{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:53:41Z","timestamp":1791917621944,"version":"4.3.4"},"reference-count":180,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01 NS022625"],"award-info":[{"award-number":["R01 NS022625"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.neuron.2018.03.017","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T10:39:59Z","timestamp":1525257599000},"page":"466-481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":477,"title":["Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease"],"prefix":"10.1016","volume":"98","author":[{"given":"Evanthia","family":"Nanou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Catterall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.03.017_bib1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature03010","article-title":"Synaptic computation","volume":"431","author":"Abbott","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.neuron.2015.08.027","article-title":"RIM-BPs mediate tight coupling of action potentials to Ca2+-triggered neurotransmitter release","volume":"87","author":"Acuna","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib3","doi-asserted-by":"crossref","first-page":"18694","DOI":"10.1073\/pnas.1009500107","article-title":"Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P\/Q-type calcium channel","volume":"107","author":"Adams","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib4","first-page":"3094","article-title":"Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice","volume":"26","author":"Aikawa","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0959-4388(03)00066-7","article-title":"Auxiliary subunits: essential components of the voltage-gated calcium channel complex","volume":"13","author":"Arikkath","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib6","doi-asserted-by":"crossref","first-page":"15432","DOI":"10.1073\/pnas.1112667108","article-title":"Mouse model of Timothy syndrome recapitulates triad of autistic traits","volume":"108","author":"Bader","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/378623a0","article-title":"Functional impact of syntaxin on gating of N-type and Q-type calcium channels","volume":"378","author":"Bezprozvanny","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0896-6273(03)00196-X","article-title":"Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals","volume":"38","author":"Blatow","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1469-7793.1998.149by.x","article-title":"Facilitation of presynaptic calcium currents in the rat brainstem","volume":"513","author":"Borst","year":"1998","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/physrev.00023.2013","article-title":"Calcium-permeable ion channels in pain signaling","volume":"94","author":"Bourinet","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuron.2018.03.017_bib11","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1073\/pnas.230362997","article-title":"Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity","volume":"97","author":"Caillard","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/310501a0","article-title":"A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones","volume":"310","author":"Carbone","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib13","doi-asserted-by":"crossref","first-page":"a00394","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib179","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neuron.2008.09.005","article-title":"Calcium channel regulation and presynaptic plasticity","volume":"59","author":"Catterall","year":"2008","journal-title":"Neuron."},{"key":"10.1016\/j.neuron.2018.03.017_bib180","doi-asserted-by":"crossref","first-page":"10742","DOI":"10.1074\/jbc.R112.411645","article-title":"Calcium channels and short-term synaptic plasticity","volume":"288","author":"Catterall","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuron.2018.03.017_bib14","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.neuron.2017.10.028","article-title":"CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons","volume":"96","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2008.01.074","article-title":"Cerebellar network plasticity: from genes to fast oscillation","volume":"153","author":"Cheron","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2018.03.017_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fncel.2014.00093","article-title":"Modulating excitation through plasticity at inhibitory synapses","volume":"8","author":"Chevaleyre","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbrc.2015.02.146","article-title":"Evolutionary and functional perspectives on signaling from neuronal surface to nucleus","volume":"460","author":"Cohen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuron.2018.03.017_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YPG.0b013e3283413382","article-title":"Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes","volume":"21","author":"Curtis","year":"2011","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1469-7793.1998.723bd.x","article-title":"Facilitation of the presynaptic calcium current at an auditory synapse in rat brainstem","volume":"512","author":"Cuttle","year":"1998","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib20","doi-asserted-by":"crossref","first-page":"39710","DOI":"10.1074\/jbc.M005462200","article-title":"Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase","volume":"275","author":"Davare","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.03.017_bib21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.293.5527.98","article-title":"A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2","volume":"293","author":"Davare","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib22","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1073\/pnas.0908735107","article-title":"The \u03b12\u03b4 subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function","volume":"107","author":"Davies","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib23","doi-asserted-by":"crossref","first-page":"14738","DOI":"10.1016\/S0021-9258(18)77174-3","article-title":"Subunits of purified calcium channels. \u03b12 and \u03b4 are encoded by the same gene","volume":"265","author":"De