{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:53:04Z","timestamp":1791334384290,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2055,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000297","name":"FRAXA Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.neuron.2007.12.001","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T11:51:07Z","timestamp":1198237867000},"page":"955-962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":869,"title":["Correction of Fragile X Syndrome in Mice"],"prefix":"10.1016","volume":"56","author":[{"given":"G\u00fcl","family":"D\u00f6len","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Osterweil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.S. Shankaranarayana","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumantra","family":"Chattarji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Bear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2007.12.001_bib1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/sj.npp.1301610","article-title":"Fragile X: Translation in action","volume":"33","author":"Bear","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2007.12.001_bib3","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1100\/tsw.2006.220","article-title":"Fmr1 KO mice as a possible model of autistic features","volume":"6","author":"Bernardet","year":"2006","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.neuron.2007.12.001_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1196\/annals.1327.031","article-title":"The phylogenetic relationship of the glutamate and pheromone G-protein-coupled receptors in different vertebrate species","volume":"1040","author":"Bjarnadottir","year":"2005","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.neuron.2007.12.001_bib5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0092-8674(01)00568-2","article-title":"Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome","volume":"107","author":"Brown","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2007.12.001_bib6","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1523\/JNEUROSCI.1777-05.2005","article-title":"Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model","volume":"25","author":"Chuang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.2573152","article-title":"A biochemical correlate of the critical period for synaptic modification in the visual cortex","volume":"246","author":"Dudek","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.neuron.2007.12.001_bib8","first-page":"23","article-title":"Fmr1 knockout mice: A model to study fragile X mental retardation","volume":"78","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2007.12.001_bib9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.neuron.2004.12.003","article-title":"How monocular deprivation shifts ocular dominance in visual cortex of young mice","volume":"44","author":"Frenkel","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib10","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1523\/JNEUROSCI.1790-06.2006","article-title":"Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond","volume":"26","author":"Grossman","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2004.05.003","article-title":"Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice","volume":"42","author":"Hayashi","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/syn.10261","article-title":"Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo","volume":"50","author":"Heidbreder","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.neuron.2007.12.001_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.neuron.2006.07.005","article-title":"Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression","volume":"51","author":"Hou","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib14","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.288.5469.1254","article-title":"Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression","volume":"288","author":"Huber","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuron.2007.12.001_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/jn.2001.86.1.321","article-title":"Chemical induction of mGluR5- and protein synthesis-dependent long-term depression in hippocampal area CA1","volume":"86","author":"Huber","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2007.12.001_bib16","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1073\/pnas.122205699","article-title":"Altered synaptic plasticity in a mouse model of fragile X mental retardation","volume":"99","author":"Huber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2007.12.001_bib17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1101\/lm.5.4.331","article-title":"Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5","volume":"5","author":"Jia","year":"1998","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuron.2007.12.001_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1152\/jn.2001.86.1.280","article-title":"Induction of long-term depression in cerebellar Purkinje cells requires a rapidly turned over protein","volume":"86","author":"Karachot","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2007.12.001_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neuron.2005.07.005","article-title":"Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome","volume":"47","author":"Koekkoek","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1527-3458.2006.00149.x","article-title":"Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP","volume":"12","author":"Lea","year":"2006","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.neuron.2007.12.001_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ajmg.1320580311","article-title":"Growth in stature in fragile X families: A mixed longitudinal study","volume":"58","author":"Loesch","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neuron.2007.12.001_bib22","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997","article-title":"Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP","volume":"17","author":"Lu","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neuron.2005.01.038","article-title":"Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome","volume":"45","author":"McBride","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/jn.1998.80.2.989","article-title":"Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges","volume":"80","author":"Merlin","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2007.12.001_bib25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/hmg\/9.8.1145","article-title":"(Over)correction of FMR1 deficiency with YAC transgenics: Behavioral and physical features","volume":"9","author":"Peier","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2007.12.001_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1101\/lm.91206","article-title":"Anisomycin infused into the hippocampus fails to block \u201creconsolidation\u201d but impairs extinction: The role of re-exposure duration","volume":"13","author":"Power","year":"2006","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neuron.2007.12.001_bib27","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1523\/JNEUROSCI.0093-05.2005","article-title":"Postadolescent changes in regional cerebral protein synthesis: An in vivo study in the FMR1 null mouse","volume":"25","author":"Qin","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1523\/JNEUROSCI.20-03-00969.2000","article-title":"Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation","volume":"20","author":"Raymond","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2007.12.001_bib29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-2999(80)90149-1","article-title":"Audiogenic seizures: Increased benzodiazepin receptor binding in a susceptible strain of mice","volume":"66","author":"Robertson","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2007.12.001_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1677\/joe.0.1700071","article-title":"Expression of metabotropic glutamate receptors in the rat and human testis","volume":"170","author":"Storto","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neuron.2007.12.001_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0896-6273(02)00673-6","article-title":"Rapid ocular dominance plasticity requires cortical but not geniculate protein synthesis","volume":"34","author":"Taha","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2007.12.001_bib32","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1093\/hmg\/ddl422","article-title":"Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome","volume":"15","author":"Tucker","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2007.12.001_bib33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1073\/pnas.032681099","article-title":"Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons","volume":"99","author":"Vanderklish","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2007.12.001_bib34","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1073\/pnas.90.15.7168","article-title":"Metabotropic glutamate receptors trigger postsynaptic protein synthesis","volume":"90","author":"Weiler","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2007.12.001_bib35","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"Whitlock","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2007.12.001_bib36","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.neuropharm.2005.06.004","article-title":"Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP","volume":"49","author":"Yan","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuron.2007.12.001_bib37","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1523\/JNEUROSCI.22-20-08838.2002","article-title":"The group I metabotropic glutamate receptor agonist (S)-3,5-dihydroxyphenylglycine induces a novel form of depotentiation in the CA1 region of the hippocampus","volume":"22","author":"Zho","year":"2002","journal-title":"J. Neurosci."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627307009646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627307009646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:44:34Z","timestamp":1760251474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627307009646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0896627307009646"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2007.12.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1097486.553559","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correction of Fragile X Syndrome in Mice","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2007.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}