{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:08:17Z","timestamp":1792062497615,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2634,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.neuron.2006.03.023","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T06:24:57Z","timestamp":1146896697000},"page":"377-388","source":"Crossref","is-referenced-by-count":868,"title":["Pten Regulates Neuronal Arborization and Social Interaction in Mice"],"prefix":"10.1016","volume":"50","author":[{"given":"Chang-Hyuk","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan W.","family":"Luikart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Matheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Parada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2006.03.023_bib1","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/jnci\/91.22.1922","article-title":"Mutational spectra of PTEN\/MMAC1 gene: a tumor suppressor with lipid phosphatase activity","volume":"91","author":"Ali","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.neuron.2006.03.023_bib2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/cne.901820508","article-title":"A Golgi study of cell types in the hilar region of the hippocampus in the rat","volume":"182","author":"Amaral","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuron.2006.03.023_bib3","series-title":"Task Force on DMS-IV","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.neuron.2006.03.023_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0361-9230(01)00642-6","article-title":"Molecular genetics and animal models in autistic disorder","volume":"57","author":"Andres","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuron.2006.03.023_bib5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.57.7.1269","article-title":"Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction","volume":"57","author":"Asano","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2006.03.023_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ng782","article-title":"Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease","volume":"29","author":"Backman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrn1667","article-title":"From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome","volume":"6","author":"Bagni","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.neuro.27.070203.144137","article-title":"Autism: a window onto the development of the social and the analytic brain","volume":"28","author":"Baron-Cohen","year":"2005","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: a review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1098-1063(1997)7:3<307::AID-HIPO6>3.0.CO;2-H","article-title":"Distribution, ultrastructure, and connectivity of calretinin-immunoreactive mossy cells of the mouse dentate gyrus","volume":"7","author":"Blasco-Ibanez","year":"1997","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuron.2006.03.023_bib11","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/0008-5472.CAN-04-1170","article-title":"Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas","volume":"64","author":"Broderick","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuron.2006.03.023_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"Butler","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0736-5748(02)00053-9","article-title":"Structural and functional magnetic resonance imaging of autism","volume":"20","author":"Cody","year":"2002","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(02)00969-8","article-title":"Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways","volume":"110","author":"Crackower","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/mrdd.20039","article-title":"Designing mouse behavioral tasks relevant to autistic-like behaviors","volume":"10","author":"Crawley","year":"2004","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.neuron.2006.03.023_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2006.03.023_bib18","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1523\/JNEUROSCI.18-08-02933.1998","article-title":"Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons","volume":"18","author":"Crowder","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neuron.2005.10.018","article-title":"Vagaries of visual perception in autism","volume":"48","author":"Dakin","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2006.03.023_bib20","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1369\/jhc.4A6371.2004","article-title":"Immersion autometallography: histochemical in situ capturing of zinc ions in catalytic zinc-sulfur nanocrystals","volume":"52","author":"Danscher","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neuron.2006.03.023_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-6147(00)88973-7","article-title":"Use of the elevated plus maze in the search for novel anxiolytic agents","volume":"16","author":"Dawson","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuron.2006.03.023_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00787-005-0443-1","article-title":"Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous Sclerosis","volume":"14","author":"de Vries","year":"2005","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.neuron.2006.03.023_bib23","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/S0028-3908(00)00030-7","article-title":"Effects of strain and serotonergic agents on prepulse inhibition and habituation in mice","volume":"39","author":"Dulawa","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2006.03.023_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng1296","article-title":"Convergent evidence for impaired AKT1\u2013GSK3beta signaling in schizophrenia","volume":"36","author":"Emamian","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1023036509476","article-title":"Microcephaly and macrocephaly in autism","volume":"29","author":"Fombonne","year":"1999","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.neuron.2006.03.023_bib26","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1158\/0008-5472.CAN-04-2487","article-title":"Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo","volume":"64","author":"Fraser","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.neuron.2006.03.023_bib27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ajmg.1477","article-title":"PTEN mutation in a family with Cowden syndrome and autism","volume":"105","author":"Goffin","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib28","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1126\/science.1065518","article-title":"Negative regulation of neural stem\/progenitor cell proliferation by the Pten tumor suppressor gene in vivo","volume":"294","author":"Groszer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuron.2006.03.023_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ccr.2005.08.008","article-title":"The Akt-mTOR tango and its relevance to cancer","volume":"8","author":"Hay","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib30","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1523\/JNEUROSCI.2270-05.2005","article-title":"Control of dendritic arborization by the phosphoinositide-3\u2032-kinase-Akt-mammalian target of rapamycin pathway","volume":"25","author":"Jaworski","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib31","first-page":"123","article-title":"Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators","volume":"120","author":"Jiang","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib32","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1523\/JNEUROSCI.18-24-10420.1998","article-title":"p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons","volume":"18","author":"Klesse","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng781","article-title":"Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease","volume":"29","author":"Kwon","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib34","doi-asserted-by":"crossref","first-page":"12923","DOI":"10.1073\/pnas.2132711100","article-title":"mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo","volume":"100","author":"Kwon","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.03.023_bib35","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/gene.20197","article-title":"A