{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:09:23Z","timestamp":1789938563827,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology (MOST), Taiwan","doi-asserted-by":"crossref","award":["MOST 103-2320-B-002-050-MY3"],"award-info":[{"award-number":["MOST 103-2320-B-002-050-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology (MOST), Taiwan","doi-asserted-by":"crossref","award":["MOST 106-2320-B-002-051-MY3"],"award-info":[{"award-number":["MOST 106-2320-B-002-051-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology (MOST), Taiwan","doi-asserted-by":"crossref","award":["MOST 105-2311-B-002-039"],"award-info":[{"award-number":["MOST 105-2311-B-002-039"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"MOST","doi-asserted-by":"crossref","award":["106-2745-B-001-001-ASP"],"award-info":[{"award-number":["106-2745-B-001-001-ASP"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.neuron.2018.03.031","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T16:10:40Z","timestamp":1524067840000},"page":"320-334.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14\/Wntless"],"prefix":"10.1016","volume":"98","author":[{"given":"Chien-Po","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ting","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Liang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.03.031_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2006.02.049","article-title":"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells","volume":"125","author":"B\u00e4nziger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/dneu.22427","article-title":"The neurotrophin receptor signaling endosome: Where trafficking meets signaling","volume":"77","author":"Barford","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.neuron.2018.03.031_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2006.04.009","article-title":"Secretion of Wnt ligands requires Evi, a conserved transmembrane protein","volume":"125","author":"Bartscherer","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.devcel.2007.12.003","article-title":"The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network","volume":"14","author":"Belenkaya","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.201502062","article-title":"Cytoskeletal dynamics: a view from the membrane","volume":"209","author":"Bezanilla","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib6","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1523\/JNEUROSCI.1445-09.2009","article-title":"Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons","volume":"29","author":"Bodmer","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.neuron.2018.03.031_bib8","doi-asserted-by":"crossref","first-page":"e1006720","DOI":"10.1371\/journal.pgen.1006720","article-title":"A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling","volume":"13","author":"Chen","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2018.03.031_bib9","doi-asserted-by":"crossref","first-page":"a020669","DOI":"10.1101\/cshperspect.a020669","article-title":"Neuronal signaling through endocytosis","volume":"6","author":"Cosker","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2013.08.059","article-title":"An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis","volume":"155","author":"Dong","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ncb1678","article-title":"Wingless secretion requires endosome-to-Golgi retrieval of Wntless\/Evi\/Sprinter by the retromer complex","volume":"10","author":"Franch-Marro","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.neuron.2014.01.009","article-title":"Dendrite self-avoidance requires cell-autonomous slit\/robo signaling in cerebellar purkinje cells","volume":"81","author":"Gibson","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1534\/genetics.112.145540","article-title":"Actin and endocytosis in budding yeast","volume":"199","author":"Goode","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.neuron.2018.03.031_bib14","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1242\/dev.02674","article-title":"Sprinter: a novel transmembrane protein required for Wg secretion and signaling","volume":"133","author":"Goodman","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.03.031_bib15","doi-asserted-by":"crossref","first-page":"a001750","DOI":"10.1101\/cshperspect.a001750","article-title":"Self-avoidance and tiling: mechanisms of dendrite and axon spacing","volume":"2","author":"Grueber","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib16","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.1106386108","article-title":"Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila","volume":"108","author":"Han","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuron.2018.03.031_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.devcel.2006.01.013","article-title":"Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans","volume":"10","author":"Hilliard","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuron.2007.04.013","article-title":"Homophilic Dscam interactions control complex dendrite morphogenesis","volume":"54","author":"Hughes","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2011.10.033","article-title":"Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in Drosophila sensory neurons","volume":"73","author":"Kim","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fncel.2017.00147","article-title":"Dendritic actin cytoskeleton: structure, functions, and regulations","volume":"11","author":"Konietzny","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2009.07.051","article-title":"Trans-synaptic transmission of vesicular Wnt signals through Evi\/Wntless","volume":"139","author":"Korkut","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib22","doi-asserted-by":"crossref","first-page":"e08964","DOI":"10.7554\/eLife.08964","article-title":"Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function","volume":"4","author":"Kostadinov","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.neuron.2018.03.031_bib23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0896-6273(02)00860-7","article-title":"WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons","volume":"35","author":"Krylova","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11305","article-title":"Protocadherins mediate dendritic self-avoidance in the mammalian nervous