{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:08Z","timestamp":1790661068021,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":383,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.neuron.2015.09.050","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T08:01:56Z","timestamp":1446537716000},"page":"720-734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"title":["Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1\u03b1"],"prefix":"10.1016","volume":"88","author":[{"given":"Yongcheol","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u00a0Eun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric\u00a0Edward","family":"Ewan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u00a0Mi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Pita-Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2015.09.050_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/MCB.22.1.12-22.2002","article-title":"c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription","volume":"22","author":"Alfranca","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2015.09.050_bib2","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.09.050_bib3","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1523\/JNEUROSCI.22-14-06239.2002","article-title":"Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis","volume":"22","author":"Baker-Herman","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nn1166","article-title":"BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia","volume":"7","author":"Baker-Herman","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-0082(00)00011-3","article-title":"Mechanisms underlying hypoxia-induced neuronal apoptosis","volume":"62","author":"Banasiak","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib6","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib7","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1093\/nar\/gkp425","article-title":"An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia","volume":"37","author":"Benita","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2015.09.050_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-398309-1.00004-4","article-title":"Molecular control of axon growth: insights from comparative gene profiling and high-throughput screening","volume":"105","author":"Blackmore","year":"2012","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrn3176","article-title":"Assembly of a new growth cone after axotomy: the precursor to axon regeneration","volume":"13","author":"Bradke","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/exnr.1997.6665","article-title":"c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy","volume":"148","author":"Broude","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib11","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00018-013-1283-7","article-title":"VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration","volume":"70","author":"Carmeliet","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuron.2015.09.050_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/MCB.20.1.402-415.2000","article-title":"Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha","volume":"20","author":"Carrero","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2015.09.050_bib13","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1038\/emboj.2012.160","article-title":"HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration","volume":"31","author":"Cho","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2015.09.050_bib14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2013.10.004","article-title":"Injury-induced HDAC5 nuclear export is essential for axon regeneration","volume":"155","author":"Cho","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2015.09.050_bib15","doi-asserted-by":"crossref","first-page":"e1000994","DOI":"10.1371\/journal.pgen.1000994","article-title":"Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia","volume":"6","author":"Dekanty","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2015.09.050_bib16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1517\/14728220903307517","article-title":"Molecular targets for axon regeneration: focus on the intrinsic pathways","volume":"13","author":"Di Giovanni","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.neuron.2015.09.050_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.devcel.2009.11.008","article-title":"The role of hypoxia in development of the Mammalian embryo","volume":"17","author":"Dunwoodie","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2015.09.050_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s12017-014-8329-3","article-title":"Spinal cord injury and the neuron-intrinsic regeneration-associated gene program","volume":"16","author":"Fagoe","year":"2014","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.neuron.2015.09.050_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.09.050_bib20","doi-asserted-by":"crossref","first-page":"e96137","DOI":"10.1371\/journal.pone.0096137","article-title":"Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury","volume":"9","author":"Figley","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2015.09.050_bib21","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1523\/JNEUROSCI.0589-13.2013","article-title":"Epigenetic regulation of sensory axon regeneration after spinal cord injury","volume":"33","author":"Finelli","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib22","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2015.09.050_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI119133","article-title":"Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes","volume":"99","author":"Goldberg","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2015.09.050_bib24","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.00235.2015","article-title":"Intermittent hypoxia and neurorehabilitation","author":"Gonzalez-Rothi","year":"2015","journal-title":"J.