{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:57:29Z","timestamp":1793271449469,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2517,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.neuron.2006.09.021","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T07:48:42Z","timestamp":1160034522000},"page":"77-92","source":"Crossref","is-referenced-by-count":1198,"title":["Mechanisms of Neuropathic Pain"],"prefix":"10.1016","volume":"52","author":[{"given":"James N.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2006.09.021_bib1","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1073\/pnas.1331358100","article-title":"Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2","volume":"100","author":"Abbadie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0306-4522(93)90551-P","article-title":"Mechanical hyperalgesia in streptozotocin-diabetic rats","volume":"52","author":"Ahlgren","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2006.09.021_bib3","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1523\/JNEUROSCI.0242-04.2004","article-title":"Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat","volume":"24","author":"Alessandri-Haber","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/jn.1999.81.2.455","article-title":"Uninjured C-fiber nociceptors develop spontaneous activity and alpha adrenergic sensitivity following L6 spinal nerve ligation in the monkey","volume":"81","author":"Ali","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3959(00)00327-4","article-title":"Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain","volume":"88","author":"Ali","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib6","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/jn.1999.81.3.1379","article-title":"Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury","volume":"81","author":"Allen","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-3959(90)90026-A","article-title":"Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies","volume":"43","author":"Arner","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1212\/WNL.53.3.548","article-title":"Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study","volume":"53","author":"Baron","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2006.09.021_bib9","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1073\/pnas.96.14.7739","article-title":"Distinct neurochemical features of acute and persistent pain","volume":"96","author":"Basbaum","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib10","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"361","article-title":"Measurrement and new technologies: rapporteur report","author":"Basbaum","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3940(98)00051-2","article-title":"Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal tansection in rats with nerve injury","volume":"241","author":"Bian","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2006.09.021_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2005.12.084","article-title":"Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice","volume":"1075","author":"Bian","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib14","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1152\/jn.1999.82.5.2776","article-title":"Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons","volume":"82","author":"Black","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0304-3959(84)90111-8","article-title":"Discharge pattern of afferent fibers from a neuroma","volume":"20","author":"Blumberg","year":"1984","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib16","series-title":"Wall and Melzack's Textbook of Pain","first-page":"1057","article-title":"Central pain","author":"Boivie","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-3959(89)90128-0","article-title":"Central post-stroke pain\u2013a study of the mechanisms through analyses of the sensory abnormalities","volume":"37","author":"Boivie","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/neu.20085","article-title":"Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease","volume":"61","author":"Borsook","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1471-4892(01)00010-8","article-title":"Neurotrophic factors and neuropathic pain","volume":"1","author":"Boucher","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neuron.2006.09.021_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.290.5489.124","article-title":"Potent analgesic effects of GDNF in neuropathic pain states","volume":"290","author":"Boucher","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuron.2006.09.021_bib21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cne.902960402","article-title":"Expression of C-fos-like protein as a marker for neuronal activity following nixious stimulation in the rat","volume":"296","author":"Bullitt","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib22","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3171\/jns.1993.78.5.0714","article-title":"The surgical treatment of painful traumatic neuromas","volume":"78","author":"Burchiel","year":"1993","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.neuron.2006.09.021_bib23","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1523\/JNEUROSCI.22-12-05129.2002","article-title":"Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain","volume":"22","author":"Burgess","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/mus.1143","article-title":"Nerve lesions and the generation of pain","volume":"24","author":"Campbell","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neuron.2006.09.021_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3959(88)90027-9","article-title":"Myelinated afferents signal the hyperalgesia associated with nerve injury","volume":"32","author":"Campbell","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3959(94)90090-6","article-title":"Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate","volume":"56","author":"Carlton","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/exnr.1999.7065","article-title":"The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior","volume":"157","author":"Colburn","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/archneur.1965.00460250076009","article-title":"Function of Posterior columns in man","volume":"12","author":"Cook","year":"1965","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib29","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/j.1432-1033.2004.04082.x","article-title":"Biochemical pharmacology of the vanilloid receptor TRPV1. An update","volume":"271","author":"Cortright","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuron.2006.09.021_bib30","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2006.09.021_bib31","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1523\/JNEUROSCI.2695-04.2004","article-title":"Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy","volume":"24","author":"Cummins","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(91)90174-V","article-title":"Sensory basis of autotomy in rats","volume":"45","author":"Devor","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib34","series-title":"Wall and Melzack's Textbook of Pain","first-page":"905","article-title":"Response of nerves to injury in relation to neuropathic pain","author":"Devor","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib35","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jpain.2005.09.006","article-title":"Sodium channels and mechanisms of neuropathic pain","volume":"7","author":"Devor","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainresrev.2004.07.015","article-title":"Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals","volume":"46","author":"Djouhri","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuron.2006.09.021_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00001756-200403010-00015","article-title":"Spinal nerve injury increases the percentage of cold-responsive DRG neurons","volume":"15","author":"Djouhri","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2006.09.021_bib38","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1523\/JNEUROSCI.3388-05.2006","article-title":"Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors","volume":"26","author":"Djouhri","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3940(00)01458-0","article-title":"Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats","volume":"292","author":"Dogrul","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuron.2006.09.021_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(03)00177-5","article-title":"Reversal