Jongh","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.03.017_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/mp.2017.133","article-title":"Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood","volume":"23","author":"Dedic","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib25","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1523\/JNEUROSCI.1362-12.2012","article-title":"T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex","volume":"32","author":"Deleuze","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/35078091","article-title":"Calmodulin bifurcates the local Ca2+ signal that modulates P\/Q-type Ca2+ channels","volume":"411","author":"DeMaria","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1523\/JNEUROSCI.03-01-00042.1983","article-title":"Structural changes during transmitter release at synapses in the frog sympathetic ganglion","volume":"3","author":"Dickinson-Nelson","year":"1983","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib28","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.celrep.2014.04.039","article-title":"Ca2+\/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A","volume":"7","author":"Dittmer","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.03.017_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2017.07.004","article-title":"Characterization of the dominant inheritance mechanism of episodic ataxia type 2","volume":"106","author":"Dorgans","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuron.2018.03.017_bib30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cell.2013.05.059","article-title":"Second cistron in CACNA1A gene encodes a transcription factor mediating cerebellar development and SCA6","volume":"154","author":"Du","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.017_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hipo.10210","article-title":"Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memory","volume":"14","author":"Dumas","year":"2004","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuron.2018.03.017_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0166-2236(95)80030-6","article-title":"Exocytotic Ca2+ channels in mammalian central neurons","volume":"18","author":"Dunlap","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib33","doi-asserted-by":"crossref","first-page":"e0157086","DOI":"10.1371\/journal.pone.0157086","article-title":"Functional characterization of schizophrenia-associated variation in CACNA1C","volume":"11","author":"Eckart","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.03.017_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.31.060407.125631","article-title":"Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system","volume":"31","author":"Flavell","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0896-6273(00)81017-X","article-title":"Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse","volume":"20","author":"Forsythe","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0006-8993(02)04190-2","article-title":"Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in\u00a0vivo","volume":"967","author":"Freir","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2018.03.017_bib37","doi-asserted-by":"crossref","first-page":"ra70","DOI":"10.1126\/scisignal.2001152","article-title":"Molecular mechanism of calcium channel regulation in the fight-or-flight response","volume":"3","author":"Fuller","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2018.03.017_bib38","doi-asserted-by":"crossref","first-page":"20160157","DOI":"10.1098\/rstb.2016.0157","article-title":"Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex","volume":"372","author":"Gainey","year":"2017","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuron.2018.03.017_bib39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2015.02.018","article-title":"The EF-hand Ca2+-binding protein super-family: a genome-wide analysis of gene expression patterns in the adult mouse brain","volume":"294","author":"Girard","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuron.2018.03.017_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awu012","article-title":"Episodic ataxia type 1: clinical characterization, quality of life and genotype-phenotype correlation","volume":"137","author":"Graves","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2018.03.017_bib41","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0896-6273(00)80482-1","article-title":"Primary structure and function of an A kinase anchoring protein associated with calcium channels","volume":"20","author":"Gray","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib42","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/mp.2009.49","article-title":"The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia","volume":"15","author":"Green","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib43","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1086\/318804","article-title":"Complete loss of P\/Q calcium channel activity caused by a CACNA1A missense mutation carried by patients with episodic ataxia type 2","volume":"68","author":"Guida","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-4615-0121-3_18","article-title":"Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme","volume":"514","author":"Haeseleer","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biopsych.2014.07.011","article-title":"Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity","volume":"77","author":"Hall","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib46","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/mp.2012.67","article-title":"Genome-wide significant associations in schizophrenia to ITIH3\/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the schizophrenia PGC","volume":"18","author":"Hamshere","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib47","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neuron.2010.12.014","article-title":"RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone","volume":"69","author":"Han","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1192\/bjp.bp.113.126979","article-title":"CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population","volume":"204","author":"He","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib49","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.123.4.949","article-title":"Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel \u03b11 subunits","volume":"123","author":"Hell","year":"1993","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib50","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1073\/pnas.93.8.3362","article-title":"N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons","volume":"93","author":"Hell","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib51","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/380258a0","article-title":"Modulation