{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:14:26Z","timestamp":1760253266302,"version":"build-2065373602"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1446,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.neuron.2009.07.024","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T04:36:27Z","timestamp":1250138187000},"page":"277-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["IGF-1: Elixir for Motor Neuron Diseases"],"prefix":"10.1016","volume":"63","author":[{"given":"Theodora","family":"Papanikolaou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2009.07.024_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1471-4159.1999.0720185.x","volume":"72","author":"Ellerby","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuron.2009.07.024_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1023\/A:1005344403603","volume":"20","author":"Fischbeck","year":"1997","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neuron.2009.07.024_bib3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1212\/WNL.36.12.1595","volume":"36","author":"Fischbeck","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2009.07.024_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mce.2008.04.020","volume":"291","author":"Kaczmarek","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neuron.2009.07.024_bib5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neuron.2009.07.024_bib6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0896-6273(02)00834-6","volume":"35","author":"Katsuno","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.07.024_bib7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nm878","volume":"9","author":"Katsuno","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2009.07.024_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1212\/WNL.18.7.671","volume":"18","author":"Kennedy","year":"1968","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2009.07.024_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/352077a0","volume":"352","author":"La Spada","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2009.07.024_bib10","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/hmg\/9.14.2197","volume":"9","author":"McCampbell","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2009.07.024_bib11","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/hmg\/ddp115","volume":"18","author":"Montie","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2009.07.024_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuron.2009.07.019","volume":"63","author":"Palazzolo","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.07.024_bib13","first-page":"909","volume":"11","author":"Sobue","year":"2003","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.neuron.2009.07.024_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/brain\/112.1.209","volume":"112","author":"Sobue","year":"1989","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2009.07.024_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0896-6273(04)00082-0","volume":"41","author":"Sopher","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2009.07.024_bib16","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1001\/archneur.59.12.1921","volume":"59","author":"Sperfeld","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuron.2009.07.024_bib17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0896-6273(02)00875-9","volume":"35","author":"Takeyama","year":"2002","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627309005510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627309005510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:51:06Z","timestamp":1760251866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627309005510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0896627309005510"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2009.07.024","relation":{},"ISSN":["0896-6273"],"issn-type":[{"type":"print","value":"0896-6273"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF-1: Elixir for Motor Neuron Diseases","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2009.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2009.07.019","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}