{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:44:37Z","timestamp":1792201477308,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1020,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["HEALTH-F2-2007-202167"],"award-info":[{"award-number":["HEALTH-F2-2007-202167"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BFU2007-064764"],"award-info":[{"award-number":["BFU2007-064764"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.neuron.2010.08.043","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T04:21:45Z","timestamp":1286425305000},"page":"113-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":466,"title":["Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes"],"prefix":"10.1016","volume":"68","author":[{"given":"Marta","family":"Navarrete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Araque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2010.08.043_bib1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1184821","article-title":"Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling","volume":"327","author":"Agulhon","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2010.08.043_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0301-0082(02)00080-1","article-title":"Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids","volume":"68","author":"Alger","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2010.08.043_bib3","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1046\/j.1460-9568.1998.00221.x","article-title":"Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons","volume":"10","author":"Araque","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.physiol.63.1.795","article-title":"Dynamic signaling between astrocytes and neurons","volume":"63","author":"Araque","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuron.2010.08.043_bib6","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1523\/JNEUROSCI.22-07-02443.2002","article-title":"Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices","volume":"22","author":"Araque","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib7","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1126\/science.1067859","article-title":"Control of synaptic strength by glial TNFalpha","volume":"295","author":"Beattie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuron.2010.08.043_bib8","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1523\/JNEUROSCI.0613-06.2006","article-title":"Brief bursts of parallel fiber activity trigger calcium signals in bergmann glia","volume":"26","author":"Beierlein","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib9","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.neuron.2007.11.014","article-title":"Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids","volume":"56","author":"Cachope","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0896-6273(03)00235-6","article-title":"Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability","volume":"38","author":"Chevaleyre","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib11","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2004.08.036","article-title":"Endocannabinoid-mediated metaplasticity in the hippocampus","volume":"43","author":"Chevaleyre","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.neuro.29.051605.112834","article-title":"Endocannabinoid-mediated synaptic plasticity in the CNS","volume":"29","author":"Chevaleyre","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","article-title":"Pharmacology and functions of metabotropic glutamate receptors","volume":"37","author":"Conn","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuron.2010.08.043_bib14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2010.08.043_bib15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0896-6273(00)80338-4","article-title":"Heterogeneity of release probability, facilitation, and depletion at central synapses","volume":"18","author":"Dobrunz","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib16","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1523\/JNEUROSCI.22-16-06885.2002","article-title":"Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression","volume":"22","author":"Faas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib17","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2010.08.043_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/1073858406296716","article-title":"Endocannabinoids and synaptic function in the CNS","volume":"13","author":"Hashimotodani","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuron.2010.08.043_bib19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1152\/physrev.00049.2005","article-title":"Astrocyte control of synaptic transmission and neurovascular coupling","volume":"86","author":"Haydon","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2010.08.043_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.physiol.010908.163149","article-title":"Endocannabinoid signaling and long-term synaptic plasticity","volume":"71","author":"Heifets","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuron.2010.08.043_bib21","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.93.16.8710","article-title":"Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells","volume":"93","author":"Isaac","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2010.08.043_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nn1849","article-title":"Glutamate exocytosis from astrocytes controls synaptic strength","volume":"10","author":"Jourdain","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/3684","article-title":"Astrocyte-mediated potentiation of inhibitory synaptic transmission","volume":"1","author":"Kang","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2010.08.043_bib25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0896-6273(01)00246-X","article-title":"Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells","volume":"29","author":"Kreitzer","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0959-4388(02)00328-8","article-title":"Retrograde signaling by endocannabinoids","volume":"12","author":"Kreitzer","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2010.08.043_bib27","doi-asserted-by":"crossref","first-page":"12664","DOI":"10.1523\/JNEUROSCI.3174-07.2007","article-title":"Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling","volume":"27","author":"Kyriakatos","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/978-3-540-74805-2_14","article-title":"Presynaptic modulation by endocannabinoids","volume":"184","author":"Lovinger","year":"2008","journal-title":"Handb Exp. Pharmacol."},{"key":"10.1016\/j.neuron.2010.08.043_bib29","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1073\/pnas.89.9.3825","article-title":"Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells","volume":"89","author":"Mackie","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2010.08.043_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tins.2006.01.008","article-title":"Involvement of the endocannabinoid system in drug addiction","volume":"29","author":"Maldonado","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib31","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1523\/JNEUROSCI.22-19-08379.2002","article-title":"Group I metabotropic glutamate receptor signaling via Galpha q\/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1","volume":"22","author":"Miura","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2008.01.029","article-title":"Endocannabinoids mediate neuron-astrocyte communication","volume":"58","author":"Navarrete","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tins.2003.08.008","article-title":"New roles for astrocytes: redefining the functional architecture of the brain","volume":"26","author":"Nedergaard","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib34","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1152\/jn.00268.2001","article-title":"Hippocampal astrocytes in\u00a0situ exhibit calcium oscillations that occur independent of neuronal activity","volume":"87","author":"Nett","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuron.2010.08.043_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0896-6273(01)00247-1","article-title":"Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals","volume":"29","author":"Ohno-Shosaku","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib36","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1523\/JNEUROSCI.22-10-03864.2002","article-title":"Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses","volume":"22","author":"Ohno-Shosaku","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/90507","article-title":"Spontaneous astrocytic Ca2+ oscillations in\u00a0situ drive NMDAR-mediated neuronal excitation","volume":"4","author":"Parri","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib38","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1523\/JNEUROSCI.3965-04.2005","article-title":"Properties of synaptically evoked astrocyte\u00a0calcium signal reveal synaptic information processing by astrocytes","volume":"25","author":"Perea","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib39","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1144640","article-title":"Astrocytes potentiate transmitter release at single hippocampal synapses","volume":"317","author":"Perea","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neuron.2010.08.043_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib42","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1523\/JNEUROSCI.16-16-05073.1996","article-title":"Hippocampal astrocytes in\u00a0situ respond to glutamate released from synaptic terminals","volume":"16","author":"Porter","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib43","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/j.1460-9568.1995.tb00709.x","article-title":"Extracellular activation of unitary excitatory synapses between hippocampal CA3 and CA1 pyramidal cells","volume":"7","author":"Raastad","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib44","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0896-6273(00)80665-0","article-title":"Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization","volume":"21","author":"Rodr\u00edguez-Moreno","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2010.08.043_bib45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.febslet.2004.09.053","article-title":"Dual signaling by mGluR5a results in bi-directional modulation of N-type Ca2+ channels","volume":"57","author":"S\u00e1nchez-Prieto","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2010.08.043_bib46","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1523\/JNEUROSCI.5255-05.2006","article-title":"GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression","volume":"26","author":"Serrano","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib47","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1523\/JNEUROSCI.1717-08.2008","article-title":"Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons","volume":"28","author":"Shigetomi","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/glia.20084","article-title":"Cannabinoid signaling in glial cells","volume":"48","author":"Stella","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.neuron.2010.08.043_bib48","series-title":"Synaptic Transmission","first-page":"164","article-title":"The Tripartite Synapse: Glia","author":"Volterra","year":"2002"},{"key":"10.1016\/j.neuron.2010.08.043_bib49","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: the revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2010.08.043_bib50","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/35069076","article-title":"Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses","volume":"410","author":"Wilson","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2010.08.043_bib51","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","article-title":"Endocannabinoid signaling in the brain","volume":"296","author":"Wilson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuron.2010.08.043_bib52","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","article-title":"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice","volume":"96","author":"Zimmer","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627310006860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627310006860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:54:25Z","timestamp":1760252065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627310006860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0896627310006860"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2010.08.043","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2010.08.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}