{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:19:58Z","timestamp":1768547998354,"version":"3.49.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 AG058505-01-A1"],"award-info":[{"award-number":["F31 AG058505-01-A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG054214-01A1"],"award-info":[{"award-number":["1R01AG054214-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG051390"],"award-info":[{"award-number":["R01AG051390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12GM081266-11"],"award-info":[{"award-number":["K12GM081266-11"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54NS100717"],"award-info":[{"award-number":["U54NS100717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.neuron.2018.02.018","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T21:58:35Z","timestamp":1520459915000},"page":"991-993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["TREM2 and Amyloid Beta: A Love-Hate Relationship"],"prefix":"10.1016","volume":"97","author":[{"given":"Joe","family":"Udeochu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faten A.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.02.018_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2018.02.018_bib2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Jay","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.02.018_bib3","first-page":"1568","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2018.02.018_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.neuron.2018.02.018_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuron.2018.02.002","article-title":"Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer\u2019s disease models","volume":"97","author":"Lee","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.02.018_bib6","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20171529","article-title":"Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism","author":"Song","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neuron.2018.02.018_bib7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.02.018_bib8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.02.018_bib9","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuron.2016.05.003","article-title":"TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy","volume":"90","author":"Yuan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.02.018_bib10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 is a receptor for \u03b2-amyloid that mediates microglial function","volume":"97","author":"Zhao","year":"2018","journal-title":"Neuron"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:09:30Z","timestamp":1760252970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318301399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0896627318301399"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.02.018","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TREM2 and Amyloid Beta: A Love-Hate Relationship","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.02.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.01.031","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}