\u00a0App. Physiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1046\/j.1471-4159.1999.0730665.x","article-title":"Hypoxia induces selective SAPK\/JNK-2-AP-1 pathway activation in the nucleus tractus solitarii of the conscious rat","volume":"73","author":"Gozal","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2015.09.050_bib26","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1038\/sj.onc.1208513","article-title":"HIF-1alpha, STAT3, CBP\/p300 and Ref-1\/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas","volume":"24","author":"Gray","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.neuron.2015.09.050_bib27","doi-asserted-by":"crossref","first-page":"14404","DOI":"10.1523\/JNEUROSCI.4908-07.2007","article-title":"Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene","volume":"27","author":"Hasegawa","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1212\/01.WNL.0000437416.34298.43","article-title":"Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial","volume":"82","author":"Hayes","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2015.09.050_bib29","first-page":"591","article-title":"VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy","volume":"197","author":"Hobson","year":"2000","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.neuron.2015.09.050_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2009.09.006","article-title":"A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons","volume":"223","author":"Hoffman","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib31","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.expneurol.2014.08.002","article-title":"A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF","volume":"261","author":"Hoyng","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1096\/fj.05-5086com","article-title":"Calcium signaling stimulates translation of HIF-alpha during hypoxia","volume":"20","author":"Hui","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.neuron.2015.09.050_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.201303066","article-title":"JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis","volume":"202","author":"Huntwork-Rodriguez","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2015.09.050_bib34","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1523\/JNEUROSCI.4539-14.2015","article-title":"Intermittent hypoxia-induced spinal inflammation impairs respiratory motor plasticity by a spinal p38 MAP kinase-dependent mechanism","volume":"35","author":"Huxtable","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib35","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1093\/emboj\/17.22.6573","article-title":"Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP\/p300 coactivator by the hypoxia-inducible factor-1alpha","volume":"17","author":"Kallio","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2015.09.050_bib36","doi-asserted-by":"crossref","first-page":"41966","DOI":"10.1074\/jbc.M406320200","article-title":"Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity","volume":"279","author":"Kato","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2015.09.050_bib37","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1349-7006.2007.00535.x","article-title":"Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia","volume":"98","author":"Lee","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.neuron.2015.09.050_bib38","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/sj.cdd.4402315","article-title":"Turn me on: regulating HIF transcriptional activity","volume":"15","author":"Lisy","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuron.2015.09.050_bib39","doi-asserted-by":"crossref","first-page":"37064","DOI":"10.1074\/jbc.M705015200","article-title":"Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization","volume":"282","author":"Liu","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2015.09.050_bib40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.nbd.2009.10.018","article-title":"An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury","volume":"37","author":"Liu","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2015.09.050_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","article-title":"Neuronal intrinsic mechanisms of axon regeneration","volume":"34","author":"Liu","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib42","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1523\/JNEUROSCI.2908-11.2012","article-title":"Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury","volume":"32","author":"Lovett-Barr","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.conb.2014.03.007","article-title":"Signaling regulations of neuronal regenerative ability","volume":"27","author":"Lu","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib44","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1113\/jphysiol.2009.176982","article-title":"Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism","volume":"587","author":"MacFarlane","year":"2009","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1242\/dev.072348","article-title":"Diverse roles for VEGF-A in the nervous system","volume":"139","author":"Mackenzie","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.neuron.2015.09.050_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archneur.1973.00490250071008","article-title":"Axon outgrowth enhanced by a previous nerve injury","volume":"29","author":"McQuarrie","year":"1973","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib47","doi-asserted-by":"crossref","first-page":"ra53","DOI":"10.1126\/scisignal.2000952","article-title":"Signaling to transcription networks in the neuronal retrograde injury response","volume":"3","author":"Michaelevski","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2015.09.050_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nn.2290","article-title":"A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration","volume":"12","author":"Miller","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib49","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/dneu.20934","article-title":"Multiple transcription factor families regulate axon growth and regeneration","volume":"71","author":"Moore","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib50","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1175737","article-title":"KLF family members regulate intrinsic axon regeneration ability","volume":"326","author":"Moore","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2015.09.050_bib51","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jcp.10176","article-title":"Role of ERK and calcium in the hypoxia-induced activation of HIF-1","volume":"194","author":"Mottet","year":"2003","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib52","doi-asserted-by":"crossref","first-page":"R1181","DOI":"10.1152\/ajpregu.00208.2014","article-title":"Therapeutic potential of intermittent hypoxia: a matter of dose","volume":"307","author":"Navarrete-Opazo","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2015.02.007","article-title":"Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury","volume":"266","author":"Navarrete-Opazo","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0896-6273(00)80755-2","article-title":"Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury","volume":"23","author":"Neumann","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.09.050_bib55","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.3859-13.2014","article-title":"Axon regeneration genes identified by RNAi screening in C. elegans","volume":"34","author":"Nix","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib56","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1074\/jbc.M110.150557","article-title":"Hypoxia-inducible factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter","volume":"286","author":"Oh","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2015.09.050_bib57","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/nar\/gkp1205","article-title":"Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in\u00a0silico