{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:03:45Z","timestamp":1780639425014,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006528","name":"ADRC","doi-asserted-by":"publisher","award":["ADRC2013"],"award-info":[{"award-number":["ADRC2013"]}],"id":[{"id":"10.13039\/100006528","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Competitive Medical Research","award":["UPMC- CMRF2013"],"award-info":[{"award-number":["UPMC- CMRF2013"]}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","award":["2013-05-70"],"award-info":[{"award-number":["2013-05-70"]}],"id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R21","award":["MH107966"],"award-info":[{"award-number":["MH107966"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neuron.2017.09.041","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T06:18:59Z","timestamp":1507875539000},"page":"355-372.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels"],"prefix":"10.1016","volume":"96","author":[{"given":"Yanjun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaprakash","family":"Sivaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haadi","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Zukowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareen","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Sklyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kodali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Borowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Beukema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary P.","family":"Wills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2017.09.041_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnmol.2013.00002","article-title":"Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics","volume":"6","author":"Akerboom","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13024-017-0169-9","article-title":"Soluble oligomeric amyloid-\u03b2 induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain","volume":"12","author":"Arbel-Ornath","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuron.2017.09.041_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuron.2004.09.006","article-title":"Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate","volume":"44","author":"Buckner","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib5","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2017.09.041_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/01.RES.83.1.103","article-title":"Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family","volume":"83","author":"Cribbs","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuron.2017.09.041_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/19978","article-title":"Dendritic spine changes associated with hippocampal long-term synaptic plasticity","volume":"399","author":"Engert","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib9","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1523\/JNEUROSCI.0482-13.2013","article-title":"Memantine rescues transient cognitive impairment caused by high-molecular-weight a\u03b2 oligomers but not the persistent impairment induced by low-molecular-weight oligomers","volume":"33","author":"Figueiredo","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib10","doi-asserted-by":"crossref","first-page":"rs12","DOI":"10.1126\/scisignal.2004135","article-title":"A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space","volume":"6","author":"Fritz","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2017.09.041_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3233\/JAD-150414","article-title":"Effects of the acetylcholine release agent ST101 with donepezil in Alzheimer\u2019s disease: a randomized phase 2 study","volume":"48","author":"Gauthier","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neuron.2017.09.041_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-3495(02)75164-3","article-title":"Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation","volume":"83","author":"Gomora","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2017.09.041_bib13","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1523\/JNEUROSCI.12-07-02685.1992","article-title":"Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation","volume":"12","author":"Harris","year":"1992","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature15257","article-title":"Labelling and optical erasure of synaptic memory traces in the motor cortex","volume":"525","author":"Hayashi-Takagi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nn1921","article-title":"Regulation of T-type calcium channels by Rho-associated kinase","volume":"10","author":"Iftinca","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuron.2017.09.041_bib17","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1074\/jbc.R115.702704","article-title":"Amyloid-\u03b2 receptors: the good, the bad, and the prion protein","volume":"291","author":"Jarosz-Griffiths","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2017.09.041_bib18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","article-title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers","volume":"457","author":"Laur\u00e9n","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuron.2008.05.025","article-title":"A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia","volume":"59","author":"Lohmann","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib20","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1152\/jn.1995.74.3.1335","article-title":"Subthreshold synaptic activation of voltage-gated Ca2+ channels mediates a localized Ca2+ influx into the dendrites of hippocampal pyramidal neurons","volume":"74","author":"Magee","year":"1995","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2017.09.041_bib21","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1111\/j.1460-9568.2006.05136.x","article-title":"Ca(V)3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons","volume":"24","author":"McKay","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tins.2013.04.003","article-title":"Where no synapses go: gatekeepers of circuit remodeling and synaptic strength","volume":"36","author":"Mironova","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1471-4159.2012.07667.x","article-title":"The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101: enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices","volume":"121","author":"Moriguchi","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2017.09.041_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature09823","article-title":"Local, persistent activation of Rho GTPases during plasticity of single dendritic spines","volume":"472","author":"Murakoshi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature13294","article-title":"Engineering a memory with LTD and