article-title":"Approaches to the pharmacological management of jet lag","volume":"78","author":"Arendt","year":"2018","journal-title":"Drugs"}],"container-title":["Revue Neurologique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378720307335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0035378720307335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T05:41:12Z","timestamp":1758519672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0035378720307335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0035378720307335"],"URL":"https:\/\/doi.org\/10.1016\/j.neurol.2020.07.021","relation":{},"ISSN":["0035-3787"],"issn-type":[{"value":"0035-3787","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin (MEL) and its use in circadian rhythm sleep-wake disorders: Recommendations of the French Medical and Research Sleep Society (SFRMS)","name":"articletitle","label":"Article Title"},{"value":"Revue Neurologique","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurol.2020.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}