of Ca2+ channels by G-protein beta\/gamma subunits","volume":"380","author":"Herlitze","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib52","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.1600179113","article-title":"Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP","volume":"113","author":"Herring","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-021014-071753","article-title":"Long-term potentiation: from CaMKII to AMPA receptor trafficking","volume":"78","author":"Herring","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib54","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.schres.2015.02.001","article-title":"Integration of gene expression and GWAS results supports involvement of calcium signaling in schizophrenia","volume":"164","author":"Hertzberg","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neuron.2018.03.017_bib55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.57.2.315","article-title":"Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction","volume":"57","author":"Heuser","year":"1973","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pneurobio.2015.09.002","article-title":"Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders","volume":"134","author":"Heyes","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature11033","article-title":"\u03b12\u03b4 expression sets presynaptic calcium channel abundance and release probability","volume":"486","author":"Hoppa","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib58","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/00001756-199506090-00013","article-title":"LTP induced by activation of voltage-dependent Ca2+ channels requires protein kinase activity","volume":"6","author":"Huber","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuron.2018.03.017_bib59","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 years","volume":"80","author":"Huganir","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/380255a0","article-title":"Voltage-dependent modulation of N-type calcium channels by G-protein beta\/gamma subunits","volume":"380","author":"Ikeda","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib61","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1523\/JNEUROSCI.2104-04.2004","article-title":"Functional compensation of P\/Q by N-type channels blocks short-term plasticity at the Calyx of Held presynaptic terminal","volume":"24","author":"Inchauspe","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature16507","article-title":"The\u00a0calcium sensor synaptotagmin 7 is required for synaptic facilitation","volume":"529","author":"Jackman","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib63","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.2158672","article-title":"Primary structure of the gamma subunit of\u00a0the DHP-sensitive calcium channel from skeletal muscle","volume":"248","author":"Jay","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib64","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/S0021-9258(18)49986-3","article-title":"Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides","volume":"266","author":"Jay","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.03.017_bib65","first-page":"459","article-title":"Genetics of episodic ataxia","volume":"89","author":"Jen","year":"2002","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neuron.2018.03.017_bib66","doi-asserted-by":"crossref","first-page":"C1209","DOI":"10.1152\/ajpcell.00247.2005","article-title":"Dominant-negative effects of human P\/Q-type Ca2+ channel mutations associated with episodic ataxia type 2","volume":"290","author":"Jeng","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib67","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/jcp.21216","article-title":"Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P\/Q-type Ca2+ channels","volume":"214","author":"Jeng","year":"2008","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib68","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/(SICI)1098-2396(19990901)33:3<172::AID-SYN2>3.0.CO;2-S","article-title":"Glutamatergic synaptic responses and long-term potentiation are impaired in the CA1 hippocampal area of calbindin D(28k)-deficient mice","volume":"33","author":"Jouvenceau","year":"1999","journal-title":"Synapse"},{"key":"10.1016\/j.neuron.2018.03.017_bib69","first-page":"1391","article-title":"Paroxysmal muscle weakness: the familial periodic paralyses","volume":"253","author":"Jurkat-Rott","year":"2006","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.neuron.2018.03.017_bib70","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1113\/JP270673","article-title":"L-type Ca2+channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes","volume":"594","author":"Kabir","year":"2016","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib71","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s13311-017-0532-0","article-title":"From gene to behavior: L-type calcium channel mechanisms underlying neuropsychiatric symptoms","volume":"14","author":"Kabir","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuron.2018.03.017_bib72","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cell.2010.12.029","article-title":"RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction","volume":"144","author":"Kaeser","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.017_bib73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.1968.sp008469","article-title":"The role of calcium in neuromuscular facilitation","volume":"195","author":"Katz","year":"1968","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib74","first-page":"302","article-title":"A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners","volume":"40","author":"Khanna","year":"2007","journal-title":"J.\u00a0Biochem. Mol. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib75","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ije\/dyu037","article-title":"Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders","volume":"43","author":"Kim","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib76","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nn1904","article-title":"RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels","volume":"10","author":"Kiyonaka","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib77","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/hmg\/ddl080","article-title":"C-termini of P\/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity","volume":"15","author":"Kordasiewicz","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib78","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1523\/JNEUROSCI.0447-05.2005","article-title":"Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2","volume":"25","author":"Lautermilch","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib79","doi-asserted-by":"crossref","first-page":"17069","DOI":"10.1073\/pnas.1215172109","article-title":"Fine-tuning synaptic plasticity by modulation of CaV2.1 channels with Ca2+ sensor proteins","volume":"109","author":"Leal","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib80","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/20194","article-title":"Ca2+\/calmodulin binds to and modulates P\/Q-type calcium channels","volume":"399","author":"Lee","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib81","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1523\/JNEUROSCI.20-18-06830.2000","article-title":"Ca2+\/calmodulin-dependent facilitation and inactivation of P\/Q-type Ca2+ channels","volume":"20","author":"Lee","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib82","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1469-7793.2000.t01-2-00419.x","article-title":"Kinetics of Ca2+ binding to parvalbumin in bovine chromaffin cells: implications for [Ca2+] transients of neuronal dendrites","volume":"525","author":"Lee","year":"2000","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib83","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nn805","article-title":"Differential modulation of Cav2.1 channels by calmodulin and Ca2+-binding protein 1","volume":"5","author":"Lee","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib84","doi-asserted-by":"crossref","first-page":"16059","DOI":"10.1073\/pnas.2237000100","article-title":"Molecular determinants of Ca2+\/calmodulin-dependent regulation of Cav2.1 channels","volume":"100","author":"Lee","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib85","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ng.2711","article-title":"Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs","volume":"45","author":"Lee","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib86","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1016\/S0021-9258(17)37372-6","article-title":"Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis","volume":"269","author":"L\u00e9v\u00eaque","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.03.017_bib87","doi-asserted-by":"crossref","first-page":"e0133247","DOI":"10.1371\/journal.pone.0133247","article-title":"Schizophrenia-related variants in CACNA1C also confer risk of autism","volume":"10","author":"Li","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuron.2018.03.017_bib88","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.aad3647","article-title":"Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression","volume":"351","author":"Li","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib89","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0896-6273(03)00560-9","article-title":"Unified mechanisms of Ca2+ regulation across the Ca2+ channel family","volume":"39","author":"Liang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib90","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00424-009-0753-0","article-title":"CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency","volume":"460","author":"Liao","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuron.2018.03.017_bib91","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00424-009-0635-5","article-title":"Alternative splicing of voltage-gated calcium channels: from molecular biology to disease","volume":"458","author":"Liao","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neuron.2018.03.017_bib92","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tins.2013.06.008","article-title":"Control of neuronal voltage-gated calcium ion channels from RNA to protein","volume":"36","author":"Lipscombe","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib93","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.1989.tb24084.x","article-title":"Voltage-dependent calcium conductances in mammalian neurons. The P channel","volume":"560","author":"Llin\u00e1s","year":"1989","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.neuron.2018.03.017_bib94","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1126\/science.1350109","article-title":"Microdomains of high calcium concentration in a presynaptic terminal","volume":"256","author":"Llin\u00e1s","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib95","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fnins.2014.00331","article-title":"Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders","volume":"8","author":"Lotan","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib96","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"Malenka","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib97","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1113\/jphysiol.1967.sp008388","article-title":"An analysis of facilitation of transmitter release at the neuromuscular junction of the frog","volume":"193","author":"Mallart","year":"1967","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib98","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1113\/jphysiol.1968.sp008525","article-title":"The relation between quantum content and facilitation at the neuromuscular junction of the frog","volume":"196","author":"Mallart","year":"1968","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib99","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1523\/JNEUROSCI.0891-15.2015","article-title":"Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity","volume":"35","author":"Mark","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib100","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1073\/pnas.0712372105","article-title":"Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis","volume":"105","author":"Maximov","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib101","doi-asserted-by":"crossref","first-page":"a775751","DOI":"10.1101\/cshperspect.a005751","article-title":"Synapses and memory storage","volume":"4","author":"Mayford","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib102","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fphys.2015.00019","article-title":"Functional role of voltage gated Ca2+ channels in heart