LTP","volume":"511","author":"Nabavi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ymeth.2005.05.021","article-title":"Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes","volume":"37","author":"Nakamura","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.neuron.2017.09.041_bib27","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/ncomms3416","article-title":"Amyloid-\u03b2 nanotubes are associated with prion protein-dependent synaptotoxicity","volume":"4","author":"Nicoll","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2017.09.041_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib29","doi-asserted-by":"crossref","first-page":"13279","DOI":"10.1523\/JNEUROSCI.4504-06.2006","article-title":"Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer\u2019s transgenic mice","volume":"26","author":"Park","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib30","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1073\/pnas.1002995107","article-title":"Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2017.09.041_bib31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnbeh.2014.00349","article-title":"An open-source toolbox for automated phenotyping of mice in behavioral tasks","volume":"8","author":"Patel","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature04665","article-title":"Spatiotemporal dynamics of RhoA activity in migrating cells","volume":"440","author":"Pertz","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib33","doi-asserted-by":"crossref","first-page":"9564","DOI":"10.1074\/jbc.270.16.9564","article-title":"Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture","volume":"270","author":"Podlisny","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2017.09.041_bib34","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/ncomms2927","article-title":"Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice","volume":"4","author":"Pozueta","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuron.2017.09.041_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200901084","article-title":"Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation","volume":"186","author":"Rex","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2017.09.041_bib36","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.neurobiolaging.2013.10.090","article-title":"Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production","volume":"35","author":"Rice","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuron.2017.09.041_bib37","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1073858407303611","article-title":"ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases","volume":"13","author":"Schmandke","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuron.2017.09.041_bib38","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1532-5415.2007.01418.x","article-title":"Serum calcium and cognitive function in old age","volume":"55","author":"Schram","year":"2007","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neuron.2017.09.041_bib39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2017.09.041_bib40","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway","volume":"27","author":"Shankar","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib41","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2017.09.041_bib42","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nn0805-977","article-title":"The synaptic Abeta hypothesis of Alzheimer disease","volume":"8","author":"Tanzi","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib43","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuron.2013.06.036","article-title":"Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer a\u03b2 oligomer bound to cellular prion protein","volume":"79","author":"Um","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in\u00a0vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2017.09.041_bib45","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1021\/bi5003053","article-title":"Secreted amyloid \u03b2-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity","volume":"53","author":"Welzel","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuron.2017.09.041_bib46","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.neuron.2011.11.029","article-title":"The nogo receptor family restricts synapse number in the developing hippocampus","volume":"73","author":"Wills","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2017.09.041_bib47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1124\/jpet.105.098640","article-title":"Effects of a novel\u00a0cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat","volume":"317","author":"Yamaguchi","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuron.2017.09.041_bib48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1254\/jphs.12233FP","article-title":"Novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation","volume":"121","author":"Yamamoto","year":"2013","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.neuron.2017.09.041_bib49","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nn1112","article-title":"Plasticity of calcium channels in dendritic spines","volume":"6","author":"Yasuda","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib50","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1523\/JNEUROSCI.3817-13.2014","article-title":"Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in\u00a0vivo","volume":"34","author":"Zemmar","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2017.09.041_bib51","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1073\/pnas.0409026102","article-title":"Genetic deletion of the Nogo receptor does not reduce neurite inhibition in\u00a0vitro or promote corticospinal tract regeneration in\u00a0vivo","volume":"102","author":"Zheng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2017.09.041_bib52","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1096\/fj.11-184325","article-title":"Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition","volume":"25","author":"Zhou","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.neuron.2017.09.041_bib53","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00401-015-1421-4","article-title":"Intraneuronal APP and extracellular A\u03b2 independently cause dendritic spine pathology in transgenic mouse models of Alzheimer\u2019s disease","volume":"129","author":"Zou","year":"2015","journal-title":"Acta Neuropathol."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627317309108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627317309108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T21:11:50Z","timestamp":1539205910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627317309108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0896627317309108"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2017.09.041","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2017.09.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}