of experimental neuropathic pain by T-type calcium channel blockers","volume":"105","author":"Dogrul","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0165-0173(93)90003-I","article-title":"Combined application of excitaory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons","volume":"18","author":"Dougherty","year":"1993","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuron.2006.09.021_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0079-6123(08)61792-6","article-title":"Release of neuropeptides in the spinal cord","volume":"104","author":"Duggan","year":"1995","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib43","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2337\/diacare.23.4.510","article-title":"Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group","volume":"23","author":"Dyck","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neuron.2006.09.021_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00002508-200201000-00006","article-title":"Microvascular decompression","volume":"18","author":"Elias","year":"2002","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0304-3959(00)00285-2","article-title":"Dorsal root section elicits signs of neuropathic pain rather than reversing them in rats with L5 spinal nerve injury","volume":"87","author":"Eschenfelder","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pain.2004.01.029","article-title":"Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy","volume":"109","author":"Flatters","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pain.2005.02.032","article-title":"Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens","volume":"115","author":"Freynhagen","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3959(98)00111-0","article-title":"Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model","volume":"78","author":"Fukuoka","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib49","series-title":"Progress in Pain Research and Management","first-page":"137","article-title":"The role of neighboring intact dorsal root ganglion neurons in a rat neuropathic pain model","author":"Fukuoka","year":"2000"},{"key":"10.1016\/j.neuron.2006.09.021_bib50","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1523\/JNEUROSCI.21-13-04891.2001","article-title":"Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model","volume":"21","author":"Fukuoka","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib51","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm944","article-title":"Multiple actions of systemic artemin in experimental neuropathy","volume":"9","author":"Gardell","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2006.09.021_bib52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3959(92)90259-E","article-title":"Painful neuropathy: altered central processing maintained dynamically by peripheral input","volume":"51","author":"Gracely","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib53","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"271","article-title":"The roles of growth factors in painful length-dependent axonal neuropathies","author":"Griffin","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib54","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/381793a0","article-title":"Synaptic strengthening through activation of Ca2+-permeable AMPA receptors","volume":"381","author":"Gu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2006.09.021_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0306-4522(96)00196-0","article-title":"Upregulation of spinal glutamate receptors in chronic pain","volume":"74","author":"Harris","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2006.09.021_bib56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/brain\/34.2-3.102","article-title":"Sensory disturbances from cerebral lesions","volume":"34","author":"Head","year":"1911","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2006.09.021_bib57","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib58","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1073\/pnas.1834309100","article-title":"Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS","volume":"100","author":"Ibrahim","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib59","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pharmthera.2005.07.001","article-title":"The function of microglia through purinergic receptors: Neuropathic pain and cytokine release","volume":"109","author":"Inoue","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuron.2006.09.021_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nbdi.2000.0360","article-title":"Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain","volume":"8","author":"Ji","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2006.09.021_bib61","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0165-5728(98)00027-7","article-title":"Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice","volume":"86","author":"Kanaan","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuron.2006.09.021_bib63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2006.01.031","article-title":"Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats","volume":"200","author":"Katsura","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib64","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1523\/JNEUROSCI.2396-04.2004","article-title":"Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization","volume":"24","author":"Kawasaki","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib65","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/jn.01136.2002","article-title":"Central origin of secondary mechanical hyperalgesia","volume":"90","author":"Klede","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib67","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneuroim.2003.12.013","article-title":"The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling","volume":"149","author":"Kleinschnitz","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuron.2006.09.021_bib68","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2005.05.035","article-title":"Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord","volume":"117","author":"Kohno","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib69","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/brain\/117.3.579","article-title":"Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain","volume":"117","author":"Koltzenburg","year":"1994","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2006.09.021_bib70","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jneumeth.2004.11.008","article-title":"Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat","volume":"144","author":"LaBuda","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuron.2006.09.021_bib71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/jn.1991.66.1.190","article-title":"Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms","volume":"66","author":"LaMotte","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib72","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jhsa.2003.08.016","article-title":"Silas Weir Mitchell, MD: the physician who discovered causalgia","volume":"29","author":"Lau","year":"2004","journal-title":"J. Hand Surg. [Am]"},{"key":"10.1016\/j.neuron.2006.09.021_bib73","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1523\/JNEUROSCI.2982-04.2004","article-title":"Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia","volume":"24","author":"Li","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib74","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0304-3959(00)00250-5","article-title":"Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers","volume":"85","author":"Li","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib75","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0304-3959(00)00251-7","article-title":"Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury","volume":"85","author":"Liu","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib76","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1523\/JNEUROSCI.2211-06.2006","article-title":"Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain","volume":"26","author":"Lopez-Santiago","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib77","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-8993(00)02451-3","article-title":"Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model","volume":"871","author":"Lyu","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib78","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0304-3959(97)00177-2","article-title":"Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans","volume":"74","author":"Magerl","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib79","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/brain\/124.9.1754","article-title":"Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia","volume":"124","author":"Magerl","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2006.09.021_bib80","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1111\/j.1460-9568.2004.03437.x","article-title":"Neural