binding site prediction","volume":"38","author":"Ortiz-Barahona","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuron.2015.09.050_bib58","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.cellsig.2013.05.018","article-title":"Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response","volume":"25","author":"Pawlus","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.neuron.2015.09.050_bib59","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1365-2990.2011.01159.x","article-title":"Enhancement of sciatic nerve regeneration after vascular endothelial growth factor (VEGF) gene therapy","volume":"37","author":"Pereira Lopes","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib60","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.3390\/ijms12074705","article-title":"Epigenetics: new questions on the response to hypoxia","volume":"12","author":"Perez-Perri","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuron.2015.09.050_bib61","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/ncomms4527","article-title":"PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system","volume":"5","author":"Puttagunta","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2015.09.050_bib62","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/309791a0","article-title":"Peripheral injury enhances central regeneration of primary sensory neurones","volume":"309","author":"Richardson","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2015.09.050_bib63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4161\/org.6.2.11687","article-title":"VEGF in the nervous system","volume":"6","author":"Rosenstein","year":"2010","journal-title":"Organogenesis"},{"key":"10.1016\/j.neuron.2015.09.050_bib64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.semcdb.2005.04.001","article-title":"Hypoxia-dependent activation of HIF into a transcriptional regulator","volume":"16","author":"Ruas","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuron.2015.09.050_bib65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physrev.00031.2008","article-title":"Role and therapeutic potential of VEGF in the nervous system","volume":"89","author":"Ruiz de Almodovar","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2015.09.050_bib66","doi-asserted-by":"crossref","first-page":"24333","DOI":"10.1074\/jbc.272.39.24333","article-title":"A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1","volume":"272","author":"Saras","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2015.09.050_bib67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.expneurol.2012.05.020","article-title":"Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus","volume":"237","author":"Satriotomo","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib68","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1046\/j.1460-9568.2000.00005.x","article-title":"Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)","volume":"12","author":"Schwaiger","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib69","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.febslet.2008.11.044","article-title":"Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1","volume":"583","author":"Seo","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neuron.2015.09.050_bib70","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2012.04.028","article-title":"Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration","volume":"74","author":"Shin","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2015.09.050_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2013.11.007","article-title":"Dynamic regulation of SCG10 in regenerating axons after injury","volume":"252","author":"Shin","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuron.2015.09.050_bib72","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1523\/JNEUROSCI.17-02-00646.1997","article-title":"A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth","volume":"17","author":"Smith","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib73","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-8993(99)02056-9","article-title":"Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts","volume":"846","author":"Sondell","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2015.09.050_bib74","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1046\/j.0953-816X.2000.01326.x","article-title":"Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor","volume":"12","author":"Sondell","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2015.09.050_bib75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1545968311412055","article-title":"Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury","volume":"26","author":"Trumbower","year":"2012","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.neuron.2015.09.050_bib76","doi-asserted-by":"crossref","DOI":"10.3791\/2899","article-title":"Induction and testing of hypoxia in cell culture","author":"Wu","year":"2011","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.neuron.2015.09.050_bib77","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.tibs.2008.08.002","article-title":"HIF-1 regulation: not so easy come, easy go","volume":"33","author":"Yee Koh","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.neuron.2015.09.050_bib78","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2014.04.052","article-title":"Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis","volume":"158","author":"Yuen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2015.09.050_bib79","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1152\/japplphysiol.00829.2003","article-title":"Whole-body hypoxic preconditioning protects mice against acute hypoxia by improving lung function","volume":"96","author":"Zhang","year":"2004","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.neuron.2015.09.050_bib80","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1073\/pnas.0914725107","article-title":"Deletion of PIK3C3\/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway","volume":"107","author":"Zhou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2015.09.050_bib81","doi-asserted-by":"crossref","first-page":"7116","DOI":"10.1523\/JNEUROSCI.5397-08.2009","article-title":"Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons","volume":"29","author":"Zou","year":"2009","journal-title":"J.\u00a0Neurosci."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627315008399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627315008399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T06:24:15Z","timestamp":1567319055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627315008399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0896627315008399"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2015.09.050","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1\u03b1","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2015.09.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}