{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:20:06Z","timestamp":1791300006444,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1568,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.neuron.2009.03.007","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T04:16:22Z","timestamp":1239855382000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":327,"title":["Pathway Interactions and Synaptic Plasticity in the Dendritic Tuft Regions of CA1 Pyramidal Neurons"],"prefix":"10.1016","volume":"62","author":[{"given":"Hiroto","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Magee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2009.03.007_bib1","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1523\/JNEUROSCI.2992-05.2005","article-title":"Hippocampal CA1 circuitry dynamically gates direct cortical inputs preferentially at theta frequencies","volume":"25","author":"Ang","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2009.03.007_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(03)02084-3","article-title":"SNX482 selectively blocks P\/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells","volume":"475","author":"Arroyo","year":"2003","journal-title":"European J. Pharm."},{"key":"10.1016\/j.neuron.2009.03.007_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/cne.903600111","article-title":"Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: I. Branching patterns","volume":"360","author":"Bannister","year":"1995","journal-title":"J\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2009.03.007_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cne.903600112","article-title":"Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: II. Spine distributions","volume":"360","author":"Bannister","year":"1995","journal-title":"J\u00a0Comp. Neurol."},{"key":"10.1016\/j.neuron.2009.03.007_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuron.2007.11.034","article-title":"Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex","volume":"57","author":"Brun","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.03.007_bib6","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1152\/jn.1995.73.6.2553","article-title":"Different Ca2+ channels in soma and dendrites of hippocampal pyramidal neurons mediate spike-induced Ca2+ influx","volume":"73","author":"Christie","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.1992.68.1.1","article-title":"Electrophysiological and pharmacological characterization of perforant path synapses in CA1: mediation by glutamate receptors","volume":"68","author":"Colbert","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.290.5492.812","article-title":"Song replay during sleep and computational rules for sensorimotor vocal learning","volume":"290","author":"Dave","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.03.007_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0006-8993(85)91584-7","article-title":"Perforant pathway-evoked long-term potentiation of CA1 neurons in the hippocampal slice preparation","volume":"333","author":"Doller","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2009.03.007_bib10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.neuron.2007.10.020","article-title":"A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity","volume":"56","author":"Dudman","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.03.007_bib11","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1152\/jn.1999.82.6.3213","article-title":"Patterned activity in stratum lacunosum moleculare inhibits CA1 pyramidal neuron firing","volume":"82","author":"Dvorak-Carbone","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/exnr.2001.7713","article-title":"The effect of interburst intervals on measures of hippocampal LTP in the freely moving adult male rat","volume":"170","author":"Fortin","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2009.03.007_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature00854","article-title":"Dendritic spikes as a mechanism for cooperative long-term potentiation","volume":"418","author":"Golding","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.03.007_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0896-6273(01)00447-0","article-title":"Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells","volume":"32","author":"Harris","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.03.007_bib15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.neunet.2005.08.007","article-title":"Hippocampal mechanisms for the context-dependent retrieval of episodes","volume":"18","author":"Hasselmo","year":"2005","journal-title":"Neural Netw."},{"key":"10.1016\/j.neuron.2009.03.007_bib16","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/nn1599","article-title":"Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons","volume":"8","author":"Jarsky","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2009.03.007_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1113\/jphysiol.2003.058842","article-title":"Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity","volume":"556","author":"Kampa","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/08990229970528","article-title":"Anatomical loops and\u00a0their electrical dynamics in relation to whisking by rat","volume":"16","author":"Kleinfeld","year":"1999","journal-title":"Somatosens. Mot.\u00a0Res."},{"key":"10.1016\/j.neuron.2009.03.007_bib19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/18686","article-title":"A new cellular mechanism for coupling inputs arriving at different cortical layers","volume":"398","author":"Larkum","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.03.007_bib20","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1523\/JNEUROSCI.2650-06.2006","article-title":"Learning rules for spike timing-dependent plasticity depend on dendritic synapse location","volume":"26","author":"Letzkus","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2009.03.007_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","article-title":"The hippocampal-VTA loop: controlling the entry of information into long-term memory","volume":"46","author":"Lisman","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.03.007_bib22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature06725","article-title":"Compartmentalized dendritic plasticity and input feature storage in neurons","volume":"452","author":"Losonczy","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.03.007_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/jphysiol.1995.sp020862","article-title":"Characterization of single voltage-gated sodium and calcium channels in the apical dendrites of rat CA1 pyramidal neurons","volume":"487","author":"Magee","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1126\/science.275.5297.209","article-title":"A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons","volume":"275","author":"Magee","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.03.007_bib25","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1152\/jn.1999.82.4.1895","article-title":"Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons","volume":"82","author":"Magee","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib26","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0306-4522(00)00496-6","article-title":"Total number and\u00a0distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells","volume":"102","author":"Megias","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2009.03.007_bib27","first-page":"69","article-title":"Cooperative LTP can map memory sequences on dendritic branches","volume":"27","author":"Mehta","year":"2004","journal-title":"TINS"},{"key":"10.1016\/j.neuron.2009.03.007_bib28","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1152\/jn.00941.2003","article-title":"Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent","volume":"91","author":"Otmakhov","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib29","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1152\/jn.1999.81.5.2103","article-title":"Modulation of inhibitory synaptic potentials in the piriform cortex","volume":"81","author":"Patil","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2006.04.019","article-title":"The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons","volume":"50","author":"Perez-Garci","year":"2006","journal-title":"Neuron"},{"issue":"Pt\u00a02","key":"10.1016\/j.neuron.2009.03.007_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1469-7793.1999.0571p.x","article-title":"Rapid report: postsynaptic bursting is essential for \u201cHebbian\u201d induction of associative long-term potentiation at excitatory synapses in rat hippocampus","volume":"518","author":"Pike","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib32","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/416736a","article-title":"Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons","volume":"416","author":"Remondes","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.03.007_bib33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1469-7793.1997.605ba.x","article-title":"Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons","volume":"505","author":"Schiller","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1113\/jphysiol.2002.020677","article-title":"Cav2.3 Ca2+ channel subunit contributes to R-type Ca2+ currents in murine hippocampal and neocortical neurons","volume":"542","author":"Sochivko","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1113\/jphysiol.1995.sp020521","article-title":"Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons","volume":"482","author":"Spruston","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuron.2009.03.007_bib36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/cne.901690306","article-title":"Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat","volume":"169","author":"Steward","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuron.2009.03.007_bib37","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1523\/JNEUROSCI.18-18-07118.1998","article-title":"Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation","volume":"18","author":"Thomas","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2009.03.007_bib38","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.neuron.2007.11.015","article-title":"HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons","volume":"56","author":"Tsay","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.03.007_bib39","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1126\/science.1061198","article-title":"Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons","volume":"293","author":"Wei","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.03.007_bib40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1748-1716.1986.tb07822.x","article-title":"Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracellularly injected depolarizing current pulses","volume":"126","author":"Wigstrom","year":"1986","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.neuron.2009.03.007_bib41","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1073\/pnas.87.15.5832","article-title":"Feedforward excitation of the hippocampus by afferents fromthe entorhinal cortex: redefinition of the role of the trisynaptic pathway","volume":"87","author":"Yeckel","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627309002062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627309002062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:50:08Z","timestamp":1760251808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627309002062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0896627309002062"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2009.03.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13378961.14748062","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathway Interactions and Synaptic Plasticity in the Dendritic Tuft Regions of CA1 Pyramidal Neurons","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2009.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}