system","volume":"488","author":"Lefebvre","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.03.031_bib26","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1242\/dev.040220","article-title":"Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila","volume":"136","author":"Long","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.03.031_bib27","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1101\/gad.16531611","article-title":"The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons","volume":"25","author":"Matsubara","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuron.2018.03.031_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2007.04.013","article-title":"Dendrite self-avoidance is controlled by Dscam","volume":"129","author":"Matthews","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib29","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.neuron.2018.03.031_bib30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tins.2016.07.003","article-title":"Captivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells","volume":"39","author":"Meunier","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib31","doi-asserted-by":"crossref","first-page":"e1002513","DOI":"10.1371\/journal.pgen.1002513","article-title":"The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena\/VASP to regulate growth cone dynamics during axon guidance","volume":"8","author":"Mohamed","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neuron.2018.03.031_bib32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.devcel.2006.02.010","article-title":"Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans","volume":"10","author":"Pan","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.devcel.2007.12.001","article-title":"C.\u00a0elegans AP-2 and retromer control Wnt signaling by regulating mig-14\/Wntless","volume":"14","author":"Pan","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ncb1687","article-title":"Wingless secretion promotes and requires retromer-dependent cycling of Wntless","volume":"10","author":"Port","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib35","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1242\/dev.02357","article-title":"Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans","volume":"133","author":"Prasad","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.neuron.2018.03.031_bib36","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1523\/JNEUROSCI.2320-08.2008","article-title":"Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli","volume":"28","author":"Purro","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nmeth.1220","article-title":"Lifeact: a versatile marker to visualize F-actin","volume":"5","author":"Riedl","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuron.2018.03.031_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/86006","article-title":"How do dendrites take their shape?","volume":"4","author":"Scott","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib39","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1038\/srep04415","article-title":"An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size","volume":"4","author":"Shimono","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuron.2018.03.031_bib40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ydbio.2010.05.502","article-title":"Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans","volume":"345","author":"Smith","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib41","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn.3065","article-title":"Netrin (UNC-6) mediates dendritic self-avoidance","volume":"15","author":"Smith","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.03.031_bib42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0092-8674(89)90293-6","article-title":"Fasciclin III: a novel homophilic adhesion molecule in Drosophila","volume":"59","author":"Snow","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuron.2007.03.029","article-title":"Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization","volume":"54","author":"Soba","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.03.031_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: connecting the membrane to the cytoskeleton","volume":"8","author":"Takenawa","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuron.2018.03.031_bib45","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/jnc.12676","article-title":"Rab-mediated trafficking role in neurite formation","volume":"129","author":"Villarroel-Campos","year":"2014","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuron.2018.03.031_bib46","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1534\/genetics.103.025676","article-title":"Caenorhabditis elegans WASP and Ena\/VASP proteins play compensatory roles in morphogenesis and neuronal cell migration","volume":"167","author":"Withee","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.neuron.2018.03.031_bib47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.devcel.2007.12.004","article-title":"Wnt signaling requires retromer-dependent recycling of MIG-14\/Wntless in Wnt-producing cells","volume":"14","author":"Yang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.devcel.2014.03.016","article-title":"WLS retrograde transport to the endoplasmic reticulum during Wnt secretion","volume":"29","author":"Yu","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neuron.2018.03.031_bib49","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1534\/genetics.108.090290","article-title":"Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development","volume":"179","author":"Zinovyeva","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.neuron.2018.03.031_bib50","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/372270a0","article-title":"Operons as a common form of chromosomal organization in C. elegans","volume":"372","author":"Zorio","year":"1994","journal-title":"Nature"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662731830237X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662731830237X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T17:54:27Z","timestamp":1668707667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089662731830237X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S089662731830237X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.03.031","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14\/Wntless","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}