{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:24:03Z","timestamp":1791275043572,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":381,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.neuron.2014.11.007","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T16:26:09Z","timestamp":1417019169000},"page":"1302-1316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects"],"prefix":"10.1016","volume":"84","author":[{"given":"Ping","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana\u00a0V.","family":"Lipina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence\u00a0K.Y.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frankie\u00a0H.F.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen\u00a0S.G.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0N.","family":"Nobrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert\u00a0H.C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0C.","family":"Roder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u00a0J.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2014.11.007_bib1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/sj.npp.1301242","article-title":"Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response\u2014a double-blind PET study in schizophrenia","volume":"32","author":"Agid","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuron.2014.11.007_bib2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.biopsych.2004.11.036","article-title":"Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum","volume":"57","author":"Alimohamad","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2014.11.007_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1503\/jpn.110011","article-title":"A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health","volume":"37","author":"Beaulieu","year":"2012","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tips.2007.02.006","article-title":"The Akt-GSK-3 signaling cascade in the actions of dopamine","volume":"28","author":"Beaulieu","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuron.2014.11.007_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","article-title":"Akt\/GSK3 signaling in the action of psychotropic drugs","volume":"49","author":"Beaulieu","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuron.2014.11.007_bib6","doi-asserted-by":"crossref","first-page":"32672","DOI":"10.1074\/jbc.M002780200","article-title":"Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch","volume":"275","author":"Bofill-Cardona","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2014.11.007_bib7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrn3120","article-title":"Linking neurodevelopmental and synaptic theories of mental illness through DISC1","volume":"12","author":"Brandon","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2007.04.015","article-title":"Behavioral phenotypes of Disc1 missense mutations in mice","volume":"54","author":"Clapcote","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbr.2011.01.025","article-title":"Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats","volume":"219","author":"Creed-Carson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuron.2014.11.007_bib10","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2007.07.010","article-title":"Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain","volume":"130","author":"Duan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2014.11.007_bib11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2009.08.015","article-title":"Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus","volume":"63","author":"Enomoto","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib12","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.pnpbp.2007.08.025","article-title":"The amphetamine-induced sensitized state as a model of schizophrenia","volume":"31","author":"Featherstone","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2014.11.007_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12035-011-8227-8","article-title":"Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop","volume":"45","author":"Fukunaga","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuron.2014.11.007_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/092986712803414259","article-title":"GPCR heteromers and their allosteric receptor-receptor interactions","volume":"19","author":"Fuxe","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuron.2014.11.007_bib15","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/bmj.321.7273.1371","article-title":"Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis","volume":"321","author":"Geddes","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.neuron.2014.11.007_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s002130100811","article-title":"Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review","volume":"156","author":"Geyer","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neuron.2014.11.007_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.pharmtox.48.113006.094830","article-title":"Regulation of GPCRs by endocytic membrane trafficking and its potential implications","volume":"48","author":"Hanyaloglu","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuron.2014.11.007_bib18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1086\/425586","article-title":"Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder","volume":"75","author":"Hodgkinson","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2014.11.007_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.mp.4001777","article-title":"Cure therapeutics and strategic prevention: raising the bar for mental health research","volume":"11","author":"Insel","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2014.11.007_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature09859","article-title":"DISC1-dependent switch from progenitor proliferation to migration in the developing cortex","volume":"473","author":"Ishizuka","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2014.11.007_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.neuron.2011.09.032","article-title":"Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia","volume":"72","author":"Kang","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2006.01.023","article-title":"Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning","volume":"49","author":"Kellendonk","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuron.2009.08.008","article-title":"DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib24","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cell.2011.12.037","article-title":"Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia","volume":"148","author":"Kim","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2014.11.007_bib25","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1073\/pnas.0802615105","article-title":"A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition","volume":"105","author":"Kvajo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2014.11.007_bib26","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1073\/pnas.93.17.9235","article-title":"Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects","volume":"93","author":"Laruelle","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2014.11.007_bib27","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/sj.emboj.7601656","article-title":"Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2014.11.007_bib28","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1523\/JNEUROSCI.4219-10.2011","article-title":"Disc1 point mutations in mice affect development of the cerebral cortex","volume":"31","author":"Lee","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(08)61764-X","article-title":"Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis","volume":"373","author":"Leucht","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.neuron.2014.11.007_bib30","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"Lieberman","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2014.11.007_bib31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cell.2008.12.044","article-title":"Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta\/beta-catenin signaling","volume":"136","author":"Mao","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2014.11.007_bib32","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1126\/science.1112915","article-title":"DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling","volume":"310","author":"Millar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuron.2014.11.007_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"Missale","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2014.11.007_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.neuro.23.1.185","article-title":"Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens","volume":"23","author":"Nicola","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neuron.2010.01.019","article-title":"Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits","volume":"65","author":"Niwa","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2005.05.031","article-title":"Par-4 links dopamine signaling and depression","volume":"122","author":"Park","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2014.11.007_bib37","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/nm.2263","article-title":"Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects","volume":"16","author":"Pei","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2014.11.007_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.mp.4002079","article-title":"Inducible expression of mutant human Dros. Inf. Serv.C1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia","volume":"13","author":"Pletnikov","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2014.11.007_bib39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molmed.2011.09.002","article-title":"DISC1 at 10: connecting psychiatric genetics and neuroscience","volume":"17","author":"Porteous","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuron.2014.11.007_bib40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1124\/jpet.104.074468","article-title":"Dopamine D1 and D2 agonist effects on prepulse inhibition and locomotion: comparison of Sprague-Dawley rats to Swiss-Webster, 129X1\/SvJ, C57BL\/6J, and DBA\/2J mice","volume":"312","author":"Ralph","year":"2005","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuron.2014.11.007_bib41","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/261717a0","article-title":"Antipsychotic drug doses and neuroleptic\/dopamine receptors","volume":"261","author":"Seeman","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2014.11.007_bib42","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1523\/JNEUROSCI.3299-08.2008","article-title":"Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1","volume":"28","author":"Shen","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0361-9230(99)00036-2","article-title":"Amphetamine dose dependently disrupts prepulse inhibition of the acoustic startle response in rats within a narrow time window","volume":"48","author":"Sills","year":"1999","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuron.2014.11.007_bib44","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuron.2010.02.014","article-title":"A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia","volume":"65","author":"Simpson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2010.06.002","article-title":"Dixdc1 is a critical regulator of DISC1 and embryonic cortical development","volume":"67","author":"Singh","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2014.11.007_bib46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2007.03.008","article-title":"D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons","volume":"30","author":"Surmeier","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2014.11.007_bib47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0888-7543(02)00026-5","article-title":"Evolutionary constraints on the Disrupted in Schizophrenia locus","volume":"81","author":"Taylor","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.neuron.2014.11.007_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0920-9964(99)00192-9","article-title":"The stanley foundation brain collection and neuropathology consortium","volume":"44","author":"Torrey","year":"2000","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neuron.2014.11.007_bib49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.nbd.2013.01.013","article-title":"Disruption of the GluR2\/GAPDH complex protects against ischemia-induced neuronal damage","volume":"54","author":"Zhai","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2014.11.007_bib50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2012.12.033","article-title":"mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons","volume":"77","author":"Zhou","year":"2013","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627314010071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627314010071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T17:41:03Z","timestamp":1566063663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627314010071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0896627314010071"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2014.11.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725251618.793502241","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2014.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}