automaticity","volume":"6","author":"Mesirca","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib103","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1523\/JNEUROSCI.2844-07.2008","article-title":"A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels","volume":"28","author":"Mezghrani","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib104","doi-asserted-by":"crossref","first-page":"14523","DOI":"10.1073\/pnas.95.24.14523","article-title":"Evidence for a voltage-dependent enhancement of neurotransmitter release mediated via the synaptic protein interaction site of N-type Ca2+ channels","volume":"95","author":"Mochida","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuron.2007.11.036","article-title":"Regulation of presynaptic Ca(V)2.1 channels by Ca2+ sensor proteins mediates short-term synaptic plasticity","volume":"57","author":"Mochida","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib106","doi-asserted-by":"crossref","first-page":"9883","DOI":"10.1523\/JNEUROSCI.1531-05.2005","article-title":"Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory","volume":"25","author":"Moosmang","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib107","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2008.133","article-title":"Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk","volume":"14","author":"Moskvina","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib108","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1523\/JNEUROSCI.5582-06.2007","article-title":"Parvalbumin is a mobile presynaptic Ca2+ buffer in the Calyx of Held that accelerates the decay of Ca2+ and short-term facilitation","volume":"27","author":"M\u00fcller","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib109","doi-asserted-by":"crossref","first-page":"14950","DOI":"10.1073\/pnas.1005940107","article-title":"Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain","volume":"107","author":"M\u00fcller","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib110","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.celrep.2014.04.027","article-title":"AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling","volume":"7","author":"Murphy","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuron.2018.03.017_bib111","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/S0006-3495(00)76537-4","article-title":"Binding kinetics of calbindin-D(28k) determined by flash photolysis of caged Ca2+","volume":"79","author":"N\u00e4gerl","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2018.03.017_bib112","doi-asserted-by":"crossref","first-page":"13209","DOI":"10.1073\/pnas.1616206113","article-title":"Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning","volume":"113","author":"Nanou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib113","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1073\/pnas.1524636113","article-title":"Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons","volume":"113","author":"Nanou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib114","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1073\/pnas.1524650113","article-title":"Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels","volume":"113","author":"Nanou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib115","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0022-18.2018","article-title":"Control of excitation\/inhibition balance in a hippocampal circuit by calcium sensor protein regulation of presynaptic calcium channels","author":"Nanou","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib116","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.1123339","article-title":"Auxiliary subunits assist AMPA-type glutamate receptors","volume":"311","author":"Nicoll","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib117","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/316440a0","article-title":"Three types of neuronal calcium channel with different calcium agonist sensitivity","volume":"316","author":"Nowycky","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib118","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/YPG.0b013e328353953c","article-title":"No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia","volume":"22","author":"Nyegaard","year":"2012","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib119","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.bi.63.070194.004135","article-title":"Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins","volume":"63","author":"Olivera","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neuron.2018.03.017_bib120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuron.2007.06.032","article-title":"AKAP79\/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling","volume":"55","author":"Oliveria","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib121","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/19336950.2015.1048936","article-title":"L-type calcium channels as drug targets in CNS disorders","volume":"10","author":"Ortner","year":"2016","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.neuron.2018.03.017_bib122","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/nm.2576","article-title":"Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome","volume":"17","author":"Pa\u015fca","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2018.03.017_bib123","article-title":"Calcium channel modulation as a target in chronic pain control","author":"Patel","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuron.2018.03.017_bib124","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.15252\/embj.201593409","article-title":"Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the \u03b22 adrenergic receptor","volume":"35","author":"Patriarchi","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.03.017_bib125","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.bbamem.2012.11.012","article-title":"Calcium channels and migraine","volume":"1828","author":"Pietrobon","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuron.2018.03.017_bib126","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1113\/JP270672","article-title":"Cav1.3 (CACNA1D) L-type Ca2+channel dysfunction in CNS disorders","volume":"594","author":"Pinggera","year":"2016","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib127","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.biopsych.2014.11.020","article-title":"CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels","volume":"77","author":"Pinggera","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuron.2018.03.017_bib128","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/hmg\/ddx175","article-title":"New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy","volume":"26","author":"Pinggera","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib129","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ajhg.2014.03.018","article-title":"Convergence