{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:45:23Z","timestamp":1793069123433,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":385,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.neuron.2015.03.060","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T18:18:35Z","timestamp":1430590715000},"page":"1000-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"title":["Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics"],"prefix":"10.1016","volume":"86","author":[{"given":"Stephane","family":"Belin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homaira","family":"Nawabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Latremoliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schorle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Uncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford J.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2015.03.060_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nn1195","article-title":"The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats","volume":"7","author":"Bareyre","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib2","doi-asserted-by":"crossref","first-page":"7517","DOI":"10.1073\/pnas.1120684109","article-title":"Kr\u00fcppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract","volume":"109","author":"Blackmore","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.03.060_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrn3176","article-title":"Assembly of a new growth cone after axotomy: the precursor to axon regeneration","volume":"13","author":"Bradke","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib4","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001","article-title":"Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate","volume":"21","author":"Cai","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-59745-562-6_4","article-title":"Neuroproteomic methods in spinal cord injury","volume":"566","author":"Chen","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuron.2015.03.060_bib6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.neuron.2011.07.009","article-title":"Axon regeneration pathways identified by systematic genetic screening in C.\u00a0elegans","volume":"71","author":"Chen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.03.060_bib7","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/j.1460-9568.2005.04066.x","article-title":"The ability of\u00a0axons to regenerate their growth cones depends on axonal type and age,\u00a0and is regulated by calcium, cAMP and ERK","volume":"21","author":"Chierzi","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2202-3-16","article-title":"Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury","volume":"3","author":"Costigan","year":"2002","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib10","doi-asserted-by":"crossref","first-page":"a014217","DOI":"10.1101\/cshperspect.a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"Dang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neuron.2015.03.060_bib11","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","article-title":"Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors","volume":"109","author":"de Lima","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.03.060_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth1036","article-title":"Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain","volume":"4","author":"Dodt","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2015.03.060_bib13","doi-asserted-by":"crossref","first-page":"e54462","DOI":"10.1371\/journal.pone.0054462","article-title":"The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons","volume":"8","author":"Dupraz","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2015.03.060_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1089\/neu.2006.23.371","article-title":"Overcoming inhibition in the damaged spinal cord","volume":"23","author":"Fawcett","year":"2006","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.neuron.2015.03.060_bib15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS","volume":"4","author":"Filbin","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib16","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","article-title":"Switching mature retinal ganglion cells to a robust growth state in\u00a0vivo: gene expression and synergy with RhoA inactivation","volume":"24","author":"Fischer","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib17","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1523\/JNEUROSCI.5464-09.2010","article-title":"Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase","volume":"30","author":"Ghosh-Roy","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib18","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0896-6273(02)00602-5","article-title":"Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity","volume":"33","author":"Goldberg","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.03.060_bib19","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1068428","article-title":"Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells","volume":"296","author":"Goldberg","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.03.060_bib20","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1021\/pr070291b","article-title":"iTRAQ reagent-based quantitative proteomic analysis on a linear ion trap mass spectrometer","volume":"6","author":"Griffin","year":"2007","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neuron.2015.03.060_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neuron.2015.03.060_bib22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.1165527","article-title":"Axon regeneration requires a conserved MAP kinase pathway","volume":"323","author":"Hammarlund","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.03.060_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2013.07.012","article-title":"Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion","volume":"1538","author":"Harel","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2015.03.060_bib24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn2699","article-title":"Experience-dependent structural synaptic plasticity in the mammalian brain","volume":"10","author":"Holtmaat","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib25","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1042\/BST20130041","article-title":"A growing role for mTOR in promoting anabolic metabolism","volume":"41","author":"Howell","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neuron.2015.03.060_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/gene.20014","article-title":"Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre\/loxP recombination and tamoxifen-mediated activation","volume":"38","author":"J\u00e4ger","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2015.03.060_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature13302","article-title":"A draft map of the human proteome","volume":"509","author":"Kim","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.03.060_bib28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2015.03.060_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2012.08.026","article-title":"Transcriptional