{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:47:09Z","timestamp":1791895629686,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["neuromodulationjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromodulation: Technology at the Neural Interface"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.neurom.2022.12.012","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T16:40:10Z","timestamp":1674232810000},"page":"1218-1226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Insular Role in Blood Pressure and Systemic Vascular Resistance Regulation"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-4980","authenticated-orcid":false,"given":"Alvaro","family":"Sanchez-Larsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Principe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Vaquerizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Langohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rocamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurom.2022.12.012_bib1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.neurom.2022.12.012_bib2","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1212\/WNL.42.9.1727","article-title":"Cardiovascular effects of human insular cortex stimulation","volume":"42","author":"Oppenheimer","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.neurom.2022.12.012_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1113\/jphysiol.2001.014621","article-title":"Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans","volume":"539","author":"Thornton","year":"2002","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1684\/epd.2007.0054","article-title":"Asystole induced by electrical stimulation of the left cingulate gyrus","volume":"9","author":"Leung","year":"2007","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.neurom.2022.12.012_bib5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000321182","article-title":"The cardioinhibitory responses of the right posterior insular cortex in an epileptic patient","volume":"88","author":"Al-Otaibi","year":"2010","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.neurom.2022.12.012_bib6","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/hbm.24548","article-title":"How the insula speaks to the heart: cardiac responses to insular stimulation in humans","volume":"40","author":"Chouchou","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neurom.2022.12.012_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropsychologia.2018.03.019","article-title":"Human amygdala stimulation effects on emotion physiology and emotional experience","volume":"145","author":"Inman","year":"2020","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurom.2022.12.012_bib8","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/ana.26074","article-title":"Characterization of the insular role in cardiac function through intracranial electrical stimulation of the human insula","volume":"89","author":"Sanchez-Larsen","year":"2021","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fneur.2019.00501","article-title":"Blood pressure in seizures and epilepsy","volume":"10","author":"Nass","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archneurpsyc.1949.02310180002001","article-title":"Frontal lobotomy and electrical stimulation of orbital surface of frontal lobes; effect on respiration and on blood pressure in man","volume":"62","author":"Chapman","year":"1949","journal-title":"Arch Neurol Psychiatry"},{"key":"10.1016\/j.neurom.2022.12.012_bib11","first-page":"421","article-title":"Stimulation of orbital surface of man prior to frontal lobotomy","volume":"27","author":"Livingston","year":"1948","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"10.1016\/j.neurom.2022.12.012_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1152\/jn.1949.12.6.385","article-title":"Autonomic effects on stimulating rostral portion of cingulate gyri in man","volume":"12","author":"Pool","year":"1949","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1152\/jn.1950.13.1.65","article-title":"Effect upon blood pressure of electrical stimulation of tips of temporal lobes in man","volume":"13","author":"Chapman","year":"1950","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib14","first-page":"457","article-title":"Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson\u2019s disease","volume":"252","author":"Sauleau","year":"2005","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jamaneurol.2017.3344","article-title":"Cortical structures associated with human blood pressure control","volume":"75","author":"Lacuey","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib16","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1097\/01.wnr.0000183904.15773.47","article-title":"Deep brain stimulation can regulate arterial blood pressure in awake humans","volume":"16","author":"Green","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurom.2022.12.012_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1525-1403.2010.00274.x","article-title":"Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans","volume":"13","author":"Green","year":"2010","journal-title":"Neuromodulation"},{"key":"10.1016\/j.neurom.2022.12.012_bib18","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1161\/HYPERTENSIONAHA.111.170183","article-title":"Deep brain stimulation of the periaqueductal grey induces vasodilation in humans","volume":"57","author":"Carter","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.neurom.2022.12.012_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5603\/CJ.a2019.0095","article-title":"Epilepsy and hypertension: the possible link for sudden unexpected death in epilepsy?","volume":"28","author":"Szczurkowska","year":"2021","journal-title":"Cardiol J"},{"key":"10.1016\/j.neurom.2022.12.012_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yebeh.2013.12.032","article-title":"Common