{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:23:03Z","timestamp":1792131783063,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91232303"],"award-info":[{"award-number":["91232303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81521062"],"award-info":[{"award-number":["81521062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81671162"],"award-info":[{"award-number":["81671162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81561168022"],"award-info":[{"award-number":["81561168022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31571049"],"award-info":[{"award-number":["31571049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB910300"],"award-info":[{"award-number":["2014CB910300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2015CB910801"],"award-info":[{"award-number":["2015CB910801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2013CB530904"],"award-info":[{"award-number":["2013CB530904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China and the Research Grants Council of Hong Kong, China","award":["8151101104"],"award-info":[{"award-number":["8151101104"]}]},{"name":"National Natural Science Foundation of China and the Research Grants Council of Hong Kong, China","award":["N_HKUST625\/15"],"award-info":[{"award-number":["N_HKUST625\/15"]}]},{"name":"Fundamental Research Funds for the Central Universities of China and Chinese Ministry of Education Project 111","award":["Program B13026"],"award-info":[{"award-number":["Program B13026"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.neuron.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T11:39:13Z","timestamp":1519904353000},"page":"1253-1260.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":144,"title":["Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice"],"prefix":"10.1016","volume":"97","author":[{"given":"Wei","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang-qiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-lan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-qing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-min","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.02.001_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fnsys.2014.00177","article-title":"The topology of connections between rat prefrontal, motor and sensory cortices","volume":"8","author":"Bedwell","year":"2014","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib2","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u2018recognition memory\u2019","volume":"1","author":"Bevins","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2018.02.001_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzs\u00e1ki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0173(83)90037-1","article-title":"Cellular bases of hippocampal EEG in the behaving rat","volume":"287","author":"Buzs\u00e1ki","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2018.02.001_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tics.2010.09.001","article-title":"The functional role of cross-frequency coupling","volume":"14","author":"Canolty","year":"2010","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neuron.2018.02.001_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nature08002","article-title":"Driving fast-spiking cells induces gamma rhythm and controls sensory responses","volume":"459","author":"Cardin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.02.001_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.14814\/phy2.12077","article-title":"Reduced inhibitory gate in the barrel cortex of Neuroligin3R451C knock-in mice, an animal model of autism spectrum disorders","volume":"2","author":"Cellot","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.neuron.2018.02.001_bib8","doi-asserted-by":"crossref","first-page":"9598","DOI":"10.1523\/JNEUROSCI.1851-04.2004","article-title":"Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period","volume":"24","author":"Chattopadhyaya","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1162\/jocn.2008.21020","article-title":"Oscillatory activity and phase-amplitude coupling in the human medial frontal cortex during decision making","volume":"21","author":"Cohen","year":"2009","journal-title":"J.\u00a0Cogn. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneumeth.2014.01.002","article-title":"Toward a proper estimation of phase-amplitude coupling in neural oscillations","volume":"225","author":"Dvorak","year":"2014","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neuron.2018.02.001_bib11","doi-asserted-by":"crossref","first-page":"13764","DOI":"10.1073\/pnas.1111093108","article-title":"Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function","volume":"108","author":"Etherton","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.02.001_bib12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuron.2013.02.036","article-title":"Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling","volume":"78","author":"F\u00f6ldy","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.02.001_bib13","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"George Paxinos","year":"2001"},{"key":"10.1016\/j.neuron.2018.02.001_bib14","doi-asserted-by":"crossref","first-page":"13295","DOI":"10.1073\/pnas.0506259102","article-title":"Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus","volume":"102","author":"Gloveli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.02.001_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11689-009-9023-x","article-title":"Common circuit defect of excitatory-inhibitory balance in mouse models of autism","volume":"1","author":"Gogolla","year":"2009","journal-title":"J.\u00a0Neurodev. Disord."},{"key":"10.1016\/j.neuron.2018.02.001_bib16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/aur.1362","article-title":"Autism-related neuroligin-3 mutation alters social behavior and spatial learning","volume":"7","author":"Jaramillo","year":"2014","journal-title":"Autism Res."},{"key":"10.1016\/j.neuron.2018.02.001_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4062\/biomolther.2014.063","article-title":"Protective effect of arabinoxylan against scopolamine-induced learning and memory impairment","volume":"22","author":"Kim","year":"2014","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.neuron.2018.02.001_bib18","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1073\/pnas.1413625112","article-title":"Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations","volume":"112","author":"Kim","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.02.001_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.neuron.2010.09.017","article-title":"NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory","volume":"68","author":"Korotkova","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.02.001_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nn.3006","article-title":"Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy","volume":"15","author":"Li","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.7770778","article-title":"Reliability of spike timing in neocortical neurons","volume":"268","author":"Mainen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.02.001_bib22","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.cell.2017.11.002","article-title":"Combined social and spatial coding in a descending projection from the prefrontal cortex","volume":"171","author":"Murugan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.02.001_bib23","doi-asserted-by":"crossref","first-page":"e3990","DOI":"10.1371\/journal.pone.0003990","article-title":"Gamma power is phase-locked to posterior alpha activity","volume":"3","author":"Osipova","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.02.001_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction","volume":"472","author":"Pe\u00e7a","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.02.001_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fncel.2013.00085","article-title":"Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism","volume":"7","author":"Pizzarelli","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nn.4471","article-title":"Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network","volume":"20","author":"Polepalli","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1601-183X.2009.00487.x","article-title":"Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit","volume":"8","author":"Radyushkin","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuron.2018.02.001_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2217\/bmm.14.15","article-title":"\u03b3-band abnormalities as markers of autism spectrum disorders","volume":"8","author":"Rojas","year":"2014","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.neuron.2018.02.001_bib29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cell.2014.04.045","article-title":"Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors","volume":"158","author":"Rothwell","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.02.001_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.1146221","article-title":"A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice","volume":"318","author":"Tabuchi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.02.001_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuron.2018.02.001_bib32","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1093\/hmg\/ddr212","article-title":"Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3","volume":"20","author":"Wang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.02.001_bib33","doi-asserted-by":"crossref","first-page":"11919","DOI":"10.1523\/JNEUROSCI.3852-11.2012","article-title":"Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase\/Akt pathway","volume":"32","author":"Wang","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib34","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/nn.3813","article-title":"Visualizing an emotional valence map in the limbic forebrain by TAI-FISH","volume":"17","author":"Xiu","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.02.001_bib35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2014.04.009","article-title":"Successful execution of working memory linked to synchronized high-frequency gamma oscillations","volume":"157","author":"Yamamoto","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.02.001_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"Yizhar","year":"2011","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1016\/j.neuron.2018.03.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T00:00:00Z","timestamp":1521590400000}},{"DOI":"10.1016\/j.neuron.2018.04.025","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000}}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:09:53Z","timestamp":1760252993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318301004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0896627318301004"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.02.001","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}