activation during experimental allodynia: a functional magnetic resonance imaging study","volume":"19","author":"Maihofner","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib81","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1212\/01.wnl.0000200961.49114.39","article-title":"Functional imaging of allodynia in complex regional pain syndrome","volume":"66","author":"Maihofner","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2006.09.021_bib82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1460-9568.2000.00946.x","article-title":"Abnormal substance P release from the spinal cord following injury to primary sensory neurons","volume":"12","author":"Malcangio","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib83","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"161","article-title":"The role of neuroimmune activation in chronic neuropathic pain and new targets for therapeutic intervention","author":"Manning","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib84","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib85","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/bja\/ael096","article-title":"Antinociceptive effects of tetrodotoxin (TTX) in rodents","volume":"96","author":"Marcil","year":"2006","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuron.2006.09.021_bib86","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3959(93)90100-4","article-title":"Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man","volume":"54","author":"Maves","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib87","series-title":"Wall and Melzack's Textbook of Pain","first-page":"3","article-title":"Peripheral mechanisms of cutaneous nociception","author":"Meyer","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib88","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1523\/JNEUROSCI.20-07-02742.2000","article-title":"Axotomized and intact muscle afferents but not skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion","volume":"20","author":"Michaelis","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib89","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1111\/j.1460-9568.2005.04470.x","article-title":"An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine","volume":"22","author":"Milligan","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib90","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroscience.2004.08.035","article-title":"T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats","volume":"129","author":"Moalem","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2006.09.021_bib91","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1523\/JNEUROSCI.22-15-06724.2002","article-title":"Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord","volume":"22","author":"Moore","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib92","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jnr.490370506","article-title":"Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons","volume":"37","author":"Noguchi","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib93","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/exnr.2001.7677","article-title":"Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain","volume":"169","author":"Okamoto","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib94","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1523\/JNEUROSCI.20-16-06289.2000","article-title":"Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin","volume":"20","author":"Opree","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib95","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1046\/j.0953-816x.2001.01596.x","article-title":"GFRalpha3 is expressed predominantly in nociceptive sensory neurons","volume":"13","author":"Orozco","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib96","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1523\/JNEUROSCI.22-22-09858.2002","article-title":"Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y","volume":"22","author":"Ossipov","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib97","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1523\/JNEUROSCI.3066-05.2005","article-title":"Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons","volume":"25","author":"Pertin","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib98","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(01)01315-2","article-title":"Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers","volume":"429","author":"Pertovaara","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2006.09.021_bib99","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1073\/pnas.96.14.7640","article-title":"A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3\/SNS and NaN\/SNS2, in rat models of chronic pain","volume":"96","author":"Porreca","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib100","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1523\/JNEUROSCI.21-14-05281.2001","article-title":"Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor","volume":"21","author":"Porreca","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib101","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00229858","article-title":"Mechanical sensitivity of regenerating myelinated skin and muscle afferents in the cat","volume":"104","author":"Proske","year":"1995","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib102","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0304-3959(03)00138-6","article-title":"Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines","volume":"104","author":"Raghavendra","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib103","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/00000542-199104000-00012","article-title":"Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain","volume":"74","author":"Raja","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuron.2006.09.021_bib104","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1523\/JNEUROSCI.13-12-05228.1993","article-title":"Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord","volume":"13","author":"Randic","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib105","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"87","article-title":"Does peripheral sensitization of primary afferents play a role in neuropathic pain?","author":"Ringkamp","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib106","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1073\/pnas.0602813103","article-title":"A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons","volume":"103","author":"Rush","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib107","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"193","article-title":"Signaling pathways in pain neuroplasticity in the\u00a0spinal dorsal horn","author":"Salter","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib108","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1126\/science.2011742","article-title":"Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury","volume":"251","author":"Sato","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.neuron.2006.09.021_bib109","series-title":"Wall and Melzack's Textbook of Pain","first-page":"973","article-title":"Painful peripheral