{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:24Z","timestamp":1790834184009,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K99NS089824"],"award-info":[{"award-number":["1K99NS089824"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS057819"],"award-info":[{"award-number":["5R01NS057819"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["1 U54 HD083092"],"award-info":[{"award-number":["1 U54 HD083092"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016499","name":"Rett Syndrome Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016499","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.neuron.2016.07.018","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T08:36:19Z","timestamp":1470386179000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model"],"prefix":"10.1016","volume":"91","author":[{"given":"Hui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Ash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Kee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Ure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Ito-Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Arenkiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios M.","family":"Smirnakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Y.","family":"Zoghbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2016.07.018_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ajpath.2013.03.019","article-title":"Mild overexpression of Mecp2 in mice causes a higher susceptibility toward seizures","volume":"183","author":"Bodda","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuron.2016.07.018_bib2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.07.018_bib3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neuron.2016.07.018_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number","volume":"56","author":"Chao","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.07.018_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.07.018_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2012.07.011","article-title":"Imaging neural activity using Thy1-GCaMP transgenic mice","volume":"76","author":"Chen","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.07.018_bib7","doi-asserted-by":"crossref","first-page":"e00647","DOI":"10.7554\/eLife.00647","article-title":"Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model","volume":"2","author":"Cheng","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2016.07.018_bib8","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/hmg\/ddh282","article-title":"Mild overexpression of MeCP2 causes a progressive neurological disorder in mice","volume":"13","author":"Collins","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2016.07.018_bib9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neuron.2012.12.004","article-title":"NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2","volume":"76","author":"Durand","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.07.018_bib10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nn.3710","article-title":"Cellular origins of auditory event-related potential deficits in Rett syndrome","volume":"17","author":"Goffin","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nn.3415","article-title":"Circuit level defects in the developing neocortex of Fragile X mice","volume":"16","author":"Gon\u00e7alves","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2016.07.018_bib13","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neuron.2016.07.018_bib14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature15694","article-title":"Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice","volume":"526","author":"Hao","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.07.018_bib15","doi-asserted-by":"crossref","first-page":"e91148","DOI":"10.1371\/journal.pone.0091148","article-title":"Network models predict that reduced excitatory fluctuations can give rise to hippocampal network hyper-excitability in MeCP2-null mice","volume":"9","author":"Ho","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2016.07.018_bib16","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature02058","article-title":"Independent rate and temporal coding in hippocampal pyramidal cells","volume":"425","author":"Huxter","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.07.018_bib17","doi-asserted-by":"crossref","first-page":"19518","DOI":"10.1523\/JNEUROSCI.1745-13.2013","article-title":"Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome","volume":"33","author":"Jiang","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2015.04.014","article-title":"Putative microcircuit-level substrates for attention are disrupted in mouse models of autism","volume":"79","author":"Luongo","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2016.07.018_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2012.11.058","article-title":"Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome","volume":"231","author":"McLeod","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2016.07.018_bib20","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/hipo.22472","article-title":"From synaptic plasticity to spatial maps and sequence learning","volume":"25","author":"Mehta","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuron.2016.07.018_bib21","first-page":"23","article-title":"Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus","volume":"6","author":"M\u00fcller","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib22","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1528-1167.2010.02597.x","article-title":"Epilepsy in Rett syndrome\u2014the experience of a National Rett Center","volume":"51","author":"Nissenkorn","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuron.2016.07.018_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn.2105","article-title":"Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities","volume":"11","author":"Okun","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib24","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1523\/JNEUROSCI.1366-14.2014","article-title":"Opposing brain differences in 16p11.2 deletion and duplication carriers","volume":"34","author":"Qureshi","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib25","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/nature07457","article-title":"Failure of neuronal homeostasis results in common neuropsychiatric phenotypes","volume":"455","author":"Ramocki","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.07.018_bib26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/ajmg.a.33184","article-title":"The MECP2 duplication syndrome","volume":"152A","author":"Ramocki","year":"2010","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.neuron.2016.07.018_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1179850","article-title":"The asynchronous state in cortical circuits","volume":"327","author":"Renart","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuron.2016.07.018_bib28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/hmg\/dds406","article-title":"Female Mecp2(+\/\u2212) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies","volume":"22","author":"Samaco","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2016.07.018_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-2999(96)00156-2","article-title":"The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons","volume":"307","author":"Uchida","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuron.2016.07.018_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2006.09.020","article-title":"Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology","volume":"52","author":"Uhlhaas","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.07.018_bib31","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1523\/JNEUROSCI.4900-12.2014","article-title":"Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.07.018_bib32","doi-asserted-by":"crossref","first-page":"a009886","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627316304032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627316304032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:38:43Z","timestamp":1784230723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627316304032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0896627316304032"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2016.07.018","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2016.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}