of genes and cellular pathways dysregulated in autism spectrum disorders","volume":"94","author":"Pinto","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/368067a0","article-title":"Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit","volume":"368","author":"Pragnell","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib131","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature12975","article-title":"A polygenic burden of rare disruptive mutations in schizophrenia","volume":"506","author":"Purcell","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib132","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1152\/jn.00374.2011","article-title":"\u03b22-adrenergic receptor supports prolonged theta tetanus-induced LTP","volume":"107","author":"Qian","year":"2012","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib133","doi-asserted-by":"crossref","first-page":"eaaf9659","DOI":"10.1126\/scisignal.aaf9659","article-title":"Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the \u03b22-adrenergic receptor in neurons","volume":"10","author":"Qian","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuron.2018.03.017_bib134","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn1848","article-title":"Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors","volume":"10","author":"Raingo","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3410\/B2-4","article-title":"Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias","volume":"2","author":"Rajakulendran","year":"2010","journal-title":"F1000 Biol. Rep."},{"key":"10.1016\/j.neuron.2018.03.017_bib136","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1126\/science.1075375","article-title":"Emerging roles of presynaptic proteins in Ca2+-triggered exocytosis","volume":"298","author":"Rettig","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib137","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1523\/JNEUROSCI.17-17-06647.1997","article-title":"Alteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel\/syntaxin interaction","volume":"17","author":"Rettig","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib138","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/301569a0","article-title":"Calcium channel modulation by neurotransmitters, enzymes and drugs","volume":"301","author":"Reuter","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib139","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","volume":"45","author":"Ripke","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib140","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1093\/hmg\/ddr243","article-title":"Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders","volume":"20","author":"Schaaf","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib141","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ng.940","article-title":"Genome-wide association study identifies five new schizophrenia loci","volume":"43","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib142","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0166-2236(02)02139-2","article-title":"Vesicle pools and short-term synaptic depression: lessons from a large synapse","volume":"25","author":"Schneggenburger","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib143","doi-asserted-by":"crossref","first-page":"a004051","DOI":"10.1101\/cshperspect.a004051","article-title":"Cytosolic Ca2+ buffers","volume":"2","author":"Schwaller","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib144","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0896-6273(94)90417-0","article-title":"Identification of a syntaxin-binding site on N-type calcium channels","volume":"13","author":"Sheng","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib145","article-title":"Recent advances in the development of T-type calcium channel blockers for pain intervention","author":"Snutch","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuron.2018.03.017_bib146","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/B978-0-444-51892-7.00029-2","article-title":"Spinocerebellar ataxia type 6","volume":"103","author":"Solodkin","year":"2012","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neuron.2018.03.017_bib147","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","article-title":"CaV1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism","volume":"119","author":"Splawski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.017_bib148","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1073\/pnas.0502506102","article-title":"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations","volume":"102","author":"Splawski","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib149","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0166-2236(97)01091-6","article-title":"The calcium channel and the organization of the presynaptic transmitter release face","volume":"20","author":"Stanley","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-8993(87)91605-2","article-title":"Stable hippocampal long-term potentiation elicited by \u2018theta\u2019 pattern stimulation","volume":"435","author":"Staubli","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2018.03.017_bib151","doi-asserted-by":"crossref","first-page":"a011353","DOI":"10.1101\/cshperspect.a011353","article-title":"Calcium control of neurotransmitter release","volume":"4","author":"S\u00fcdhof","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.017_bib152","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1073\/pnas.84.15.5478","article-title":"Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle","volume":"84","author":"Takahashi","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib153","doi-asserted-by":"crossref","first-page":"13284","DOI":"10.1073\/pnas.192242399","article-title":"Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons","volume":"99","author":"Tottene","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib154","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2009.01.027","article-title":"Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Cav2.1 knockin migraine