neuron-specific enolase-cre line with cre activity in specific neuronal populations","volume":"44","author":"Kwon","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2006.03.023_bib36","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1242\/dev.129.17.4159","article-title":"Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland","volume":"129","author":"Li","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.neuron.2006.03.023_bib37","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0092-8674(00)80354-2","article-title":"Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1","volume":"90","author":"Lijam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0896-6273(01)00433-0","article-title":"A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala","volume":"31","author":"Lin","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2006.03.023_bib39","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1523\/JNEUROSCI.0041-05.2005","article-title":"TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses","volume":"25","author":"Luikart","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1535-6108(03)00248-4","article-title":"Targeting the PI3K-Akt pathway in human cancer: rationale and promise","volume":"4","author":"Luo","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib41","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","article-title":"The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate","volume":"273","author":"Maehama","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuron.2006.03.023_bib42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bst0310573","article-title":"United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase\/Akt pathway to mammalian target of rapamycin (mTOR) signalling","volume":"31","author":"Manning","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neuron.2006.03.023_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(02)00752-3","article-title":"Raf and akt mediate distinct aspects of sensory axon growth","volume":"35","author":"Markus","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2006.03.023_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajmg.b.20119","article-title":"Association between the neurofibromatosis-1 (NF1) locus and autism in the Japanese population","volume":"131","author":"Marui","year":"2004","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib45","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<729::AID-AJMG26>3.0.CO;2-Q","article-title":"Association study of the NF1 gene and autistic disorder","volume":"88","author":"Mbarek","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/hmg\/ddi016","article-title":"Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome","volume":"14","author":"Moretti","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuron.2006.03.023_bib48","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1542\/peds.113.5.e472","article-title":"The genetics of autism","volume":"113","author":"Muhle","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuron.2006.03.023_bib49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ijdevneu.2004.07.001","article-title":"A question of balance: a proposal for new mouse models of autism","volume":"23","author":"Murcia","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbrainres.2004.05.021","article-title":"Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development","volume":"128","author":"Perandones","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuron.2006.03.023_bib51","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0896-6273(04)00146-1","article-title":"The presynaptic active zone protein RIM1alpha is critical for normal learning and memory","volume":"42","author":"Powell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2006.03.023_bib52","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1523\/JNEUROSCI.1297-04.2004","article-title":"The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages","volume":"24","author":"Schumann","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.03.023_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresrev.2004.08.003","article-title":"Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents","volume":"48","author":"Shapiro","year":"2005","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuron.2006.03.023_bib54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib55","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ydbio.2004.06.008","article-title":"PTENless means more","volume":"273","author":"Stiles","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuron.2006.03.023_bib56","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1074-7613(01)00134-0","article-title":"T cell-specific loss of pten leads to defects in central and peripheral tolerance","volume":"14","author":"Suzuki","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2006.03.023_bib57","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1073\/pnas.012605299","article-title":"A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus","volume":"99","author":"Tang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.03.023_bib58","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1086\/340026","article-title":"Protean PTEN: form and function","volume":"70","author":"Waite","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2006.03.023_bib59","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/08830738040190090701","article-title":"Autism and tuberous sclerosis","volume":"19","author":"Wiznitzer","year":"2004","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.neuron.2006.03.023_bib60","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","article-title":"GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity","volume":"120","author":"Yoshimura","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0092-8674(03)00079-5","article-title":"The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses","volume":"112","author":"Zalfa","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2006.03.023_bib62","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1089071","article-title":"Postnatal neurodevelopmental disorders: meeting at the synapse?","volume":"302","author":"Zoghbi","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuron.2006.03.023_bib63","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-8628(19981204)80:4<399::AID-AJMG18>3.0.CO;2-O","article-title":"Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome","volume":"80","author":"Zori","year":"1998","journal-title":"Am. J. Med. Genet."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627306002200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627306002200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T15:45:22Z","timestamp":1627314322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627306002200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0896627306002200"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2006.03.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032383.374088","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1032383.373220","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1032383.388931","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}