{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:10:19Z","timestamp":1790647819679,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS87988"],"award-info":[{"award-number":["NS87988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM11401"],"award-info":[{"award-number":["R01GM11401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE22743"],"award-info":[{"award-number":["DE22743"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM064803"],"award-info":[{"award-number":["R01GM064803"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE17794"],"award-info":[{"award-number":["DE17794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuron"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neuron.2018.06.039","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T22:55:41Z","timestamp":1532040941000},"page":"449-463.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus"],"prefix":"10.1016","volume":"99","author":[{"given":"Qingjian","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Convertino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nackley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay V.","family":"Dokholyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Rong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuron.2018.06.039_bib1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI64551","article-title":"The TGR5 receptor mediates bile acid-induced itch and analgesia","volume":"123","author":"Alemi","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2018.06.039_bib2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12264-017-0139-9","article-title":"Investigation of pain mechanisms by calcium imaging approaches","volume":"34","author":"Anderson","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2018.06.039_bib3","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/nn.2643","article-title":"Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing","volume":"13","author":"Andrade","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.06.039_bib5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.06.039_bib6","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.bbamem.2010.12.024","article-title":"The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings","volume":"1808","author":"Bobkov","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuron.2018.06.039_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.aac8653","article-title":"Gate control of mechanical itch by a subpopulation of spinal cord interneurons","volume":"350","author":"Bourane","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.06.039_bib8","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1182\/blood-2008-10-184168","article-title":"Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases","volume":"113","author":"Bradford","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.neuron.2018.06.039_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12264-017-0132-3","article-title":"Expression and role of voltage-gated sodium channels in human dorsal root ganglion neurons with special focus on Nav1.7, species differences, and regulation by paclitaxel","volume":"34","author":"Chang","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2018.06.039_bib10","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.neuron.2018.06.039_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuron.2018.06.039_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1359-0278(98)00072-8","article-title":"Discrete molecular dynamics studies of the folding of a protein-like model","volume":"3","author":"Dokholyan","year":"1998","journal-title":"Fold. Des."},{"key":"10.1016\/j.neuron.2018.06.039_bib13","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s13555-016-0143-4","article-title":"Pruritus reduction with systemic anti-lymphoma treatments in patients with cutaneous T\u00a0cell lymphoma: a narrative review","volume":"6","author":"Field","year":"2016","journal-title":"Dermatol. Ther. (Heidelb.)"},{"key":"10.1016\/j.neuron.2018.06.039_bib14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nn.3289","article-title":"A subpopulation of nociceptors specifically linked to itch","volume":"16","author":"Han","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib15","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.neuron.2016.11.007","article-title":"SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons","volume":"92","author":"Han","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2018.06.039_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41593-018-0119-z","article-title":"Circuit dissection of the role of somatostatin in itch and pain","volume":"21","author":"Huang","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12264-018-0204-z","article-title":"Recent progress in understanding the mechanisms of pain and itch: the second special issue","volume":"34","author":"Ji","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuron.2018.06.039_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd4334","article-title":"Emerging targets in neuroinflammation-driven chronic pain","volume":"13","author":"Ji","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuron.2018.06.039_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bpj.2009.11.007","article-title":"Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1","volume":"98","author":"Karashima","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuron.2018.06.039_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","article-title":"Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord","volume":"82","author":"Kardon","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib22","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1113\/JP273961","article-title":"Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1\/TRPV1","volume":"595","author":"Kittaka","year":"2017","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.neuron.2018.06.039_bib23","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/bioinformatics\/btr374","article-title":"Gaia: automated quality assessment of protein structure models","volume":"27","author":"Kota","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2018.06.039_bib24","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1093\/bioinformatics\/btv221","article-title":"iFoldRNA v2: folding RNA with constraints","volume":"31","author":"Krokhotin","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2018.06.039_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrn3641","article-title":"Sensory neurons and circuits mediating itch","volume":"15","author":"LaMotte","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nn.3113","article-title":"An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration","volume":"15","author":"Lehmann","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.06.039_bib28","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/nn.2683","article-title":"Toll-like receptor 7 mediates