{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:53:50Z","timestamp":1790830430515,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale pour la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BLANC-SVSE4"],"award-info":[{"award-number":["ANR-12-BLANC-SVSE4"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20120323715"],"award-info":[{"award-number":["DEQ20120323715"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006431","name":"Canc\u00e9rop\u00f4le Ile-de France","doi-asserted-by":"publisher","award":["INCA_6517"],"award-info":[{"award-number":["INCA_6517"]}],"id":[{"id":"10.13039\/501100006431","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NERF Ile de France"},{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.neuron.2016.11.035","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T20:32:16Z","timestamp":1482438736000},"page":"99-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology"],"prefix":"10.1016","volume":"93","author":[{"given":"Monia","family":"Barnat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Le Friec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Benstaali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2016.11.035_bib1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2015.07.018","article-title":"Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin\/Catenin Complexes","volume":"162","author":"Bian","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2016.11.035_bib2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fncel.2014.00386","article-title":"Molecules and mechanisms that regulate multipolar migration in the intermediate zone","volume":"8","author":"Cooper","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.neubiorev.2016.04.008","article-title":"Impairments in dendrite morphogenesis as etiology for neurodevelopmental disorders and implications for therapeutic treatments","volume":"68","author":"Copf","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuron.2016.11.035_bib4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/hmg\/ddn324","article-title":"Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages","volume":"18","author":"Dietrich","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2016.11.035_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/81593","article-title":"Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice","volume":"26","author":"Dragatsis","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2016.11.035_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington\u2019s disease gene homolog Hdh","volume":"269","author":"Duyao","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neuron.2016.11.035_bib7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature06063","article-title":"Gap junction adhesion is necessary for radial migration in the neocortex","volume":"448","author":"Elias","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.11.035_bib8","doi-asserted-by":"crossref","first-page":"e1002142","DOI":"10.1371\/journal.pbio.1002142","article-title":"Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC","volume":"13","author":"Elias","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuron.2016.11.035_bib9","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/emboj.2012.41","article-title":"N-cadherin specifies first asymmetry in developing neurons","volume":"31","author":"G\u00e4rtner","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2016.11.035_bib10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.neuron.2010.06.027","article-title":"Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis","volume":"67","author":"Godin","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.11.035_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/dvg.20256","article-title":"Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice","volume":"44","author":"Goebbels","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.neuron.2016.11.035_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00310376","article-title":"Cortical and striatal neurone number in Huntington\u2019s disease","volume":"88","author":"Heinsen","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuron.2016.11.035_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature07198","article-title":"Neurogenin 2 controls cortical neuron migration through regulation of Rnd2","volume":"455","author":"Heng","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2016.11.035_bib14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nn.2816","article-title":"Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex","volume":"14","author":"Jossin","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuron.2010.07.007","article-title":"Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking","volume":"67","author":"Kawauchi","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.11.035_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tins.2004.05.001","article-title":"Patterns of neuronal migration in the embryonic cortex","volume":"27","author":"Kriegstein","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1212\/WNL.0b013e3182648b65","article-title":"Measures of growth in children at risk for Huntington disease","volume":"79","author":"Lee","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2016.11.035_bib18","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1097\/WNR.0b013e328315cd4c","article-title":"A function of huntingtin in guanine nucleotide exchange on Rab11","volume":"19","author":"Li","year":"2008","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2016.11.035_bib19","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1128\/MCB.00420-09","article-title":"Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity","volume":"29","author":"Li","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neuron.2016.11.035_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1073\/pnas.0610155104","article-title":"Controlled expression of transgenes introduced by in\u00a0vivo electroporation","volume":"104","author":"Matsuda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2016.11.035_bib21","doi-asserted-by":"crossref","first-page":"9455","DOI":"10.1523\/JNEUROSCI.4699-13.2014","article-title":"Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits","volume":"34","author":"McKinstry","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib22","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1073\/pnas.1603871113","article-title":"Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington\u2019s disease","volume":"113","author":"Molero","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2016.11.035_bib23","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.1523\/JNEUROSCI.0715-14.2014","article-title":"Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex","volume":"34","author":"Molina-Calavita","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JHD-140092","article-title":"Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington\u2019s disease","volume":"3","author":"Nana","year":"2014","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.neuron.2016.11.035_bib25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","article-title":"Targeted disruption of the Huntington\u2019s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes","volume":"81","author":"Nasir","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2016.11.035_bib26","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nbd.2010.07.014","article-title":"Cerebral cortex structure in prodromal Huntington disease","volume":"40","author":"Nopoulos","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2016.11.035_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1756-6606-3-17","article-title":"pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking","volume":"3","author":"Pardo","year":"2010","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuron.2016.11.035_bib28","doi-asserted-by":"crossref","first-page":"pl9","DOI":"10.1126\/stke.2002.136.pl9","article-title":"The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal development","volume":"2002","author":"Polleux","year":"2002","journal-title":"Sci. STKE"},{"key":"10.1016\/j.neuron.2016.11.035_bib29","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/WNR.0b013e328359d990","article-title":"In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin","volume":"23","author":"Power","year":"2012","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2016.11.035_bib30","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/embj.201386591","article-title":"miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin","volume":"33","author":"Rago","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2016.11.035_bib31","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1523\/JNEUROSCI.21-19-07608.2001","article-title":"Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice","volume":"21","author":"Reiner","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.58.5.695","article-title":"Regional and progressive thinning of the cortical ribbon in Huntington\u2019s disease","volume":"58","author":"Rosas","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuron.2016.11.035_bib33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/brain\/awn025","article-title":"Cerebral cortex and the clinical expression of Huntington\u2019s disease: complexity and heterogeneity","volume":"131","author":"Rosas","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2016.11.035_bib34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fnins.2015.00116","article-title":"Neuronal polarization in the developing cerebral cortex","volume":"9","author":"Sakakibara","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib35","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The Biology of Huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2016.11.035_bib36","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4161\/cib.4.3.14886","article-title":"N-cadherin regulates radial glial fiber-dependent migration of cortical locomoting neurons","volume":"4","author":"Shikanai","year":"2011","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.neuron.2016.11.035_bib37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fncel.2013.00221","article-title":"Production and organization of neocortical interneurons","volume":"7","author":"Sultan","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuron.2016.11.035_bib39","doi-asserted-by":"crossref","first-page":"14794","DOI":"10.1523\/JNEUROSCI.2774-11.2011","article-title":"Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development","volume":"31","author":"Tong","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2016.11.035_bib40","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.celrep.2014.03.075","article-title":"MicroRNA targeting of CoREST controls polarization of migrating cortical neurons","volume":"7","author":"Volvert","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2016.11.035_bib41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntington\u2019s disease CAG expansion","volume":"17","author":"White","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2016.11.035_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington\u2019s disease gene homologue","volume":"11","author":"Zeitlin","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2016.11.035_bib43","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.devcel.2009.12.025","article-title":"Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling","volume":"18","author":"Zhang","year":"2010","journal-title":"Dev. Cell"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627316309035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627316309035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T22:46:01Z","timestamp":1656801961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627316309035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0896627316309035"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2016.11.035","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727146613.793528753","asserted-by":"object"}]},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2016.11.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}