{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:16:09Z","timestamp":1793042169601,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1477,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS056217"],"award-info":[{"award-number":["NS056217"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["MH082441-02"],"award-info":[{"award-number":["MH082441-02"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["GM008719"],"award-info":[{"award-number":["GM008719"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["GM07040-34"],"award-info":[{"award-number":["GM07040-34"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["HD040127"],"award-info":[{"award-number":["HD040127"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM074554"],"award-info":[{"award-number":["GM074554"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM007250"],"award-info":[{"award-number":["GM007250"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS060326"],"award-info":[{"award-number":["NS060326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD03110"],"award-info":[{"award-number":["HD03110"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NS049534"],"award-info":[{"award-number":["NS049534"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.neuron.2009.06.014","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T04:09:37Z","timestamp":1247717377000},"page":"27-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":968,"title":["Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors"],"prefix":"10.1016","volume":"63","author":[{"given":"Georgia M.","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Rogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atheir I.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine N.","family":"Armbruster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Nonneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl S.","family":"Moy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Nicolelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan L.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2009.06.014_bib1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nature07926","article-title":"Temporally precise in\u00a0vivo control of intracellular signalling","volume":"458","author":"Airan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.06.014_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nmeth.1190","article-title":"Genetic control of neuronal activity in mice conditionally expressing TRPV1","volume":"5","author":"Arenkiel","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2009.06.014_bib3","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.0700293104","article-title":"Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand","volume":"104","author":"Armbruster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2009.06.014_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0969-8051(94)90080-9","article-title":"Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice","volume":"21","author":"Bender","year":"1994","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.neuron.2009.06.014_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nn.2247","article-title":"Bi-stable neural state switches","volume":"12","author":"Berndt","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.279.5349.403","article-title":"A potassium channel mutation in neonatal human epilepsy","volume":"279","author":"Biervert","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.06.014_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-4886(03)00086-4","article-title":"Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model","volume":"182","author":"Borges","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2009.06.014_bib9","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nn1525","article-title":"Millisecond-timescale, genetically targeted optical control of neural activity","volume":"8","author":"Boyden","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0079-6107(00)00004-3","article-title":"Modulation and genetic identification of the M channel","volume":"73","author":"Brown","year":"2000","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.neuron.2009.06.014_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nature08002","article-title":"Driving fast-spiking cells induces gamma rhythm and controls sensory responses","volume":"459","author":"Cardin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.06.014_bib12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nmeth.1232","article-title":"Engineering GPCR signaling pathways with RASSLs","volume":"5","author":"Conklin","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2009.06.014_bib13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/28179","article-title":"Cholinergic induction of network oscillations at 40 Hz in the hippocampus in\u00a0vitro","volume":"394","author":"Fisahn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.06.014_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.bi.61.070192.003015","article-title":"Neuronal Ca2+\/calmodulin-dependent protein kinases","volume":"61","author":"Hanson","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neuron.2009.06.014_bib15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nn887","article-title":"Single granule cells reliably discharge targets in the hippocampal CA3 network in\u00a0vivo","volume":"5","author":"Henze","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib16","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1073\/pnas.0707457105","article-title":"Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass","volume":"105","author":"Hsiao","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2009.06.014_bib17","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1523\/JNEUROSCI.22-13-05287.2002","article-title":"A genetic method for selective and quickly reversible silencing of Mammalian neurons","volume":"22","author":"Lechner","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib18","doi-asserted-by":"crossref","first-page":"17816","DOI":"10.1073\/pnas.0509030102","article-title":"Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2009.06.014_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuron.2008.01.002","article-title":"Genetic dissection of neural circuits","volume":"57","author":"Luo","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.06.014_bib20","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.274.5293.1678","article-title":"Control of memory formation through regulated expression of a CaMKII transgene","volume":"274","author":"Mayford","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.06.014_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-2697(80)90515-1","article-title":"Ligand: a versatile computerized approach for characterization of ligand-binding systems","volume":"107","author":"Munson","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuron.2009.06.014_bib22","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1124\/mol.108.049353","article-title":"New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug)","volume":"74","author":"Nawaratne","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuron.2009.06.014_bib23","first-page":"313","article-title":"Engineered GPCRs as tools to modulate signal transduction","volume":"23","author":"Pei","year":"2008","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.neuron.2009.06.014_bib24","series-title":"Epilepsy and the Functional Anatomy of the Human Brain","author":"Penfield","year":"1954"},{"key":"10.1016\/j.neuron.2009.06.014_bib25","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/en.2007-0235","article-title":"Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia","volume":"149","author":"Peng","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuron.2009.06.014_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.neuron.2009.06.014_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/6165","article-title":"Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice","volume":"17","author":"Redfern","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neuron.2009.06.014_bib28","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.97.9.4826","article-title":"Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy","volume":"97","author":"Redfern","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2009.06.014_bib29","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0165-6147(00)01743-0","article-title":"Engineering receptors activated solely by synthetic ligands (RASSLs)","volume":"22","author":"Scearce-Levie","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuron.2009.06.014_bib30","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1523\/JNEUROSCI.4565-06.2007","article-title":"Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes","volume":"27","author":"Sweger","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuron.2006.06.018","article-title":"Selective and quickly reversible inactivation of mammalian neurons in\u00a0vivo using the Drosophila allatostatin receptor","volume":"51","author":"Tan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.06.014_bib32","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1126\/science.282.5395.1890","article-title":"KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel","volume":"282","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.06.014_bib33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0896-6273(03)00125-9","article-title":"PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents","volume":"37","author":"Zhang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.06.014_bib34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature05744","article-title":"Multimodal fast optical interrogation of neural circuitry","volume":"446","author":"Zhang","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.06.014_bib35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nn.2120","article-title":"Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri","volume":"11","author":"Zhang","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2009.06.014_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(03)00844-4","article-title":"The receptors for mammalian sweet and umami taste","volume":"115","author":"Zhao","year":"2003","journal-title":"Cell"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662730900467X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662730900467X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:31:49Z","timestamp":1778700709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089662730900467X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S089662730900467X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2009.06.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1700956.1207054","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2009.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}