comorbidities in women and men with epilepsy and the relationship between number of comorbidities and health plan paid costs in 2010","volume":"32","author":"Wilner","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.neurom.2022.12.012_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/epi.13504","article-title":"Seizure-related modulation of systemic arterial blood pressure in focal epilepsy","volume":"57","author":"Hampel","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurom.2022.12.012_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.eplepsyres.2016.02.008","article-title":"Heart rate and blood pressure in sudden unexpected death in epilepsy (SUDEP)","volume":"122","author":"Nei","year":"2016","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.neurom.2022.12.012_bib23","doi-asserted-by":"crossref","DOI":"10.6061\/clinics\/2021\/e3023","article-title":"Sudden death in a patient with epilepsy and arterial hypertension: time for re-assessment","volume":"76","author":"Scorza","year":"2021","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.neurom.2022.12.012_bib24","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/cphy.c140076","article-title":"The insular cortex and the regulation of cardiac","volume":"6","author":"Oppenheimer","year":"2016","journal-title":"function. Compr Physiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib25","series-title":"Textbook of Epilepsy Surgery","first-page":"963","article-title":"General principles of cortical mapping by electrical stimulation","author":"L\u00fcders","year":"2008"},{"key":"10.1016\/j.neurom.2022.12.012_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/EJA.0000000000000136","article-title":"Comparison of a continuous noninvasive arterial pressure device with invasive measurements in cardiovascular postsurgical intensive care patients: a prospective observational study","volume":"32","author":"Ilies","year":"2015","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.compbiomed.2005.06.001","article-title":"Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement","volume":"36","author":"Fortin","year":"2006","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.neurom.2022.12.012_bib28","first-page":"17","article-title":"The crosstalk between autonomic nervous system and blood vessels","volume":"10","author":"Sheng","year":"2018","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.neurom.2022.12.012_bib29","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.clinph.2011.03.013","article-title":"Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula","volume":"122","author":"Pugnaghi","year":"2011","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1212\/WNL.0000000000001235","article-title":"On the origin of painful somatosensory seizures","volume":"84","author":"Montavont","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurom.2022.12.012_bib31","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/hc4501.099308","article-title":"Altered autonomic support of arterial blood pressure with age in healthy men","volume":"104","author":"Jones","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.neurom.2022.12.012_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pharma.2008.05.002","article-title":"Short-term variability of blood pressure: physiology and pharmacology","volume":"66","author":"Elghozi","year":"2008","journal-title":"Ann Pharm Fr"},{"key":"10.1016\/j.neurom.2022.12.012_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0014-2999(95)00721-0","article-title":"Contribution of the renin-angiotensin and kallikrein-kinin systems to short-term variability of blood pressure in two-kidney, one-clip hypertensive rats","volume":"297","author":"Ponchon","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neurom.2022.12.012_bib34","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/CIRCULATIONAHA.118.035628","article-title":"Heart, spleen, brain","volume":"138","author":"Carnevale","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.neurom.2022.12.012_bib35","first-page":"508","article-title":"The cardiovagal, cardiosympathetic and vasosympathetic arterial baroreflexes and the neural control of short-term blood pressure","volume":"59","author":"Robles-Cabrera","year":"2014","journal-title":"Rev Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib36","first-page":"69","article-title":"Cardiac arrhythmias during or after epileptic seizures","volume":"87","author":"van der Lende","year":"2016","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurom.2022.12.012_bib37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000114609","article-title":"Circulatory and respiratory changes in spontaneous epileptic seizures in man","volume":"12","author":"Magnaes","year":"1974","journal-title":"Eur Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib38","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1111\/epi.12251","article-title":"Significant postictal hypotension: expanding the spectrum of seizure-induced autonomic dysregulation","volume":"54","author":"Bozorgi","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurom.2022.12.012_bib39","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10571-015-0278-3","article-title":"Long-term treatment with losartan attenuates seizure activity and neuronal damage without affecting behavioral changes in a model of co-morbid hypertension and epilepsy","volume":"36","author":"Tchekalarova","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neurom.2022.12.012_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mcn.2015.02.014","article-title":"Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus","volume":"65","author":"Sun","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neurom.2022.12.012_bib41","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10072-019-03913-4","article-title":"Hypertension, seizures, and epilepsy: a review on pathophysiology and management","volume":"40","author":"Gasparini","year":"2019","journal-title":"Neurol Sci"},{"key":"10.1016\/j.neurom.2022.12.012_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.seizure.2019.07.002","article-title":"Epilepsy and ultra-structural heart changes: the role of catecholaminergic toxicity and myocardial fibrosis. What can we learn from cardiology?","volume":"71","author":"Fialho","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.neurom.2022.12.012_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/CIRCULATIONAHA.106.678995","article-title":"The brain-heart connection","volume":"116","author":"Samuels","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.neurom.2022.12.012_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/epi.14637","article-title":"Blood markers of cardiac stress after generalized convulsive seizures","volume":"60","author":"Nass","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurom.2022.12.012_bib45","first-page":"1300","article-title":"Impaired baroreflex function in temporal lobe epilepsy","volume":"253","author":"D\u00fctsch","year":"2006","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1212\/WNL.0b013e3182088108","article-title":"Deep brain stimulation relieves refractory hypertension","volume":"76","author":"Patel","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurom.2022.12.012_bib47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrneurol.2012.100","article-title":"The autonomic effects of deep brain stimulation--a therapeutic opportunity","volume":"8","author":"Hyam","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib48","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1291\/hypres.31.1851","article-title":"N-acetylaspartate\/creatine and choline\/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly","volume":"31","author":"Ben Salem","year":"2008","journal-title":"Hypertens Res"},{"key":"10.1016\/j.neurom.2022.12.012_bib49","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/ajh.2009.71","article-title":"Insular cortex atrophy as an independent determinant of disrupted diurnal rhythm of ambulatory blood pressure in elderly hypertension","volume":"22","author":"Nagai","year":"2009","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.neurom.2022.12.012_bib50","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/s41371-020-00476-2","article-title":"Brainstem network connectivity with mid-anterior insula predicts lower systolic blood pressure at rest in older adults with hypertension","volume":"35","author":"McIntosh","year":"2021","journal-title":"J\u00a0Hum Hypertens"},{"key":"10.1016\/j.neurom.2022.12.012_bib51","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1080\/02688697.2021.1888871","article-title":"Refractory hypotension in post-operative setting with raised intracranial pressure: insula at play?","volume":"37","author":"Sharma","year":"2023","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.neurom.2022.12.012_bib52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00001756-200402090-00029","article-title":"Lateralization in autonomic dysfunction in ischemic stroke involving the insular cortex","volume":"15","author":"Meyer","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.neurom.2022.12.012_bib53","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13156","article-title":"Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation","volume":"5","author":"Marins","year":"2017","journal-title":"Physiol Rep"},{"key":"10.1016\/j.neurom.2022.12.012_bib54","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S1474-4422(13)70214-X","article-title":"Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study","volume":"12","author":"Ryvlin","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurom.2022.12.012_bib55","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.seizure.2019.05.014","article-title":"SUDEP in Spain: an epilepsy Monitoring Unit based case series","volume":"69","author":"Sanchez-Larsen","year":"2019","journal-title":"Seizure"},{"key":"10.1016\/j.neurom.2022.12.012_bib56","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1212\/WNL.0b013e318258f7f1","article-title":"Autonomic changes with seizures correlate with postictal EEG suppression","volume":"78","author":"Poh","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurom.2022.12.012_bib57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ebcr.2017.06.005","article-title":"Post-ictal atrial fibrillation detected during video-EEG monitoring: case report, proposed physiopathologic mechanism and therapeutic considerations","volume":"8","author":"Sanchez-Larsen","year":"2017","journal-title":"Epilepsy Behav Case Rep"},{"key":"10.1016\/j.neurom.2022.12.012_bib58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/WNP.0000000000000147","article-title":"Postictal generalized EEG suppression and SUDEP: a review","volume":"32","author":"Rajakulendran","year":"2015","journal-title":"J\u00a0Clin Neurophysiol"}],"container-title":["Neuromodulation: Technology at the Neural Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715923000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715923000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:43:20Z","timestamp":1727934200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094715923000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1094715923000065"],"URL":"https:\/\/doi.org\/10.1016\/j.neurom.2022.12.012","relation":{},"ISSN":["1094-7159"],"issn-type":[{"value":"1094-7159","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insular Role in Blood Pressure and Systemic Vascular Resistance Regulation","name":"articletitle","label":"Article Title"},{"value":"Neuromodulation: Technology at the Neural Interface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurom.2022.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}