neuropathies","author":"Scadding","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib110","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1523\/JNEUROSCI.23-07-03028.2003","article-title":"Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation","volume":"23","author":"Sch\u00e4fers","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib111","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury","volume":"25","author":"Scholz","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib112","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroimage.2006.03.024","article-title":"An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients","volume":"32","author":"Schweinhardt","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuron.2006.09.021_bib113","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib114","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0304-3959(01)00429-8","article-title":"Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat","volume":"96","author":"Sheth","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2004.12.036","article-title":"Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy","volume":"132","author":"Shim","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2006.09.021_bib116","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1152\/jn.1991.66.1.228","article-title":"Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons","volume":"66","author":"Simone","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib117","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(01)02743-3","article-title":"Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy","volume":"913","author":"Sommer","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib118","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0306-4522(97)00147-4","article-title":"Tumour necrosis factor-\u03b1 induces ectopic activity in nociceptive primary afferent fibres","volume":"81","author":"Sorkin","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2006.09.021_bib119","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1523\/JNEUROSCI.23-12-05031.2003","article-title":"A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain","volume":"23","author":"South","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(95)00110-E","article-title":"Reflex sympathetic dystrophy: changing concepts and taxonomy","volume":"63","author":"Stanton-Hicks","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib121","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1460-9568.2000.00922.x","article-title":"Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro","volume":"12","author":"Sugiura","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib122","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1090-3801(03)00086-7","article-title":"Key role of the dorsal root ganglion in neuropathic tactile hypersensibility","volume":"8","author":"Sukhotinsky","year":"2004","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib123","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3959(00)00392-4","article-title":"Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections","volume":"90","author":"Sun","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib124","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2005.06.015","article-title":"Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin","volume":"117","author":"Suzuki","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib125","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.0501634102","article-title":"The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy","volume":"102","author":"Tanga","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2006.09.021_bib126","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1523\/JNEUROSCI.22-15-06696.2002","article-title":"Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF","volume":"22","author":"Tofaris","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib127","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molbrainres.2005.02.003","article-title":"Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus","volume":"136","author":"Tomiyama","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neuron.2006.09.021_bib128","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.1992.sp019069","article-title":"Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans","volume":"448","author":"Torebj\u00f6rk","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib129","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia","volume":"38","author":"Treede","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib130","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jn.1998.80.3.1082","article-title":"Myelinated mechanically insensitive afferents from monkey hairy skin: heat-response properties","volume":"80","author":"Treede","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2006.09.021_bib131","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/01.ajp.0000169673.57062.40","article-title":"A randomized, double-masked, placebo-controlled pilot trial of extended IV lidocaine infusion for relief of ongoing neuropathic pain","volume":"22","author":"Tremont-Lukats","year":"2006","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib132","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u201csmall\u201d glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib133","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0304-3959(00)00456-5","article-title":"Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia","volume":"91","author":"Tsuzuki","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib134","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"475","article-title":"Animal studies of pain: lessons for drug development","author":"Vierck","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib135","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0304-3959(99)00129-3","article-title":"Effects of combined hemotoxic and anterolateral spinal lesions on nociceptive sensitivity","volume":"83","author":"Vierck","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib136","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1097\/00001756-199611250-00018","article-title":"Endoneurial injection of TNF-alpha produces neuropathic pain behaviors","volume":"7","author":"Wagner","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2006.09.021_bib137","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2796.2004.01443.x","article-title":"Immune regulation of central nervous system functions: from sickness responses to pathological pain","volume":"257","author":"Watkins","year":"2005","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neuron.2006.09.021_bib138","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.molmed.2005.10.004","article-title":"Erythermalgia: molecular basis for an inherited pain syndrome","volume":"11","author":"Waxman","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuron.2006.09.021_bib139","series-title":"Emerging Strategies for the Treatment of Neuropathic Pain","first-page":"105","article-title":"Central nervous system targets: rapporteur report","author":"Willis","year":"2006"},{"key":"10.1016\/j.neuron.2006.09.021_bib140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2005.11.011","article-title":"Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice","volume":"120","author":"Wolf","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib141","first-page":"255","article-title":"Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro","volume":"83","author":"Woolf","year":"1988","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.neuron.2006.09.021_bib142","doi-asserted-by":"crossref","first-page":"RC140","DOI":"10.1523\/JNEUROSCI.21-08-j0002.2001","article-title":"Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers","volume":"21","author":"Wu","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib143","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1523\/JNEUROSCI.22-17-07746.2002","article-title":"Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents","volume":"22","author":"Wu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2006.09.021_bib144","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pain.2006.03.011","article-title":"The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat","volume":"123","author":"Xu","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2006.09.021_bib145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/cne.20899","article-title":"Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury","volume":"495","author":"Yen","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuron.2006.09.021_bib146","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neures.2006.04.015","article-title":"Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain","volume":"56","author":"Yoshimura","year":"2006","journal-title":"Neurosci. Res."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627306007288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627306007288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T09:40:16Z","timestamp":1555839616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627306007288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":146,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0896627306007288"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2006.09.021","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}