pruritus","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib29","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.13-229948","article-title":"TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis","volume":"27","author":"Liu","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.neuron.2018.06.039_bib30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/j.pain.0000000000000439","article-title":"Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice","volume":"157","author":"Liu","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2018.06.039_bib31","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1172\/JCI43426","article-title":"Labeled lines meet and talk: population coding of somatic sensations","volume":"120","author":"Ma","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neuron.2018.06.039_bib32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.06.039_bib33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0166-2236(92)90102-E","article-title":"Itching for an explanation","volume":"15","author":"McMahon","year":"1992","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-genet-120116-024723","article-title":"Mas-related G protein-coupled receptors and the biology of itch sensation","volume":"51","author":"Meixiong","year":"2017","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.neuron.2018.06.039_bib35","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.06.039_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuron.2015.05.044","article-title":"HTR7 mediates serotonergic acute and chronic itch","volume":"87","author":"Morita","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuron.2014.02.011","article-title":"Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1","volume":"82","author":"Park","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrd2757","article-title":"Transient receptor potential channels: targeting pain at the source","volume":"8","author":"Patapoutian","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neuron.2018.06.039_bib39","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature14367","article-title":"Structure of the TRPA1 ion channel suggests regulatory mechanisms","volume":"520","author":"Paulsen","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.06.039_bib40","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1007\/s12035-015-9281-4","article-title":"Circulating microRNA signatures in rodent models of pain","volume":"53","author":"Qureshi","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuron.2018.06.039_bib41","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1182\/blood-2011-06-358382","article-title":"Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)","volume":"118","author":"Ralfkiaer","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.neuron.2018.06.039_bib42","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nn.3404","article-title":"Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons","volume":"16","author":"Roberson","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib43","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.conb.2011.10.012","article-title":"Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease","volume":"21","author":"Ross","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuron.2018.06.039_bib44","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2010.02.025","article-title":"Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice","volume":"65","author":"Ross","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib45","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/jid.2014.487","article-title":"MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma","volume":"135","author":"Sandoval","year":"2015","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.neuron.2018.06.039_bib46","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1093\/bioinformatics\/btl460","article-title":"iFold: a platform for interactive folding simulations of proteins","volume":"22","author":"Sharma","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuron.2018.06.039_bib47","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","article-title":"Behavioral differentiation between itch and pain in mouse","volume":"139","author":"Shimada","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuron.2018.06.039_bib48","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/jp2114576","article-title":"Discrete molecular dynamics: an efficient and versatile simulation method for fine protein characterization","volume":"116","author":"Shirvanyants","year":"2012","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.neuron.2018.06.039_bib49","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.06.039_bib50","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuron.2018.06.039_bib51","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1174868","article-title":"Cellular basis of itch sensation","volume":"325","author":"Sun","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuron.2018.06.039_bib52","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.neuron.2017.01.012","article-title":"Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord","volume":"93","author":"Sun","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuron.2018.06.039_bib53","doi-asserted-by":"crossref","first-page":"32691","DOI":"10.1074\/jbc.M803568200","article-title":"The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions","volume":"283","author":"Wang","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuron.2018.06.039_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-0366-5_1","article-title":"Protein structure modeling with MODELLER","volume":"1137","author":"Webb","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuron.2018.06.039_bib55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib56","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1523\/JNEUROSCI.5318-12.2013","article-title":"The ion channel TRPA1 is required for chronic itch","volume":"33","author":"Wilson","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuron.2018.06.039_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuron.2018.06.039_bib58","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/nm.3978","article-title":"Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade","volume":"21","author":"Xu","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuron.2018.06.039_bib59","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMcp1208814","article-title":"Clinical practice. chronic pruritus","volume":"368","author":"Yosipovitch","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuron.2018.06.039_bib60","doi-asserted-by":"crossref","first-page":"14931","DOI":"10.1073\/pnas.201543998","article-title":"The free energy landscape for beta hairpin folding in explicit water","volume":"98","author":"Zhou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662731830535X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089662731830535X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:12:53Z","timestamp":1760253173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089662731830535X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S089662731830535X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuron.2018.06.039","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus","name":"articletitle","label":"Article Title"},{"value":"Neuron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuron.2018.06.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}