{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:52:23Z","timestamp":1782489143899,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["09150171910022"],"award-info":[{"award-number":["09150171910022"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"The Michael J Fox Foundation for Parkinson&apos;s Research","doi-asserted-by":"publisher","award":["MJFF-019718"],"award-info":[{"award-number":["MJFF-019718"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neuromodulationjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromodulation: Technology at the Neural Interface"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neurom.2026.04.012","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:03:58Z","timestamp":1777932238000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-Time Evaluation of Magnetoelectric Nanoparticle-Induced Neurostimulation in Ex Vivo Human Brain"],"prefix":"10.1016","author":[{"given":"Berkhan","family":"Genc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz A.M.","family":"Eggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Rijkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Milojkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Schijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dominguez-Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Dings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Temel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Kozielski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Jahanshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurom.2026.04.012_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/496159a","article-title":"A jump-start for electroceuticals","volume":"496","author":"Famm","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neurom.2026.04.012_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41582-018-0128-2","article-title":"Deep brain stimulation: current challenges and future directions","volume":"15","author":"Lozano","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurom.2026.04.012_bib3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/ner.13360","article-title":"Surgical and hardware complications of deep brain stimulation\u2014a single surgeon experience of 519 cases over 20 years","volume":"25","author":"Doshi","year":"2022","journal-title":"Neuromodulation: Technol Neural Interface"},{"key":"10.1016\/j.neurom.2026.04.012_bib4","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1038\/s41467-021-25837-4","article-title":"Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice","volume":"12","author":"Hescham","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurom.2026.04.012_bib5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nmeth.3536","article-title":"Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice","volume":"12","author":"Montgomery","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.neurom.2026.04.012_bib6","series-title":"2016 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems (BioWireleSS)","article-title":"A miniaturized ultrasonically powered programmable optogenetic implant stimulator system","author":"Weber","year":"2016"},{"key":"10.1016\/j.neurom.2026.04.012_bib7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1088\/0031-9155\/35\/8\/008","article-title":"The distribution of induced currents in magnetic stimulation of the nervous system","volume":"35","author":"Tofts","year":"1990","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.neurom.2026.04.012_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.rehab.2015.05.005","article-title":"Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS)","volume":"58","author":"Klomjai","year":"2015","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.neurom.2026.04.012_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brs.2012.02.005","article-title":"Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs","volume":"6","author":"Deng","year":"2013","journal-title":"Brain Stimul"},{"key":"10.1016\/j.neurom.2026.04.012_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/WNP.0b013e31802fa393","article-title":"Three-dimensional distribution of the electric field induced in the brain by transcranial magnetic stimulation using figure-8 and deep H-coils","volume":"24","author":"Roth","year":"2007","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.neurom.2026.04.012_bib11","doi-asserted-by":"crossref","first-page":"7678","DOI":"10.1021\/acsnano.5b03162","article-title":"Piezoelectric nanoparticle-assisted wireless neuronal stimulation","volume":"9","author":"Marino","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.neurom.2026.04.012_bib12","article-title":"Multiscale modeling of magnetoelectric nanoparticles for the analysis of spatially selective neural stimulation","volume":"13","author":"Kumari","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.neurom.2026.04.012_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4189","article-title":"Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice","volume":"7","author":"Kozielski","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.neurom.2026.04.012_bib14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.brs.2025.08.008","article-title":"Magnetoelectric nanoparticle technology for mitigating motor deficits in Parkinsonian mice","volume":"18","author":"Dominguez-Paredes","year":"2025","journal-title":"Brain Stimul"},{"key":"10.1016\/j.neurom.2026.04.012_bib15","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1093\/cercor\/bhv188","article-title":"Dendritic and axonal architecture of individual pyramidal neurons across layers of adult human neocortex","volume":"25","author":"Mohan","year":"2015","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neurom.2026.04.012_bib16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41593-018-0205-2","article-title":"Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type","volume":"21","author":"Boldog","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neurom.2026.04.012_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48417","article-title":"Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease","volume":"8","author":"Schwarz","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.neurom.2026.04.012_bib18","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/ae34e9","article-title":"Organotypic