mice","volume":"61","author":"Tottene","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib155","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ejpn.2016.11.005","article-title":"Missense mutations of CACNA1A are a frequent cause of autosomal dominant nonprogressive congenital ataxia","volume":"21","author":"Travaglini","year":"2017","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.neuron.2018.03.017_bib156","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1126\/science.1068278","article-title":"Neuronal calcium sensor 1 and activity-dependent facilitation of P\/Q-type calcium currents at presynaptic nerve terminals","volume":"295","author":"Tsujimoto","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib157","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.21815","article-title":"High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice","volume":"67","author":"van den Maagdenberg","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuron.2018.03.017_bib158","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fncel.2015.00008","article-title":"Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans","volume":"9","author":"Vecchia","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib159","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/brain\/awh639","article-title":"The primary periodic paralyses: diagnosis, pathogenesis and treatment","volume":"129","author":"Venance","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neuron.2018.03.017_bib160","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrcardio.2012.93","article-title":"Inherited calcium channelopathies in the pathophysiology of arrhythmias","volume":"9","author":"Venetucci","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib161","doi-asserted-by":"crossref","first-page":"E8518","DOI":"10.1073\/pnas.1710708114","article-title":"Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release","volume":"114","author":"Voleti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib162","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neuron.2007.01.021","article-title":"The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release","volume":"53","author":"Wadel","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib163","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fncel.2014.00455","article-title":"Presynaptic nanodomains: a tale of two synapses","volume":"8","author":"Wang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib164","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature12809","article-title":"Ultrafast endocytosis at mouse hippocampal synapses","volume":"504","author":"Watanabe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib165","doi-asserted-by":"crossref","first-page":"11987","DOI":"10.1073\/pnas.0804350105","article-title":"Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels","volume":"105","author":"Watase","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.017_bib166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.02.036","article-title":"Differential alterations of synaptic plasticity in dentate gyrus and CA1 hippocampal area of Calbindin-D28K knockout mice","volume":"1450","author":"Westerink","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neuron.2018.03.017_bib167","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7832825","article-title":"Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission","volume":"264","author":"Wheeler","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib168","doi-asserted-by":"crossref","first-page":"aad2395","DOI":"10.1126\/science.aad2395","article-title":"Structure of the voltage-gated calcium channel Cav1.1 complex","volume":"350","author":"Wu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.03.017_bib169","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature19321","article-title":"Structure of the voltage-gated calcium channel Cav1.1 at 3.6\u2009\u00c5 resolution","volume":"537","author":"Wu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib170","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2005.03.024","article-title":"The decrease in the presynaptic calcium current is a major cause of short-term depression at a calyx-type synapse","volume":"46","author":"Xu","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.017_bib171","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mcn.2014.11.001","article-title":"Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation","volume":"63","author":"Yan","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib172","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1007\/s00018-014-1680-6","article-title":"Ionic mechanisms in pancreatic \u03b2 cell signaling","volume":"71","author":"Yang","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuron.2018.03.017_bib173","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/385442a0","article-title":"Crosstalk between G proteins and protein kinase C mediated by the calcium channel \u03b11 subunit","volume":"385","author":"Zamponi","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.017_bib174","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuron.2018.03.017_bib175","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/14721","article-title":"Reciprocal regulation of P\/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin","volume":"2","author":"Zhong","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.017_bib176","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0197-62","article-title":"Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel","volume":"15","author":"Zhuchenko","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuron.2018.03.017_bib177","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.physiol.64.092501.114547","article-title":"Short-term synaptic plasticity","volume":"64","author":"Zucker","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neuron.2018.03.017_bib178","doi-asserted-by":"crossref","first-page":"21121","DOI":"10.1074\/jbc.M002986200","article-title":"Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the \u03b11C subunit","volume":"275","author":"Z\u00fchlke","year":"2000","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896627318301946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T11:43:04Z","timestamp":1661082184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627318301946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":180,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0896627318301946"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.03.017","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}