amplification in tumor cells with elevated c-Myc","volume":"151","author":"Lin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2015.03.060_bib30","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn.2603","article-title":"PTEN deletion enhances the regenerative ability of adult corticospinal neurons","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.expneurol.2013.03.001","article-title":"Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury","volume":"247","author":"Luo","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.03.060_bib32","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/pr2004055","article-title":"Quantitative iTRAQ analysis of retinal ganglion cell degeneration after optic nerve crush","volume":"10","author":"Magharious","year":"2011","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neuron.2015.03.060_bib33","doi-asserted-by":"crossref","first-page":"ra53","DOI":"10.1126\/scisignal.2000952","article-title":"Signaling to transcription networks in the neuronal retrograde injury response","volume":"3","author":"Michaelevski","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2015.03.060_bib34","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1175737","article-title":"KLF family members regulate intrinsic axon regeneration ability","volume":"326","author":"Moore","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.03.060_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1101\/gad.542510","article-title":"A midline switch of receptor processing regulates commissural axon guidance in vertebrates","volume":"24","author":"Nawabi","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2015.03.060_bib36","doi-asserted-by":"crossref","first-page":"11716","DOI":"10.1073\/pnas.89.24.11716","article-title":"Insulin-like growth factor II stimulates motor nerve regeneration","volume":"89","author":"Near","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.03.060_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","article-title":"c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells","volume":"151","author":"Nie","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2015.03.060_bib38","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.03.060_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature12204","article-title":"RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1","volume":"498","author":"Park","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.03.060_bib40","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/35067570","article-title":"Plasticity of motor systems after incomplete spinal cord injury","volume":"2","author":"Raineteau","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib41","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/nn.2691","article-title":"Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury","volume":"13","author":"Rosenzweig","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2006.12.001","article-title":"Regulation of intrinsic neuronal properties for axon growth and regeneration","volume":"81","author":"Rossi","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2015.03.060_bib43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cbpa.2009.10.042","article-title":"Activating transcription factor 3 (ATF3) expression in the neural retina and optic nerve of zebrafish during optic nerve regeneration","volume":"155","author":"Saul","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.neuron.2015.03.060_bib44","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nature04869","article-title":"Ras, PI(3)K and mTOR signalling controls tumour cell growth","volume":"441","author":"Shaw","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.03.060_bib45","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in\u00a0vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.03.060_bib46","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1021\/pr070308q","article-title":"Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma","volume":"6","author":"Staab","year":"2007","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neuron.2015.03.060_bib47","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.03.060_bib48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/neu.1016","article-title":"RISK-1: a novel MAPK homologue in axoplasm that is activated and retrogradely transported after nerve injury","volume":"47","author":"Sung","year":"2001","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.neuron.2015.03.060_bib49","doi-asserted-by":"crossref","first-page":"9675","DOI":"10.1523\/JNEUROSCI.23-29-09675.2003","article-title":"Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth","volume":"23","author":"Tanabe","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib50","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"Thompson","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.neuron.2015.03.060_bib51","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuroscience.2005.11.065","article-title":"Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin","volume":"139","author":"Toth","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2015.03.060_bib52","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.1217416","article-title":"Restoring voluntary control of locomotion after paralyzing spinal cord injury","volume":"336","author":"van den Brand","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.03.060_bib53","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1211074110","article-title":"DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury","volume":"110","author":"Watkins","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.03.060_bib54","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature13319","article-title":"Mass-spectrometry-based draft of the human proteome","volume":"509","author":"Wilhelm","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.03.060_bib55","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/ncb2877","article-title":"Crosstalk between mTOR complexes","volume":"15","author":"Xie","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2015.03.060_bib56","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1523\/JNEUROSCI.5174-09.2010","article-title":"Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2","volume":"30","author":"Zhu","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.03.060_bib57","doi-asserted-by":"crossref","first-page":"15350","DOI":"10.1523\/JNEUROSCI.2510-13.2013","article-title":"Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury","volume":"33","author":"Zukor","year":"2013","journal-title":"J.\u00a0Neurosci."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627315002846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627315002846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T09:22:36Z","timestamp":1566638556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627315002846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0896627315002846"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2015.03.060","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2015.03.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}