human brain slice cultures as a translational testing platform for novel neuromodulation devices","volume":"23","author":"Eggert","year":"2026","journal-title":"J Neural Eng"},{"key":"10.1016\/j.neurom.2026.04.012_bib19","doi-asserted-by":"crossref","first-page":"18453","DOI":"10.1073\/pnas.1112378108","article-title":"Astrocytic regulation of cortical UP states","volume":"108","author":"Poskanzer","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurom.2026.04.012_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.110055","article-title":"Human organotypic brain slice cultures: a detailed and improved protocol for preparation and long-term maintenance","volume":"404","author":"Bak","year":"2024","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neurom.2026.04.012_bib21","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.actamat.2009.09.054","article-title":"Synthesis and characterization of novel Co2Fe2O4-BaTiO3 multiferroic core-shell-type nanostructures","volume":"58","author":"Corral-Flores","year":"2010","journal-title":"Acta Mater"},{"key":"10.1016\/j.neurom.2026.04.012_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4939-1096-0_14","article-title":"Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics","volume":"1183","author":"Ting","year":"2014","journal-title":"Methods Mol Biol (Clifton N J)"},{"key":"10.1016\/j.neurom.2026.04.012_bib24","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3683","article-title":"Method for prolonged incubation of brain slices","volume":"10","author":"K\u00e9kesi","year":"2020","journal-title":"Bio-Protoc"},{"key":"10.1016\/j.neurom.2026.04.012_bib25","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.neurom.2026.04.012_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fncel.2018.00093","article-title":"Ionic mechanism underlying rebound depolarization in medial prefrontal cortex pyramidal neurons","volume":"12","author":"Kurowski","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neurom.2026.04.012_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.12717\/DR.2015.19.2.061","article-title":"A brief introduction to the transduction of neural activity into Fos signal","volume":"19(2)","author":"Chung","year":"2015","journal-title":"Dev Reprod"},{"key":"10.1016\/j.neurom.2026.04.012_bib28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.12688\/f1000research.51755.2","article-title":"Calcium imaging analysis \u2013 how far have we come?","volume":"10","author":"Robbins","year":"2021","journal-title":"F1000Research"},{"key":"10.1016\/j.neurom.2026.04.012_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/mcne.2000.0929","article-title":"Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors","volume":"17","author":"K\u00fcgler","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neurom.2026.04.012_bib30","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.cub.2012.06.007","article-title":"Dissection of cortical microcircuits by single-neuron stimulation in vivo","volume":"22","author":"Kwan","year":"2012","journal-title":"Curr Biol"},{"key":"10.1016\/j.neurom.2026.04.012_bib31","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1523\/JNEUROSCI.17-19-07404.1997","article-title":"All-or-none Ca2+ release from intracellular stores triggered by Ca2+ influx through voltage-gated Ca2+ channels in rat sensory neurons","volume":"17","author":"Usachev","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neurom.2026.04.012_bib32","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1089\/neu.2017.5029","article-title":"Mild blast injury produces acute changes in basal intracellular calcium levels and activity patterns in mouse hippocampal neurons","volume":"35","author":"Hansen","year":"2018","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.neurom.2026.04.012_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.843225","article-title":"Bradykinin-induced sensitization of transient receptor potential channel melastatin 3 calcium responses in mouse nociceptive neurons","volume":"16","author":"Behrendt","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neurom.2026.04.012_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121086","article-title":"Surfactants influence polymer nanoparticle fate within the brain","volume":"277","author":"Joseph","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.neurom.2026.04.012_bib35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jconrel.2017.07.028","article-title":"Strategies to enhance the distribution of nanotherapeutics in the brain","volume":"267","author":"Zhang","year":"2017","journal-title":"J Control Release"},{"key":"10.1016\/j.neurom.2026.04.012_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003594","article-title":"A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue","volume":"4","author":"Nance","year":"2012","journal-title":"Sci Transl Med"}],"container-title":["Neuromodulation: Technology at the Neural Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715926001108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715926001108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:32:11Z","timestamp":1782487931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094715926001108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":35,"alternative-id":["S1094715926001108"],"URL":"https:\/\/doi.org\/10.1016\/j.neurom.2026.04.012","relation":{},"ISSN":["1094-7159"],"issn-type":[{"value":"1094-7159","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-Time Evaluation of Magnetoelectric Nanoparticle-Induced Neurostimulation in Ex Vivo Human Brain","name":"articletitle","label":"Article Title"},{"value":"Neuromodulation: Technology at the Neural Interface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurom.2026.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the International Neuromodulation Society.","name":"copyright","label":"Copyright"}]}}